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Chemical Structure| 932-17-2 Chemical Structure| 932-17-2

Structure of 932-17-2

Chemical Structure| 932-17-2

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Product Details of [ 932-17-2 ]

CAS No. :932-17-2
Formula : C6H9NO2
M.W : 127.14
SMILES Code : O=C1N(C(C)=O)CCC1
MDL No. :MFCD00014101
InChI Key :YLHUPYSUKYAIBW-UHFFFAOYSA-N
Pubchem ID :70266

Safety of [ 932-17-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 932-17-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 932-17-2 ]

[ 932-17-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 159981-19-8 ]
  • [ 932-17-2 ]
  • 3-[1-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]meth-(E)-ylidene]pyrrolidin-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
To a suspension of NaH (2.0 g) in THF (100 mL) was added a mixture of 1-acetyl-pyrrolidin-2-one (1.6 g), <strong>[159981-19-8]6-(2,2,2-trifluoro-ethoxy)-pyridine-3-carbaldehyde</strong> (2.6 g) and THF (5 mL) dropwise at ice-bath temperature. After the addition was complete, the reaction mixture was stirred for 10 min at ice-bath temperature. Acetic acid (5 mL) was slowly added dropwise to destroy the excess NaH. The reaction mixture was poured into ice-water and extracted with EA (100 mL*2). The combined organic layers were dried over Na2SO4, filtered and concentrated. The residue was purified by SGC (DCM/MeOH=20:1) to provide 3-[1-[6-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-meth-(E)-ylidene]-pyrrolidin-2-one. MS ESI+: m/z=273 [M+H]+.
 

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[ 932-17-2 ]

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