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Chemical Structure| 93071-75-1 Chemical Structure| 93071-75-1

Structure of 93071-75-1

Chemical Structure| 93071-75-1

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Product Details of [ 93071-75-1 ]

CAS No. :93071-75-1
Formula : C8H8F3NO
M.W : 191.15
SMILES Code : NCC1=CC=CC(OC(F)(F)F)=C1
MDL No. :MFCD00061267
Boiling Point : No data available
InChI Key :TUPUHSXMDIWJQT-UHFFFAOYSA-N
Pubchem ID :145264

Safety of [ 93071-75-1 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:2735
Packing Group:

Application In Synthesis of [ 93071-75-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 93071-75-1 ]

[ 93071-75-1 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 1031335-25-7 ]
  • [ 93071-75-1 ]
  • C18H25F3N2O3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
A slurry of 5 (6.45 g, 32.2 mmol) and NaBH(OAc)3 (10.92 g, 51.5 mmol) in dichloroethane (150 mL) was stirred 15 min. then treated with m-trifluoro- methoxybenzaldehyde (4.6 mL, 32.2 mmol) and additional dichloroethane (60 mL). After 4 h the reaction was quenched with water, the layers were separated and the aqueous layer was extracted with dichloromethane (2x). The combined organic layer was washed with brine and filtered through a cotton plug. Some solids were dissolved and rinsed through with sat. ammonia CHCI3 and solution was concentrated to an oil. Trituration provided 3.08 g of 6 as white solids and the filtrate was concentrated to 10.37 g of a yellow oil.
  • 2
  • [ 41716-18-1 ]
  • [ 93071-75-1 ]
  • 1-methyl-N-[3-(trifluoromethoxy)phenyl]methyl}-1H imidazole-4-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
98% With 1-hydroxy-1H-benzotriazol hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20℃; To a solution of 1-methyl-1Himidazole-4-carboxylic acid (0.50 g, 4.0 mmol), 1-hydroxybenztriazole monohydrate (0.74 g, 4.8 mmol), and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (0.92 g, 4.8 mmol) in acetonitrile (10 mL) was added a solution of 3-(trifluoromethoxy) benzylamine 8(0.84 g, 4.4 mmol) in acetonitrile (10 mL), and the mixture was stirred at room temperature for overnight. The reaction mixture was concentrated in vacuo, and saturated aqueous NaHCO3solution was added to the residue. After extraction with ethyl acetate, the organic layer was dried over anhydrous MgSO4, filtered, and concentrated in vacuo. The residue was purified using silica gel column chromatography (0?10percent MeOH in CHCl3) to obtain 9(1.18 g, 98percent) as a colorless powder.1H-NMR (600 MHz, CDCl3) delta: 3.73 (3 H, s), 4.62 (2 H, d, J=6.0 Hz), 7.08?7.13 (1 H, m), 7.18 (1 H, s), 7.26?7.29 (1 H, m), 7.31?7.37 (2 H, m), 7.44?7.51 (1 H, m), 7.55 (1 H, d, J=1.4 Hz); MS ESI: m/z300 [M+H]+.
  • 3
  • [ 4385-76-6 ]
  • [ 93071-75-1 ]
  • 4-(pyridin-4-yl)-N-(3-(trifluoromethoxy)benzyl)benzamide [ No CAS ]
 

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