1031335-25-7|(1S,3R)-3-Amino-1-(Boc-amino)cyclopentane| Ambeed

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Quality Control of [ 1031335-25-7 ] Purity: 98% SDS Specification

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Product Details of [ 1031335-25-7 ]

CAS No. :	1031335-25-7
Formula :	C₁₀H₂₀N₂O₂
M.W :	200.28
SMILES Code :	O=C(OC(C)(C)C)N[C@@H]1C[C@H](N)CC1
MDL No. :	MFCD22394009
InChI Key :	PGBVMVTUWHCOHX-SFYZADRCSA-N
Pubchem ID :	51776940

Safety of [ 1031335-25-7 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of [ 1031335-25-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 1031335-25-7 ]

[ 1031335-25-7 ] Synthesis Path-Downstream 1~13

1
[ 24424-99-5 ]
[ 1031335-25-7 ]

Yield	Reaction Conditions	Operation in experiment
	In methanol; sodium hydroxide;	(8) cis-3-amino-1-(tert.-butyloxycarbonylamino)-cyclopentane Carried out with di-tert.butyl pyrocarbonate in the presence of 1N sodium hydroxide solution in methanol. Rf value: 0.63 (silica gel, methylene chloride/methanol/conc. aqueous ammonia=40:10:1) Mass spectrum (ESI+): m/z=201 [M+H]+

References: [1]Patent: US2002/198205,2002,A1 .

2
[ 1031335-25-7 ]
[ 93071-75-1 ]
C₁₈H₂₅F₃N₂O₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		A slurry of 5 (6.45 g, 32.2 mmol) and NaBH(OAc)3 (10.92 g, 51.5 mmol) in dichloroethane (150 mL) was stirred 15 min. then treated with m-trifluoro- methoxybenzaldehyde (4.6 mL, 32.2 mmol) and additional dichloroethane (60 mL). After 4 h the reaction was quenched with water, the layers were separated and the aqueous layer was extracted with dichloromethane (2x). The combined organic layer was washed with brine and filtered through a cotton plug. Some solids were dissolved and rinsed through with sat. ammonia CHCI3 and solution was concentrated to an oil. Trituration provided 3.08 g of 6 as white solids and the filtrate was concentrated to 10.37 g of a yellow oil.

References: [1]Patent: WO2008/65500,2008,A2 .Location in patent: Page/Page column 67; 68.

3
C₁₀H₁₈N₂O₂ [ No CAS ]
[ 1031335-25-7 ]

Yield	Reaction Conditions	Operation in experiment
88.1%	With hydrogen;nickel; In methanol; water; at 20 - 60℃; for 24h;	A mixture of 4 (48 g, 242 mmol) and Raney Ni 2800 (slurry in water, 30 g) in 400 mL of methanol was sealed under H2 (180 psi) at rt. The mixture then was heated to 60 0C and stirred at 60 C for 24 h. After cooling to rt, the mixture was filtered. The filtrate was concentrated to give a light yellow oil. Chromatography on Biotage 75 with 10% MeOH/DCM (0.5% NH4OH) gave 42.7 g (88.1 %) of 5 as waxy solid.

References: [1]Patent: WO2008/65500,2008,A2 .Location in patent: Page/Page column 67; 68.

4
[ 1031335-25-7 ]
methyl 4-[[(3R)-3-(tert-butoxycarbonylamino)cyclopentyl]amino]-3-iodo-benzoate [ No CAS ]