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Chemical Structure| 926922-28-3 Chemical Structure| 926922-28-3

Structure of 926922-28-3

Chemical Structure| 926922-28-3

2-Chloro-3-iodo-4-methylpyridine

CAS No.: 926922-28-3

4.5 *For Research Use Only !

Cat. No.: A442340 Purity: 95%

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Product Details of [ 926922-28-3 ]

CAS No. :926922-28-3
Formula : C6H5ClIN
M.W : 253.47
SMILES Code : CC1=C(I)C(Cl)=NC=C1
MDL No. :MFCD11878566
InChI Key :ZWXCPWVRUTYWCA-UHFFFAOYSA-N
Pubchem ID :45108207

Safety of [ 926922-28-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P280-P305+P351+P338-P310

Application In Synthesis of [ 926922-28-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 926922-28-3 ]

[ 926922-28-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 133627-45-9 ]
  • [ 926922-28-3 ]
YieldReaction ConditionsOperation in experiment
47% A mixture of <strong>[133627-45-9]2-chloro-4-methylpyridin-3-amine</strong> (1.0 g, 7.0 mmol) and concentrated hydrochloric acid (4.4 mL) was cooled to 0 C and a solution of sodium nitrite (0.5 g, 7.5 mmol) in water (8 mL) was added dropwise. The mixture was stirred for 1 hour at 0 C and then was added dropwise to a stirred solution of potassium iodide (1.6 g, 9.6 mmol) in water (9 mL). The mixture was warmed to ambient temperature and stirred overnight. The mixture was extracted with diethyl ether and the organic phase was washed with aqueous sodium thiosulphate, brine, dried (MgSO4) and evaporated in vacuo. The crude product was recrystallized from hexane to give the title compound (0.88 g, 47%) as a white solid. LRMS (m/z): 254 (M+1)+. 1H-NMR delta (CDCl3): 2.50 (s, 3H), 7.05 (d, J=4.9 Hz, 1 H), 8.15 (d, J=4.9 Hz, 1 H).
A) 2-Chloro-3-iodo-4-methylpyridine; <strong>[133627-45-9]2-Chloro-3-amino-4-methylpyridine</strong> (2.0 g, 14.6 mmol) ) in concentrated HCI (8.8 mL) was coooled to 0 0C. A solution of sodium nitrite(1.03 g, 15.02 mmol) in water (17.6 mL) was added and the mix. was stirred at 0 0C for 1 h. This mixture was added dropwise to a solution of Kl (3.2 g, 18.9 mmol) in water (17.6 mL) at 0 0C. The reaction mix was allowed to warm to rt. This was stirred at this temp, for 12 h. The mixture was extracted with ether (3X15OmL). The combined extracts were washed with saturated aq. sodium chloride, dried (Na2SO4) and concentrated in vacuo. Recrystallized from Hexane/ethyl acetate and used as such in the next step.
 

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[ 926922-28-3 ]

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