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Chemical Structure| 59782-91-1 Chemical Structure| 59782-91-1

Structure of 59782-91-1

Chemical Structure| 59782-91-1

2-Chloro-3-iodo-5-methylpyridine

CAS No.: 59782-91-1

4.5 *For Research Use Only !

Cat. No.: A381589 Purity: 98%

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Product Details of [ 59782-91-1 ]

CAS No. :59782-91-1
Formula : C6H5ClIN
M.W : 253.47
SMILES Code : CC1=CN=C(Cl)C(I)=C1
MDL No. :MFCD09839273
InChI Key :RBZFLTOFXAWOOQ-UHFFFAOYSA-N
Pubchem ID :29919374

Safety of [ 59782-91-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H319
Precautionary Statements:P305+P351+P338

Application In Synthesis of [ 59782-91-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 59782-91-1 ]

[ 59782-91-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 211308-79-1 ]
  • [ 59782-91-1 ]
YieldReaction ConditionsOperation in experiment
72% With hydrogenchloride; sodium nitrite; In water; at -10 - 20℃; for 2.33333h; From compound 19: To a solution of <strong>[211308-79-1]2-amino-3-iodo-5-methylpyridine</strong> (19) (115 mg, 0.49 mmol) in a concentrated aqueous hydrochloric acid solution (37%, w/w, 2.5 mL), was added portionwise at -10 C, sodium nitrite (54 mg, 0.79 mmol). The reaction was stirred at 0 C for 20 min, then at room temperature for 2 h. The reaction was quenched at 0 C by a slow addition of a 6 N aqueous sodium hydroxide solution until pH = 11. After extraction with dichloromethane (3 x 20 mL), the combined organic layers were dried over magnesium sulfate, filtered and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel (ethyl acetate/cyclohexane, 2/8, v/v) to give 2-chloro-3-iodo-5-methylpyridine (20) (89 mg, 0.35 mmol) as a yellow solid. Yield 72%.
 

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[ 59782-91-1 ]

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