92289-14-0|3-(4-Nitrophenyl)pentanedioic acid| Ambeed

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Quality Control of [ 92289-14-0 ] Purity: 95% SDS Specification

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Product Details of [ 92289-14-0 ]

CAS No. :	92289-14-0
Formula :	C₁₁H₁₁NO₆
M.W :	253.21
SMILES Code :	O=C(O)CC(C1=CC=C([N+]([O-])=O)C=C1)CC(O)=O
MDL No. :	MFCD11110458
InChI Key :	YNPLFNKGJKRZNX-UHFFFAOYSA-N
Pubchem ID :	18404630

Safety of [ 92289-14-0 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of [ 92289-14-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 92289-14-0 ]

[ 92289-14-0 ] Synthesis Path-Downstream 1~35

1
[ 92289-14-0 ]
[ 53911-69-6 ]

Yield	Reaction Conditions	Operation in experiment
70%	With acetic anhydride; at 80℃; for 1h;	b) 4-(4-Nitro-phenyl)-dihydro-pyran-2,6-dione A flask was charged with 20.0 g (79.0 mmol) of 3-(4-nitro-phenyl)-pentanedioic acid (as prepared in the previous step) and 22.4 mL (237 mmol) of acetic anhydride. The mixture was heated to 80 C. for 1 h, cooled to RT, and treated slowly with ether until the product began to precipitate. After allowing the solid to fully precipitate, the solid was filtered, washed with ether, and air-dried to afford 13.0 g (70%) of the title compound as an off-white solid: 1H-NMR (CDCl3; 400 MHz): δ 8.28 (d, 2H, J=8.8 Hz), 7.41 (d, 2H, J=8.8 Hz), 3.64-3.53 (m, 1H), 3.22-3.13 (m, 2H), 2.96-2.85 (m, 2H).

References: [1]Patent: US2007/249593,2007,A1 .Location in patent: Page/Page column 26.
[2]American Chemical Journal,1902,vol. 28,p. 57.

2
[ 92289-14-0 ]
[ 120066-99-1 ]

References: [1]Chemische Berichte,1902,vol. 35,p. 2074.
Chemische Berichte,1903,vol. 36,p. 2670.
[2]Chemische Berichte,1902,vol. 35,p. 2074.
Chemische Berichte,1903,vol. 36,p. 2670.

3
[ 92289-14-0 ]
3-(2,4-dinitro-phenyl)-glutaric acid [ No CAS ]

References: [1]Chemische Berichte,1902,vol. 35,p. 2074.
Chemische Berichte,1903,vol. 36,p. 2670.

4
[ 64-17-5 ]
[ 53911-69-6 ]
[ 92289-14-0 ]

References: [1]American Chemical Journal,1902,vol. 28,p. 57.

5
[ 126989-14-8 ]
[ 92289-14-0 ]

Yield	Reaction Conditions	Operation in experiment
88%	With hydrogenchloride; water; at 100℃; for 22h;Product distribution / selectivity;	g) 3-(4-Nitro-phenyl)-pentanedioic acid A suspension of 7.32 g (16.1 mmol) of 2,4-bis-ethoxycarbonyl-3-(4-nitro-phenyl)-pentanedioic acid diethyl ester (as prepared in the previous step) in concentrated HCl (15 mL) was heated to 100 C. for 22 h. The mixture was cooled to RT, and the resulting precipitate was filtered, washed with cold water, and air-dried to afford 3.58 g (88%) of the title compound as an off-white solid: 1H-NMR (CD3OD; 400 MHz): δ 8.12 (d, 2H, J=8.8 Hz), 7.58 (d, 2H, J=8.8 Hz), 3.77-3.68 (m, 1H), 2.87-2.66 (m, 4H).

References: [1]Patent: US2007/249593,2007,A1 .Location in patent: Page/Page column 24.
[2]Journal fur praktische Chemie (Leipzig 1954),1907,vol. <2> 75,p. 508.

6
[ 555-16-8 ]
[ 105-53-3 ]
[ 92289-14-0 ]

References: [1]Journal of the Indian Chemical Society,1931,vol. 8,p. 37,42.

8
1-methyl-3-<4-nitro-phenyl>-cyclohexanol-(1)-one-(5)-dicarboxylic acid-(2.4)-diethyl ester [ No CAS ]
[ 92289-14-0 ]

References: [1]Justus Liebigs Annalen der Chemie,1902,vol. 323,p. 103.

9
4-hydroxy-6-oxo-4-methyl-2-<4-nitro-phenyl>-cyclohexane-dicarboxylic acid-(1.3)-diethyl ester [ No CAS ]
[ 92289-14-0 ]

References: [1]Journal of the Chemical Society,1949,p. 3177,3179.

10
[ 92289-14-0 ]
[ 7783-06-4 ]
[ 7664-41-7 ]
[ 120066-99-1 ]

References: [1]Chemische Berichte,1902,vol. 35,p. 2074.
Chemische Berichte,1903,vol. 36,p. 2670.

11
[ 92289-14-0 ]
hydrogen trichloro-stannate(II) [ No CAS ]
[ 120066-99-1 ]

References: [1]Chemische Berichte,1902,vol. 35,p. 2074.
Chemische Berichte,1903,vol. 36,p. 2670.

12
[ 92289-14-0 ]
[ 7664-93-9 ]
[ 7697-37-2 ]
3-(2,4-dinitro-phenyl)-glutaric acid [ No CAS ]

References: [1]Chemische Berichte,1902,vol. 35,p. 2074.
Chemische Berichte,1903,vol. 36,p. 2670.

13
[ 7647-01-0 ]
[ 126989-14-8 ]
[ 92289-14-0 ]

References: [1]Journal fur praktische Chemie (Leipzig 1954),1907,vol. <2> 75,p. 508.

14
[ 93711-15-0 ]
diluted KOH-solution [ No CAS ]
[ 92289-14-0 ]

References: [1]Justus Liebigs Annalen der Chemie,1898,vol. 303,p. 238.

15
[ 92289-14-0 ]
[ 57-13-6 ]
[ 954124-21-1 ]

Yield	Reaction Conditions	Operation in experiment
61%	at 160℃; for 1h;	General procedure: 3-Phenylpentanedioic acid (5) (5.00 g, 24.01 mmol) and urea (3.60 g, 59.94 mmol) were mixed and heated at 160 C for 1 h. After being cooled, the reaction mixture was poured into water (20 mL). The solid was filtered off, washed with water and dried. Recrystallization from toluene gave 9 (3.26 g, 72%) as a white powder: mp 173-174 C; IR (KBr) cm-1 3184 (NH), 1734, 1686 (CO); 1H NMR (DMSO-d6) δ 10.86 (br s, 1H, NH which exchanges with D2O), 7.42-7.18 (m, 5H, aromatic), 3.50-3.35 (m, 1H, CH), 2.90-2.43 (m, 4H, CH2). Anal. (C11H11NO2) calcd: C 69.83, H 5.86, N 7.40; found: C 69.71, H 5.83, N 7.29.
22%	at 150℃; for 0.666667h;Product distribution / selectivity;	h) 4-(4-Nitro-phenyl)-piperidine-2,6-dione A mixture of 250 mg (0.987 mmol) of 3-(4-nitro-phenyl)-pentanedioic acid (as prepared in the previous step) and 119 mg (1.98 mmol) of urea was heated to 150 C. for 40 min (until all solid melted and gas evolution stopped). The mixture was cooled to RT, taken up in EtOAc (70 mL), washed with saturated aqueous NaHCO3 (2*40 mL), dried (MgSO4), and concentrated in vacuo to afford 52.0 mg (22%) of the title compound as a brown solid: 1H-NMR (CDCl3; 400 MHz): δ 8.28 (d, 2H, J=8.8 Hz), 7.44 (d, 2H, J=8.8 Hz), 3.64-3.54 (m, 1H), 3.04-2.96 (m, 2H), 2.86-2.76 (m, 2H).

References: [1]European Journal of Medicinal Chemistry,2011,vol. 46,p. 2676 - 2690.
[2]Patent: US2007/249593,2007,A1 .Location in patent: Page/Page column 24.

16
[ 4165-96-2 ]
[ 92289-14-0 ]

Yield	Reaction Conditions	Operation in experiment
94%		a) 3-(4-Nitro-phenyl)-pentanedioic acid A flask charged with concentrated H2SO4 (400 mL) was cooled to 0 C. and treated with 50.0 g (240 mmol) of 3-phenyl-pentanedioic acid portionwise over 20 min and with fuming HNO3 (10 mL) dropwise over 20 min. The mixture was stirred at RT for 3 h, poured over ice (amount equivalent to 1000 mL), and the precipitate was filtered, washed with cold water, air-dried, and dried in a vacuum dessicator. The solid was triturated with a minimum amount of CH3CN, filtered, and air-dried. The filtrate was concentrated and triturated again with a minimum amount of CH3CN, filtered, and air-dried to afford a second batch. The two batches were combined to afford 56.9 g (94%) of the title compound as an off-white solid: 1H-NMR (DMSO-d6; 400 MHz): δ 8.15 (d, 2H, J=8.8 Hz), 7.58 (d, 2H, J=8.8 Hz), 3.62-3.50 (m, 1H), 2.79-2.57 (m, 4H).

References: [1]Patent: US2007/249593,2007,A1 .Location in patent: Page/Page column 26.

17
[ 92289-14-0 ]
[ 79-22-1 ]
[ 954124-21-1 ]

Yield	Reaction Conditions	Operation in experiment
43%		Alternatively, the title compound can be obtained in the following manner: A solution of 500 mg (1.97 mmol) of 3-(4-nitro-phenyl)-pentanedioic acid (as prepared in the previous step) in 50 mL dioxane was cooled to 10 C. and treated with 229 μL (2.96 mmol) of methyl chloroformate and 936 μL (6.71 mmol) of triethylamine for 7.2 h. A solution of 0.5 M ammonia in dioxane (15.8 mL, 7.90 mmol) was added at 10 C. and the mixture stirred at RT for 72 h. The mixture was filtered through Celite, the filter cake washed with EtOAc, and the solvents were evaporated in vacuo. The residue was treated with solid 1.30 g (15.8 mmol) of NaOAc and acetic anhydride (4 mL) and heated to 100 C. for 1 h. The mixture was cooled to RT and concentrated to half the original volume. The residue was taken up in EtOAc (100 mL), washed with saturated aqueous NaHCO3 (1×75 mL), brine (1×75 mL), and water (1×75 mL). The organic layer was dried (MgSO4) and concentrated in vacuo. Silica gel chromatography of the residue on a 50-g Varian MegaBond Elut SPE column with 50-60% EtOAc-hexane afforded 197 mg (43%) of the title compound as an off-white solid (see spectrum above).

References: [1]Patent: US2007/249593,2007,A1 .Location in patent: Page/Page column 24.

18
[ 1123-49-5 ]
[ 555-16-8 ]
[ 92289-14-0 ]

References: [1]Tetrahedron,2007,vol. 63,p. 9741 - 9745.

19
[ 92289-14-0 ]
(7-nitro-2-oxo-1,2,3,4-tetrahydro-[4]quinolyl)-acetic acid [ No CAS ]

References: [1]Chemische Berichte,1902,vol. 35,p. 2074.
Chemische Berichte,1903,vol. 36,p. 2670.

20
[ 92289-14-0 ]
3-(2,4-diamino-phenyl)-glutaric acid [ No CAS ]

References: [1]Chemische Berichte,1902,vol. 35,p. 2074.
Chemische Berichte,1903,vol. 36,p. 2670.

21
[ 64-17-5 ]
[ 92289-14-0 ]
diethyl 3-(4-nitro-phenyl)-glutarate [ No CAS ]

References: [1]Patent: US6344562,2002,B1 .Location in patent: Page column 76.

22
[ 159088-58-1 ]
[ 108-24-7 ]
[ 92289-14-0 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,p. 3925 - 3929.

23
[ 92289-14-0 ]
[ 954124-21-1 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,p. 3925 - 3929.

24
[ 92289-14-0 ]
[ 74-89-5 ]
[ 954124-90-4 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,p. 3925 - 3929.

25
[ 92289-14-0 ]
[ 1312808-99-3 ]

References: [1]European Journal of Medicinal Chemistry,2011,vol. 46,p. 2676 - 2690.

26
[ 92289-14-0 ]
[ 1312809-00-9 ]

References: [1]European Journal of Medicinal Chemistry,2011,vol. 46,p. 2676 - 2690.

27
[ 92289-14-0 ]
[ 1312809-17-8 ]

References: [1]European Journal of Medicinal Chemistry,2011,vol. 46,p. 2676 - 2690.

28
[ 92289-14-0 ]
[ 1312809-18-9 ]

References: [1]European Journal of Medicinal Chemistry,2011,vol. 46,p. 2676 - 2690.

29
[ 92289-14-0 ]
[ 1616787-08-6 ]

Yield	Reaction Conditions	Operation in experiment
100%	With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 3h;Inert atmosphere;	Step 1 In a round bottom flask purged with N2, containing 3-(4-Nitro-phenyl)-pentanedioic acid (45, 110 mg, 0.434 mmol) in 5 mL of anhydrous DCM was added Oxalyl Chloride (0.911 mmol, 0.082 mL). To this solution was added 1 drop of N,N-dimethylformamide. The reaction mixture was stirred for 3 hours and concentrated in vacuo to afford (46) as a white solid (125 mg, 0.434 mmol, quantitative). LCMS, taken in methanol: m/z 282.0 [M+H+, for bis methanolysis product].
	With tin(ll) chloride; In dichloromethane; at 20℃;Reflux;	SOCl2 (0.45mL, 6mmol) was added to a suspension of diacid 5 (0.506g, 2mmol) in dry CH2Cl2 (20mL) while stirring at room temperature. After 2h, the mixture was heated under reflux overnight. The solvent was removed under reduced pressure and the diacid chloride 6 was directly used in the next step without further purification.
	With thionyl chloride; In dichloromethane; at 20℃; for 2h;	SOCl2 (0.45 mL,6 mmol) was added to a suspension of diacid 5 (0.506 g, 2 mmol) in dry CH2Cl2 (20 mL) while stirring at room temperature. After 2 h, the mixture was heated under reflux overnight. The solvent was removed under reduced pressure and the diacid chloride 6 was directly used in the next step without further purification.

References: [1]Patent: US10086085,2018,B2 .Location in patent: Page/Page column 79-80.
[2]Tetrahedron,2014,vol. 70,p. 5064 - 5072.
[3]Tetrahedron,2014,vol. 70,p. 5064 - 5072.

30
[ 92289-14-0 ]
[ 1616787-10-0 ]

References: [1]Tetrahedron,2014,vol. 70,p. 5064 - 5072.
[2]Tetrahedron,2014,vol. 70,p. 5064 - 5072.

31
[ 92289-14-0 ]
[ 1616787-11-1 ]

References: [1]Tetrahedron,2014,vol. 70,p. 5064 - 5072.
[2]Tetrahedron,2014,vol. 70,p. 5064 - 5072.

32
[ 92289-14-0 ]
[ 1616787-07-5 ]

References: [1]Tetrahedron,2014,vol. 70,p. 5064 - 5072.

33
[ 340265-92-1 ]
[ 92289-14-0 ]

Yield	Reaction Conditions	Operation in experiment
60%	With sodium hydroxide; In water; for 3h;Reflux;	Compound 4 (45 mmol) was dissolved in a mixture of distilled water (67.5 mL) and sodium hydroxide (67.5 g). The resulting mixture was refluxed vigorously for 3 h, and then cooled to room temperature and poured into water (340 mL). The resulting mixture was extracted with ether (2x100 mL). The water phase was acidified with concentrated hydrochloric acid (190 mL). The precipitated glutaric acid was removed by filtration and washed with cold water to remove sodium chloride. The acid was recrystallized from water and dried in vacuum to give a pale brown solid (6.84 g), 60% yield, mp 236-237 C. 1H NMR (400 MHz, CDCl3) δ/ppm: 12.20 (s, 2H), 8.15 (d, J=6.9 Hz, 2H), 7.57 (d, J=6.9 Hz, 2H), 3.60-3.50 (m, 1H), 2.73 (dd, J=8.1-8.1 Hz, 2H), 2.60 (dd, J=8.1-8.1 Hz, 2H); 13C NMR (100 MHz, CDCl3) δ/ppm: 172.9, 152.1, 146.6, 129.4, 123.7, 39.9, 38.3; FTIR (cm-1): 3209, 2983, 2933, 2907, 1696, 1607, 1515, 1402, 1347, 1311, 1286, 1250, 1220, 1186, 1162, 1118, 884, 862, 849, 753, 698. Anal. Calcd for C11H11NO6: C, 52.18; H, 4.38; N, 5.53. Found: C, 52.16; H, 4.40; N, 5.57.
60%	With water; sodium hydroxide; at 100℃; for 3h;	Compound 4 (45 mmol) was dissolved in a mixture of distilled water (67.5 mL) and sodium hydroxide (67.5 g). The resulting mixture was refluxed vigorously for 3 h, and then cooled to room temperature and poured into water (340 mL). The resulting mixture was extracted with ether (2x100 mL). The water phase was acidified with concentrated hydrochloric acid (190 mL). The precipitated glutaric acid was removed by filtration and washed with cold water to remove sodium chloride. The acid was recrystallized from water and dried in vacuum to give a pale brown solid (6.84 g), 60% yield, mp 236-237 C .1H NMR (400 MHz, CDCl3) d/ppm: 12.20 (s, 2H), 8.15 (d, J6.9 Hz,2H), 7.57 (d, J6.9 Hz, 2H), 3.60e3.50 (m,1H), 2.73 (dd, J8.1e8.1 Hz,2H), 2.60 (dd, J8.1e8.1 Hz, 2H); 13C NMR (100 MHz, CDCl3) d/ppm:172.9, 152.1, 146.6, 129.4, 123.7, 39.9, 38.3; FTIR (cm1): 3209, 2983,2933, 2907,1696,1607,1515,1402,1347,1311,1286,1250,1220,1186,1162, 1118, 884, 862, 849, 753, 698. Anal. Calcd for C11H11NO6: C,52.18; H, 4.38; N, 5.53. Found: C, 52.16; H, 4.40; N, 5.57.

References: [1]Tetrahedron,2014,vol. 70,p. 5064 - 5072.
[2]Tetrahedron,2014,vol. 70,p. 5064 - 5072.

34
[ 92289-14-0 ]
[ 1616787-09-7 ]

References: [1]Tetrahedron,2014,vol. 70,p. 5064 - 5072.

35
[ 92289-14-0 ]
1-(4-[3,4-bis(2,5-dimethyl-3-thienyl)cyclopent-3-en-1-yl]phenyl)-2,5-di-2-thienyl-1H-pyrrole [ No CAS ]

References: [1]Tetrahedron,2014,vol. 70,p. 5064 - 5072.

Historical Records

Technical Information

• Arndt-Eistert Homologation • Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Friedel-Crafts Reaction • Hunsdiecker-Borodin Reaction • Hydrogenolysis of Benzyl Ether • Passerini Reaction • Preparation of Alkylbenzene • Preparation of Amines • Preparation of Carboxylic Acids • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Carboxylic Acids • Schmidt Reaction • Specialized Acylation Reagents-Ketenes • Ugi Reaction • Vilsmeier-Haack Reaction

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P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 92289-14-0

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