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Chemical Structure| 91958-67-7 Chemical Structure| 91958-67-7

Structure of 91958-67-7

Chemical Structure| 91958-67-7
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Product Details of [ 91958-67-7 ]

CAS No. :91958-67-7
Formula : C13H15NO5
M.W : 265.26
SMILES Code : O=C(C1N(C(OCC2=CC=CC=C2)=O)CC(O)C1)O
MDL No. :MFCD00991046

Safety of [ 91958-67-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H332
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501

Application In Synthesis of [ 91958-67-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 91958-67-7 ]

[ 91958-67-7 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 91958-67-7 ]
  • [ 23357-46-2 ]
  • [ 876624-27-0 ]
YieldReaction ConditionsOperation in experiment
88% With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃; for 18h; To a solution of 4-hydroxy-pyrrolidine-l,2-dicarboxylic 1 -benzyl ester ( 2.07 g, 7.81 mmol) in dimethylformamide (DMF, 15 mL) was added 1-hydroxybenzotriazole (HOBt, 1.37 g, 10.15 mmol ), l-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI, 1.95 g, 10.15 mmol), i?-l,2,3,4-tetrahydro-l-naphthylamine (1.28 g, 8.95 mmol), and diisopropylethylamine (DIEA, 2 mL, 11.72 mmol). The resulting mixture was stirred at room temperature for 18 hours. It was then diluted with ethyl acetate (100 mL), and washed successively with aq. 5% KHSO4, saturated sodium bicarbonate solution, brine, dried (Na2SO4), and concentrated under reduced pressure. After removal of solvent , the residue was triturated with ether to give the pure title compound (0.7g, 88%).TLC (40% ethyl acetate/hexane) Rf = 0.18. MS (ES) for C23H38N2O4 (MW=394.46): positive 395(M+H).
 

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