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Chemical Structure| 91367-09-8 Chemical Structure| 91367-09-8

Structure of 91367-09-8

Chemical Structure| 91367-09-8

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Product Details of [ 91367-09-8 ]

CAS No. :91367-09-8
Formula : C9H9ClO3
M.W : 200.62
SMILES Code : O=C(O)CC1=CC=C(OC)C=C1Cl
MDL No. :MFCD02664702
InChI Key :KINVBFAPQYQPTG-UHFFFAOYSA-N
Pubchem ID :4209132

Safety of [ 91367-09-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 91367-09-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 91367-09-8 ]

[ 91367-09-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 91367-09-8 ]
  • [ 677-22-5 ]
  • [ 23088-23-5 ]
  • [ 1246383-16-3 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; In tetrahydrofuran; diethyl ether; water; Step 1: 2-(2-Chloro-4-methoxy-phenyl)-1-quinoxalin-6-yl-ethanone A 2M solution of tert-butylmagnesium chloride (CAS Reg. No. 677-22-5) in diethyl ether (5.9 ml) was added to 2-chloro-4-methoxyphenylacetic acid (1.173 g, CAS Reg. No. 91367-09-8) in THF (10 ml). The mixture was stirred at room temperature for 30 min. A solution of methyl 6-quinoxalinecarboxylate (1 g, CAS Reg. No. 23088-23-5) in THF (3 ml) was added and the resulting mixture was stirred overnight. Aqueous HCl (25%, 1.5 ml) and water (30 ml) were added and extracted with EtOAc. The combined organic layers were dried over Na2SO4 and then concentrated to an oil. The residue was purified by flash chromatography (SiO2, EtOAc/heptane 1:2) to give the title compound (480 mg) as a light brown solid. MS (m/e)=313.2 [M+H+].
 

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