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Chemical Structure| 887475-71-0 Chemical Structure| 887475-71-0

Structure of 887475-71-0

Chemical Structure| 887475-71-0

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Product Details of [ 887475-71-0 ]

CAS No. :887475-71-0
Formula : C7H6BrN3S
M.W : 244.11
SMILES Code : CSC1=NC(Br)=CN2C1=NC=C2
MDL No. :MFCD11100003

Safety of [ 887475-71-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 887475-71-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 887475-71-0 ]

[ 887475-71-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 885693-20-9 ]
  • [ 887475-71-0 ]
  • [ 887475-83-4 ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate;(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 80℃; To a 25 mL round bottom flask charged with boronate 197 (456 mg, 1.5 mmol), K2CO3 (800 mg, 6 mmol), and Pd(dppf)Cl2 (160 mg, 0.2 mmol) was added a solution of product from example 177(360 mg, 1.5 mmol) in DMF (10 mL). The mixture was degassed thoroughly and placed under argon. This resulting mixture was then heated at 80° C. overnight. The reaction mixture was diluted with EtOAc (40 mL) and filtered through Celite. After concentration, the residue was purified by column chromatography (silica gel, Hexane/EtOAc=60/40) to give the product 198 (258 mg) as an oil. HPLC-MS tR=1.91 min (UV254 nm); mass calculated for formula C17H22N4O2S, 346.1; observed MH+ (LCMS) 347.2 (m/z).
 

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