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Chemical Structure| 886762-48-7 Chemical Structure| 886762-48-7

Structure of 886762-48-7

Chemical Structure| 886762-48-7

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Product Details of [ 886762-48-7 ]

CAS No. :886762-48-7
Formula : C7H3Cl2F3O3S
M.W : 295.06
SMILES Code : O=S(C1=CC=C(OC(F)(F)F)C(Cl)=C1)(Cl)=O
MDL No. :MFCD04972750

Safety of [ 886762-48-7 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P301+P330+P331-P310-P305+P351+P338
Class:8
UN#:3265
Packing Group:

Application In Synthesis of [ 886762-48-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 886762-48-7 ]

[ 886762-48-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 832710-65-3 ]
  • [ 886762-48-7 ]
  • [ 1349633-02-8 ]
YieldReaction ConditionsOperation in experiment
66% With triethylamine; In dichloromethane; for 16h; 2,8-Diazaspiro[4.5]decan-1 -one hydrogen chloride (185 mg, 0.973 mmol) was dissolved in a mixture of triethylamine (0.542 ml_, 3.89 mmol) and dichloromethane (10 ml_), and 3-chloro-4-[(trifluoromethyl)oxy]benzenesulfonyl chloride (344 mg, 1 .167 mmol) was added. After 16 h the reaction mixture was concentrated in vacuo and the resulting residue was purified by silica column chromatography on SP4 (gradient elution: 0 - 20% MeOH - DCM) to give a yellow solid. The yellow solid was further purified on MDAP to give 8-({3-chloro-4-[(trifluoromethyl)oxy]phenyl}sulfonyl)- 2,8-diazaspiro[4.5]decan-1 -one (269 mg, 0.645 mmol, 66% yield) as a white solid. 1 H NMR (400 MHz, DMSO-d6) delta ppm 1 .40 - 1.51 (m, 2 H) 1.61 - 1 .72 (m, 2 H) 1 .80 (t, J=6.80 Hz, 2 H) 2.62 - 2.73 (m, 2 H) 3.10 (t, J=6.82 Hz, 2 H) 3.51 (ddd, J=12.00, 4.38, 4.17 Hz, 2 H) 7.61 (s, 1 H) 7.80 - 7.89 (m, 2 H) 8.02 - 8.07 (m, 1 H). MS ES+ve m/z 413 (M+H)
 

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