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Chemical Structure| 886499-99-6 Chemical Structure| 886499-99-6

Structure of 886499-99-6

Chemical Structure| 886499-99-6

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Product Details of [ 886499-99-6 ]

CAS No. :886499-99-6
Formula : C7H3ClF4O2S
M.W : 262.61
SMILES Code : O=S(C1=CC(C(F)(F)F)=CC(F)=C1)(Cl)=O
MDL No. :MFCD06660226

Safety of [ 886499-99-6 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501
Class:8
UN#:3265
Packing Group:

Application In Synthesis of [ 886499-99-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 886499-99-6 ]

[ 886499-99-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 832710-65-3 ]
  • [ 886499-99-6 ]
  • [ 1349632-94-5 ]
YieldReaction ConditionsOperation in experiment
42% With triethylamine; In dichloromethane; for 17h; 2,8-Diazaspiro[4.5]decan-1 -one hydrogen chloride (100 mg, 0.524 mmol) was dissolved in dichloromethane (10 mL) and triethylamine (0.219 mL, 1 .573 mmol). Then 3-fluoro-5-(trifluoromethyl)benzenesulfonyl chloride (165 mg, 0.629 mmol) was added and stirred for 17 h. The mixture was concentrated in vacuo and the resulting residue was purified by MDAP to give two batches of product: 8-[3-fluoro-5-(trifluoromethyl)phenyl]sulfonyl}-2,8-diazaspiro[4.5]decan-1 -one (33.74 mg, 0.087 mmol, 17% yield) and 8-[3-fluoro-5-(trifluoromethyl)phenyl]sulfonyl}-2,8- diazaspiro[4.5]decan-1 -one (51 mg, 0.131 mmol, 25% yield) both as a white solid. 1 H NMR (400 MHz, DMSO-d6) delta ppm 1 .41 - 1.48 (m, 2 H) 1.61 - 1 .70 (m, 2 H) 1 .80 (t, J=6.80 Hz, 2 H) 2.64 - 2.73 (m, 2 H) 3.10 (t, J=6.80 Hz, 2 H) 3.55 (ddd, J=12.15, 4.34, 4.1 1 Hz, 2 H) 7.61 (s, 1 H) 7.84 (s, 1 H) 8.00 (d, J=7.73 Hz, 1 H) 8.18 (d, J=8.50 Hz, 1 H). MS ES+ve m/z 381 (M+H)
 

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