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Chemical Structure| 870889-89-7 Chemical Structure| 870889-89-7

Structure of 870889-89-7

Chemical Structure| 870889-89-7

3-Methyl-3-hydroxy-8-azabicyclo-[3.2.1]octane hydrochloride

CAS No.: 870889-89-7

4.5 *For Research Use Only !

Cat. No.: A497950 Purity: 95+%

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Product Details of [ 870889-89-7 ]

CAS No. :870889-89-7
Formula : C8H16ClNO
M.W : 177.67
SMILES Code : OC1(C)CC(N2)CCC2C1.[H]Cl
MDL No. :MFCD21602803

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Application In Synthesis of [ 870889-89-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 870889-89-7 ]

[ 870889-89-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 796600-15-2 ]
  • [ 870889-89-7 ]
  • [ 899821-23-9 ]
YieldReaction ConditionsOperation in experiment
40% With potassium carbonate; In dimethyl sulfoxide; at 80℃; for 18h; Example 26 2-Chloro-4-(3-endo-hydroxy-3-exo-methyl-8-azabicyclo[3.2.1]oct-8-yl)-3-methylbenzonitrile (198RL93) <strong>[796600-15-2]2-Chloro-4-fluoro-3-methylbenzonitrile</strong> (<strong>[796600-15-2]198RL18</strong>, 2.48 g, 14.6 mmol), endo-3-exo-methyl-8-azabicyclo[3.2.1]octan-3-ol hydrochloride (197FBA20a, 3.37 g, 19.0 mmol), and potassium carbonate (6.67 g, 48.2 mmol) were dissolved in dimethyl sulphoxide (40 mL), and the mixture stirred under argon at 80 C. for 18 hours. The reaction mixture was poured into water (200 mL) and stirred for 30 min. The off-white solid was filtered off and recrystallised twice from toluene, giving a white powder (1.53 g). The mother liquor was evaporated and the residue recrystallised to yield a second batch of compound (210 mg), giving an overall yield of 40%. Mp=145-147 C. Rf=0.68 (ethyl acetate/dichloromethane 1:1) LC/MS m/z 291 [M+H]+. 1H-NMR (CDCl3) delta 7.39 (d, 1H, J=8.6, Ar-H), 6.84 (d, 1H, J=8.6, Ar-H), 3.82 (m, 2H, Tr-H), 2.36 (s, 3H, Ar-CH3), 2.32-2.22 (m, 2H, Tr-H), 2.17-1.98 (m, 2H, Tr-H), 1.92-1.77 (m, 4H, Tr-H), 1.26 (s, 3H, Tr-CH3).
  • 2
  • [ 796600-15-2 ]
  • [ 870889-89-7 ]
  • 2-chloro-4-(3-endo-hydroxy-3-exo-methyl-8-azabicyclo[3.2.1]-oct-8-yl)-3-methylbenzonitrile hydrochloride [ No CAS ]
 

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