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Chemical Structure| 850222-41-2 Chemical Structure| 850222-41-2
Chemical Structure| 850222-41-2

(S)-3-(Dimethylamino)-1-(3-methoxyphenyl)-2-methylpropan-1-one (2R,3R)-2,3-bis(benzoyloxy)succinate

CAS No.: 850222-41-2

4.5 *For Research Use Only !

Cat. No.: A1004797 Purity: 97%

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Product Details of [ 850222-41-2 ]

CAS No. :850222-41-2
Formula : C31H33NO10
M.W : 579.59
SMILES Code : O=C(O)[C@H](OC(C1=CC=CC=C1)=O)[C@@H](OC(C2=CC=CC=C2)=O)C(O)=O.O=C(C3=CC=CC(OC)=C3)[C@@H](C)CN(C)C
MDL No. :N/A
InChI Key :BTQXAVPTGXQONO-LITMDOGYSA-N
Pubchem ID :25146675

Safety of [ 850222-41-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 850222-41-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 850222-41-2 ]

[ 850222-41-2 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 850222-41-2 ]
  • [ 850222-40-1 ]
YieldReaction ConditionsOperation in experiment
96.5% With diethylamine In tert-butyl methyl ether at 20 - 25℃; for 1.5 h; 2. Preparation of (S)-3-(dimethylamino)-1-(3-methoxyphenyl)-2-methylpropan-1- one (Ia); <n="21"/>(S)-3-(Dimethylamino)-1 -(3-methoxyphenyl)-2-methylpropan-1 -one (2R,3R)-O,O'- dibenzoyltartrate (968 g, 1.67 mmol, ee 98 percent) was suspended in tert-butylmethyl ether (6 L) in a 10 L double jacket vessel equipped with an electrical impeller stirrer, a gas transition line, R100 temperature measuring equipment and an oil based cooling/heating system and diethylamine (384 g, 5.25 mol) was added. The reaction mixture was stirred at 20 0C to 25 0C for 90 minutes and a solid was siphoned off. The filtrate was concentrated at a temperature of 40 0C in vacuo until a pressure of 4 mbar was reached. (S)-3-(dimethylamino)-1-(3-methoxyphenyl)-2-methylpropan-1- one was obtained as a colorless oil (356.7 g, 96.5 percent, ee 98 percent).
References: [1] Patent: WO2008/12047, 2008, A1, . Location in patent: Page/Page column 19-20.
[2] Patent: WO2008/12283, 2008, A1, . Location in patent: Page/Page column 8.
[3] Patent: WO2008/12283, 2008, A1, . Location in patent: Page/Page column 9.
[4] Patent: US2011/190267, 2011, A1, . Location in patent: Page/Page column 67.
 

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