79636-94-5|5-Bromo-2-ethoxybenzaldehyde| Ambeed

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Quality Control of [ 79636-94-5 ] Purity: 98% SDS Specification

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Product Details of [ 79636-94-5 ]

CAS No. :	79636-94-5
Formula :	C₉H₉BrO₂
M.W :	229.07
SMILES Code :	O=CC1=CC(Br)=CC=C1OCC
MDL No. :	MFCD00016600
Boiling Point :	No data available
InChI Key :	NFCBVQSSJAXEJD-UHFFFAOYSA-N
Pubchem ID :	144901

Safety of [ 79636-94-5 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P233-P260-P261-P264-P270-P271-P280-P301+P312-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P330-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501

Application In Synthesis of [ 79636-94-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 79636-94-5 ]

[ 79636-94-5 ] Synthesis Path-Downstream 1~35

1
[ 613-69-4 ]
[ 79636-94-5 ]

References: [1]Justus Liebigs Annalen der Chemie,1868,vol. 145,p. 302.
Journal of the Chemical Society,1889,vol. 55,p. 550.

2
[ 79636-94-5 ]
[ 98-86-2 ]
2-ethoxy-5-bromo-chalcone [ No CAS ]

References: [1]Chemische Berichte,1896,vol. 29,p. 245 Anm..

3
[ 79636-94-5 ]
[ 122-00-9 ]
2-ethoxy-5-bromo-4'-methyl-<i>trans</i>-chalcone [ No CAS ]

References: [1]Journal of Organic Chemistry,1941,vol. 6,p. 722,725, 729.

4
[ 79636-93-4 ]
[ 79636-94-5 ]

References: [1]Tetrahedron Letters,1981,vol. 22,p. 2605 - 2608.

5
[ 79636-94-5 ]
[ 808103-13-1 ]
1-[3-(5-bromo-2-ethoxy-benzylamino)-propyl]-3-(4-trifluoromethyl-phenyl)-urea [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2004,vol. 14,p. 5569 - 5572.

6
[ 79636-94-5 ]
[ 126747-14-6 ]
4'-ethoxy-3'-formyl-biphenyl-4-carbonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
73%	With caesium carbonate;tetrakis(triphenylphosphine) palladium(0); In ethanol; toluene; at 20 - 105℃; for 4.25 - 6.25h;	4f-Ethoxy-3'-formyI-biphenyl-4-carbonitriIe (38)4-cyanophenylboronic acid (500 mg, 3.40 mmol) is coupled to 5-bromo-2- ethoxybenzaldehyde (780 mg, 3.40 mmol) using Method A to give the title compound.Yield: 625 mg (73%).LC/MS tr 1.58 min. MS(ES+) m/z 252 (M+H).; Method A - Suzuki coupling (thermal conditions)Cs2CO3 PhMe, EtOH 80-1050C1 N2 or0 I H A ArDBr ∑HO^Z " XArPd(PPh3)4Cs2CO3 PhMe, EtOH 80-105C, N2A stirred suspension of the boronic acid (1 equiv.), aryl halide/triflate (1 - 1.2 equiv.), cesium carbonate (2 - 2.2 equiv.) and tetrakis(triphenyl- phosphine)palladium(O) (0.05 - 0.1 equiv.) in toluene (40 vol) and EtOH (10 vol) at RT is degassed with nitrogen for 15 minutes. The mixture is then warmed to 80- 105C (external temperature). The reaction is monitored by LC/MS and, if incomplete after 3-4 h, more tetrakis(triphenyl-phosphine)palladium(0) (0.05 - 0.1 equiv.) is added and the reaction heated further (1-2 h). On completion, the reaction mixture is allowed to cool to RT then filtered through celite, washing the solid residues with DCM (100 vol). The filtrate is then reduced in vacuo and the residue purified by chromatography (EtOAc in heptane plus 0.5% tri ethyl amine) to afford the desired biaryl, Z-Ar
73%	With caesium carbonate;tetrakis(triphenylphosphine) palladium(0); In ethanol; toluene; at 20 - 105℃; for 4 - 6h;	Method A - Suzuki coupling (thermal conditions)HO' TB"Af Pd Z(PBPrh3)4 XArCs2CO3 PhMe1 EtOH 80-1050C, N2or?H ArBr .HO'B^Z Pd(PPh3), VCs2CO3 PhMe, EtOH 80-1050C, N2A stirred suspension of the boronic acid (1 equiv.), aryl halide/triflate (1 - 1.2 equiv:), cesium carbonate (2 - 2.2 equiv.) and tetrakis(triphenyl- phosphine)palladium(O) (0.05 - 0.1 equiv.) in toluene (40 vol) and EtOH (10 vol) at RT was degassed with nitrogen for 15 minutes. The mixture was then warmed to 80- 105C (external temperature). The reaction was monitored by LC/MS and, if incomplete after 3-4 h, more tetrakis(triphenyl-phosphine)palladium(0) (0.05 - 0.1 equiv.) was added and the reaction heated further (1-2 h). On completion, the reaction mixture was allowed to cool to RT then filtered through celite, washing the solid residues with DCM (100 vol). The filtrate was then reduced in vacuo and the residue purified by chromatography (EtOAc in heptane plus 0.5% triethyl amine) to afford the desired biaryl, Z-Ar.; Synthesis of Compound R24 '-Ethoxy-3 '-formyl-biphenyI-4-carbonitrile (38)4-cyanophenylboronic acid (500 mg, 3.40 mmol) was coupled to 5-bromo-2- ethoxybenzaldehyde (780 mg, 3.40 mmol) using Method A to give the title compound.Yield: 625 mg (73%).LC/MS tr 1.58 min. MS(ES+) m/z 252 (M+H).
73%	With caesium carbonate;tetrakis(triphenylphosphine) palladium(0); In ethanol; toluene; at 20 - 105℃; for 4.25 - 6.25h;	A stirred suspension of the boronic acid (1 equiv.), aryl halide/triflate (1 - 1.2 equiv.), cesium carbonate (2 - 2.2 equiv.) and tetrakis(triphenyl- phosphine)palladium(O) (0.05 - 0.1 equiv.) in toluene (40 vol) and EtOH (10 vol) at RT is degassed with nitrogen for 15 minutes. The mixture is then warmed to 80- 105C (external temperature). The reaction is monitored by LC/MS and, if incomplete after 3-4 h, more tetrakis(triphenyl-phosphine)palladium(0) (0.05 - 0.1 equiv.) is added and the reaction heated further (1-2 h). On completion, the reaction mixture is allowed to cool to RT then filtered through celite, washing the solid residues with DCM (100 vol). The filtrate is then reduced in vacuo and the residue purified by chromatography (EtOAc in heptane plus 0.5% triethylamine) to afford the desired biaryl, Z-Ar.; 4'-Ethoxy-3'-formyl-biphenyl-4-carbonitrile (38); 4-cyanophenylboronic acid (500 mg, 3.40 mmol) is coupled to 5-bromo-2- ethoxybenzaldehyde (780 mg, 3.40 mmol) using Method A to give the title compound.Yield: 625 mg (73%).LC/MS /, 1.58 min. MS(ES+) m/z 252 (M+H).

63%

With caesium carbonate;tetrakis(triphenylphosphine) palladium(0); In ethanol; toluene; at 20 - 105℃; for 3.25 - 6.25h;

Method A - Suzuki coupling (thermal conditions); A stirred suspension of the boronic acid (1 equiv.), aryl halide/triflate (1 - 1.2 equiv.), cesium carbonate (2 - 2.2 equiv.) and tetrakis(triphenyl- phosphine)palladium(O) (0.05 - 0.1 equiv.) in toluene (40 vol) and EtOH (10 vol) at RT is degassed with nitrogen for 15 minutes. The mixture is then warmed to 80- 105C (external temperature). The reaction is monitored by LC/MS and, if incomplete after 3-4 h, more tetrakis(triphenyl-phosphine)palladium(0) (0.05 - 0.1 equiv.) is added and the reaction heated further (1-2 h). On completion, the reaction mixture is allowed to cool to RT then filtered through celite, washing the solid residues with DCM (100 vol). The filtrate is then reduced in vacuo and the residue purified by chromatography (EtOAc in heptane plus 0.5% triethylamine) to afford the desired biaryl, Z-Ar.; Synthesis of Compound R2; 4'-Ethoxy-3'-formyl-biphenyl-4-carbonitriIe (38); 4-cyanophenylboronic acid (500 mg, 3.40 mmol) is coupled to 5-bromo-2- ethoxybenzaldehyde (780 mg, 3.40 mmol) using Method A to give the title compound.Yield: 625 mg (73%).LCTMS /r 1.58 min. MS(ES+) m/z 252 (M+H).

References: [1]Patent: WO2008/57497,2008,A2 .Location in patent: Page/Page column 222; 190.
[2]Patent: WO2007/89669,2007,A2 .Location in patent: Page/Page column 103; 134.
[3]Patent: WO2008/57469,2008,A1 .Location in patent: Page/Page column 190; 222.
[4]Patent: WO2008/57468,2008,A1 .Location in patent: Page/Page column 190; 222.

7
[ 201230-82-2 ]
[ 79636-94-5 ]
4-ethoxy-3-formylbenzoic acid [ No CAS ]

References: [1]Russian Journal of Applied Chemistry,2005,vol. 78,p. 1844 - 1848.

8
[ 79636-94-5 ]
3-(2-ethoxy-5-bromo-phenyl)-2,3-dibromo-1-phenyl-propan-1-one [ No CAS ]

References: [1]Chemische Berichte,1896,vol. 29,p. 245 Anm..

9
[ 79636-94-5 ]
N-(2-(5-Bromo-2-ethoxy)phenethyl-N'-(2-thiazolyl)thiourea [ No CAS ]
[ 149489-19-0 ]

Yield	Reaction Conditions	Operation in experiment
		3) Following the procedure of Example 151, the aldehyde was transformed to 2-(5-bromo-2-ethoxyphenyl)ethylamine, which was condensed with the product of Example 103, using the procedure of Example 105, to give the titled product. 1 H-NMR (250 MHz, DMSO): δ7.10-6.62 (m, 5H, phenyl, thiazole), 3.73 (q, 2H, CH2 CH3), 3.52 (q, 2H, CH2 NH), 2.62 (t, 2H, phenyl-CH2), 1.07 (t, 3H, CH2 CH3).

References: [1]Patent: US5593993,1997,A .

10
[ 149489-18-9 ]
[ 79636-94-5 ]

Yield	Reaction Conditions	Operation in experiment
	In dichloromethane;	2) 5-Bromo-2-ethoxybenzyl alcohol (2.78 g, 12.0 mmol) and pyridinium dichromate (4.51 g, 12.0 mmol) in 120 ml of CH2 Cl2 was stirred at RT for 6 h. The mixture was filtered, washed with H2 O, 0.5 N HCl and brine and dried over Na2 SO4. The product was purified by silica gel column chromatography (EtOAc/petroleum ether 10:100) to give 5-bromo-2-ethoxybenzaldehyde. Yield: 2.33 g (85%). 1 H-NMR (250 MHz, CDCl3): δ10.4 (s, 1H, CHO), 7.91 (d, 1H, phenyl), 7.60 (dd, 1H, phenyl), 6.88 (d, 1H, phenyl), 4.14 (q, 2H, CH2 CH3), 1.51 (t, 3H, CH2 CH3).

References: [1]Patent: US5593993,1997,A .

Yield	Reaction Conditions	Operation in experiment
		(1) In 100 ml of dimethylformamide was dissolved 10 g of 4-bromosalicyl aldehyde, the mixture was cooled by ice-bath, and 2.0 g of sodium hydride (60% in oil) was gradually added to the mixture and the resulting mixture was stirred for one hour. Thereafter, 10 ml of ethyl iodide was added to the mixture and the resulting mixture was stirred at room temperature for 5 hours. To the reaction mixture were added water, brine and ethyl acetate to effect extraction, and the liquids were separated. After the organic layer was dried, concentrated and the concentrated residue was recrystallized from hexane and ethyl acetate to give 7.8 g of 2-ethoxy-5-bromobenzaldehyde. m.p.=70-71ØC.
	With potassium carbonate; In N,N-dimethyl-formamide; at 60℃; for 2h;	General procedure: [0376] Potassium carbonate (89.0 g) and iodoethane (60.1 mL) was added to a solution of 4-bromo-3,5-dihydroxybenzoic acid (50.0 g) in DMF (300 mL), and the resultant was stirred for 2 hours at 60C. After the reaction mixture was cooled to room temperature, water was added thereto, extraction thereof was performed using ethyl acetate, and the resultant was washed with a saturated saline solution. The obtained organic layer was passed through a silica gel column chromatography (NH, ethyl acetate), and then the solvent was distilled off under reduced pressure. The obtained solid was sequentially washed with diethyl ether and hexane, thereby obtaining the title compound (55.8 g). 1H NMR (300 MHz, CDC13) δ 1.40 (3H, t, J = 7.1 Hz), 1.49 (6H, t, J = 7.0 Hz), 4.17 (4H, q, J - 7.0 Hz), 4.38 (2H, q, J = 7.1 Hz), 7.21 (2H, s).

12
[ 79636-94-5 ]
5-bromo-2-ethyoxyl-benzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With hydroxylamine hydrochloride; In formic acid;	Reference Example 109 In formic acid (85.5 ml) was dissolved <strong>[79636-94-5]5-bromo-2-ethoxybenzaldehyde</strong> (17.1 g). To the mixture was added hydroxylamine hydrochloride (7.8 g), and the mixture was refluxed for 7 hours and cooled to room temperature. Under reduced pressure, the solvent was evaporated, and the residue was washed with water and dried to give 5-bromo-2-ethoxybenzonitrile (15.8 g). 1H-NMR (200 MHz, CDCl3) δ 1.48 (3H, t, J=7.0 Hz), 4.14 (2H, q, J=7.0 Hz), 6.85 (1H, d, J=8.8 Hz), 7.57-7.66 (2H, m); IR(KBr) 2984, 2230, 1591, 1489, 1393, 1314, 1284, 1134, 1038, 810 cm-1.

References: [1]Patent: US6235771,2001,B1 .

13
[ 75-03-6 ]
[ 1761-61-1 ]
[ 79636-94-5 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate; In water; N,N-dimethyl-formamide;	Reference Example 108 In DMF (150 ml) was dissolved 5-bromosalicylaldehyde (18.6 g). To the mixture was added at room temperature potassium carbonate (16.6 g) and then was added iodoethane (17.3 ml), and the mixture was stirred at 90 C. for 3 hours and cooled to room temperature. The reaction mixture was added to water, and the mixture was extracted with ethyl acetate, washed with saturated brine and dried with magnesium sulfate. Under reduced pressure, the solvent was evaporated, and the residue was purified with silica gel column chromatography (hexane/ethyl acetate=8/1) to give 5-bromo-2-ethoxybenzaldehyde (17.2 g). 1H-NMR (200 MHz, CDCl3) δ 1.48 (3H, t, J=7.2 Hz), 3.13-3.20 (2H, m), 4.14 (2H, q, J=7.0 Hz), 6.87 (1H, d, J=8.8 Hz), 7.60 (1H, d, J=8.8, 2.6 Hz), 7.91 (1H, d, J=2.6 Hz), 10.41 (1H, s).

References: [1]Patent: US6235771,2001,B1 .

14
[ 64-17-5 ]
[ 79636-94-5 ]
[ 122-51-0 ]
[ 945997-02-4 ]

Yield	Reaction Conditions	Operation in experiment
	ammonium chloride; at 45℃; for 1h;	To a solution of <strong>[79636-94-5]5-bromo-2-ethoxybenzaldehyde</strong> (1.0 g, 4.37 mmol) in EtOH (10 mL) was added triethylorthoformate (1.09 mL, 6.55 mmol) and ammonium chloride (12 mg, 0.22 mmol). The resulting solution was stirred 1 h at 45C to afford the protected aldehyde. TLC (1 :1 EtOAc:heptane) at this juncture confirmed consumption of the starting material. The solvent was removed in vacuo to give the protected aldehyde as a yellow oil (1.5 g).

References: [1]Patent: WO2007/89669,2007,A2 .Location in patent: Page/Page column 118.

15
[ 79636-94-5 ]
[ 122-51-0 ]
C₁₁H₁₅BrO₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With ammonium chloride; In ethanol; at 45℃; for 1h;	4-Ethoxy-3-formyl-benzene boronic acid (10)OHTo a solution of <strong>[79636-94-5]5-bromo-2-ethoxybenzaldehyde</strong> (1.0 g, 4.37 mmol) in EtOH (10 mL) is added triethylorthoformate (1.09 mL, 6.55 mmol) and ammonium chloride (12 mg, 0.22 mmol). The resulting solution is stirred 1 h at 45C to afford the protected aldehyde. TLC (1 :1 EtOAc:heptane) at this juncture confirmed consumption of the starting material. The solvent is removed in vacuo to give the protected aldehyde as a yellow oil (1.5 g). This is dissolved in diethyl ether (10 mL) and cooled to -78C under N2. ϖ-BuLi (3.0 mL, 4.80 mmol, 1.6 M in hexanes) is added dropwise via syringe over 10 minutes and the reaction mixture stirred 30 minutes at -78C. Triethylborate (2.95 mL, 10.9 mmol) is added as a solution in diethyl ether (5 mL) dropwise via syringe over 10 minutes, then stirring at -78C is continued for 4 h. 6 M HCl (1.3 mL) is added, the reaction warmed to RT, stirred 16 h then heated to reflux 1.5 h. The reaction is then cooled (0C) and basifed with 4 M NaOH to pH 14. The layers are separated and the organic layer washed with 2 M NaOH (2 x 20 mL); the aqueous phases are then combined and washed with TBME (2 x 40 mL). The aqueous layer is cooled to 0C and acidified with 2 M HCl to pH 1. The resultant precipitate is isolated by filtration to give the title compound. Yield: 306 mg (36%). LOMS tr- 1.05 min. MS(ES+) m/z 195 (M+H).
	With ammonium chloride; In ethanol; at 45℃; for 1h;	4-Ethoxy-3-formyl-benzene boronic acid (10); To a solution of <strong>[79636-94-5]5-bromo-2-ethoxybenzaldehyde</strong> (1.0 g, 4.37 mmol) in EtOH (10 mL) is added triethylorthoformate (1.09 mL, 6.55 mmol) and ammonium chloride (12 mg, 0.22 mmol). The resulting solution is stirred 1 h at 45C to afford the protected aldehyde. TLC (1 :1 EtOAc:heptane) at this juncture confirmed consumption of the starting material. The solvent is removed in vacuo to give the protected aldehyde as a yellow oil (1.5 g). This is dissolved in diethyl ether (10 mL) and cooled to -78C under N2. n-BuLi (3.0 mL, 4.80 mmol, 1.6 M in hexanes) is added dropwise via syringe over 10 minutes and the reaction mixture stirred 30 minutes at -78C. Triethylborate (2.95 mL, 10.9 mmol) is added as a solution in diethyl ether (5 mL) dropwise via syringe over 10 minutes, then stirring at -78C is continued for 4 h. 6 M HCl (1.3 mL) is added, the reaction warmed to RT, stirred 16 h then heated to reflux 1.5 h. The reaction is then cooled (0C) and basified with 4 M NaOH to pH 14. The layers are separated and the organic layer washed with 2 M NaOH (2 x 20 mL); the aqueous phases are then combined and washed with TBME (2 x 40 mL). The aqueous layer is cooled to 0C and acidified with 2 M HCl to pH 1. The resultant precipitate is isolated by filtration to give the title compound. Yield: 306 mg (36%). LC/MS tr 1.05 min. MS(ES+) m/z 195 (M+H).

References: [1]Patent: WO2008/57497,2008,A2 .Location in patent: Page/Page column 205.
[2]Patent: WO2008/57468,2008,A1 .Location in patent: Page/Page column 205.

16
[ 79636-94-5 ]
[ 120-92-3 ]
[ 1261266-26-5 ]

References: [1]European Journal of Medicinal Chemistry,2010,vol. 45,p. 5773 - 5780.

17
[ 79636-94-5 ]
[ 67-64-1 ]
(1E,4E)-1,5-bis(5-bromo-2-ethoxyphenyl)penta-1,4-dien-3-one [ No CAS ]

References: [1]European Journal of Medicinal Chemistry,2010,vol. 45,p. 5773 - 5780.

18
[ 3042-01-1 ]
[ 79636-94-5 ]
[ 1443655-18-2 ]

References: [1]European Journal of Medicinal Chemistry,2013,vol. 64,p. 292 - 301.

19
[ 79636-94-5 ]
[ 1443430-15-6 ]

References: [1]Journal of Medicinal Chemistry,2013,vol. 56,p. 5019 - 5032.

20
[ 79636-94-5 ]
[ 118-93-4 ]
[ 1443430-06-5 ]

References: [1]Journal of Medicinal Chemistry,2013,vol. 56,p. 5019 - 5032.

21
[ 74-96-4 ]
[ 1761-61-1 ]
[ 79636-94-5 ]

References: [1]Journal of Medicinal Chemistry,2019,vol. 62,p. 4142 - 4157.
[2]Journal of Medicinal Chemistry,2013,vol. 56,p. 5019 - 5032.
[3]Bioorganic and Medicinal Chemistry,2016,vol. 24,p. 2768 - 2776.

22
C₁₄H₁₆O₃ [ No CAS ]
[ 79636-94-5 ]
(2E,6E)-2-(5-bromo-2-ethoxybenzylidene)-6-(4-hydroxy-3-methoxybenzylidene)cyclohexanone [ No CAS ]

References: [1]MedChemComm,2015,vol. 6,p. 1544 - 1553.

23
[ 4047-24-9 ]
[ 79636-94-5 ]
(E)-1-(2-(benzyloxy)-6-hydroxyphenyl)-3-(5-bromo-2-ethoxyphenyl)prop-2-en-1-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
75%	With potassium hydroxide; In methanol; at 85℃; for 3h;	5-Bromo-2-ethoxy-benzaldehyde 7a (473 mg, 2.06 mmol), 1-(2-benzyloxy-6-hydroxy-phenyl)-ethanone 6 (500 mg, 2.06 mmol),and MeOH (9 mL) were combined and KOH in methanol (40%weight/volume, 8.24 mL) added at room temperature. A water condenser was attached to the flask, and the orange solution quickly turned dark red upon heating and was stirred at reflux in an oilbath at 85 C for 3 h. Workup involved evaporation of the solvent and addition of 1 N HCl until the solution was at pH 1, followed by extraction with ethyl acetate (twice). The organic layer was separated,dried over anhydrous Na2SO4, filtered, and concentrated to give an orange solid. Column chromatography was performed (10%EtOAc:hexane) to purify the product. A crystallization step was then performed (ethyl acetate/hexane) to obtain the pure product(75% yield). 8o: mp 107-109 C, 1H NMR (CDCl3): d 13.08 (s,0.76H), 8.07 (d, 1H), 8.03 (d, 0.53H), 7.81 (d, 0.58H), 7.78 (d,0.47H), 7.41 (m, 2H), 7.37 (m, 2H), 7.33 (d, 1H), 7.29 (m, 3H),6.73 (d, 2H, J = 8.8 Hz), 6.66 (d, 1H, J = 1.2 Hz), 6.64 (d, 1H,J = 1 Hz), 6.55 (d, 1H, J = 1 Hz), 6.53 (d, 1H, J = 0.7 Hz), 5.14 (s,2H), 4.00 (1, 2H), 1.54 (s, 0.93H), 1.41 (t, 3H). 13C NMR (CDCl3): d165.05, 160.17, 157.1, 136.20, 133.87, 130.38, 128.76, 127.59,126.20, 113.68, 112.76, 102.71, 71.36, 64.31, 14.68; Anal.C24H21BrO4: C, H; HRMS for C24H22BrO4 (M+H): theory 453.0701;found 453.0691.

References: [1]Bioorganic and Medicinal Chemistry,2016,vol. 24,p. 2768 - 2776.

24
[ 4047-24-9 ]
[ 79636-94-5 ]
4-benzyloxy-2-(5-bromo-2-ethoxy-benzylidene)-benzofuran-3-one [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2016,vol. 24,p. 2768 - 2776.

25
[ 29202-80-0 ]
[ 79636-94-5 ]
(2E,6E)-2-(2-ethoxy-5-bromobenzylidene)-6-(2-nitrobenzylidene)cyclohexanone [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
67.8%	With sodium hydroxide; In ethanol; at 20℃; for 24h;	(E) -2- (2-nitrobenzylidene) cyclohexanone (100 mg, 0.43 mmol)2-ethoxy-5-bromobenzaldehyde (99.06 mg, 0.43 mmol)Dissolved in 6 mL of anhydrous ethanol,Dropping 20% sodium hydroxide solution with 6 drops,Room temperature reaction 24h,The solution has yellow precipitation,Filtered, washed with water and diluted ethanol until TLC was tested. The yield was 67.8%.

References: [1]Patent: CN104557558,2017,B .Location in patent: Paragraph 0091; 0092; 0093; 0094.

26
[ 79636-94-5 ]
[ 126747-14-6 ]
trans-tert-butyl {4-[(4'-cyano-4-ethoxy-biphenyl-3-ylmethyl)-amino]-cyclohexyl}-methyl-carbamate [ No CAS ]

References: [1]Patent: WO2008/57469,2008,A1 .

27
[ 79636-94-5 ]
[ 126747-14-6 ]
[ 945997-80-8 ]

References: [1]Patent: WO2008/57468,2008,A1 .

28
[ 79636-94-5 ]
C₃₇H₄₈N₂O₇ [ No CAS ]