Home Cart Sign in  
Chemical Structure| 78706-26-0 Chemical Structure| 78706-26-0

Structure of 78706-26-0

Chemical Structure| 78706-26-0

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 78706-26-0 ]

CAS No. :78706-26-0
Formula : C5H2Cl2N4
M.W : 189.00
SMILES Code : ClC1=CC(Cl)=NC2=NC=NN12
MDL No. :MFCD10000845

Safety of [ 78706-26-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 78706-26-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 78706-26-0 ]

[ 78706-26-0 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 1709-59-7 ]
  • [ 78706-26-0 ]
  • 4-(5-chloro-[1,2,4]triazolo[1,5-<i>a</i>]pyrimidin-7-ylamino)-<i>N</i>,<i>N</i>-dimethyl-benzenesulfonamide [ No CAS ]
  • 2
  • [ 1123-63-3 ]
  • [ 78706-26-0 ]
  • [ 1621983-53-6 ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In N,N-dimethyl-formamide; at 30℃; General procedure: The appropriate substituted phenols or anilines (about 2.7 mmol) were dissolved in anhydrous DMF (15 mL) in the presence of anhydrous K2CO3 (about 5.4 mmol) at room temperature followed by addition of the intermediate 5,7-dichloro-[1,2,4]triazolo[1,5-a]pyrimidine (3) (about 3 mmol). The reaction mixture was stirred at 30 C for 6-12h (monitored by TLC). Then some water was added to the reaction mixture. The formed solid was filtered, washed with water, and dried under vacuum to give the desired intermediates 6(a-h), which were used in the following step without further purification. Yields ranged from 50 to 90%. The mixture of the corresponding intermediate 6(a-h) (about 1.5 mmol) and 4-aminobenzonitrile (about 5.25 mmol) was stirred at 150 C for about 2h (monitored by TLC) according to the reported method. The mixture was cooled to room temperature, diluted with DMF to get a clear solution, then concentrated with a balanced amount of silica gel in vacuo. Products were purified by column chromatography with ethyl acetate/petroleum ether (1:2) to afford 15 target compounds 7a-o, respectively. Yields ranged from 60 to 80%.
  • 3
  • [ 39959-67-6 ]
  • [ 78706-26-0 ]
  • C13H11Cl2N5 [ No CAS ]
  • 4
  • [ 53332-78-8 ]
  • [ 78706-26-0 ]
  • 5-chloro-N-(thiazol-2-ylmethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
80% With triethylamine; In 1,4-dioxane; at 25℃;Inert atmosphere; General procedure: Example 7. General Procedure G A mixture of the desired chlorotriazolopyrimidines i-G (1 equiv), desired aminomethyl heterocycle or benzylamine ii-G (1.2 equiv), and triethylamine (NEt3) (1.5- 3.5 equiv) in 1,4-dioxane (~0.2 M) was stirred at room temperature until the reaction was complete by LC-MS and/or TLC analysis. The crude reaction mixture was directly purified by silica gel chromatography (typical eluents included either a mixture of hexanes and EtOAc or a mixture of CH2Cl2 and MeOH or an 80:18:2 mixture of CH2Cl2/CH3OH/concentrated NH4OH) to afford the desired product iii-G. The product structures prepared according to General Procedure G were confirmed by 1H NMR and/or by mass analysis.
 

Historical Records

Technical Information

Categories