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Chemical Structure| 39959-67-6 Chemical Structure| 39959-67-6

Structure of 39959-67-6

Chemical Structure| 39959-67-6

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Product Details of [ 39959-67-6 ]

CAS No. :39959-67-6
Formula : C8H10ClN
M.W : 155.62
SMILES Code : CC(N)C1=CC=CC=C1Cl
MDL No. :MFCD05215230
InChI Key :RJPLGQTZHLRZGX-UHFFFAOYSA-N
Pubchem ID :299767

Safety of [ 39959-67-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 39959-67-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 39959-67-6 ]

[ 39959-67-6 ] Synthesis Path-Downstream   1~22

YieldReaction ConditionsOperation in experiment
Specific examples. of the optically active amine (3) include optically active isomers of alpha-ethylbenzylamine, alpha-propylbenzylamine, alpha-isopropybenzylamine, alpha,4-dimethylbenzylamine, alpha,2,5-trimethylbenzylamine, alpha,2,4,6-tetramethylbenzylamine, alpha-methyl-4-isopropylbenzylamine, 2-fluoro-alpha-methylbenzylamine, 3-fluoro-alpha-methylbenzylamine, 4-fluoro-alpha-methylbenzylamine, 4-bromo-alpha-methylbenzylamine, 2-chloro-alpha-methylbenzylamine, 3-chloro-alpha-methylbenzylamine, 4-chloro-alpha-methylbenzylamine, 2,3-dichloro-alpha-methylbenzylamine, 2,4-dichloro-alpha-methylbenzylamine, 2-methoxy-alpha-methylbenzylamine, 4-methoxy-alpha-methylbenzylamine, 2-ethoxy-alpha-methylbenzylamine, 3,4-dimethoxy-alpha-methylbenzylamine, 5-fluoro-2-methoxy-alpha-methylbenzylamine, alpha,beta-diphenylethylamine, ...
6.4 g of a 27% aqueous sodium hydroxide solution was added to the aqueous layer after extracted with toluene, the aqueous solution was extracted with 50 g of toluene, and the toluene was distilled off to obtain 4.1 g of 1-(2'-chlorophenyl)ethylamine. A portion of the latter was taken out and analyzed by high performance liquid column chromatography using the optically active column.
Comparative Example 11 0.6 g of potassium t-butoxide was added to a mixture of 2 g of (R)-1-(2'-chlorophenyl)ethylamine used in Example 36 and 10 g of dimethyl sulfoxide at 80 C., and the mixture was continued to stir at the same temperature for 6 hours. Then, 10 g of toluene was added thereto, and the reaction mixture was washed twice with 10 g of saturated sodium chloride solution, dried over anhydrous sodium sulfate, and the toluene was distilled off to obtain 2.1 g of brown oil. Purification by distillation afforded 1.58 g of 1-(2'-chlorophenyl)ethylamine. A portion thereof was taken out and optical isomer ratio was analyzed by high performance liquid chromatography with the optically active column. The optical isomer ratio S/R=28.4/71.6.
  • 4
  • [ 39959-67-6 ]
  • [ 98303-20-9 ]
  • 2-[1-(2-chloro-phenyl)-ethylcarbamoyl]-piperidine-1-carboxylic acid <i>tert</i>-butyl ester [ No CAS ]
  • 5
  • [ 83834-86-0 ]
  • [ 39959-67-6 ]
  • 6
  • O-benzyl-2'-chloroacetophenone oxime [ No CAS ]
  • [ 39959-67-6 ]
  • 7
  • [ 39959-67-6 ]
  • piperidine-2-carboxylic acid [1-(2-chloro-phenyl)-ethyl]-amide; hydrochloride [ No CAS ]
  • 8
  • [ 39959-67-6 ]
  • [ 127733-51-1 ]
  • 9
  • [ 39959-67-6 ]
  • [ 93-97-0 ]
  • [ 1198107-19-5 ]
  • [ 1198107-13-9 ]
  • 10
  • [ 39959-67-6 ]
  • [ 93-97-0 ]
  • [ 1198107-13-9 ]
  • 11
  • [ 39959-67-6 ]
  • [ 1067670-78-3 ]
  • 12
  • [ 39959-67-6 ]
  • [ 908811-99-4 ]
  • 13
  • [ 1943-83-5 ]
  • [ 39959-67-6 ]
  • [ 1067671-84-4 ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In dichloromethane; at 20℃; for 15h; Step 1 3,2 g (20.6mmol) 1-(2-chlorophenyl)ethaneamine [CAS 39959-67-6] and 52.3 g (22.6 mmol) triethylamine were given into 20 ml dichloromethane and afterwards 2.4 g (22.6 mmol) 2-chloroethylisocyanat werde added dropwise. The mixture was allowed to react 15 hours at 20C. The volatile components were evaporated to give 1-(2-chloroethyl)-3-[1-(2-chlorophenyl)ethyl]urea (log p = 2.3) that was used in step 2 without further purification
  • 14
  • [ 39959-67-6 ]
  • [ 104316-32-7 ]
  • [ 1528751-69-0 ]
  • 15
  • [ 39959-67-6 ]
  • [ 78706-26-0 ]
  • C13H11Cl2N5 [ No CAS ]
  • 16
  • methyl (2,2,2-trifluoroethyl) oxalate [ No CAS ]
  • [ 39959-67-6 ]
  • [ 893641-32-2 ]
  • C17H20ClN3O3 [ No CAS ]
  • 17
  • [ 39959-67-6 ]
  • [ 98-74-8 ]
  • (S)-N-(1-(2-chlorophenyl)ethyl)-4-nitrobenzenesulfonamide [ No CAS ]
  • methyl (R)-3'-chloro-2'-(1-(4-nitrophenylsulfonamido)ethyl)-[1,1'-biphenyl]-4-carboxylate [ No CAS ]
  • 18
  • [ 39959-67-6 ]
  • [ 98-74-8 ]
  • N-(1-(2-chlorophenyl)ethyl)-4-nitrobenzenesulfonamide [ No CAS ]
  • 20
  • [ 39959-67-6 ]
  • [ 407-25-0 ]
  • N-(1-(2-chlorophenyl)ethyl)-2,2,2-trifluoroacetamide [ No CAS ]
  • 21
  • [ 51934-41-9 ]
  • [ 39959-67-6 ]
  • ethyl 2'-(1-aminoethyl)-3'-chloro-[1,1'-biphenyl]-4-carboxylate [ No CAS ]
  • 22
  • [ 3482-49-3 ]
  • [ 39959-67-6 ]
  • N-((S)-1-(2-chlorophenyl)ethyl)fusidic acid amide [ No CAS ]
  • N-((R)-1-(2-chlorophenyl)ethyl)fusidic acid amide [ No CAS ]
 

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Related Functional Groups of
[ 39959-67-6 ]

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