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Chemical Structure| 764-93-2 Chemical Structure| 764-93-2

Structure of 764-93-2

Chemical Structure| 764-93-2

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Product Details of [ 764-93-2 ]

CAS No. :764-93-2
Formula : C10H18
M.W : 138.25
SMILES Code : C#CCCCCCCCC
MDL No. :MFCD00009576
InChI Key :ILLHQJIJCRNRCJ-UHFFFAOYSA-N
Pubchem ID :12997

Safety of [ 764-93-2 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225
Precautionary Statements:P210-P233-P240-P241-P242-P243
Class:3
UN#:3295
Packing Group:

Application In Synthesis of [ 764-93-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 764-93-2 ]

[ 764-93-2 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 764-93-2 ]
  • [ 82632-80-2 ]
  • [ 125594-11-8 ]
  • 2
  • [ 764-93-2 ]
  • [ 2296-23-3 ]
  • [ 1218818-18-8 ]
YieldReaction ConditionsOperation in experiment
55% With triethylamine;copper(l) iodide; palladium diacetate; CyJohnPhos; In acetonitrile; at 60℃; for 18h; To a stirred solution of <strong>[2296-23-3]4-hydroxy-3-iodobenzonitrile</strong> (LXXX) (4.55 g, 18.57 mmol), 1-decyne (LXXXI) (2.57 g, 18.57 mmol), (2-biphenyl)dicyclohexylphosphine (0.325 g, 0.928 mmol), (or using same moles of triphenylphosphine) and triethylamine (5.64 g, 55.71 mmol) in acetonitrile (100 mL) was added palladium(II) acetate (0.208 g, 0.928 mmol) and copper(I) iodide (0.354 g, 1.86 mmol). The reaction mixture was heated to 60 C. After 18 hours, the reaction mixture was allowed to cool to room temperature and was concentrated. The residue was dissolved in ethyl acetate and washed with IN hydrochloric acid, 6N ammonium hydroxide, and brine. The organic phase was dried (magnesium sulfate), filtered, and concentrated to provide 5.29 g of a brown oil. Flash chromatography using an Isco Combiflash unit (90 g SiO2 column, 10-20% ethyl acetate/hexanes) afforded 2.62 g (55% yield) of 2- octylbenzofuran-5-carbonitrile (LXXXII) as a yellow solid: 1H NMR (CDCl3) delta 7.80 (s, 1H), 7.52-7.43 (m, 2H), 6.43 (s, 1H), 2.78 (t, J= 7.6 Hz, 2H), 1.80-1.69 (m, 2H), 1.44-1.20 (m, 10H), 0.88 (t, 7= 6.9 Hz, 3H) ppm.
  • 3
  • [ 764-93-2 ]
  • [ 615-37-2 ]
  • 1-methyl-2-dec-1-ynyl-benzene [ No CAS ]
YieldReaction ConditionsOperation in experiment
83% With copper(I) oxide; caesium carbonate; In N,N-dimethyl-formamide; at 135℃; for 48h;Inert atmosphere; General procedure: A sealable vial equipped with a magnetic stir bar was charged with Cs2CO3 (652 mg, 2.0 mmol), Cu2O (14.0 mg, 0.10 mmol) under a nitrogen atmosphere. The aperture of the vial was then covered with a rubber septum. Under a nitrogen atmosphere, alkyl alkyne (4, 1.5 mmol), aryl iodide (2, 1.0 mmol) and DMF (0.5mL) were added by syringe. The septum was then replaced by a screw cap containing a Teflon-coated septum, and the reaction vessel was placed at 135 C. After stirring at this temperature for 48 h, the heterogeneous mixture was cooled to room temperature and diluted with ethyl acetate (20 mL). The resulting solution was filtered through a pad of silica gel then washed with ethyl acetate (20 mL) and concentrated to give the crude material which was then purified by column chromatography on silica gel toyield alkyne 5.
  • 4
  • [ 764-93-2 ]
  • [ 1006-64-0 ]
  • [ 100-52-7 ]
  • [ 1376191-20-6 ]
 

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