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Chemical Structure| 74974-54-2 Chemical Structure| 74974-54-2
Chemical Structure| 74974-54-2

2-Chloro-1,1,1-trimethoxyethane

CAS No.: 74974-54-2

4.5 *For Research Use Only !

Cat. No.: A381525 Purity: 98% GC

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Product Details of 2-Chloro-1,1,1-trimethoxyethane

CAS No. :74974-54-2
Formula : C5H11ClO3
M.W : 154.59
SMILES Code : COC(OC)(OC)CCl
MDL No. :MFCD00216629
InChI Key :NPEIUNVTLXEOLT-UHFFFAOYSA-N
Pubchem ID :144702

Safety of 2-Chloro-1,1,1-trimethoxyethane

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225
Precautionary Statements:P210-P403+P235
Class:3
UN#:1993
Packing Group:

Application In Synthesis of 2-Chloro-1,1,1-trimethoxyethane

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 74974-54-2 ]
  • Downstream synthetic route of [ 74974-54-2 ]

[ 74974-54-2 ] Synthesis Path-Upstream   1~3

  • 1
  • [ 563-41-7 ]
  • [ 74974-54-2 ]
  • [ 252742-72-6 ]
YieldReaction ConditionsOperation in experiment
62% at 20℃; 4.0 g Semicarbazide hydrochloride, 9.67 mL 2-chloro-1,1,1-trimethoxyethane and 40 mL methanol were combined and stirred at ambient temperature for 3 d. After this time additional 3.5 mL 2-chloro-1,1,1-trimethoxyethane was added to complete the reaction. The mixture was then concentrated under reduced pressure and the crude product was partitioned between ethyl acetate and 1N hydrochloric acid. The organic phase separated and it was washed with additional 1N hydrochloric acid (.x.2). The combined aqueous extracts were extracted with ethyl acetate (.x.5) and all of the organic fraction were then combined, dried over sodium sulfate, filtered and the filtrate was concentrated under reduced pressure. The solid that remained was triturated with ethyl acetate to give the title compound which was used without further purification.Yield: 2.97g (62percent of theory)Analysis: 1H NMR (500 MHz, dimethyl sulfoxide-d6) in ppm 4.49 (2H, s), 11.55 (1H, br. s.), 11.70 (1H, br. s.)
References: [1] Tetrahedron Letters, 2000, vol. 41, # 44, p. 8661 - 8664.
[2] Patent: US2012/28939, 2012, A1, . Location in patent: Page/Page column 27.
[3] Patent: WO2011/92128, 2011, A1, . Location in patent: Page/Page column 51-52.
[4] Patent: WO2014/139328, 2014, A1, . Location in patent: Page/Page column 614.
[5] Patent: WO2006/133426, 2006, A2, . Location in patent: Page/Page column 276.
  • 2
  • [ 74974-54-2 ]
  • [ 252742-72-6 ]
References: [1] Patent: US2003/187274, 2003, A1, .
  • 3
  • [ 4426-72-6 ]
  • [ 74974-54-2 ]
  • [ 252742-72-6 ]
References: [1] Patent: WO2009/67233, 2009, A1, . Location in patent: Page/Page column 69.
 

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