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Chemical Structure| 1006601-77-9 Chemical Structure| 1006601-77-9

Structure of 1006601-77-9

Chemical Structure| 1006601-77-9

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Product Details of [ 1006601-77-9 ]

CAS No. :1006601-77-9
Formula : C10H8ClNO3
M.W : 225.63
SMILES Code : O=C(C1=C2N=C(CCl)OC2=CC=C1)OC

Safety of [ 1006601-77-9 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H314
Precautionary Statements:P264-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P403+P233-P501
Class:8
UN#:3261
Packing Group:

Application In Synthesis of [ 1006601-77-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1006601-77-9 ]

[ 1006601-77-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 17672-21-8 ]
  • [ 74974-54-2 ]
  • [ 1006601-77-9 ]
YieldReaction ConditionsOperation in experiment
66% In ethanol; for 6h;Heating / reflux; Step B: A mixture of <strong>[17672-21-8]methyl 2-amino-3-hydroxybenzoate</strong> (3.5 g, 20.70 mmol) and 2-chloro-1,1,1-trimethoxyethane (3.0 mL, 22.06 mmol) in ethanol (30 mL) was stirred under reflux for 6 h. The reaction mixture was cooled to ambient temperature and the solvent volume was reduced under reduced pressure approximately to 2/3 of initial volume. The precipitate formed was filtered, washed with ether (3*10 mL), and dried under vacuum to afford methyl 2-(chloromethyl)benzoxazole-4-carboxylate (3.1 g, 66%) as a yellow solid: 1H NMR (500 MHz, CDCl3) delta 8.05 (dd, J=8.0, 1.0 Hz, 1H), 7.78 (dd, J=9.0, 1.0 Hz 1H), 7.47 (t, J=5.0 Hz, 1H), 4.84 (s, 2H), 4.04 (s, 3H); (APCI+) m/z 226 (M+H).
 

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