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Chemical Structure| 7324-05-2 Chemical Structure| 7324-05-2

Structure of 7324-05-2

Chemical Structure| 7324-05-2

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Product Details of [ 7324-05-2 ]

CAS No. :7324-05-2
Formula : C3H8N2O
M.W : 88.11
SMILES Code : C[C@H](N)C(N)=O
MDL No. :MFCD03840583

Safety of [ 7324-05-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 7324-05-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 7324-05-2 ]
  • Downstream synthetic route of [ 7324-05-2 ]

[ 7324-05-2 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 7324-05-2 ]
  • [ 66742-57-2 ]
  • [ 133865-89-1 ]
YieldReaction ConditionsOperation in experiment
92%
Stage #1: at 20 - 25℃; for 1 h;
Stage #2: With hydrogen In methanol at 20 - 35℃; for 5 h;
6.3 Preparation of (S)-2-[4-(3-fluorobenzyloxy)benzylamino] propanamide (Ia) of high purity degree (one pot reaction) by using L- alaninamide base(S)-2-[4-(3-fluorobenzyloxy]benzaldehyde (1Og) is reacted according to the same procedure of Example 6, but using L-alaninamide base, instead of its hydrochloride and triethylamine. The yield of (S)-2-[4-(3- fluorobenzyloxy)benzylamino] propanamide is 92percent with a HPLC purity of 99.7 (area percent, see Example 17A) and a content of (S)-2-[3-(3-fluorobenzyl)-4- (3-fluorobenzyloxy)benzylamino]propanamide lower than 0.005percent by weight determined by HPLC (see Example 17B).
References: [1] Patent: WO2007/147491, 2007, A1, . Location in patent: Page/Page column 32.
 

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