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Chemical Structure| 5672-83-3 Chemical Structure| 5672-83-3
Chemical Structure| 5672-83-3

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Z-Glu-OMe is a glutamic acid derivative, commonly used in biochemical research and drug synthesis.

Synonyms: N-Benzyloxycarbonyl-L-glutamic acid 1-methyl ester

4.5 *For Research Use Only !

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Product Details of Z-Glu-OMe

CAS No. :5672-83-3
Formula : C14H17NO6
M.W : 295.29
SMILES Code : O=C(O)CC[C@@H](C(OC)=O)NC(OCC1=CC=CC=C1)=O
Synonyms :
N-Benzyloxycarbonyl-L-glutamic acid 1-methyl ester
MDL No. :MFCD00083278
InChI Key :BGMCTGARFXPQML-NSHDSACASA-N
Pubchem ID :2733408

Safety of Z-Glu-OMe

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Z-Glu-OMe

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5672-83-3 ]

[ 5672-83-3 ] Synthesis Path-Downstream   1~35

  • 1
  • [ 67101-54-6 ]
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  • <i>N</i>-benzyloxycarbonyl-L-glutamic acid-1-methyl ester-5-chloride [ No CAS ]
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  • [ 124-41-4 ]
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  • 7
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  • Benzyloxycarbonyl-L-glutaminsaeure-1-methylester-5-(4-nitro-phenylester) [ No CAS ]
  • 8
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  • 9
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  • 11
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  • 12
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  • [ 95-95-4 ]
  • α-Methyl-γ-(2,4,5-trichlor-phenyl)-N-benzyloxycarbonyl-L-glutamat [ No CAS ]
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  • [ 115-11-7 ]
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  • 15
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  • Benzyloxycarbonyl-L-glutaminsaeure-1-methylester-5-phenylester [ No CAS ]
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  • 18
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  • (S)-2-Benzyloxycarbonylamino-pentanedioic acid 1-methyl ester 5-(2-thioxo-2H-pyridin-1-yl) ester [ No CAS ]
  • 19
  • [ 13031-53-3 ]
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  • 35
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  • [ 541-41-3 ]
  • [ 117836-15-4 ]
YieldReaction ConditionsOperation in experiment
With 4-methyl-morpholine; In tetrahydrofuran; at -15℃; for 0.25h; To a stirred solution of N-(benzyloxycarbonyl-l-glutamic acid (methyl ester)) 20 (4.16g, 14.0mmol) in THF (70mL) at ?15°C, N-methylmorpholine (1.85mL, 16.8mmol) was added followed by ethyl chloroformate (1.61mL, 16.8 mmol). The reaction mixture was stirred at the same temperature for 15 min, and NaBH4 (1.60g, 42.4mmol) in H2O (20mL) was added, followed by addition of H2O (300 mL) at ?15°C immediately afterward. The solution was stirred for 15min and neutralized with 1N aq HCl. The reaction mixture was extracted with EtOAc (3×100mL). The combined organic phase was washed with 1N aq HCl (70mL), H2O (2×70mL), 5percent aq NaHCO3 (2×70mL), dried over MgSO4, and evaporated under reduced pressure. The residue was purified by silica gel chromatography eluting with 30?50percent EtOAc/hexane to afford the amino alcohol 21 as a colorless oil (3.19g, 81percent yield);
 

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