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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Z-Glu-OMe is a glutamic acid derivative, commonly used in biochemical research and drug synthesis.
Synonyms: N-Benzyloxycarbonyl-L-glutamic acid 1-methyl ester
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Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 5672-83-3 |
Formula : | C14H17NO6 |
M.W : | 295.29 |
SMILES Code : | O=C(O)CC[C@@H](C(OC)=O)NC(OCC1=CC=CC=C1)=O |
Synonyms : |
N-Benzyloxycarbonyl-L-glutamic acid 1-methyl ester
|
MDL No. : | MFCD00083278 |
InChI Key : | BGMCTGARFXPQML-NSHDSACASA-N |
Pubchem ID : | 2733408 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With 4-methyl-morpholine; In tetrahydrofuran; at -15℃; for 0.25h; | To a stirred solution of N-(benzyloxycarbonyl-l-glutamic acid (methyl ester)) 20 (4.16g, 14.0mmol) in THF (70mL) at ?15°C, N-methylmorpholine (1.85mL, 16.8mmol) was added followed by ethyl chloroformate (1.61mL, 16.8 mmol). The reaction mixture was stirred at the same temperature for 15 min, and NaBH4 (1.60g, 42.4mmol) in H2O (20mL) was added, followed by addition of H2O (300 mL) at ?15°C immediately afterward. The solution was stirred for 15min and neutralized with 1N aq HCl. The reaction mixture was extracted with EtOAc (3×100mL). The combined organic phase was washed with 1N aq HCl (70mL), H2O (2×70mL), 5percent aq NaHCO3 (2×70mL), dried over MgSO4, and evaporated under reduced pressure. The residue was purified by silica gel chromatography eluting with 30?50percent EtOAc/hexane to afford the amino alcohol 21 as a colorless oil (3.19g, 81percent yield); |