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Chemical Structure| 72849-42-4 Chemical Structure| 72849-42-4

Structure of 72849-42-4

Chemical Structure| 72849-42-4

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Product Details of [ 72849-42-4 ]

CAS No. :72849-42-4
Formula : C18H34O4
M.W : 314.46
SMILES Code : O=C(OC)CCCCCCCCCCCCCCCC(O)=O
MDL No. :N/A
InChI Key :ACZRHOXYVXBTNB-UHFFFAOYSA-M
Pubchem ID :71402171

Safety of [ 72849-42-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 72849-42-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 72849-42-4 ]

[ 72849-42-4 ] Synthesis Path-Downstream   1~20

  • 6
  • [ 72849-42-4 ]
  • [ 13099-34-8 ]
YieldReaction ConditionsOperation in experiment
Example 4 The same procedures as in Example 1 were followed, except that 6.29 g (20 mmol) of <strong>[72849-42-4]heptadecanedioic acid monomethyl ester</strong> was used in place of the pentadecanedioic acid monomethyl ester, to obtain ω-hydroxyheptadecanoic acid. The yield of the product was 52.6%.
  • 7
  • [ 1374572-51-6 ]
  • [ 72849-42-4 ]
  • 8
  • [ 505-52-2 ]
  • [ 72849-42-4 ]
  • 10
  • [ 19102-92-2 ]
  • [ 72849-42-4 ]
YieldReaction ConditionsOperation in experiment
83.7% With methanol; barium(II) hydroxide; at 10 - 25℃; for 34.0h;Inert atmosphere; To a suspension of compound 10b (3.02 g, 9.19 mmol) in MeOH (12.0 mL ) was added a solution of Ba(OH)2 (866 mg, 5.05 mmol) in MeOH (12 mL ) at 10-20 C under N2 atmosphere and kept stirred at 15-25 C for 22 hou rs under N2 atmosphere. 1 H NMR showed the compound 10b was retained (one drop reaction solution was added to a drop 12 M HCI, then determined by 1 H NMR). The reaction mixture was stirred at 15-25 C for 12 hours under N2 atmosphere. 1 H NMR showed the most compound 10c was found (one drop reaction solution was added to a drop 12 M HCI, then determined by 1 H NMR). The reaction mixture was filtered and the filter cake was suspension in 4 M HCI solution (15 mL ) at 15-25 C and kept stirred at 15-25 C for 30 mins, then the mixt ure was filtered and filter cake was dried under reduced pressure to give compound 10c (2.42 g, 7.70 mmol, 83.7% yield) as a white solid, which was confirmed by 1 H NMR. 1H NMR: 400 MHz, CDCI3 δ 3.60 (s, 3H), 2.19-2.33 (m, 4H), 1.48-1.63 (m, 4H), 1.12-1.33 (m, 22H).
  • 11
  • [ 72849-42-4 ]
  • [ 1374572-46-9 ]
  • 12
  • [ 72849-42-4 ]
  • [ 1374572-50-5 ]
  • 13
  • [ 72849-42-4 ]
  • [ 1374572-33-4 ]
  • 14
  • [ 72849-42-4 ]
  • C18H33ClO3 [ No CAS ]
  • 15
  • [ 35691-43-1 ]
  • [ 72849-42-4 ]
  • 16
  • [ 247599-36-6 ]
  • [ 72849-42-4 ]
  • 17
  • [ 72849-42-4 ]
  • [ 94036-00-7 ]
YieldReaction ConditionsOperation in experiment
85.6% With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 20℃; for 12.0h;Inert atmosphere; To a suspension of compound 10c (2.42 g, 7.70 mmol) in THF (25.0 mL ) was added dropwise BH3-Me2S (10.0 M, 940 uL) at 0-10 C under N2 atmosphere and kept stirred at 10-20 C for 12 hour s under N2 atmosphere. 1 H NMR showed the most compound 10d was found (one drop reaction solution was added to a drop 12 M HCI, then determined by 1 H NMR). The reaction mixture was poured into saturated NH4CI solution (25 mL) at 0-10 C and kept stirred at 10-20 C for 15 mins, the aqueous phase was extracted with EtOAc (50 mL x 2), the combined organic phase was dried over anhydrous Na2SO4, filtered and filtrate was concentrated under reduced pressure. The residue was checked by 1 H NMR. TLC 1 (Petroleum ether/Ethyl acetate = 3/1 ). The residue was purified by silica gel column (Petroleum ether/Ethyl acetate, 20/1 to 3/1 ), the spot (Rf = 0.32) was collected to give compound 10d (1.98 g, 6.59 mmol, 85.6% yield) as a white solid, which was confirmed by 1 H NMR. 1H NMR: 400 MHz, CDCI3 δ 3.60 (s, 3H), 3.57 (t, J = 7.2 Hz, 2 H), 2.23 (t, J = 7.2 Hz, 2H), 1.44-1.61 (m, 4H), 1.13-1.33 (m, 22H).
  • 18
  • [ 72849-42-4 ]
  • C25H42O5S [ No CAS ]
  • 19
  • [ 72849-42-4 ]
  • C18H35N3O2 [ No CAS ]
  • 20
  • [ 72849-42-4 ]
  • [ 72849-39-9 ]
 

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