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Chemical Structure| 714971-09-2 Chemical Structure| 714971-09-2
Chemical Structure| 714971-09-2

BMS-599626

CAS No.: 714971-09-2

AC480 is a selective and efficacious inhibitor of HER1 andHER2 with IC50 of 20 nM and 30 nM, ~8-fold less potent to HER4, > 100-fold to VEGFR2, c-Kit, Lck, MET etc.

Synonyms: AC480

4.5 *For Research Use Only !

Cat. No.: A434248 Purity: 98%

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Product Details of [ BMS-599626 ]

CAS No. :714971-09-2
Formula : C27H27FN8O3
M.W : 530.55
SMILES Code : O=C(OC[C@H]1NCCOC1)NC2=CN3N=CN=C(NC4=CC5=C(N(CC6=CC=CC(F)=C6)N=C5)C=C4)C3=C2C
Synonyms :
AC480
MDL No. :MFCD10565678

Safety of [ BMS-599626 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of [ BMS-599626 ]

RTK
JAK-STAT

Isoform Comparison

Biological Activity

Target
  • EGFR/ErbB1

    HER1, IC50:20 nM

  • HER2/ErbB2

    HER2, IC50:30 nM

  • ErbB4

    HER4, IC50:190 nM

  • HER2

    HER2, IC50:30 nM

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00093730 Unspecified Adult Solid Tumor,... More >> Protocol Specific Less << Phase 1 Completed - United States, California ... More >> Jonsson Comprehensive Cancer Center at UCLA Los Angeles, California, United States, 90095-1781 Less <<
NCT00207012 HER2 or EGFR Expressing Advanc... More >>ed Solid Malignancies Less << Phase 1 Completed - France ... More >> Local Institution Villejuif Cedex, France Spain Local Institution Barcelona, Spain Less <<
NCT00095537 Cancer Metast... More >>ases Less << Phase 1 Completed - United States, Arizona ... More >> Local Institution Scottsdale, Arizona, United States Local Institution Tucson, Arizona, United States United States, California Local Institution Los Angeles, California, United States Less <<
NCT00979173 Glioma Phase 1 Completed - United States, North Carolina ... More >> The Preston Robert Tisch Brain Tumor Center at Duke University Medical Center Durham, North Carolina, United States, 27710 Less <<
NCT01245543 Solid Tumors Phase 1 Withdrawn(Clinical investigati... More >>ons have been discontinued and transfer to BMS 3/24/2015) Less << - United States, California ... More >> University of California San Francisco (UCSF) San Francisco, California, United States, 94118 United States, Texas South Texas Accelerated Research Therapeutics (START) San Antonio, Texas, United States, 78229 Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.88mL

0.38mL

0.19mL

9.42mL

1.88mL

0.94mL

18.85mL

3.77mL

1.88mL

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