70987-78-9|(s)-(+)-oxirane-2-methanol p-toluenesulfonate| Ambeed

Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

{[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

Quality Control of [ 70987-78-9 ] Purity: 98% SDS Specification

COA

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

NMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

CNMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

HPLC

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

LC-MS

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

1-2 Day Shipping
High Quality
Technical Support

Product Details of [ 70987-78-9 ]

CAS No. :	70987-78-9
Formula :	C₁₀H₁₂O₄S
M.W :	228.26
SMILES Code :	O=S(OC[C@@H]1CO1)(C2=CC=C(C)C=C2)=O
MDL No. :	MFCD00064489
InChI Key :	NOQXXYIGRPAZJC-VIFPVBQESA-N
Pubchem ID :	153296

Safety of [ 70987-78-9 ]

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H317-H318-H341-H350-H411
Precautionary Statements:	P201-P273-P280-P305+P351+P338-P308+P313
Class:	9
UN#:	3077
Packing Group:	Ⅲ

Application In Synthesis of [ 70987-78-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 70987-78-9 ]

[ 70987-78-9 ] Synthesis Path-Downstream 1~15

1
[ 18362-30-6 ]
[ 70987-78-9 ]
(R)-2-chloro-6-(2,3-epoxypropoxy)benzaldehyde [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate; In N-methyl-acetamide; dichloromethane; water; Petroleum ether;	EXAMPLE 2 A stirred mixture of <strong>[18362-30-6]2-chloro-6-hydroxybenzaldehyde</strong> (4.4 g), (R)-glycidyl 4-toluenesulphonate (5.0 g) and potassium carbonate (3.9 g) in dimethylformamide (120 ml) was heated at 60° C. for 5 hours then allowed to stand at ambient temperature for 18 hours. The solvent was removed in vacuo, water (60 ml) was added and the mixture extracted with ether (3*100 ml). The combined extracts were dried over magnesium sulphate and the solvent evaporated. The residue was purified by flash chromatography on silica eluding with a 1:1 mixture of petroleum ether (b.p. 60-80° C.) and dichloromethane followed by a 19:1 mixture of dichloromethane and industrial methylated spirit. Appropriate fractions were combined and the solvent was removed in vacuo to give (R)-2-chloro-6-(2,3-epoxypropoxy)benzaldehyde (2.8 g) m.p. 62-64° C.
	With potassium carbonate; In N-methyl-acetamide; dichloromethane; water; Petroleum ether;	EXAMPLE 9 A mixture of <strong>[18362-30-6]2-chloro-6-hydroxybenzaldehyde</strong> (4.4 g), (R)-glycidyl 4-toluenesulphonate (5.0 g) and potassium carbonate (3.9 g) in dimethylformamide (120 ml) was stirred and heated at 60° C. for 5 hours and allowed to cool over 18 hours. The solvent was removed in vacuo, water (60 ml) was added to the residue and the mixture extracted with ether (3*100 ml). The combined extracts were dried over magnesium sulphate and the solvent was evaporated. The residual oil was purified by flash chromatography on silica eluding with a 1:1 mixture of petroleum ether (b.p. 40-60° C.) and dichloromethane, followed by neat dichloromethane then a 19:1 mixture of dichloromethane and industrial methylated spirit. Appropriate fractions were combined and the solvent removed in vacuo to give (R)-2-chloro-6-(2,3-epoxypropoxy)benzaldehyde as a pale yellow solid (2.8 g). Other, incompletely purified, fractions gave material which was subjected to repeat chromatography, providing a second crop of product (0.5 g).

References: [1]Patent: US5935973,1999,A .
[2]Patent: US5935973,1999,A .

2
[ 30992-63-3 ]
[ 70987-78-9 ]
[ 1106940-36-6 ]

Yield	Reaction Conditions	Operation in experiment
		l-[5-Benzyloxy-2-((R)-l-oxiranylmethoxy)phenyl]ethanone. To a stirred solution of l-(5-benzyloxy-2-hydroxyphenyl)ethanone (3.0 g, 12.4 mmol) in anhydrous DMF (15 ml) was added NaH (0.55 g, 13.6 mmol). The mixture was allowed to stir at RT for 30 min and then heated to 60 C. A solution of (i?)-oxiran-2- ylmethyl 4-methylbenzenesulfonate (2.83 g, 12.4 mmol) in DMF was added dropwise at 60 C during 1 h. Stirring was then continued at 60 C for 3 h. The cooled reaction was quenched by addition of water (80 ml) and extracted three times with EtOAc. The combined organic layers were extracted twice with aq 1 M NaOH and washed with water and brine. The organic layer was dried with Na2SO4 and concentrated. The crude product obtained was purified by column chromatography with EtO Ac/toluene as eluent to afford the title compound (2.35 g) as a white solid.1H NMR (CDCl3): delta 2.67 (s, 3H), 2.75 (m, IH), 2.93 (t, IH), 3.37-3.40 (m, IH), 3.96 (dd, IH), 4.32 (dd, IH), 5.04 (s, 2H), 6.89 (d, IH), 7.08 (dd, IH), 7.32-7.43 (m, 6H).

References: [1]Patent: WO2009/13390,2009,A1 .Location in patent: Page/Page column 53-54.

3
[ 4018-65-9 ]
[ 70987-78-9 ]
[ 1074-82-4 ]
[ 98-59-9 ]
C₁₇H₁₂ClNO₄ [ No CAS ]