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(R)-1-methyl-5-(oxiran-2-ylmethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine[ No CAS ]
(R)-2-methyl-5-(oxiran-2-ylmethyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
To a mixture of 1 -methyl-4,5 ,6,7-tetrahydro- 1 H-pyrazolo [4,3-c]pyridine and 2- methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine (2.8 g, crude) and KF (3.1 g, 53.7 mmol) in THF(200 mL) was added (S)-oxiran-2-ylmethyl 3-nitrobenzenesulfonate (9.2 g, 35.8 mmol) at 20 C. The mixture was stirred at 40 C for 16 h, at which time LCMS showed the completion of the reactions. The mixture was filtered and concentrated to give the crude mixed product (4.9 g, crude), which was used in next step without further purification. LCMS (mlz): 194.2 [M+H]+.
Chemistry
Pharmaceutical Intermediates
Inhibitors/Agonists
Material Science
