6938-07-4|Diethyl 3,3'-(benzylazanediyl)dipropanoate| Ambeed

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Quality Control of [ 6938-07-4 ] Purity: 97% SDS Specification

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Product Details of [ 6938-07-4 ]

CAS No. :	6938-07-4
Formula :	C₁₇H₂₅NO₄
M.W :	307.38
SMILES Code :	O=C(OCC)CCN(CC1=CC=CC=C1)CCC(OCC)=O
MDL No. :	MFCD00026918
InChI Key :	RWQXNROEHRGDNP-UHFFFAOYSA-N
Pubchem ID :	81354

Safety of [ 6938-07-4 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 6938-07-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 6938-07-4 ]

[ 6938-07-4 ] Synthesis Path-Downstream 1~35

1
[ 6938-07-4 ]
[ 3612-20-2 ]

References: [1]Helvetica Chimica Acta,1958,vol. 41,p. 1184,1187.

2
[ 6938-07-4 ]
[ 41276-30-6 ]

References: [1]Tetrahedron,2001,vol. 57,p. 9045 - 9048.
[2]Synthetic Communications,1995,vol. 25,p. 177 - 182.
[3]Russian Journal of Organic Chemistry,2003,vol. 39,p. 49 - 56.
[4]Bulletin of the Chemical Society of Japan,1958,vol. 31,p. 418,420.
[5]Archiv der Pharmazie,2008,vol. 341,p. 780 - 786.
[6]Monatshefte fur Chemie,2015,vol. 146,p. 973 - 981.

3
[ 64-17-5 ]
[ 100-46-9 ]
[ 140-88-5 ]
[ 23583-21-3 ]
[ 6938-07-4 ]

References: [1]Journal of the American Chemical Society,1947,vol. 69,p. 971.

4
[ 100-46-9 ]
[ 140-88-5 ]
[ 23583-21-3 ]
[ 6938-07-4 ]

Yield	Reaction Conditions	Operation in experiment
80%; 10%	With aluminum oxide; In neat (no solvent); at 95℃; for 3.0h;Green chemistry;	General procedure: The amine (7.5 mmol) and the Michael acceptor (5 mmol) in a molar ratio of 1.5:1 were refluxedwith stirring in the presence of acidic alumina (1 g, 200 mol%). Heating was performed using an oilbath and the reaction was followed by TLC and GC until completion. The reaction was then allowedto cool down to room temperature and filtered through a filter paper. The catalyst was rinsed withethyl acetate/hexane and then concentrated by rotary evaporation. The crude reaction mixture waspurified using a silica-filled chromatographic column using hexane/ethyl acetate as eluents. Usually,for aliphatic amines, the mono-adduct was eluted using 7:3, 6:4 or 5:5 hexane/ethyl acetate whilstfor aromatic ones the solvent mixture used was 8:2 hexane/ethyl acetate. The yields of the purifiedproducts were recorded and then IR and NMR spectroscopy and MS spectrometry were performed.

References: [1]Molecules,2016,vol. 21.
[2]Journal of the American Chemical Society,1947,vol. 69,p. 971.
[3]New Journal of Chemistry,2004,vol. 28,p. 183 - 184.
[4]Synthetic Communications,2013,vol. 43,p. 758 - 767.

5
[ 6938-07-4 ]
[ 5279-23-2 ]

References: [1]Chemische Berichte,1991,vol. 124,p. 487 - 491.
[2]Organometallics,2011,vol. 30,p. 1818 - 1829.
[3]Chemical and pharmaceutical bulletin,1965,vol. 13,p. 1363 - 1365.
[4]Patent: US2019/54455,2019,A1 .Location in patent: Paragraph 0031.
[5]Dalton Transactions,2019,vol. 48,p. 12577 - 12590.

6
[ 100-46-9 ]
[ 140-88-5 ]
[ 6938-07-4 ]

Yield	Reaction Conditions	Operation in experiment
97%	In ethanol; at 20 - 105℃; for 24.5h;Inert atmosphere;	Example 3 Synthesis of β-Alanine, N-(3-ethoxy-3-oxopropyl)-N-(phenylmethyl)-, ethyl ester (N, N-3-diethyl propionate) N, N-di ethyl propionate benzyl amine To a stirred mixture of ethyl acrylate (100 g, 1000 mmol) in ethanol (300 mL) under nitrogen atmosphere, benzyl amine (30 g, 280 mmol) was added drop wise at room temperature over a period of 30 minutes. The reaction mixture was refluxed at 100-105 C. for 24 hours. The excess of ethyl acrylate was removed under reduced pressure to give β-Alanine, N-(3-ethoxy-3-oxopropyl)-N-(phenylmethyl)-, ethyl ester (74 g, 97%) as pale yellow viscous oil. IR (cm-1): 1730, 2825, 2981. 1H NMR (CDCl3): δ 1.13 (6H, t, J=6 Hz), 2.38 (4H, t, J=6 Hz), 2.69 (4H, t, J=5.4), 3.49 (2H, s), 4.0 (4H, q, J=5.4 Hz), 7.1 to 7.2 (5H, Ar)

References: [1]Organometallics,2011,vol. 30,p. 1818 - 1829.
[2]Patent: US2017/274362,2017,A1 .Location in patent: Paragraph 0063-0065.
[3]Tetrahedron Letters,2004,vol. 45,p. 4135 - 4138.
[4]Phosphorus, Sulfur and Silicon and the Related Elements,2007,vol. 182,p. 1203 - 1217.
[5]Asian Journal of Chemistry,2011,vol. 23,p. 3792 - 3794.
[6]Tetrahedron,2001,vol. 57,p. 9045 - 9048.
[7]Tetrahedron Letters,2006,vol. 47,p. 5433 - 5436.
[8]Letters in Organic Chemistry,2009,vol. 6,p. 272 - 277.
[9]Russian Journal of Organic Chemistry,2003,vol. 39,p. 49 - 56.
[10]Chemische Berichte,1991,vol. 124,p. 487 - 491.
[11]Archiv der Pharmazie,2008,vol. 341,p. 780 - 786.
[12]Synthetic Communications,2009,vol. 39,p. 4039 - 4052.
[13]Patent: US2019/54455,2019,A1 .Location in patent: Paragraph 0031.
[14]Dalton Transactions,2019,vol. 48,p. 12577 - 12590.
[15]Acta poloniae pharmaceutica,2021,vol. 78,p. 329 - 337.

7
[ 6938-07-4 ]
[ 867-44-7 ]
6-benzyl-2-methylthio-1,4,5,6,7,8-hexahydroimidazo<4,5-d>azepine [ No CAS ]

References: [1]Polish Journal of Chemistry,1996,vol. 70,p. 296 - 301.

8
[ 6938-07-4 ]
[ 95-92-1 ]
1-Benzyl-4,5-dioxo-azepane-3,6-dicarboxylic acid dimethyl ester [ No CAS ]

References: [1]Polish Journal of Chemistry,1996,vol. 70,p. 296 - 301.

10
[ 539-74-2 ]
N-<β-ethoxycarbonyl-ethyl>-benzylamine [ No CAS ]
[ 6938-07-4 ]

References: [1]Journal of the American Chemical Society,1927,vol. 49,p. 2865.

11
[ 6938-07-4 ]
[ 6405-28-3 ]

References: [1]Phosphorus, Sulfur and Silicon and the Related Elements,2007,vol. 182,p. 1203 - 1217.
[2]Tetrahedron Letters,2004,vol. 45,p. 4135 - 4138.

12
[ 6938-07-4 ]
[ 108-00-9 ]
1,15-bis(N,N-dimethyl)-5,11-dioxo-8-(N-benzyl)-1,4,8,12,15-pentaazapentadecane [ No CAS ]

References: [1]Dalton Transactions,2006,p. 4029 - 4038.

13
[ 539-74-2 ]
[ 100-46-9 ]
[ 23583-21-3 ]
[ 6938-07-4 ]

References: [1]Dalton Transactions,2006,p. 4029 - 4038.

14
[ 6938-07-4 ]
ethyl 3-benzyl-6-hydroxy-6-methyl-9-oxo-3-azabicyclo[3.3.1]nonane-1-carboxylate [ No CAS ]

References: [1]Russian Journal of Organic Chemistry,2003,vol. 39,p. 49 - 56.

15
[ 6938-07-4 ]
[ 177280-02-3 ]

References: [1]Polish Journal of Chemistry,1996,vol. 70,p. 296 - 301.

16
[ 6938-07-4 ]
6-benzyl-2-methylthio-1,4,5,6,7,8-hexahydroimidazo<4,5-d>azepine [ No CAS ]

References: [1]Polish Journal of Chemistry,1996,vol. 70,p. 296 - 301.

17
[ 6938-07-4 ]
[ 177280-03-4 ]

References: [1]Polish Journal of Chemistry,1996,vol. 70,p. 296 - 301.

18
[ 6938-07-4 ]
[ 34753-62-3 ]

References: [1]Chemische Berichte,1991,vol. 124,p. 487 - 491.
[2]Organometallics,2011,vol. 30,p. 1818 - 1829.

19
[ 6938-07-4 ]
[ 129917-37-9 ]

References: [1]Chemische Berichte,1991,vol. 124,p. 487 - 491.

20
[ 6938-07-4 ]
[ 129917-34-6 ]

References: [1]Chemische Berichte,1991,vol. 124,p. 487 - 491.

21
[ 6938-07-4 ]
[ 129917-36-8 ]

References: [1]Chemische Berichte,1991,vol. 124,p. 487 - 491.
[2]Chemische Berichte,1991,vol. 124,p. 487 - 491.

22
[ 6938-07-4 ]
[ 129917-35-7 ]

References: [1]Chemische Berichte,1991,vol. 124,p. 487 - 491.

23
[ 6938-07-4 ]
[ 2181-19-3 ]

References: [1]Helvetica Chimica Acta,1958,vol. 41,p. 1184,1187.

24
[ 6938-07-4 ]
[ 27573-97-3 ]

References: [1]Helvetica Chimica Acta,1958,vol. 41,p. 1184,1187.

25
[ 6938-07-4 ]
[ 67281-07-6 ]

References: [1]Helvetica Chimica Acta,1958,vol. 41,p. 1184,1187.

26
[ 6938-07-4 ]
[ 100792-35-6 ]

References: [1]Helvetica Chimica Acta,1958,vol. 41,p. 1184,1187.

27
[ 6938-07-4 ]
[ 109187-97-5 ]

References: [1]Helvetica Chimica Acta,1958,vol. 41,p. 1184,1187.

28
[ 6938-07-4 ]
[ 55023-26-2 ]

References: [1]Helvetica Chimica Acta,1958,vol. 41,p. 1184,1187.

29
[ 6938-07-4 ]
3,3'-Dimesyloxy-N-benzyl-dipropylamin [ No CAS ]

References: [1]Chemical and pharmaceutical bulletin,1965,vol. 13,p. 1363 - 1365.

30
[ 6335-80-4 ]
[ 140-88-5 ]
[ 6938-07-4 ]
[ 58859-66-8 ]

Yield	Reaction Conditions	Operation in experiment
	In ethanol;	A. To a stirred and refluxing mixture of 403 parts of ethyl 3-[(phenylmethyl)amino]butanoate and 160 parts of ethanol are added dropwise 100 parts of ethyl 2-propenoate. After stirring overnight at reflux temperature, a second portion of 100 parts of ethyl 2-propenoate is added dropwise. Upon completion, stirring is continued at reflux for 48 hours. The reaction mixture is evaporated, yielding a mixture of ethyl N-[2-(ethoxycarbonyl)-1-methylethyl]-N-(phenylmethyl)-β-alanine and ethyl N-[2-(ethoxycarbonyl)ethyl]-N-(phenylmethyl)-β-alanine as an oily residue.

References: [1]Patent: US3989707,1976,A .

31
[ 6938-07-4 ]
[ 59045-43-1 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; hydrogen;palladium; In ethanol;	A mixture of 192.8 parts of ethyl N-[2(ethoxycarbonyl)-ethyl]-N-(phenylmethyl)-β-alanine and 280 parts of absolute ethanol is stirred in an hydrogenation vessel. Then there are added 45 parts of hydrochloric acid solution. After cooling, 10 parts of palladium-on-charcoal catalyst 5% are added and the whole is shaken at room temperature while one equivalent of hydrogen is taken up. The catalyst is filtered off and the filtrate is evaporated, yielding ethyl N-[2-(ethoxycarbonyl)ethyl]-β-alanine hydrochloride as an oily residue.

References: [1]Patent: US3989707,1976,A .

32
[ 6938-07-4 ]
[ 3518-88-5 ]

Yield	Reaction Conditions	Operation in experiment
96%	With palladium 10% on activated carbon; ammonium formate; In ethanol; for 2.0h;Reflux;	Diethyl 3,3'-(benzylazanediyl)dipropanoate (16) was made according to the literature method14 in a yield of 91.2%. 1H NMR (400 MHz, CDCl3) δ 1.23 (t, J = 7.1 Hz, 6H), 2.45 (t, J = 7.1 Hz, 4H), 2.81 (t, J = 7.1 Hz, 4H), 3.60 (s, 2H), 4.10 (q, J = 7.1 Hz, 4H), 7.22-7.29 (m, 5H). MS (APCI+): m/z 308.2 (M+1). Calcd for C17H25NO4: M+ 307.2.A mixture of 16 (4.88 g, 15.9 mmol), HCO2NH4 (10.0 g, 159 mmol) and 10% Pd-C catalyst (2.44 g) in EtOH (ca. 350 mL) was heated at reflux and stirred for 2 h before all the volatiles were removed under reduced pressure. The residue was dissolved in CH2Cl2, filtered through Celite, and evaporated to give diethyl 3,3'-azanediyldipropanoate (17) as a pale yellow liquid (3.30 g, 96%), which had identical 1H NMR characteristics to those reported in the literature.13 MS (APCI+): m/z 218.1 (M+1). Calcd for C10H19NO4: M+ 217.1.Oxalyl chloride (3.92 mL, 46.33 mmol) was added dropwise to a stirred solution of 6-bromohexanoic acid (4.39 g, 22.50 mmol) and DMF (ca. 0.2 mL) in dry CH2Cl2 (50 mL), and the reaction was then stirred overnight. All the volatiles were removed under reduced pressure, and the resulting oil was pumped under high vacuum. The crude 6-bromohexanoyl chloride was dissolved in CH2Cl2 (40 mL) and added portionwise by syringe into a solution of 17 (3.20 g, 14.73 mmol) and NEt3 (10.45 ml, 75.00 mmol) in CH2Cl2 (25 mL). LC-MS was used to monitor the reaction. After 30 mL of the acid chloride solution was added, LC-MS showed most of the diethyl 3,3'-azanediyldipropanoate had reacted. The mixture was stirred for a further 2 h before being washed with aqueous NaHCO3, brine, dried over anhydrous Na2SO4 and filtered. Solvent was removed and the crude product was subjected to flash chromatography (4 × 20 cm silica gel; EtOAc/petroleum ether; 1:3 to 1:1, gradient elution) to give diethyl 3,3'-(6-bromohexanoylazanediyl)dipropanoate (18) as a colorless oil (4.73 g, 81%): 1H NMR (400 MHz, CDCl3) δ 1.24-1.29 (m, 6H), 1.44-1.52 (m, 2H), 1.62-1.70 (m, 2H), 1.85-1.92 (m, 2H), 2.35 (t, J = 7.4 Hz, 2H), 2.55-2.61 (m, 4H), 3.42 (t, J = 6.8 Hz, 2H), 3.58 (t, J = 7.0 Hz, 2H), 3.64 (t, J = 7.3 Hz, 2H), 4.10-4.18 (m, 4H). MS (APCI+): m/z 394.3/396.3 (1:1, M+1). Calcd for C16H2879/81BrNO5: M+ 393.1/395.1.A mixture of 18 (830 mg, 2.11 mmol), dibenzyl 1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate (19)16 (440 mg, 1.00 mmol), and K2CO3 (552 mg, 4.00 mmol) in DMF (10 mL) was stirred at room temperature for 7 h and then at 60 C for 15 h. The mixture was poured into water and extracted with Et2O (×4). The extracts were combined and washed with water, brine, dried over Na2SO4 and filtered. The filtrate was evaporated and the residue obtained was subjected to flash chromatography (silica gel: NEt3/MeOH/CH2Cl2; 0.25:2.5:100 to 0.5:5:100, gradient elution) to give dibenzyl 4,10-bis(6-(bis(3-ethoxy-3-oxopropyl)amino)-6-oxohexyl)-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate (20) (506 mg, 47%) as a colorless oil: 1H NMR (400 MHz, CDCl3) δ 1.23-1.28 (m, 16H), 1.41 (br, 4H), 1.58 (br, 4H), 2.29-2.42 (br, 8H), 2.54-2.65 (m, 16H), 3.42 (br, 8H), 3.55-3.64 (m, 8H), 4.10-4.17 (m, 8H), 5.12 (s, 4H), 7.27-7.35 (m, 10H). MS (APCI+): m/z 1068.0 (M+1). Calcd for C56H86N6O14: M+ 1066.6. Further elution with NEt3/MeOH/CH2Cl2 (1:10:100) gave another colorless oil (202 mg, 27%), which appeared by NMR and MS to be the mono-alkylated product: 1H NMR (400 MHz, CDCl3) δ 1.23-1.60 (m, 16H), 2.25-2.76 (m, 12H), 3.40-3.65 (m, 12H), 4.10-4.16 (m, 4H), 45.12-5.17 (m, 4H), 7.28-7.34 (m, 10H), 11.0 (br, 1H). MS (APCI+): m/z 754.3 (M+1). Calcd for C40H59N5O9: M+ 753.4.A mixture of 20 (155 mg, 0.14 mmol) and 5% Pd-C (80 mg) in EtOH (5 mL) was hydrogenated under 60 psi of hydrogen gas for 15 h. Solvent was removed and the resulting residue was taken up in CH2Cl2 and the catalyst was filtered off. Removal of the solvent gave 1,7-bis(6-(bis(3-ethoxy-3-oxopropyl)amino)-6-oxohexyl)-1,4,7,10-tetraazacyclododecane (21) (100 mg, 86%) as a colorless viscous oil: 1H NMR (400 MHz, CDCl3) δ 1.24-1.36 (m, 16H), 1.45-1.53 (m, 4H), 1.60-1.67 (m, 4H), 2.35 (t, J = 7.4 Hz, 4H), 2.52-2.62 (m, 12H), 2.75 (br, 8H), 2.86 (br, 8H), 3.57 (t, J = 7.0 Hz, 4H), 3.65 (t, J = 7.2 Hz, 4H), 4.10-4.18 (m, 8H). 13C NMR (100 MHz, CDCl3) single peaks at δ 14.01, 24.80, 26.66, 26.75, 32.67, 33.87, 41.99, 44.00, 47.15, 51.31, 56.24, 60.37, 60.74, 170.80, 171.77, 172.77. MS (APCI+): m/z 799.6 (M+1). Calcd for C40H74N6O10: M+ 798.5.A solution of 21 (100 mg, 0.12 mmol) and NaOH (1 mL, 1.0 mol L-1) in EtOH (5 mL) was stirred for 15 h. The mixture was neutralized with HCl (1 mL, 1.0 mol L-1) to pH 5-6. All volatiles were removed and the residue was extracted with EtOH and the solid (NaCl) was filtered off. Removal of solvent gave 3,3',3,3-(6,6'-(1,4,7,10-tetraazacyclododecane-1,7-diyl)bis(hexanoyl)bis(azanediyl))tetrapropanoic acid (H4L11) (90 mg, 100%) as a pale yellow solid: 1H NMR (400 MHz, D2O) δ 1.31-1.35 (m, 4H), 1.59-1.63 (m, 8H), 2.45 (t, J = 7.4 Hz, 4H), 2.61 (t...
93.4%	With 5%-palladium/activated carbon; hydrogen; In ethanol; under 760.051 Torr; for 20.0h;	Example 4 Synthesis of Diethyl 3, 3'-iminodipropionate The Michael adduct of benzyl amine and ethyl acrylate of Example 3 (10 g, 32.5 mmol) in ethanol (50 mL) and Pd on charcoal (5% Pd/C, 100 mg) was stirred under hydrogen at atmospheric pressure for 20 hours. The catalyst was filtered off and the filtrate was made free of any volatiles by rotary evaporation under reduced pressure at 50 C. to yield diethyl iminodipropionate (6.6 g, 93.4%) as pale yellow viscous liquid. IR (cm-1): 1728, 2838, 2981 and 3330 1H NMR (CDCl3): δ 1.90 (6H, t, J=5.4 Hz), 2.82 (4H, t, J=6 Hz), 2.43 (4H, t, J=4.8 Hz), 4.0 (4H, q, J=5.4 Hz)

References: [1]Bioorganic and Medicinal Chemistry,2011,vol. 19,p. 4861 - 4867.
[2]Patent: US2017/274362,2017,A1 .Location in patent: Paragraph 0066-0068.
[3]Letters in Organic Chemistry,2009,vol. 6,p. 272 - 277.
[4]Letters in Organic Chemistry,2011,vol. 8,p. 454 - 460.

33
[ 4530-20-5 ]
[ 6938-07-4 ]
C₁₇H₃₀N₂O₇ [ No CAS ]

References: [1]Synthetic Communications,2009,vol. 39,p. 4039 - 4052.
[2]Acta poloniae pharmaceutica,2021,vol. 78,p. 329 - 337.

34
[ 6938-07-4 ]
[ 22204-53-1 ]
[ 1195100-16-3 ]

References: [1]Synthetic Communications,2009,vol. 39,p. 4039 - 4052.

35
[ 6938-07-4 ]
[MeC(H)N(Bn)C(H)Me] *2[Cl] [ No CAS ]

References: [1]Organometallics,2011,vol. 30,p. 1818 - 1829.

Historical Records

Technical Information

• Acyl Group Substitution • Bouveault-Blanc Reduction • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Catalytic Hydrogenation • Chan-Lam Coupling Reaction • Complex Metal Hydride Reductions • Ester Cleavage • Hydride Reductions • Leuckart-Wallach Reaction • Mannich Reaction • Petasis Reaction • Preparation of Amines • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions with Organometallic Reagents • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Vilsmeier Reagent • Ugi Reaction

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P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 6938-07-4

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