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Chemical Structure| 6758-40-3 Chemical Structure| 6758-40-3

Structure of 6758-40-3

Chemical Structure| 6758-40-3

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Product Details of [ 6758-40-3 ]

CAS No. :6758-40-3
Formula : C12H12N2O7
M.W : 296.23
SMILES Code : O=C(O)[C@@H](NC(C1=CC=C([N+]([O-])=O)C=C1)=O)CCC(O)=O
MDL No. :MFCD00007348
InChI Key :NOJZBJAFCSWMKC-VIFPVBQESA-N
Pubchem ID :2724179

Safety of [ 6758-40-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 6758-40-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 6758-40-3 ]

[ 6758-40-3 ] Synthesis Path-Upstream   1~6

  • 1
  • [ 122-04-3 ]
  • [ 142-47-2 ]
  • [ 6758-40-3 ]
YieldReaction ConditionsOperation in experiment
29.81 g With sodium hydroxide In water at 0 - 20℃; for 1 h; In the reaction vessel, sodium glutamate 18.73g (0.11mol), water, 75g, stirring with 1mol / L aqueous sodium hydroxide solution of PH = 8, and slowly added dropwise at 0 28.31g step (1) of the resulting dichloroethane, nitrobenzene chloride solution, was dropwise added to 1mol / L aqueous sodium hydroxide to adjust the PH value of the reaction system was kept PH = 8, the reaction solution changed from white to purple discoloration, the addition was complete 1 hour reaction at room temperature, static layers were separated and the organic layer was extracted twice with water, the combined aqueous layer was acidified with hydrochloric PH = 1, the precipitated crystals were filtered and dried to give N- Nitrobenzoylhydrazone -L- glutamic acid 29.81 g, HPLC purity of 98.43percent, a yield of 99.03percent (with on-nitro benzoic acid).
References: [1] Patent: CN105439895, 2016, A, . Location in patent: Paragraph 0027; 0028.
  • 2
  • [ 122-04-3 ]
  • [ 32221-81-1 ]
  • [ 6758-40-3 ]
YieldReaction ConditionsOperation in experiment
29.3 g
Stage #1: With sodium hydroxide In water
Stage #2: at 5℃;
2 Add 75g of water and 16.9g of sodium glutamate (0.1mol) to the reaction unit, adjust the pH to 8 with a 1mol/L sodium hydroxide solution with stirring, then cool to 5±1°C, slowly add dropwise The solution containing p-nitrobenzoyl chloride obtained in the step 1 was maintained at pH = 8 during the dropwise addition, and the reaction was completed until the temperature was 5 ± 1 ° C. After completion of the reaction, the pH was adjusted to 1 with dilute hydrochloric acid, crystallized, filtered, and the filter cake was washed with water and dried under reduced pressure to give 29.3 g of N-p-nitrobenzoyl-L-glutamic acid with a purity of 99.4percent ( HPLC), a two-step yield of 99.0percent based on p-nitrobenzoic acid.
References: [1] Patent: CN108147977, 2018, A, . Location in patent: Paragraph 0015; 0017; 0018; 0021; 0022; 0024.
  • 3
  • [ 56-86-0 ]
  • [ 122-04-3 ]
  • [ 6758-40-3 ]
References: [1] Chirality, 2010, vol. 22, # 2, p. 252 - 257.
  • 4
  • [ 62-23-7 ]
  • [ 6758-40-3 ]
References: [1] Patent: CN105439895, 2016, A, .
[2] Patent: CN108147977, 2018, A, .
  • 5
  • [ 7148-24-5 ]
  • [ 6758-40-3 ]
References: [1] Journal of the Chemical Society, 1949, p. 1401,1404.
[2] Journal of the Chemical Society, 1949, p. 1401,1404.
  • 6
  • [ 122-04-3 ]
  • [ 6758-40-3 ]
References: [1] Journal of the Chemical Society, 1949, p. 1401,1404.
 

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