67242-59-5|N-Methyl-N-(pyridin-2-yl)formamide| Ambeed

Yield	Reaction Conditions	Operation in experiment
		a) According to reference (Synthesis 1984,1048-1050), to a solution of 5- [PHENYLOXAZOLE] (1.5 g, 10.3 mmol) in THF: diethyl ether (2: 1,50 mL) at-78 C is added n-butyl lithium (7.1 [ML] of 1.6 M solution in hexanes, 11.4 mmol). The reaction is stirred at-78 C for 30 minutes after which time a solution of N-methyl-2- pyridyl formamide (1.85 mL, 15.5 mmol) in THF (20 mL) is added. The reaction mixture is stirred at-78 C for 30 min and then at [25 C] for 14 hours. It is quenched by addition of water and extracted with ethyl acetate. The combined organic layers are washed with 10 % [HCI,] saturated sodium bicarbonate and brine before being dried over sodium sulfate and concentrated. The resulting oil is purified by column chromatography (5% ethyl acetate in hexanes) to afford 246 mg [OF 5-PHENYL-1,] 3- oxazole-2-carbaldehyde.
		A solution of <strong>[1006-68-4]5-phenyloxazole</strong> (0.192 g) in 2: 1 tetrahydrofuran/diethyl ether (7 mL) was cooled to -780C, and treated with n-butyl lithium (0.582 mL) dropwise under Argon. The mixture was stirred for 30 minutes at -780C, at this time a solution of N-methyl-N-(pyridin-2-yl) formamide (0.270 g) in tetrahydrofuran (2.6 mL) was added dropwise to the solution. After stirring at -780C for 30 minutes, the mixture was allowed to warm up to room temperature and stirring continued overnight. The mixture was quenched by the addition of water and extracted with ethyl acetate. The combined extracts were washed with 10% hydrochloric acid, saturated aqueous solution of sodium bicarbonate and brine, dried and concentrated in vacuo and purified by column chromatography on silica gel (10-50% ethyl acetate in hexane) to provide the title compound (0.016 g) with the following physical data.1H NMR (DMSO-d6): δ 9.72 (s, IH), 8.12 (s, IH), 7.88 (d, J = 7.02 Hz, IH), 7.60-7.49 (m, 4H); Mass data (APCI, Pos ): m/z 174 (M + H)+.

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N-Methyl-N-(pyridin-2-yl)formamide

CAS No.: 67242-59-5

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Product Details of [ 67242-59-5 ]

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Application In Synthesis of [ 67242-59-5 ]

[ 67242-59-5 ] Synthesis Path-Downstream 1~2

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
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H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed