155601-65-3|2,6-Difluoronicotinaldehyde| Ambeed

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Quality Control of [ 155601-65-3 ] Purity: 98% SDS Specification

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Product Details of [ 155601-65-3 ]

CAS No. :	155601-65-3
Formula :	C₆H₃F₂NO
M.W :	143.09
SMILES Code :	O=CC1=C(F)N=C(F)C=C1
MDL No. :	MFCD08277633
InChI Key :	ZYCCUPSLEFLBNR-UHFFFAOYSA-N
Pubchem ID :	10701929

Safety of [ 155601-65-3 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302
Precautionary Statements:	P280-P305+P351+P338

Computational Chemistry of [ 155601-65-3 ] Show Less

Physicochemical Properties

Num. heavy atoms	10
Num. arom. heavy atoms	6
Fraction Csp3	0.0
Num. rotatable bonds	1
Num. H-bond acceptors	4.0
Num. H-bond donors	0.0
Molar Refractivity	29.54
TPSA ? Topological Polar Surface Area: Calculated from Ertl P. et al. 2000 J. Med. Chem.	29.96 Å²

Lipophilicity

Log P_o/w (iLOGP)? iLOGP: in-house physics-based method implemented from Daina A et al. 2014 J. Chem. Inf. Model.	1.22
Log P_o/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by XLOGP program, version 3.2.2, courtesy of CCBG, Shanghai Institute of Organic Chemistry	1.18
Log P_o/w (WLOGP)? WLOGP: Atomistic method implemented from Wildman SA and Crippen GM. 1999 J. Chem. Inf. Model.	2.01
Log P_o/w (MLOGP)? MLOGP: Topological method implemented from Moriguchi I. et al. 1992 Chem. Pharm. Bull. Moriguchi I. et al. 1994 Chem. Pharm. Bull. Lipinski PA. et al. 2001 Adv. Drug. Deliv. Rev.	0.66
Log P_o/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	2.35
Consensus Log P_o/w? Consensus Log P_o/w: Average of all five predictions	1.49

Water Solubility

Log S (ESOL):? ESOL: Topological method implemented from Delaney JS. 2004 J. Chem. Inf. Model.	-1.85
Solubility	2.03 mg/ml ; 0.0142 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Very soluble
Log S (Ali)? Ali: Topological method implemented from Ali J. et al. 2012 J. Chem. Inf. Model.	-1.4
Solubility	5.63 mg/ml ; 0.0394 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Very soluble
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	-2.51
Solubility	0.445 mg/ml ; 0.00311 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble

Pharmacokinetics

GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg	High
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg	Yes
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) and tested on 415 molecules (test set) 10-fold CV: ACC=0.72 / AUC=0.77 External: ACC=0.88 / AUC=0.94	No
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.83 / AUC=0.90 External: ACC=0.84 / AUC=0.91	No
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.80 / AUC=0.86 External: ACC=0.80 / AUC=0.87	No
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) and tested on 2075 molecules (test set) 10-fold CV: ACC=0.78 / AUC=0.85 External: ACC=0.71 / AUC=0.81	No
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) and tested on 1068 molecules (test set) 10-fold CV: ACC=0.79 / AUC=0.85 External: ACC=0.81 / AUC=0.87	No
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) and tested on 2579 molecules (test set) 10-fold CV: ACC=0.77 / AUC=0.85 External: ACC=0.78 / AUC=0.86	No
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from Potts RO and Guy RH. 1992 Pharm. Res.	-6.34 cm/s

Druglikeness

Lipinski? Lipinski (Pfizer) filter: implemented from Lipinski CA. et al. 2001 Adv. Drug Deliv. Rev. MW ≤ 500 MLOGP ≤ 4.15 N or O ≤ 10 NH or OH ≤ 5	0.0
Ghose? Ghose filter: implemented from Ghose AK. et al. 1999 J. Comb. Chem. 160 ≤ MW ≤ 480 -0.4 ≤ WLOGP ≤ 5.6 40 ≤ MR ≤ 130 20 ≤ atoms ≤ 70	None
Veber? Veber (GSK) filter: implemented from Veber DF. et al. 2002 J. Med. Chem. Rotatable bonds ≤ 10 TPSA ≤ 140	0.0
Egan? Egan (Pharmacia) filter: implemented from Egan WJ. et al. 2000 J. Med. Chem. WLOGP ≤ 5.88 TPSA ≤ 131.6	0.0
Muegge? Muegge (Bayer) filter: implemented from Muegge I. et al. 2001 J. Med. Chem. 200 ≤ MW ≤ 600 -2 ≤ XLOGP ≤ 5 TPSA ≤ 150 Num. rings ≤ 7 Num. carbon > 4 Num. heteroatoms > 1 Num. rotatable bonds ≤ 15 H-bond acc. ≤ 10 H-bond don. ≤ 5	1.0
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat implemented from Martin YC. 2005 J. Med. Chem.	0.55

Medicinal Chemistry

PAINS? Pan Assay Interference Structures: implemented from Baell JB. & Holloway GA. 2010 J. Med. Chem.	0.0 alert
Brenk? Structural Alert: implemented from Brenk R. et al. 2008 ChemMedChem	2.0 alert: heavy_metal
Leadlikeness? Leadlikeness: implemented from Teague SJ. 1999 Angew. Chem. Int. Ed. 250 ≤ MW ≤ 350 XLOGP ≤ 3.5 Num. rotatable bonds ≤ 7	No; 1 violation:MW<1.0
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) based on 1024 fragmental contributions (FP2) modulated by size and complexity penaties, trained on 12'782'590 molecules and tested on 40 external molecules (r² = 0.94)	1.61

Application In Synthesis of [ 155601-65-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 155601-65-3 ]

[ 155601-65-3 ] Synthesis Path-Downstream 1~22

1
[ 109-01-3 ]
[ 155601-65-3 ]
[ 155601-66-4 ]

Yield	Reaction Conditions	Operation in experiment
6.25 g (82%)	With sodium hydroxide; In 1-methyl-pyrrolidin-2-one;	Part (b) 2,6-Difluoropyridine-3-carboxaldehyde (4.89 g, 0.034 mole) was dissolved in 20 mL of N-methylpyrrolidone and chilled in an ice/water bath. N-methylpiperazine (3.5 g, 0.035 mole) was added dropwise and the reaction mixture was stirred for 15 minutes and then distributed between 5% NaOH and Et2 O. The organic phase was dried and concentrated to give 6.25 g (82%) of product. An analytical sample was obtained by recrystallization from pentane, mp 77-78 C. Analysis: Calculated for C11 H14 FN3 O: 59.18% C; 6.32% H; 18.82% N; Found: 58.97% C; 6.31% H; 18.95% N.

References: [1]Journal of Heterocyclic Chemistry,1997,vol. 34,p. 789 - 795.
[2]Patent: US5300498,1994,A .

2
[ 1513-65-1 ]
[ 67242-59-5 ]
[ 155601-65-3 ]

References: [1]Journal of Heterocyclic Chemistry,1997,vol. 34,p. 789 - 795.

3
[ 155601-65-3 ]
[ 171178-50-0 ]

References: [1]Journal of Heterocyclic Chemistry,1997,vol. 34,p. 789 - 795.

4
[ 1513-65-1 ]
[ 68-12-2 ]
[ 155601-65-3 ]

References: [1]European Journal of Organic Chemistry,2004,p. 1018 - 1024.

5
[ 685517-67-3 ]
[ 155601-65-3 ]

References: [1]European Journal of Organic Chemistry,2004,p. 1018 - 1024.

6
[ 155601-65-3 ]
1-methyl-6-(4-methyl-1-piperazinyl)-1H-pyrazolo[3,4-b]pyridine [ No CAS ]

References: [1]Journal of Heterocyclic Chemistry,1997,vol. 34,p. 789 - 795.

7
[ 155601-65-3 ]
6-(4-methyl-1-piperazinyl)-1H-pyrazolo[3,4-b]pyridine [ No CAS ]

References: [1]Journal of Heterocyclic Chemistry,1997,vol. 34,p. 789 - 795.

8
[ 155601-65-3 ]
[ 193481-65-1 ]

References: [1]Journal of Heterocyclic Chemistry,1997,vol. 34,p. 789 - 795.

9
[ 99-76-3 ]
[ 155601-65-3 ]
[ 926302-81-0 ]

Yield	Reaction Conditions	Operation in experiment
70%	With potassium carbonate; In N,N-dimethyl-formamide; at 100℃; for 2h;	A mixture of <strong>[155601-65-3]2,6-difluoro-pyridine-3-carbaldehyde</strong> (1.10 g, 7.69 mmol), 4-hydroxy- benzoic acid methyl ester (1.17 g, 7.69 mmol) and K2CO3 (0.552 g, 4.00 mmol) in DMF (10 mL) was stirred at 100 0C for 2 h. The mixture was cooled to room temperature and DMF was removed. Aqueous work-up and purification by flash chromatography on silica gel (EtOAc/hexanes, 1 :4 in v/v) followed by recrystallization from EtOAc/hexanes afforded 4-(6- fluoro-5-formyl-pyridin-2-yloxy)-benzoic acid methyl ester as a white solid (1.48 g, 70%). H NMR (CDCl3) 6 3.94 (s, 2H), 6.94 (d, IH, J= 8.4 Hz), 122-126 (m, 2H), 8.12-8.16 (m, 2H), 8.29-8.35 (m, IH), 10.19 (s, IH).

References: [1]Patent: WO2007/22371,2007,A2 .Location in patent: Page/Page column 61.

10
[ 122-51-0 ]
[ 155601-65-3 ]
[ 1105510-16-4 ]

Yield	Reaction Conditions	Operation in experiment
	toluene-4-sulfonic acid; In ethanol;Heating / reflux;	A solution of <strong>[155601-65-3]2,6-difluoronicotinaldehyde</strong> (5 g, 34.94 mmol), triethyl orthoformate (8.72 ml, 52.41 mmol) and p-toluenesulfonic acid (0.562 mL, 3.49 mmol) in ethanol (50 mL) was heated at reflux overnight. Solvent was removed and the residue was diluted with EtOAc and washed with aqueous K2CO3 and brine. Drying (MgSO4) and removal of solvent gave an oil. The oil was distilled under high vacuum conditions bulb-to-bulb to give 2.85 g of product as a clear, colorless oil.1H NMR: 1.25 (t, 3H), 3.5-3.7 (m 2H), 5.6 (s, IH), 6.85 (d, 2H), 8.1 (dd, IH).

References: [1]Patent: WO2009/10801,2009,A1 .Location in patent: Page/Page column 73.

11
[ 2591-86-8 ]
[ 1513-65-1 ]
[ 155601-65-3 ]

Yield	Reaction Conditions	Operation in experiment
60%		Under N2, to a solution of 2,6-difluoropyridine (4.95 g, 43.0 mmol) in anhydrous THF (100 mL) cooled at- -78C was added LDA (2.0 M in heptane/THF/ethylbenzene, 23.0 mL, 46.0 mmol). After the mixture was stirred at -780C for 30 min 1-formylpiperidine (4.98 g, 44.0 mmol) was added. The mixture was stirred at -78C for 20 min, and at -78C aqueous HCl (3 N, 60 mL) and Et2O (50 mL) were added. The ether layer was collected and the aqueous layer was extracted with Et2O (3 X 100 mL). The combined extracts were dried over anhydrous Na2SO4. After filtration the solvent was removed, and the residue was purified by flash chromatography on silica gel (CH2Cl2/hexanes, 1:1 v/v) to afford 2,6-difluoro-pyridme-3- carbaldehyde as a pale yellow liquid (1.41 g, 60%).

References: [1]Patent: WO2007/22371,2007,A2 .Location in patent: Page/Page column 61.

12
[ 2835-98-5 ]
[ 135636-66-7 ]
[ 155601-65-3 ]
[ 1360427-70-8 ]

Yield	Reaction Conditions	Operation in experiment
68%		A mixture of <strong>[155601-65-3]2,6-difluoronicotinaldehyde</strong> (2 g, 13.9 mmol), 2-amino-5-methylphenol (1.7 g, 13.8 mmol) and 2,3-butanedione monoxime (1.065 g, 10.5 mnol) in acetic acid (120 mL) was heated at 120 C for 1.5 hours. After cooling down to room temperature, zinc powder (2 g) was added and the mixture heated one hour at 120 C and left overnight at room temperature. The suspension is then filtered and filtrate is reduced to about 20 mL. Water was added (about 100 mL) and aqueous KOH was added up to pH ~ 8. The mixture was extracted with dichloromethane and the crude obtained purified by column chromatography using CH2Cl2/Et2O as eluent. The ligand was obtained as a beige solid (2.14 g, yield 68 %) 1H NMR (CDCl3, 400 MHz): delta 8.28 (t, J= 8.0 Hz, 1H); 7.25 (d, J= 1.6 Hz, 1H); 7.09 (d, J= 8.4 Hz, 1H); 6.99 (ddd, J= 8.0, 2.0, 0.8 Hz, 1H); 6.79 (dd, J= 8.4, 2.8 Hz, 1H); 2.27 (s, 3H); 2.24 (d, J= 0.8 Hz, 3H); 2.19 (d, J= 0.8 Hz, 3H).
68%		<strong>[155601-65-3]2,6-difluoronicotinaldehyde</strong> was obtained as described in M. Schlosser and T. Rausis, Eur. J. Org. Chem. 2004, 1018.A mixture of <strong>[155601-65-3]2,6-difluoronicotinaldehyde</strong> (2 g, 13.9 mmol), 2-amino-5- methylphenol (1.7 g, 13.8 mmol) and 2,3-butanedione monoxime (1.065 g, 10.5 mmol) in acetic acid (120 mL) was heated at 120C for 1.5 hours. After cooling down to room temperature, zinc powder (2 g) was added and the mixture heated one hour at 120C and left overnight at room temperature. The suspension is then filtered and filtrate is reduced to about 20 mL. Water was added (about 100 mL) and aqueous KOH was added up to pH ~ 8. The mixture was extracted with dichloromethane and the crude obtained purified by column chromatography using CH2Cl2/Et20 as eluent. The ligand was obtained as a beige solid (2.14 g, yield 68 %).1H MR (CDC13, 400 MHz) : delta 8.28 (t, J= 8.0 Hz, IH) ; 7.25 (d, J= 1.6 Hz, IH) ; 7.09 (d, J= 8.4 Hz, IH) ; 6.99 (ddd, J= 8.0, 2.0, 0.8 Hz, IH) ; 6.79 (dd, J= 8.4, 2.8 Hz, IH) ; 2.27 (s, 3H) ; 2.24 (d, J= 0.8 Hz, 3H) ; 2.19 (d, J= 0.8 Hz, 3H).

References: [1]Patent: EP2423214,2012,A1 .Location in patent: Page/Page column 24.
[2]Patent: WO2012/19948,2012,A1 .Location in patent: Page/Page column 32.

13
[ 1258861-52-7 ]
[ 155601-65-3 ]
N-[(2,6-difluoro-3-pyridyl)methyl]-1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
26%	With sodium tris(acetoxy)borohydride; In dichloromethane; at 20℃; for 72h;Inert atmosphere;	To a solution of 1 -[4-(2-methylpyrazol-3-yl)phthalazin-1 -yl]piperidin-4-amine (135mg, 0.44mmol) and <strong>[155601-65-3]2,6-difluoropyridine-3-carbaldehyde</strong> (63mg, 0.44mmol) in DCM (2mL) at room temperature was added sodium triacetoxyborohydride (131 mg, 0.62mmol). The reaction mixture was stirred at room temperature under nitrogen for 72h. The reaction was quenched with a saturated NaHCO3 solution (aq) and extracted with ethyl acetate. The organic layer was concentrated in vacuo. Purification bysilica flash column chromatography with 10% ethyl acetate in heptane with a gradient increasing to80% ethyl acetate followed by 2% DCM in methanol with a gradient increasing to 10% MeOHafforded the crude product as a brown oil. Further purification by preparative LCMS afforded N[(2,6-difluoro-3-pyridyl)methyl]-1 -[4-(2-methylpyrazol-3-yl)phthalazin-1 -yl]piperidin-4-amine (50mg,0.11 mmol, 26%) as a colourless oil.1H NMR (400MHz, MeOD) O/ppm: 8.25 (d, J8.2Hz, 1H), 8.2-8.14 (dd, J8.OHz, 3JHF 17.0Hz, 1H),8.04-7.99 (m,1H), 7.97-7.94 (m, 2H), 7.70 (d, J2.OHz, 1H), 7.01 (dd, J8.2Hz, 2.5Hz, 1H), 6.69 (d, J2.0Hz, 1H) 4.1 0-4.03 (m(br), 2H), 3.94 (s, 2H), 3.91 (s, 3H), 3.25-3.27 (m, 2H), 2.87 (tt, J10.7Hz,4.1Hz, 1 H), 2.24-2.17 (m(br), 2H), 1.87-1.76 (m, 2H).MS Method 1: RT: 2.89mm, m/z 436.4 [M÷H]

References: [1]Patent: WO2014/191737,2014,A1 .Location in patent: Paragraph 00254; 00255.

14
benzyl 2-((3-benzyl-5-phenylpyrazin-2-yl)amino)-2-(diethoxyphosphoryl)acetate [ No CAS ]
[ 155601-65-3 ]
C₂₅H₁₆F₂N₄O [ No CAS ]

References: [1]Chemistry - A European Journal,2016,vol. 22,p. 10369 - 10375.

15
C₃₈H₅₂N₇O₉Pol [ No CAS ]
[ 155601-65-3 ]
C₄₄H₅₃F₂N₈O₉Pol [ No CAS ]

References: [1]ACS Combinatorial Science,2018,vol. 20,p. 61 - 69.

16
[ 113885-21-5 ]
[ 155601-65-3 ]
C₁₃H₁₁F₂N₅O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; In 1,4-dioxane; dimethyl sulfoxide; N,N-dimethyl-formamide; at 100℃; for 0.75h;	To a mixture of intermediate 3.1 (500 mg, 2.71 mmol) and 2,6-difluoro-pyridine-3- carbaldehyde (388 mg, 2.71 mmol) in DMF (1 .00 mL) and DMSO (1 .00 mL) was added dropwise HCI solution in dioxane (136 muIota, 0.543 mmol). The mixture was stirred for 45 min at 100 C, then H2O was added, stirred for 30 min at rt, the precipitate was filtered, washed with H2O and dried to obtain the product.MS (ESI+): (M+H)+308HPLC: RT = 0.68 min, Method F

References: [1]Patent: WO2019/11802,2019,A1 .Location in patent: Page/Page column 28.

17
[ 137-07-5 ]
[ 155601-65-3 ]
2-(2,6-difluoropyridin-3-yl)benzo[d]thiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82.1%	In ethanol; at 70℃; for 6h;	Both <strong>[155601-65-3]2,6-difluoronicotinaldehyde</strong> (1.0 mmol) and 2-aminobenzenethiol(1.0 mmol) were dissolved in ethanol. After reaction for 6 h at70 C, yellow solid product was obtained once the reaction system wascooled to room temperature. Yield:82.1%. M.p:145.1-145.7 C. 1H NMR (500 MHz, CDCl3) delta: 8.99 (dd, J=16.7, 8.3 Hz, 1H), 8.11 (d,J=8.2 Hz, 1H), 7.97 (d, J=8.0 Hz, 1H), 7.58-7.52 (m, 1H), 7.46 (t,J=7.6 Hz, 1H), 7.04 (dd, J=8.3, 2.9 Hz, 1H). 13C NMR (125 MHz,CDCl3) delta: 162.75, 161.08, 159.22, 158.32, 157.55, 152.53, 144.73,135.59, 126.71, 125.85, 123.42, 121.67, 113.99, 107.57, 107.34.HRMS (ESI) m/z: [M + H+]: 249.0300.

References: [1]Dyes and Pigments,2019,vol. 166,p. 254 - 259.
[2]Journal of Materials Chemistry C,2019,vol. 7,p. 4178 - 4184.

18
[ 155601-65-3 ]
[iridium(III)(2-(2,6-difluoropyridin-3-yl)benzo[d]thiazole)₂(acetylacetonate)] [ No CAS ]

References: [1]Journal of Materials Chemistry C,2019,vol. 7,p. 4178 - 4184.

19
[ 155601-65-3 ]
[iridium(2-(2,6-difluoropyridin-3-yl)-1-phenyl-1H-benzo[d]-imidazole)₄] [ No CAS ]

References: [1]Journal of Materials Chemistry C,2019,vol. 7,p. 4178 - 4184.

20
[ 155601-65-3 ]
[iridium(2-(2,6-difluoropyridin-3-yl)-1-phenyl-1H-benzo[d]-imidazole)₂(acetylacetonate)] [ No CAS ]

References: [1]Journal of Materials Chemistry C,2019,vol. 7,p. 4178 - 4184.

21
[ 155601-65-3 ]
[iridium(2-(2,6-difluoropyridin-3-yl)benzo[d]thiazole)₄] [ No CAS ]

References: [1]Journal of Materials Chemistry C,2019,vol. 7,p. 4178 - 4184.

22
[ 155601-65-3 ]
[ 534-85-0 ]
2-(2,6-difluoropyridin-3-yl)-1-phenyl-1H-benzo[d]-imidazole [ No CAS ]

References: [1]Journal of Materials Chemistry C,2019,vol. 7,p. 4178 - 4184.

Historical Records

Technical Information

• Alkyl Halide Occurrence • Barbier Coupling Reaction • Baylis-Hillman Reaction • Bucherer-Bergs Reaction • Clemmensen Reduction • Complex Metal Hydride Reductions • Corey-Chaykovsky Reaction • Corey-Fuchs Reaction • Fischer Indole Synthesis • Grignard Reaction • Hantzsch Dihydropyridine Synthesis • Henry Nitroaldol Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Julia-Kocienski Olefination • Knoevenagel Condensation • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Mukaiyama Aldol Reaction • Nozaki-Hiyama-Kishi Reaction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Amines • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Amines • Reformatsky Reaction • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Stetter Reaction • Stobbe Condensation • Tebbe Olefination • Ugi Reaction • Wittig Reaction • Wolff-Kishner Reduction

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P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 155601-65-3

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CAS No.: 155601-65-3

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