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Chemical Structure| 6630-33-7 Chemical Structure| 6630-33-7

Structure of 6630-33-7

Chemical Structure| 6630-33-7

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Product Details of [ 6630-33-7 ]

CAS No. :6630-33-7
Formula : C7H5BrO
M.W : 185.02
SMILES Code : O=CC1=CC=CC=C1Br
MDL No. :MFCD00003300
InChI Key :NDOPHXWIAZIXPR-UHFFFAOYSA-N
Pubchem ID :81129

Safety of [ 6630-33-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Computational Chemistry of [ 6630-33-7 ] Show Less

Physicochemical Properties

Num. heavy atoms 9
Num. arom. heavy atoms 6
Fraction Csp3 0.0
Num. rotatable bonds 1
Num. H-bond acceptors 1.0
Num. H-bond donors 0.0
Molar Refractivity 39.53
TPSA ?

Topological Polar Surface Area: Calculated from
Ertl P. et al. 2000 J. Med. Chem.

17.07 Ų

Lipophilicity

Log Po/w (iLOGP)?

iLOGP: in-house physics-based method implemented from
Daina A et al. 2014 J. Chem. Inf. Model.

1.73
Log Po/w (XLOGP3)?

XLOGP3: Atomistic and knowledge-based method calculated by
XLOGP program, version 3.2.2, courtesy of CCBG, Shanghai Institute of Organic Chemistry

2.39
Log Po/w (WLOGP)?

WLOGP: Atomistic method implemented from
Wildman SA and Crippen GM. 1999 J. Chem. Inf. Model.

2.26
Log Po/w (MLOGP)?

MLOGP: Topological method implemented from
Moriguchi I. et al. 1992 Chem. Pharm. Bull.
Moriguchi I. et al. 1994 Chem. Pharm. Bull.
Lipinski PA. et al. 2001 Adv. Drug. Deliv. Rev.

2.21
Log Po/w (SILICOS-IT)?

SILICOS-IT: Hybrid fragmental/topological method calculated by
FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com

2.68
Consensus Log Po/w?

Consensus Log Po/w: Average of all five predictions

2.25

Water Solubility

Log S (ESOL):?

ESOL: Topological method implemented from
Delaney JS. 2004 J. Chem. Inf. Model.

-2.92
Solubility 0.222 mg/ml ; 0.0012 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Soluble
Log S (Ali)?

Ali: Topological method implemented from
Ali J. et al. 2012 J. Chem. Inf. Model.

-2.39
Solubility 0.754 mg/ml ; 0.00408 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Soluble
Log S (SILICOS-IT)?

SILICOS-IT: Fragmental method calculated by
FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com

-3.2
Solubility 0.117 mg/ml ; 0.000634 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Soluble

Pharmacokinetics

GI absorption?

Gatrointestinal absorption: according to the white of the BOILED-Egg

High
BBB permeant?

BBB permeation: according to the yolk of the BOILED-Egg

Yes
P-gp substrate?

P-glycoprotein substrate: SVM model built on 1033 molecules (training set)
and tested on 415 molecules (test set)
10-fold CV: ACC=0.72 / AUC=0.77
External: ACC=0.88 / AUC=0.94

No
CYP1A2 inhibitor?

Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set)
and tested on 3000 molecules (test set)
10-fold CV: ACC=0.83 / AUC=0.90
External: ACC=0.84 / AUC=0.91

Yes
CYP2C19 inhibitor?

Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set)
and tested on 3000 molecules (test set)
10-fold CV: ACC=0.80 / AUC=0.86
External: ACC=0.80 / AUC=0.87

No
CYP2C9 inhibitor?

Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set)
and tested on 2075 molecules (test set)
10-fold CV: ACC=0.78 / AUC=0.85
External: ACC=0.71 / AUC=0.81

No
CYP2D6 inhibitor?

Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set)
and tested on 1068 molecules (test set)
10-fold CV: ACC=0.79 / AUC=0.85
External: ACC=0.81 / AUC=0.87

No
CYP3A4 inhibitor?

Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set)
and tested on 2579 molecules (test set)
10-fold CV: ACC=0.77 / AUC=0.85
External: ACC=0.78 / AUC=0.86

No
Log Kp (skin permeation)?

Skin permeation: QSPR model implemented from
Potts RO and Guy RH. 1992 Pharm. Res.

-5.73 cm/s

Druglikeness

Lipinski?

Lipinski (Pfizer) filter: implemented from
Lipinski CA. et al. 2001 Adv. Drug Deliv. Rev.
MW ≤ 500
MLOGP ≤ 4.15
N or O ≤ 10
NH or OH ≤ 5

0.0
Ghose?

Ghose filter: implemented from
Ghose AK. et al. 1999 J. Comb. Chem.
160 ≤ MW ≤ 480
-0.4 ≤ WLOGP ≤ 5.6
40 ≤ MR ≤ 130
20 ≤ atoms ≤ 70

None
Veber?

Veber (GSK) filter: implemented from
Veber DF. et al. 2002 J. Med. Chem.
Rotatable bonds ≤ 10
TPSA ≤ 140

0.0
Egan?

Egan (Pharmacia) filter: implemented from
Egan WJ. et al. 2000 J. Med. Chem.
WLOGP ≤ 5.88
TPSA ≤ 131.6

0.0
Muegge?

Muegge (Bayer) filter: implemented from
Muegge I. et al. 2001 J. Med. Chem.
200 ≤ MW ≤ 600
-2 ≤ XLOGP ≤ 5
TPSA ≤ 150
Num. rings ≤ 7
Num. carbon > 4
Num. heteroatoms > 1
Num. rotatable bonds ≤ 15
H-bond acc. ≤ 10
H-bond don. ≤ 5

2.0
Bioavailability Score?

Abbott Bioavailability Score: Probability of F > 10% in rat
implemented from
Martin YC. 2005 J. Med. Chem.

0.55

Medicinal Chemistry

PAINS?

Pan Assay Interference Structures: implemented from
Baell JB. & Holloway GA. 2010 J. Med. Chem.

0.0 alert
Brenk?

Structural Alert: implemented from
Brenk R. et al. 2008 ChemMedChem

1.0 alert: heavy_metal
Leadlikeness?

Leadlikeness: implemented from
Teague SJ. 1999 Angew. Chem. Int. Ed.
250 ≤ MW ≤ 350
XLOGP ≤ 3.5
Num. rotatable bonds ≤ 7

No; 1 violation:MW<1.0
Synthetic accessibility?

Synthetic accessibility score: from 1 (very easy) to 10 (very difficult)
based on 1024 fragmental contributions (FP2) modulated by size and complexity penaties,
trained on 12'782'590 molecules and tested on 40 external molecules (r2 = 0.94)

1.0

Application In Synthesis of [ 6630-33-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6630-33-7 ]

[ 6630-33-7 ] Synthesis Path-Downstream   1~35

  • 1
  • [ 3034-53-5 ]
  • [ 6630-33-7 ]
  • [ 223575-69-7 ]
  • 2
  • [ 53903-49-4 ]
  • [ 6630-33-7 ]
  • [1-(2-Bromo-phenyl)-meth-(E)-ylidene]-(4-methoxy-2-trifluoromethyl-phenyl)-amine [ No CAS ]
  • 3
  • [ 216019-28-2 ]
  • [ 6630-33-7 ]
  • [ 916888-07-8 ]
  • 4
  • [ 6630-33-7 ]
  • [ 63927-22-0 ]
  • 5
  • [ 6630-33-7 ]
  • [ 50777-83-8 ]
  • 6
  • bromobenzalaminoacetal [ No CAS ]
  • [ 14000-31-8 ]
  • [ 645-36-3 ]
  • [ 6630-33-7 ]
  • [ 63927-22-0 ]
YieldReaction ConditionsOperation in experiment
In sulfuric acid; 8-bromoisoquinoline (24). To 7.0 mL (60.0 mmol) 2-bromobenzaldehyde (23) was added 10.0 mL (69.0 mmol) aminoacetaldehyde diethyl acetal. After 3 h at 100° C., the reaction mixture was cooled to room temperature and the layers separated. The organic layer was purified by vaccum distillation to give 15.89 g bromobenzalaminoacetal (b.p. 141-148° C. at approximately 1 mm Hg). To 143 g concentrated sulfuric acid at 0° C. was added 15.89 g bromobenzalaminoacetal. With mechanical stirring, the resulting mixture was added in portions over 5 min to 20 g phosphoric anhydride in 10 g concentrated sulfuric acid maintained at 160° C. After 25 min at 160° C., the reaction mixture was cooled, poured onto ice and washed with 300 mL ethyl ether. The aqueous layer was basified with solid NaOH to pH=10 and extracted with EtOAc repeatedly. The combined EtOAc layers were washed with brine, dried over Na2SO4, filtered and concentrated in vacuo. Purification by flash chromatography (75*110 mm silica gel, linear gradient 0.5-3percent (10percent NH4H:MeOH):CH2CI2) produced 24. 1H NMR (CDCl3, 400 MHz) 89.627 (s, 1H, ArH); 8.622 (d, 1H, J=5.67 Hz, ArH); 7.858 (dd, 1H, J=0.87, 7.45 Hz, ArH); 7.799 (d, 1H, J=8.32 Hz, ArH); 7.631 (d, 1H, J=5.76 Hz, ArH); 7.538 (dd, 1H, J=7.50, 8.23 Hz, ArH); MS (Electrospray): m/z 207.9, 209.0 (M+H, 79Br, 81Br).
  • 7
  • [ 6630-33-7 ]
  • [ 350597-49-8 ]
  • 2-[2-(2-bromophenyl)vinyl]-5-chloronicotinic acid hydrochloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
Bromobenzaldehyde (4. 15mL, 35.8mmol) was added to a hexane (500mL) solution of Compound 36 (6.63g, 35. 8mmol) under nitrogen. The reaction mixture was cooled in an ice bath and potassium-t-butoxide solution (1. OM, 71. 6mL, 71.6mmol) was added. After 15min, tetrahydrofuran (150mL) was added and the reaction mixture was slowly warmed to room temperature. After 24h, the solvent was removed in vacuo and water (100mL) and 6N hydrochloric acid were added. Trituration of the resulting oil with ethanol gave Compound 37 as a yellow solid. 1H NMR (DMSO-d6, 400MHz) o 13. 9 (s, br, 1H); 8.85 (d, 1H); 8.28 (d, 1H) ; 8.18-8. 00 (m, 2H), 7.80 (m, 1H) ; 7.72 (m, 1H) ; 7.48 (m, 1H) ; 7.31 (m, 1H).
  • 8
  • [ 1455-20-5 ]
  • [ 6630-33-7 ]
  • [ 1186368-89-7 ]
  • 9
  • [ 6630-33-7 ]
  • [ 350597-49-8 ]
  • [ 766506-30-3 ]
  • 10
  • [ 24629-25-2 ]
  • [ 6630-33-7 ]
  • [ 1340477-07-7 ]
  • 11
  • [ 25475-67-6 ]
  • [ 6630-33-7 ]
  • [ 1370708-55-6 ]
YieldReaction ConditionsOperation in experiment
84% With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane; for 2h;Inert atmosphere; General procedure: A round-bottomed flask was charged with Pd2(dba)3 (5 mol percent ), ligand (10 molpercent), aryl halide (1mmol), appropriate isoquinolinamine (1 mmol), base (1.5 mmol) and dry solvent (5 mL). Theflask was flushed with argon for 5 min. The mixture was heated at reflux under magnetic stirring.After cooling down to room temperature, the reaction mixture was concentrated and the residuewas purified by flash column chromatography on silica gel.
  • 12
  • [ 1025707-93-0 ]
  • [ 6630-33-7 ]
  • 2-(5,6-dihydro-4<i>H</i>-pyran-2-yl)-benzaldehyde [ No CAS ]
  • 13
  • [ 34800-90-3 ]
  • [ 6630-33-7 ]
  • C19H15BrN2O [ No CAS ]
YieldReaction ConditionsOperation in experiment
70.8% In ethanol;Reflux; General procedure: solutionof acid hydrazide (0.01 mol) and appropriate benzaldehyde/acetophenone (0.01 mol) in ethanol was refluxed for 5-6 h. The precipitated title compounds were then filtered off, washed with water and recrystallized from ethanol.
  • 14
  • [ 20197-92-6 ]
  • [ 107-11-9 ]
  • [ 6630-33-7 ]
  • C19H16N2O3 [ No CAS ]
  • 15
  • [ 86-86-2 ]
  • [ 6630-33-7 ]
  • 3-(naphthalen-1-yl)quinolin-2(1H)-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
90% With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In toluene; at 115℃; for 18h;Schlenk technique; Inert atmosphere; General procedure: In a typical procedure, the p-methoxybenzyl protected N-oxy amide (0.64 mmol.), cesium carbonate (248 mg, 0.76 mmol), Pd2(dba)3 (5 mg, 0.005 mmol) and Xantphos (9 mg, 0.016 mmol) was added into a Schlenk tube. The mixture was evacuated in vacuo, and then refilled with nitrogen gas. Degassed toluene (2 ml) was added into the tube, after which 2-bromobenzaldehyde (100 mg, 0.54 mmol) or methyl 2-bromobenzoate (117 mg, 0.54 mmol) was added. The suspension was stirred at 115 C for 18h. After that, water (10 ml) was added to quench the reaction and the solvent was removed in vacuo. The residue was dissolved with water (20 ml) and extracted with DCM (3 x 20 ml). The combined organic layers were washed with brine, dried with anhydrous Na2SO4 and concentrated in vacuo. The crude product was purified with column chromatography (20% EA/Petroleum ether) to obtain white solid in 57-96% yield.
  • 16
  • [ 78364-55-3 ]
  • [ 6630-33-7 ]
  • 2-(2-(2-bromobenzylidene)hydrazino)-6-fluorobenzothiazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
76% With acetic acid; In ethanol; at 80℃; for 0.166667h;Microwave irradiation; General procedure: 2-(2-Arylidenehydrazino)-6-fluorobenzothiazoles 6a-r. General Procedure D. A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 °C for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from the appropriate solvent to give the desired compounds 6a-r.
  • 17
  • [ 57497-39-9 ]
  • [ 6630-33-7 ]
  • C11H14BrNO [ No CAS ]
  • 18
  • [ 119072-55-8 ]
  • [ 5369-19-7 ]
  • [ 18698-97-0 ]
  • [ 6630-33-7 ]
  • 2-bromo-N-(1-(2-bromophenyl)-2-(tert-butylamino)-2-oxoethyl)-N-(3-(trifluoromethyl)phenyl)benzamide [ No CAS ]
  • 19
  • [ 5369-19-7 ]
  • [ 18698-97-0 ]
  • [ 6630-33-7 ]
  • 1-(tert-butyl)-2'-(3-(trifluoromethyl)phenyl)spiro[indoline-3,1'-isoindoline]-2,3'-dione [ No CAS ]
  • 20
  • [ 6630-33-7 ]
  • [ 22483-09-6 ]
  • [ 63927-22-0 ]
YieldReaction ConditionsOperation in experiment
49.8% A mixture of 2-bromobenzaldehyde (50 g, 270 mmol) , aminoacetaldehyde dimethyl acetal (28.4 g, 270 mmol) and toluene (400 mL) was refluxed under argon. Dehydration was carried out using dean stark for 2.0 hours. After removal of calculated amount of water, the reflux was continued for 1.0 hour. The toluene was evaporated under reduced pressure, the residue was dissolved in dichloromethane (600 mL) , and the solution was cooled to 0°C. To the cooled solution was slowly added aluminium chloride (118.9 g, 891.7 mmol) under argon. The reaction mixture was stirred at 45°C for 2.0 hours. After the completion of the reaction was confirmed by TLC, the mixture was cooled to room temperature and slowly poured into an ice water. The mixture was basified with 10percent sodium hydroxide solution, and the dichloromethane layer was separated. The aqueous layer was re-extracted with dichloromethane (2 x 100 mL) . The combined dichloromethane layers were washed with brine, and dried over sodium sulfate. The dichloromethane was evaporated, and the residue was purified by silica gel (100-200 mesh) column chromatography 5 with 8-12percent. ethyl acetate in hexane as a mobile phase to give the title compound as an off-white solid (28 g, 49.8percent). MS(ESI)m/z: 208 [M (79Br)+l] ,210 [M (81Br)+l]; XH NMR (400 MHz, DMSO-d5) : delta 7.17 (t, J= 7.8 Hz, 1H) ; 7.91 (d, J= 6.0 Hz, 1H) ; 8.02 (d, J = 8.4 Hz, 1H) ; 8.05 (d, J = 8.8 Hz, 1H) ; 8.65 10 (d, J = 5.2 Hz, 1H) 9.48 (s, IH) .
  • 21
  • [ 39998-25-9 ]
  • [ 6630-33-7 ]
  • 3-(benzo[b]thiophene-2-yl)pyridine [ No CAS ]
  • 22
  • [ 6630-33-7 ]
  • [ 42538-40-9 ]
  • 23
  • [ 3325-11-9 ]
  • [ 126-81-8 ]
  • [ 6630-33-7 ]
  • 12,12-dimethyl-12,13-dihydroquinolino[4,3,2-mn][1,2,3]triazolo[4,5,1-de]acridin-14(11H)-one [ No CAS ]
  • 24
  • [ 4341-24-6 ]
  • [ 3325-11-9 ]
  • [ 6630-33-7 ]
  • 12-methyl-12,13-dihydroquinolino[4,3,2-mn][1,2,3]triazolo[4,5,1-de]acridin-14(11H)-one [ No CAS ]
  • 25
  • [ 3325-11-9 ]
  • [ 504-02-9 ]
  • [ 6630-33-7 ]
  • 12,13-dihydroquinolino[4,3,2-mn][1,2,3]triazolo[4,5,1-de]acridin-14(11H)-one [ No CAS ]
  • 26
  • [ 456-14-4 ]
  • [ 6630-33-7 ]
  • [ 1208259-07-7 ]
  • 27
  • [ 57297-29-7 ]
  • [ 6630-33-7 ]
  • [ 1208259-27-1 ]
  • 28
  • [ 201230-82-2 ]
  • [ 5900-59-4 ]
  • [ 6630-33-7 ]
  • 2-chloro-6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-dione [ No CAS ]
  • 29
  • [ 5754-35-8 ]
  • [ 119072-55-8 ]
  • [ 6630-33-7 ]
  • [ 637-44-5 ]
  • C26H29BrN2O4 [ No CAS ]
  • 30
  • [ 1986-47-6 ]
  • [ 6630-33-7 ]
  • (1S*,2R*)-N-(2-bromobenzyl)-2-phenylcyclopropan-1-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
58% General procedure: Trans-2-phenylcyclopropylamine hydrochloride (1.0 eq.), acetic acid (1.0eq.) and the appropriate aldehyde (0.9 eq.) were dissolved in around bottom flask in 10 mL dry DCE. The reaction mixture was stirred gently at room temperature for 2 h before sodium triacetoxyborohydride (3.0 eq.) was added in small portions to the reaction vessel. The reaction was monitored by TLC and quenched using 10 mL of an aqueous (5%) NaHCO3 solution. The organic layer was separated and the aqueous layer extracted three times with10 mL of DCE. All organic layers were combined, dried over anhydrous Na2SO4, concentrated in vacuo and purified using flash chromatography (silica gel; cyclohexane/ethyl acetate) to give the desired compound.
  • 31
  • [ 6630-33-7 ]
  • [ 628692-15-9 ]
  • 2-(2-methoxypyrimidin-5-yl)benzaldehyde [ No CAS ]
  • 32
  • [ 67-56-1 ]
  • [ 6630-33-7 ]
  • [ 126712-07-0 ]
  • 33
  • [ 621-38-5 ]
  • [ 6630-33-7 ]
  • C15H11Br2NO2 [ No CAS ]
  • 34
  • [ 3469-20-3 ]
  • [ 6630-33-7 ]
  • C27H19NO [ No CAS ]
YieldReaction ConditionsOperation in experiment
80% With potassium carbonate; copper(II) oxide; In N,N-dimethyl-formamide; at 50℃; for 24h;Reflux; Intermediate 1-5 (16.0 g of 59.45 mmol) and o-bromobenzeneboronic acid (12.54 g 62.43 mmol) were added to dry DMF (300 mL), and anhydrous potassium carbonate (24.69 g 178.62 mmol) was added and gradually stirred at 50 At C, copper oxide (0.24 g of 3 mmol) was added and the mixture was heated to reflux for 24 h.After completion of the reaction, the mixture was cooled to room temperature, and the excess inorganic salt was filtered off, and then added with 2M aqueous hydrochloric acid (360 mL), heated to 60 C, stirred for 4 h, cooled to room temperature, washed with water, extracted with ethyl acetate, dried organic Separation and purification by chromatography gave Intermediate 1-7 (17.75 g, 80%), MW: 373.64.
  • 35
  • [ 110-89-4 ]
  • [ 6630-33-7 ]
  • [ 34595-26-1 ]
YieldReaction ConditionsOperation in experiment
95.6% With potassium carbonate; In dimethyl sulfoxide; for 15h;Reflux; O-bromobenzaldehyde 92.5g (0.5mol, 1.0eq), dimethylsulfoxide 300g, potassium carbonate 276.4g (2.0mol, 4.0eq) and piperidine 127.7g (1.5mol, 3.0eq) were placed in the reaction flask and heated to reflux for 15 h. TLC control starting material in the reaction was complete, cooled, the reaction solution was poured into ice water and extracted with methyl tert-butyl ether. The organic layers were combined and concentrated under reduced pressure to give a yellow oil 90.5g, HPLC purity 96.1%, yield 95.6%.
 

Historical Records

Technical Information

• Alkyl Halide Occurrence • Barbier Coupling Reaction • Baylis-Hillman Reaction • Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Bucherer-Bergs Reaction • Clemmensen Reduction • Complex Metal Hydride Reductions • Corey-Chaykovsky Reaction • Corey-Fuchs Reaction • Fischer Indole Synthesis • Friedel-Crafts Reaction • General Reactivity • Grignard Reaction • Hantzsch Dihydropyridine Synthesis • Henry Nitroaldol Reaction • Hiyama Cross-Coupling Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Hydrogenolysis of Benzyl Ether • Julia-Kocienski Olefination • Kinetics of Alkyl Halides • Knoevenagel Condensation • Kumada Cross-Coupling Reaction • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Mukaiyama Aldol Reaction • Nozaki-Hiyama-Kishi Reaction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Alkylbenzene • Preparation of Amines • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Dihalides • Reformatsky Reaction • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Stetter Reaction • Stille Coupling • Stobbe Condensation • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Tebbe Olefination • Ugi Reaction • Vilsmeier-Haack Reaction • Wittig Reaction • Wolff-Kishner Reduction

Categories

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[ 6630-33-7 ]

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