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CAS No. : | 65202-58-6 |
Formula : | C5H5BrN2 |
M.W : | 173.01 |
SMILES Code : | BrC1=CC=C(N=N1)C |
MDL No. : | MFCD09831907 |
InChI Key : | RACIHBXDZONTQJ-UHFFFAOYSA-N |
Pubchem ID : | 11959086 |
GHS Pictogram: | ![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H332-H335 |
Precautionary Statements: | P261-P280-P305+P351+P338 |
Num. heavy atoms | 8 |
Num. arom. heavy atoms | 6 |
Fraction Csp3 | 0.2 |
Num. rotatable bonds | 0 |
Num. H-bond acceptors | 2.0 |
Num. H-bond donors | 0.0 |
Molar Refractivity | 34.7 |
TPSA ? Topological Polar Surface Area: Calculated from | 25.78 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from | 1.79 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by | 1.27 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from | 1.55 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from | 1.12 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by | 2.08 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions | 1.56 |
Log S (ESOL):? ESOL: Topological method implemented from | -2.27 |
Solubility | 0.934 mg/ml ; 0.0054 mol/l |
Class? Solubility class: Log S scale | Soluble |
Log S (Ali)? Ali: Topological method implemented from | -1.41 |
Solubility | 6.72 mg/ml ; 0.0389 mol/l |
Class? Solubility class: Log S scale | Very soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by | -2.89 |
Solubility | 0.224 mg/ml ; 0.0013 mol/l |
Class? Solubility class: Log S scale | Soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg | High |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg | Yes |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) | No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) | Yes |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) | No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) | No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) | No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) | No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from | -6.45 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from | 0.0 |
Ghose? Ghose filter: implemented from | None |
Veber? Veber (GSK) filter: implemented from | 0.0 |
Egan? Egan (Pharmacia) filter: implemented from | 0.0 |
Muegge? Muegge (Bayer) filter: implemented from | 1.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat | 0.55 |
PAINS? Pan Assay Interference Structures: implemented from | 0.0 alert |
Brenk? Structural Alert: implemented from | 0.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from | No; 1 violation:MW<1.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) | 1.78 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
31% | at 70℃; | A mixture of Example 13B (18g, 163.44mmol) and phosphorus oxybromide (93.8g, 327.6mmol) was stirred at70°C overnight. The mixture was cooled to 40°C, poured into ice-water, quenched with saturated sodium bicarbonate(20mL) and extracted with dichloromethane (100mL 3 3). The organic layers were combined, dried over anhydroussodium sulfate, filtered and evaporated to give the title compound, 3-bromo-6-methylpyridazine (8g, yield 31percent). LCMS(ESI) m/z: 173[M+1]+. 1H NMR (CHLOROFORM-d, BrukerAvance 400MHz): ppm 7.86-7.88 (d, 1H, J = 8 Hz), 7.52-7.54(d, 1H, J = 8 Hz), 2.55(s, 3H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
24% | With N-ethyl-N,N-diisopropylamine; | EXAMPLE 5 Following a procedure similar to that of Example 3, 81 millimoles of <strong>[65202-58-6]6-methyl-3-bromopyridazine</strong> was combined with 16 mL DIPEA and 163 mmoles of 4-hydroxypiperidine and heated to 120 for 16 hours to obtain 6-methyl-3-(4-hydroxy-1-piperdinyl)pyridazine (Formula IV: Y=bond, R=CH3) in 24% yield. 6.8 Mmols of the latter and 7.4 mmoles of 2-methyl-5-(4-hydroxy-3,5-dimethyl phenyl)-2H-tetrazole (Formula III: R2 =R3 =R4 =CH3) were reacted with equimolar amounts of DEAD and TPP essentially as described above in Example 1c. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In water; dimethyl sulfoxide; | Step B Ethyl difluoro(6-methylpyridazin-3-yl)acetate This procedure is derived from the general method of T. Taguchi, et al. (Tetrahedron Lett., 1986,27,6103-6106). Ethyl difluoroiodoacetate (0.355 mL, 651 mg, 2.60 mmol) was added to a rapidly stirred suspension of copper powder (333 mg, 5.24 mmol) in DMSO (6.5 mL) at RT. After 50 min., <strong>[65202-58-6]3-bromo-6-methylpyridazine</strong> (300 mg, 1.73 mmol) was added in DMSO (1.0 mL). After 20 h, the mixture was transferred to a separatory funnel containing water (25 mL) and saturated aq. NH4Cl (25 mL), and extracted with EtOAc (2*50 mL). The organic extracts were washed with saturated aq. NaCl, dried (Na2SO4), decanted, and evaporated. Purification by flash column chromatography on silica gel, eluding with 70:30 v/v hexanes/EtOAc, gave 363 mg of the title compound as an amber liquid. For the title compound: 1H NMR (500 MHz, CDCl3) delta 7.79 (d, J=9, 1H), 7.53 (d, J=9, 1H), 4.43 (q, J=7, 2H), 2.82 (s, 3H), 1.38 (t, J=7, 3H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydroxide; hydrogen bromide; In acetic acid; | Step A 3-Bromo-6-methylpyridazine A solution (3.0 mL) containing 30%HBr in acetic acid was added to 3-(trifluoromethanesulfonyloxy)-6-methylpyridazine (prepared as described by M. Rohr, et al., Heterocycles, 1996, 43, 1459-64) and the mixture was heated in a 100 C. oil bath for 2.5 h. The mixture was cooled in an ice bath, adjusted to pH >=9 (as determined using pH paper) by the careful addition of 20% aqueous NaOH, and extracted with ether (3*20 mL). The organic layers were dried (Na2SO4), decanted, and evaporated to give title compound as 359 mg of pale tan crystals. For the title compound: 1H NMR (500 MHz, CDCl3) delta 7.56 (d, J=9, 1H), 7.22 (d, J=9, 1H), 2.70 (s, 3H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With caesium carbonate;triphenylphosphine; palladium dichloride; In tetrahydrofuran; water; at 75 - 80℃; for 22h;Inert atmosphere; | Potassium vinyltrifluoroborate (Aldrich, 1.71 g, 12.7 mmol), 3-bromo-6- methylpyridazine (Example 148A, 1.95 g, 11.3 mmol) and triphenylphosphine (0.18 g, 0.67 mmol) were added at room temperature to a solution Of Cs2CO3 (10.1 g, 31.0 mmol) in water (9.5 mL). Tetrahydrofuran (85 mL) was added, and the reaction flask was evacuated and purged with nitrogen (3 cycles). PdCl2 (50 mg, 0.28 mmol) was added, and the reaction flask was again evacuated and purged with nitrogen (3 cycles), then heated under nitrogen at 75-80 0C for 22 hours. The mixture was cooled to room temperature and the aqueous layer was separated and extracted with ethyl ether (3chi50 mL). The combined organic phase was concentrated to a volume of approximately 5 mL, and the residue was purified by flash chromatography (80 g silica, eluted with hexanes-ethyl acetate, 100:0 - 90:10): 1H NMR (300 MHz, methanol-^) delta ppm 2.71 (s, 3 H) 5.63 (d, J=I 1.2 Hz, 1 H) 6.18 (d, J=18.3 Hz, 1 H) 7.04 (dd, J=17.8, 11.0 Hz, 1 H) 7.23 - 7.34 (m, J=8.8 Hz, 1 H) 7.49 (d, J=8.8 Hz, 1 H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
31% | With phosphorus(V) oxybromide; at 70℃; | A mixture of Example 13B (18g, 163.44mmol) and phosphorus oxybromide (93.8g, 327.6mmol) was stirred at70C overnight. The mixture was cooled to 40C, poured into ice-water, quenched with saturated sodium bicarbonate(20mL) and extracted with dichloromethane (100mL 3 3). The organic layers were combined, dried over anhydroussodium sulfate, filtered and evaporated to give the title compound, 3-bromo-6-methylpyridazine (8g, yield 31%). LCMS(ESI) m/z: 173[M+1]+. 1H NMR (CHLOROFORM-d, BrukerAvance 400MHz): ppm 7.86-7.88 (d, 1H, J = 8 Hz), 7.52-7.54(d, 1H, J = 8 Hz), 2.55(s, 3H). |
6-Methylpyridazin-3(2H)-one (Alfa, 2.5 g, 22.70 mmol) and phosphorus oxybromide (Aldrich, 16.27 g, 56.8 mmol) were heated at 90 C under a nitrogen atmosphere for 1.5 hours. After cooling, the mixture was poured onto ice (100 g), neutralized with sodium bicarbonate, and the aqueous phase was extracted with CH2Cl2 (3chi30 mL). The combined organic phase was washed with 5% NaHCO3, brine, dried (Na2SO4) and concentrated. The residue was dissolved in hot ethyl acetate and washed through a plug of silica gel, eluting with ethyl acetate and concentrated. MS (DCI/NH3) m/z 172 (M+H)+, 190 (M+NH4)+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
8.3% | Example 194 Preparation of 4-((lR,3aS,5aR,5bR,7aR, l laS, l lbR,13aR,13bR)-5a,5b,8,8,l la- pentamethyl-3 a-(2-(6-methylpyridazin-3 -ylamino)ethylamino)- 1 -(prop- 1 -en-2-yl)- 2,3,3a,4,5,5a,5b,6,7,7a,8, l l, l la, l lb, 12, 13, 13a, 13b-octadecahydro-lH- cyclopenta[a]chrysen-9-yl)benzoic acid.In a 1 dram vial under nitrogen were combined (2R)-l-[(lR)-l-[bis(l, l- dimethylethyl)phosphino]ethyl]-2-(dicyclohexylphosphino)ferrocene (CASNo. 158923- 11-6) (2.52 mg, 4.55 muiotaetaomicron), palladium(II) acetate (1.02 mg, 4.55 muiotaetaomicron) and dry DME (0.5 ml). The contents of the vial were stirred for 10 min, and were then added all at once to a separate mixture of <strong>[65202-58-6]3-bromo-6-methylpyridazine</strong> (0.017 g, 0.100 mmol) and sodium tert-butoxide, 2.0M solution in THF (0.200 mL, 0.400 mmol) in dry DME (0.500 mL) contained in a separate 1 dram vial. The resulting mixture was allowed to stir very briefly (1 min) before solid methyl 4-((lR,3aS,5aR,5bR,7aR, l laS, l lbR, 13aR,13bR)-3a-(2-aminoethylamino)- 5a,5b,8,8, 1 1 a-pentamethyl- 1 -(prop- 1 -en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8, l l, l la, l lb, 12, 13, 13a, 13b-octadecahydro-lH- cyclopenta[a]chrysen-9-yl)benzoate bis HC1 salt (0.060 g, 0.091 mmol) was added in one portion. The mixture was heated to 1 10 C overnight. Iterative purification of the crude mixture by reverse phase preparative HPLC first using Prep HPLC Method 9 and then repurification by Prep HPLC Method 10 gave the title compound (0.0070 g, 8.3% yield) as a white glassy solid bis TFA salt. LCMS: m/e 665.5 (M+H)+, 2.22 min (method 11). XH NMR (500 MHz, 1 : 1 mixture of CDC13 and MeOD, MeOD lock) delta ppm 7.90 (d, J=8.5 Hz, 2H), 7.49 - 7.42 (m, 1H), 7.32 - 7.23 (m, 1H), 7.18 (d, J=8.2 Hz, 2H), 5.27 (dd, J=6.0, 1.4 Hz, 1H), 4.88 (br. s., 1H), 4.72 (br. s., 1H), 3.94 - 3.84 (m, 1H), 3.84 - 3.73 (m, 1H), 3.26 - 3.13 (m, 1H), 2.84 (d, J=12.5 Hz, 1H), 2.57 (s, 3H), 2.12 (dd, J=16.9, 6.3 Hz, 1H), 2.05 (d, J=15.6 Hz, 1H), 2.01 - 1.91 (m, 2H), 1.91 - 1.74 (m, 2H), 1.70 (s, 3H), 1.69 - 1.59 (m, 2H), 1.59 - 1.43 (m, 4H), 1.43 - 1.28 (m, 4H), 1.28 - 1.18 (m, 4H), 1.18 - 1.06 (m, 2H), 1.05 (s, 3H), 0.99 (s, 3H), 0.97 (s, 3H), 0.92 (s, 3H), 0.92 - 0.89 (m, 3H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
28% | With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium carbonate; In dimethyl sulfoxide; at 80℃; for 3h; | Prepared by the reaction of 5-fluoro-3-(2-methoxyethyl)-1 H-benzimidazol-2-one (100 mg, 0.48 mmol) with <strong>[65202-58-6]3-bromo-6-methylpyridazine</strong> (90.54 mg, 0.52 mmol), potassiumcarbonate (197 mg, 1.43 mmol), copper iodide (9.1 mg, 0.05 mmol) and trans-A/,/V-20 dimethylcyclohexane-1,2-diamine (0.02 ml_, 0.10 mmol) in DMSO (2.5 ml.) at 80 C for 3 h.The desired product 5-fluoro-3-(2-methoxyethyl)-1-(6-methylpyridazin-3-yl)benzimidazol-2-one was isolated as a white solid (41 mg, 0.136 mmol, 28%).[00499] 1H NMR (300MHz, DMSO-d6) Shift = 8.29 (d, J=9.0 Hz, 1H), 7.97 (dd, J=4.9,8.9 Hz, 1H), 7.79 (d, J=9.0 Hz, 1H), 7.35 (dd, J=2.5, 9.1 Hz, 1H), 6.98 (ddd, J=2.6, 8.9, 9.925 Hz, 1 H), 4.11 (t, J=5.3 Hz, 2H), 3.67 (t, J=5.3 Hz, 2H), 3.26 (s, 3H), 2.68 (s, 3H) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
77% | With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium carbonate; In 1,4-dioxane; at 80℃; for 16h; | Prepared by the reaction of 5-fluoro-3-methyl-1 /-/-benzimidazol-2-one (150 mg, 0.90 mmol) with <strong>[65202-58-6]3-bromo-6-methylpyridazine</strong> (172 mg, 0.99 mmol), potassium carbonate37415 mg, 2.71 mmol), copper iodide (17 mg, 0.09 mmol) and trans-A/,/V-dimethylcyclohexane-1,2-diamine (0.03 ml_, 0.18 mmol) in 1,4-dioxane (2.5 ml.) at 80 C for 16 h. The desired product5-fluoro-3-methyl-1 -(6-methylpyridazin-3-yl)benzimidazol-2-one was isolated as a yellow solid(180 mg, 0.697 mmol, 77%).[00502] 1H NMR (300MHz, DMSO-d6) Shift = 8.30 (d, J=9.0 Hz, 1H), 7.99 (dd, J=4.9,20 8.9 Hz, 1H), 7.78 (d, J=9.1 Hz, 1H), 7.31 (dd, J=2.5, 8.9 Hz, 1H), 6.98 (ddd, J=2.6, 8.9, 10.0Hz, 1 H), 3.41 (s, 3H), 2.67 (s, 3H) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
73% | A solution of Intermediate 3 (130 mg, 0.52 mmol), <strong>[65202-58-6]3-bromo-6-methyl-pyridazine</strong>(135 mg, 0.78 mmol) and caesium carbonate (340 mg, 1.04 mmol) in DMF (2.5 mL)was heated in the microwave to 120C for 45 mm, then for a further 20 mm at thesame temperature. The reaction mixture was concentrated under reduced pressureand the residue taken up in methanol (5 mL) and treated with 1M LiCH (2.5 mL). After 1 .5h, the reaction was concentrated to remove the organics, before being diluted with water (10 mL) and extracted with EtOAc (2 x 10 mL). The aqueous layer was acidified to -pH 4 with 2M HCI, the extracted with DCM (3 x 10 mL). Thecombined organics were dried over MgSO4, filtered and concentrated under reduced pressure to afford 143 mg (73% yield) of the title compound as brown gum. 1H NMR (500 MHz, Chloroform-d): 6 [ppm] 8.48 (5, 1H), 8.06 (5, 1H), 8.00 - 7.96 (m, 1H), 7.59 (5, 1H), 7.42 (d, J = 9.0 Hz, 1H), 7.19 (d, J = 9.0 Hz, 1H), 2.70 (d, J = 7.7 Hz, 3H), 2.53 (5, 3H).LCMS (Analytical Method A) Rt = 1.01 mm, MS (ESIpos): m/z = 328.05 (M+H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With 18-crown-6 ether; potassium carbonate; In N,N-dimethyl-formamide; at 100℃; for 24h;Inert atmosphere; Sealed tube; | Step I : tert-Butyl 2-(3-acetyl-5-((6-raethylpyridazin-3-yl)oxy)-lH-indazol-'l-yl)acetate {237} [0737] A mixture of tert-butyl 2-(3-acetyl-5-hydroxy-l H-indazol-l -yl)acetate (1 equiv), <strong>[65202-58-6]3-bromo-6-methylpyridazine</strong> (1.1 equiv), K2CO3 (3 equivj and 18-Crown-6 (1 equiv) in DMF (10 vol) under argon, the pressure vessel was sealed and heated at 100 C for 24 h. The reaction mixture was cooled to rt and diluted with water, then extracted with DCM. The organic layer was washed with brine, dried over anhydrous NaiSCXt, filtered, and then concentrated. The residue was purified by column chromatography on silica gel (EtOAc/DCM) to give compound 237. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
19% | With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; at 80℃; for 12h; | Example 13C (8.0g, 48.0mmol) and NBS (9.44g, 48.0mmol) were dissolved in carbon tetrachloride (200mL)and AIBN (1.58g, 9.6mmol) was added and the mixture was reacted at 80C for 12 hours. The mixture was filtered andconcentrated. The residue was purified by flash silica gel column chromatography to give the target compound 3-bromo-6-(bromomethyl)pyridazine (2.2g, yield 19%). LCMS (ESI) m/z: 332[M+1]+. 1H NMR (400 MHz, CHLOROFORM-d) ppm7.69 (d, J=8.53 Hz, 1H), 7.56 (d, J=9.04 Hz, 1H). |
Tags: 65202-58-6 synthesis path| 65202-58-6 SDS| 65202-58-6 COA| 65202-58-6 purity| 65202-58-6 application| 65202-58-6 NMR| 65202-58-6 COA| 65202-58-6 structure
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P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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