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Chemical Structure| 348133-45-9 Chemical Structure| 348133-45-9

Structure of 348133-45-9

Chemical Structure| 348133-45-9

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Product Details of [ 348133-45-9 ]

CAS No. :348133-45-9
Formula : C8H7FN2O
M.W : 166.15
SMILES Code : O=C1NC2=CC=C(F)C=C2N1C

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Application In Synthesis of [ 348133-45-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 348133-45-9 ]

[ 348133-45-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 65202-58-6 ]
  • [ 348133-45-9 ]
  • 5-fluoro-3-methyl-1-(6-methylpyridazin-3-yl)benzimidazol-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
77% With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium carbonate; In 1,4-dioxane; at 80℃; for 16h; Prepared by the reaction of 5-fluoro-3-methyl-1 /-/-benzimidazol-2-one (150 mg, 0.90 mmol) with <strong>[65202-58-6]3-bromo-6-methylpyridazine</strong> (172 mg, 0.99 mmol), potassium carbonate37415 mg, 2.71 mmol), copper iodide (17 mg, 0.09 mmol) and trans-A/,/V-dimethylcyclohexane-1,2-diamine (0.03 ml_, 0.18 mmol) in 1,4-dioxane (2.5 ml.) at 80 C for 16 h. The desired product5-fluoro-3-methyl-1 -(6-methylpyridazin-3-yl)benzimidazol-2-one was isolated as a yellow solid(180 mg, 0.697 mmol, 77%).[00502] 1H NMR (300MHz, DMSO-d6) Shift = 8.30 (d, J=9.0 Hz, 1H), 7.99 (dd, J=4.9,20 8.9 Hz, 1H), 7.78 (d, J=9.1 Hz, 1H), 7.31 (dd, J=2.5, 8.9 Hz, 1H), 6.98 (ddd, J=2.6, 8.9, 10.0Hz, 1 H), 3.41 (s, 3H), 2.67 (s, 3H)
 

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