Home Cart Sign in  
Chemical Structure| 64671-30-3 Chemical Structure| 64671-30-3

Structure of 64671-30-3

Chemical Structure| 64671-30-3

*Storage: .

*Shipping: Normal

(2-Fluorophenyl)(1-methylpiperidin-4-yl)methanone hydrochloride

CAS No.: 64671-30-3

,98%

4.5 *For Research Use Only !

Cat. No.: A1425939 Purity: 98%

Change View

Size Price

US Stock

Global Stock

In Stock

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

    In Stock

    - +

    US Stock: ship in 0-1 business day
    Global Stock: ship in 2 weeks

    • 1-2 Day Shipping
    • High Quality
    • Technical Support
    Product Citations

    Alternative Products

    Product Details of [ 64671-30-3 ]

    CAS No. :64671-30-3
    Formula : C13H17ClFNO
    M.W : 257.73
    SMILES Code : O=C(C1=CC=CC=C1F)C2CCN(C)CC2.[H]Cl

    Safety of [ 64671-30-3 ]

    Application In Synthesis of [ 64671-30-3 ]

    * All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

    • Downstream synthetic route of [ 64671-30-3 ]

    [ 64671-30-3 ] Synthesis Path-Downstream   1~1

    • 1
    • [ 84163-45-1 ]
    • [ 6971-45-5 ]
    • [ 64671-30-3 ]
    • [ 110-17-8 ]
    • 1-(2-methoxyphenyl)-3-(1-methyl-4-piperidinyl)-1H-indazole fumarate [ No CAS ]
    YieldReaction ConditionsOperation in experiment
    2.15 g (15%) With NaH; sodium acetate; In N,N-dimethyl-formamide; butan-1-ol; EXAMPLE 107 1-(2-Methoxyphenyl)-3-(1-methyl-4-piperidinyl)-1H-indazole fumarate A mixture of 4-(2-fluorobenzoyl)-1-methylpiperidine (14.6 g. 0.066 moles) of Example 1, <strong>[6971-45-5]2-methoxyphenylhydrazine hydrochloride</strong> (14.5 g, 0.083 moles) and sodium acetate (16.0 g, 0.195 moles) in n-butanol (280 ml) was refluxed for 7 hours. The mixture was cooled, filtered, and then concentrated to yield 22 g (100%) of an oil. To a solution of the oil (21.6 g, 0.063 moles) in DMF (220 ml) was added NaH (6.7 g, 0.139 moles, 50% oil dispersion). The mixture was stirred at 80 C. for 3 hours and then cooled and poured into H2 O. The aqueous mixture was extracted with ethyl acetate, dried (MgSO4) and concentrated to yield 22 g of an oil. A portion of the oil (9.5 g) was purified using HPLC (silica gel, 100% methanol) to yield 4.5 g of an oil. The oil was dissolved in ether and a solution of fumaric acid in ether was added to form a salt. The salt was recrystallized three times from ethanol-ether to yield 2.15 g (15%) of 1-(2-methoxyphenyl)-3-(1-methyl-4-piperidinyl)-1H-indazole fumarate, m.p. 177-178 C. ANALYSIS: Calculated for C20 H23 N3 O.C4 H4 O4: 65.94%C, 6.21H, 9.59%N. Found: 65.87%C, 6.34%H, 9.57%N.
     

    Historical Records