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Chemical Structure| 638217-08-0 Chemical Structure| 638217-08-0

Structure of 638217-08-0

Chemical Structure| 638217-08-0

6-Hydroxy-N,2-dimethylbenzofuran-3-carboxamide

CAS No.: 638217-08-0

4.5 *For Research Use Only !

Cat. No.: A581037 Purity: 97%

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Product Details of [ 638217-08-0 ]

CAS No. :638217-08-0
Formula : C11H11NO3
M.W : 205.21
SMILES Code : CNC(=O)C1=C(C)OC2=C1C=CC(O)=C2
MDL No. :MFCD09836137

Safety of [ 638217-08-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 638217-08-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 638217-08-0 ]

[ 638217-08-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 68500-37-8 ]
  • [ 638217-08-0 ]
  • 6-[(7-methoxyquinolin-4-yl)oxy]-N,2-dimethyl-1-benzofuran-3-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With caesium carbonate; In dimethyl sulfoxide; at 120℃; for 2h; A mixture of 28-E (1.4 g, 7.3 mmol), 6-hydroxy-N, 2-dimethyl-1-benzofuran-3- carboxamide 28-F (1.5 g, 7.3 mmol) and Cs2CO3 (3.6, 11 mmol) in 12 ml of DMSO was heated to 120 C for 2 hours, poured into water and extracted with EtOAc. Silica gel chromatography using 2percent MeOH/CH2CI2 offered 1.4 g of 6- [ (7-methoxyquinolin-4-yl) oxy] -N, 2-dimethyl-1-benzofuran-3- carboxamide 28-G.
  • 2
  • [ 22200-50-6 ]
  • [ 638217-08-0 ]
  • [ 854514-50-4 ]
YieldReaction ConditionsOperation in experiment
54% With caesium carbonate; In dimethyl sulfoxide; at 120℃; for 1.0h; A mixture of compound 6-G (500 mg, 1.7 mmol), 6-hydroxy-N, 2-dimethyl-1-benzofuran-3- carboxamide 6-H (354 mg, 1.7 mmol) (the product of Example 5) and Cs2CO3 (920 mg, 2.6 mmol) in DMSO (5 mL) was heated to 120 C for 1 hours. The solution was extracted with Silica gel column chromatography eluted with hexane/ethyl acetate (3: 1 to 1: 1) gave the title compound 6 (427 mg, 54percent yield). 1H NMR (300 MHz, CHLOROFORM-d) o ppm 2.67 (s, 3 H) 3.00 (d, J=4.90 Hz, 3 H) 5.82 (s, 1 H) 6.48 (d, J=5.27 Hz, 1 H) 7.07 (dd, J=8.57, 2.17 Hz, 1 H) 7.23 (d, J=2.07 Hz, 1 H) 7.81 (dd, J=8.76, 1.60 Hz, 1 H) 8.04 (d, J=8.85 Hz, 1 H) 8.51 (d, J=1.32 Hz, 1 H) 8.56 (d, J=5.27 Hz, 1 H). LC/MS (APCI, pos. ): 459.0 (M+H).
 

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