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Chemical Structure| 63734-73-6 Chemical Structure| 63734-73-6

Structure of 63734-73-6

Chemical Structure| 63734-73-6

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Product Details of [ 63734-73-6 ]

CAS No. :63734-73-6
Formula : C6H8O5
M.W : 160.12
SMILES Code : O=C([C@@H]1O[C@H]1C(O)=O)OCC

Safety of [ 63734-73-6 ]

Application In Synthesis of [ 63734-73-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 63734-73-6 ]

[ 63734-73-6 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 4985-46-0 ]
  • [ 63734-73-6 ]
  • (2S,3S)-3-[(S)-1-Carbamoyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-oxirane-2-carboxylic acid ethyl ester [ No CAS ]
  • 2
  • C21H20N3O5Pol [ No CAS ]
  • [ 71989-31-6 ]
  • [ 108-24-7 ]
  • [ 63734-73-6 ]
  • [ 198561-07-8 ]
  • [ 1361051-69-5 ]
YieldReaction ConditionsOperation in experiment
General procedure: All aza-peptidyl inhibitors and probes were synthesized by following the previously reported procedures 1, 2 with slight modifications. Fmoc protecting groups from Rink SS resin (0.75 mmol/g) were removed by treatment with 20percent piperidine in DMF for 15 min, followed by three washes with DMF. A 1.2 M solution of bromoacetic acid (10 eq) in NMP and DIC (10 eq) were added to the resin. The resin was shaken 1.5 hrs and washed three times. A solution of Mono-Fmoc protected hydrazide (3 eq) in NMP was added and shaken overnight. Resin loading was determined by Fmoc-quantification (0.2-0.3 mmol/g). A 0.5M solution of N-Fmoc-protected amino acid (3 eq.) and HOBt (3 eq.) in DMF and DIC (3 eq.) were added to the resin. The resin was shaken 1.5-2hrs. For each of the following steps, Fmoc-deprotection and coupling reactions were repeated as described above. Capping of N-terminal amine was achieved by shaking the resin with a 0.5 M solution of acetic anhydride (5 eq.) and DIEA (5 eq.) in DMF for 5 min.
 

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