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Chemical Structure| 633335-73-6 Chemical Structure| 633335-73-6

Structure of 633335-73-6

Chemical Structure| 633335-73-6

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Product Details of [ 633335-73-6 ]

CAS No. :633335-73-6
Formula : C8H14O5S
M.W : 222.26
SMILES Code : CCOC(=O)C1(COS(C)(=O)=O)CC1
MDL No. :MFCD31381699

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Application In Synthesis of [ 633335-73-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 633335-73-6 ]

[ 633335-73-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 178546-34-4 ]
  • [ 633335-73-6 ]
  • ethyl 1-((2-bromo-4-fluoro-6-formylphenoxy)methyl)cyclopropane-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
38% With caesium carbonate; In N,N-dimethyl-formamide; at 80℃; A round-bottom flask was charged with <strong>[178546-34-4]3-bromo-5-fluoro-2-hydroxybenzaldehyde</strong> (1.00 g, 4.59 mmol, 1.00 equiv), ethyl 1-[(methanesulfonyloxy)methyl]cyclopropane-1-carboxylate (1.53 g, 6.88 mmol, 1.50 equiv), cesium carbonate (4.49 g, 13.8 mmol, 3.00 equiv), and DMF (10 mL). The reaction mixture was stirred overnight at 80 C. and quenched with water (30 mL). The resulting solution was extracted with EtOAc (2*50 mL), and the organic layers were combined, washed with brine (2*30 mL), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was chromatographed on a silica gel column to provide 0.600 g (38% yield) of ethyl 1-(2-bromo-4-fluoro-6-formylphenoxymethyl)cyclopropane-1-carboxylate. LCMS (ESI, m/z): 345 [M+H]+.
 

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