63304-81-4|2-(3-Amino-4-methoxyphenyl)acetic acid| Ambeed

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Quality Control of [ 63304-81-4 ] Purity: 95% SDS Specification

COA

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NMR

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Product Details of [ 63304-81-4 ]

CAS No. :	63304-81-4
Formula :	C₉H₁₁NO₃
M.W :	181.19
SMILES Code :	O=C(O)CC1=CC=C(OC)C(N)=C1
MDL No. :	MFCD12913543
InChI Key :	PFRXANWOMDQZHR-UHFFFAOYSA-N
Pubchem ID :	17855201

Safety of [ 63304-81-4 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 63304-81-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 63304-81-4 ]

[ 63304-81-4 ] Synthesis Path-Downstream 1~32

1
[ 63304-81-4 ]
[ 1131-94-8 ]

References: [1]Journal of Organic Chemistry,1940,vol. 5,p. 606,608.

2
[ 63304-81-4 ]
[ 104967-36-4 ]

References: [1]Journal of Organic Chemistry,1940,vol. 5,p. 606,608.

3
[ 63304-80-3 ]
[ 63304-81-4 ]

Yield	Reaction Conditions	Operation in experiment
94%	With palladium 10% on activated carbon; hydrogen; In methanol; at 20℃; for 12.0h;	Step 1: Pd/C (10%) (100 mg) was added to a solution of 2-(4-methoxy-3- nitrophenyl)acetic acid (1 .0 g, 4.7 mmol) in MeOH (5 mL) at rt. Then hydrogen was filled and the reaction mixture was stirred for 12h. The solution was filtered through a pad of Celite and the filtrate was concentrated under vacuum to afford the product (803 mg, 94%). The residue was used in the next step without further purification
90%	With palladium 10% on activated carbon; hydrogen; In methanol; at 20℃; for 15.0h;	2-(4-methoxy-3-nitrophenyl)acetic acid (1.30 g,6.16 mmol) prepared in step 1 was dissolved in methanol (150 mE), to which 10 weight % Pd/C (0.62 g, 0.62 mmol) was added. The mixture was stirred at room temperature for 15 hours while purging hydrogen gas. Upon completion of the reaction, a new spot was formed under the starting material, which was confirmed by TEC. 10 weight % Pd/C was filtered and the reaction mixture was concentrated under reduced pressure. Then, purification was performed by MPEC to give the target compound 2-(3-amino-4-methoxy- phenyl)acetic acid (1.00 g, 5.52 mmol, yield: 90%). ‘H-NMR (300 MHz, CDC13) ö 6.74-6.72 (m, 1H), 6.65-6.62 (m, 2H), 4.67 (br, s, 3H), 3.83 (s, 3H), 3.50 (s, 2H); EC/MS 182 [M+H].

References: [1]Patent: WO2018/138359,2018,A1 .Location in patent: Page/Page column 41; 50.
[2]Patent: US2018/111905,2018,A1 .Location in patent: Paragraph 0327; 0330; 0331.
[3]Journal of Organic Chemistry,2004,vol. 69,p. 2920 - 2928.
[4]Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences,1946,vol. 223,p. 675.
[5]Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences,1946,vol. 223,p. 675.
[6]Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences,1946,vol. 223,p. 675.

4
[ 63304-81-4 ]
[ 108-24-7 ]
[ 857554-33-7 ]

References: [1]Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences,1946,vol. 223,p. 675.

5
[ 63304-81-4 ]
[ 179469-45-5 ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 2920 - 2928.

6
[ 904-42-7 ]
[ 63304-81-4 ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 2920 - 2928.

7
[ 63304-81-4 ]
[ 160857-73-8 ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 2920 - 2928.

8
[ 63304-81-4 ]
1-(3-azido-4-methoxybenzyl)-5-bromo-8-benzyloxy-7-methoxy-3,4-dihydroisoquinoline [ No CAS ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 2920 - 2928.

9
[ 123-11-5 ]
α-hydrazino-phenylacetic acid [ No CAS ]
[ 63304-81-4 ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 2920 - 2928.

10
[ 31680-08-7 ]
[ 63304-81-4 ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 2920 - 2928.

11
[ 104-01-8 ]
[ 63304-81-4 ]

References: [1]Journal of Organic Chemistry,1940,vol. 5,p. 606,608.
[2]Patent: US2018/111905,2018,A1 .

12
[ 6343-93-7 ]
[ 63304-81-4 ]

References: [1]Journal of Organic Chemistry,1940,vol. 5,p. 606,608.

13
[ 56245-07-9 ]
[ 63304-81-4 ]

References: [1]Journal of Organic Chemistry,1940,vol. 5,p. 606,608.
[2]Chemische Berichte,1942,vol. 75,p. 123,129.

14
[ 63304-81-4 ]
2-amino-3-(5-carboxymethyl-2-methoxy-phenylsulfanyl)-benzoic acid [ No CAS ]

References: [1]Journal of Organic Chemistry,1940,vol. 5,p. 606,608.

15
[ 63304-81-4 ]
[ 857544-42-4 ]

References: [1]Journal of Organic Chemistry,1940,vol. 5,p. 606,608.

16
[ 6378-19-4 ]
[ 63304-81-4 ]

References: [1]Journal of Organic Chemistry,1940,vol. 5,p. 606,608.
[2]Chemische Berichte,1942,vol. 75,p. 123,129.

17
[ 857544-00-4 ]
[ 63304-81-4 ]

References: [1]Chemische Berichte,1942,vol. 75,p. 123,129.

18
[ 63304-81-4 ]
(5-acetylamino-4-methoxy-2-nitro-phenyl)-acetic acid [ No CAS ]

References: [1]Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences,1946,vol. 223,p. 675.

19
[ 110-80-5 ]
[ 761440-16-8 ]
[ 63304-81-4 ]
2-ethoxyethyl 2-(3-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidine-2-yl)amino)-4-methoxyphenyl)acetate [ No CAS ]