Name: 6284-40-8|(2R,3R,4R,5S)-6-(Methylamino)hexane-1,2,3,4,5-pentaol|99%
Brand: Ambeed
SKU: A112809
Price: 17.0 USD
Availability: InStock
Rating: 90 (29 reviews)

1
[ 50-99-7 ]
[ 74-89-5 ]
[ 6284-40-8 ]

Yield	Reaction Conditions	Operation in experiment
62.5%	With hydrogen; In water; at 10 - 100℃; under 5171.62 - 25858.1 Torr; for 21.5h;	A 160 ml Parr reactor was charged with Raney nickel (2.7 g, 15 wt % based on D-glucose, Grace 4200) and water (20 g). The reactor was sealed, purged three times with 300 PSI N2 followed by three times with 300 PSI H2. The reactor was then charged with 300 PSI H2, at which point stiffing was begun at 400 RPM, and heated to 100-110 C. for 1 hr. The reactor and contents were cooled to 10 C. with external cooling; stir rate was slowed to 100 RPM and vented to 100 PSI. Next D-glucose was added (45 g 40% aqueous solution, 100 mmoles, Amresco) followed by methyl amine (15.37 g 40% aqueous solution, 150 mmoles, Aldrich) via an HPLC pump at 5 ml/min while maintaining a temperature of around 10 C. Reactor was charged to 450 PSI H2, stir rate was increased to 400 RPM and allowed to warm to ambient temperature over 30 min. The reactor was then externally heated to 35 C. for 18 hrs, 50 C. for 1 hr, 75 C. for 1 hr and finally 100 C. for 1 hr during which time pressure was maintained at 300-500 PSI H2. The reactor was cooled to ambient temperature, vented and purged three times with 300 PSI N2. The contents were filtered and stripped of water under reduced pressure on a rotary-evaporator at 70 C. The resultant solid was dissolved in refluxing methanol (35 ml) and allowed to stand at ambient temperature 18 hrs to yield a white solid, which was filtered and dried to yield 12.2 g (62.5% yield); GC Analysis was conducted by derivatizing 2 mg analyte in pyridine (1.5 ml, Aldrich BioTech Grade) with 99:1 BSTFA+TMCS (0.5 ml, Supelco, Sylon BFT) at 70-80 C. for 30 min. The retention time of material matched standard from Aldrich, and showed 99% pure product by area percent.

Reference： [1]Patent: US2014/255330,2014,A1 .Location in patent: Paragraph 0207
[2]Patent: US1994467,1932,
[3]Helvetica Chimica Acta,1937,vol. 20,p. 83,85
[4]Chemische Berichte,1966,vol. 99,p. 812 - 822
[5]RSC Advances,2014,vol. 4,p. 5152 - 5155
[6]Patent: GB426062,

2
[ 6284-40-8 ]
[ 265121-01-5 ]
Fosaprepitant dimeglumine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
80%	With palladium on activated charcoal; hydrogen; In methanol; at 20 - 30℃; under 2250.23 Torr; for 48h;	To the autoclave, the compound of formula II (30g), methanol (240m1), N-methyl Dglucamine (14.75m1) and Pd/C (1.5g) were charged and the reaction mass was hydrogenated at 3.0 kg/cm2 hydrogen pressure at 20-30C for 24 h. After completion of the reaction, the catalyst was filtered through hyflo. To the filtrate smopex 234 (1.5g) wasadded and reaction mixture was stirred for 24 hours at 20-30C. The reaction mixture was filtered through hyflo. To the filtrate triphenyl phosphine (1. 5g) was added and reaction mixture was stirred for 24 hours at 20-30C. The reaction mixture was filtered through 0.4 micron. The filtrate was collected and concentrated under vacuum up to 2 to 3 volume to obtain concentrated solution. To the concentrated solution 11% orthophosphuric acidsolution (5.5m1) was added to maintain the pH 6.5-7.5. To the reaction mixture methanol(80m1) was added. The resulting reaction mixture was added to the isopropyl alcohol(750m1) to precipitate a solid. The precipitated solid was then filtered and washed with30% methanol- isopropyl alcohol solution (30m1) followed by acetone (90m1). The solidwas then dried under vacuum at a temperature of 20-30C to yield dimeglumine salt of thecompound of formula I having Pd content less than 1 ppm. Yield 80%, purity 99%, Pdcontent 0.3 ppm.
	With hydrogen;palladium 10% on activated carbon; In methanol; under 5171.62 Torr; for 1h;Product distribution / selectivity;	EXAMPLE 2: PREPARATION OF FOSAPREPITANT DIMEGLUMINE; 200 ml of methanol, 10 g of dibenzyl ester fosaprepitant of formula 11 obtained in EXAMPLE 1 and 6.0 gm of N-methyl -D- glucamine were charged in a clean and dry 4 neck round bottom flask. 2.0gm of palladium-carbon ( 10%) was charged and 100 psi of anhydrous hydrogen pressure was passed for about 60 minutes under agitation. The reaction progress was monitored by HPLC. Monobenzyl impurity of formula (III) should be less than 0.1 %. After completion of the reaction, the reaction suspension was filtered on celite and the celite was washed with 20ml of methanol. The filtrate was distilled completely at about 65C under vacuum and 100ml of methanol was charged. The resultant residual suspension was stirred for about 1 5 minutes and the solution obtained was added to 200ml of isopropyl alcohol over about 10 minutes. The resultant reaction suspension was stirred for about 30 minutes. The separated solid was filtered and dried (Formula (I)) at about 300C under vacuum for about 1 hour to yield 8.2 gms of the title compound in crude form. Purity by HPLC: 94.5% with dibenzyl fosaprepitant (I I) : Not detected, monobenzyl fosaprepitant (II I): Not detected, aprepitant: 0.2%, desflouroaprepitant: 0.08%.; EXAMPLE 3: PURIFICATION OF FOSAPREPITANTDIMEGLUMINE; 10 gms of crude Fosaprepitant dimeglumine, as obtained in Example 2 and 100 ml of methanol were charged into a clean and dry 4 neck round bottom flask under nitrogen followed by stirring at about 300C for about 10 minutes. 300 ml of acetone(prefiltered) was charged into another clean and dry 4 neck round bottom flask. The above solution of fosaprepitant dimeglumine in methanol was added to acetone at about25C over about 15 minutes under nitrogen atmosphere. The resultant reaction suspension was stirred for about 30 minutes. The separated solid was filtered under nitrogen atmosphere and the solid was washed with 50 ml of acetone. The solid (Formula(I)) obtained was dried at about 300C under vacuum for about 1 hour to yield 8 gms of the title compound in pure form.Purity by chiral HPLC: 99.76% with Aprepitant: 0.05%; desflouro fosaprepitant: 0.06%, monobenzyl fosaprepitant (II I): below detection limit, desflouro aprepitant: below detection limit, diastereomer of fosaprepitant: below detection limit.All other individual impurities are below 0.05%.Assay (on anhydrous basis): 100.5%w/wPalladium content: below detection limit.Content of N-methyl-D-glucamine (on anhydrous basis): 39.7%w/w. Water content by KF: 3.2%w/w; heavy metals: less than 20ppm.
	With hydrogen;palladium 10% on activated carbon; In methanol; under 5171.62 Torr; for 1h;Product distribution / selectivity;	Example 2Preparation of Fosaprepitant Dimeglumine200 ml of methanol, 10 gm of dibenzyl ester fosaprepitant of formula II obtained in example 1 and 6.0 gm of N-methyl-D-glucamine were charged in a clean and dry 4 neck round bottom flask. 2.0 gm of palladium-carbon (10%) was charged and 100 psi of anhydrous hydrogen pressure was passed for about 60 minutes under agitation. The reaction progress was monitored by HPLC. Monobenzyl impurity of formula (III) should be less than 0.1%. After completion of the reaction, the reaction suspension was filtered on celite and the celite was washed with 20 ml of methanol. The filtrate was distilled completely at about 65 C. under vacuum and 100 ml of methanol was charged. The resultant residual suspension was stirred for about 15 minutes and the solution obtained was added to 200 ml of isopropyl alcohol over about 10 minutes. The resultant reaction suspension was stirred for about 30 minutes. The separated solid was filtered and dried (Formula I) at about 30 C. under vacuum for about 1 hour to yield 8.2 gm of the title compound in crude form.Purity by HPLC: 94.5% with dibenzyl fosaprepitant (II): Not detected, monobenzyl fosaprepitant (III): Not detected, aprepitant: 0.2%, desfluoroaprepitant: 0.08%.

		Dibenzyl fosaprepitant (50 gm), N-methyl-D-glucamine (25 gm), palladium carbon (10 gm) and methanol (410 gm) were added at room temperature and then applied 40 percent hydrogen pressure for 5 hours. The reaction mass was filtered through hyflow- bed. To the filtrate thus obtained was added SiliaBond dimercaptotriazine (5 gm) and maintained for 15 hours at room temperature. The reaction mass was filtered through hyflow-bed and the solvent was distilled off under vacuum pressure at 30 to 35C to obtain a residual solid. The residual solid obtained was co-distilled with isopropyl alcohol and acetonitrile. To the reaction mass was added acetonitrile (200 ml) under nitrogen atmosphere and stirred for 15 hours at room temperature. The solid obtained was collected by filtration and dried to obtain 28 gm of fosaprepitant dimeglumine (Palladium content: 3 ppm).
		To fosaprepitant dibenzyl ester (110 g) of formula II as an oil obtained in example-1, methanol (800 mL) added and stirred for a while followed by addition of 5 % Pd/C and methanol (110mL). Hydrogen pressure 2.5kg /cm2 to 3.0 kg /cm2 was applied and stirred at 20-30 C for 4 h. Nmethyl D-glucamine (55 g) and methanol (200 mL) was added into the reaction mixture and hydrogen pressure 2.5kg /cm2 to 3.0 kg /cm2 was applied. The reaction mixture was stirred at 20- 30C for 20 h. Pd/C was filtered from the reaction mixture and fresh methanol (220 mL) was added into it followed by addition of tributyl phosphine (6.6 mL), methanol (220 mL) and stirred for about 20-23 h under nitrogen at 20-30 C. To the reaction mixture activated carbon (11 g) was added and stirred for about 1 h. The reaction mixture was filtered and concentrated under vacuum up to -2.0-3.5 volume at 20-30 C. Then after 11 % orthophosphoric acid solution wasadded to adjust the pH reaction mass to 7.5-8.5 followed by addition of methanol (300 mL) and isopropyl alcohol (2750 mL) to the reaction mixture. The reaction mixture was stirred for 1 h, filtered and washed with mixture of methanol and isopropyl alcohol solution, acetone and methyl tert-butyl ether followed by drying at under vacuum below 25 C for 3-4 h to yield fosaprepitant dimeglumine (50-64 %) having purity more than 99 %.

Reference： [1]Journal of Medicinal Chemistry,2000,vol. 43,p. 1234 - 1241
[2]Patent: WO2015/83033,2015,A1 .Location in patent: Page/Page column 11
[3]Patent: WO2010/18595,2010,A2 .Location in patent: Page/Page column 26
[4]Patent: US2011/130366,2011,A1 .Location in patent: Page/Page column 9
[5]Patent: WO2012/164576,2012,A2 .Location in patent: Page/Page column 6-7
[6]Patent: WO2017/93899,2017,A1 .Location in patent: Page/Page column 17; 18

3
[ 6284-40-8 ]
[ 144701-48-4 ]
[ 960356-45-0 ]

Yield	Reaction Conditions	Operation in experiment
	In methanol;	<strong>[144701-48-4]Telmisartan</strong> meglumine salt1 g (2mmol ) of telmisartan is added to 10 mL of methanol and0.39 g (2 mmol) of meglumine, and the suspension is heated until all components are dissolved. The solution is cooled to room temperature and volatile components are evaporated. 10 mL of isopropyl acetate are added and the mixture is stirred at room temperature. The precipitate is filtered and dried for 1 h in a vacuum drier at 40 0C. 1.2 g of the product is isolated.Elemental analysis for C40H47N5O7:C: 67.43 % (67.68 %) , H: 6.88 % (6.67 %) , N: 9.82 % (9.87 %) .Molar ratio of telmisartan: 0.49Water content: 0.14%T: 198-205 0CIR: 1603, 1557, 1456, 1384, 1079, 1031, 751XRD: crystalline, figure 6Crystal shape: round shape, figure 7;
	In methanol;Product distribution / selectivity;	<strong>[144701-48-4]Telmisartan</strong> meglumine saltI g (2 mmol) of telmisartan is added to 10 ml of methanol and 0.39 g (2 mmol) of meglumine, and the suspension is heated until all components are dissolved. The solution is cooled to room temperature and volatile components are evaporated to solid residue. 1.33 g of the product is isolated. <n="39"/>T : 86-91 0CIR: 1560, 1557, 1457, 1388, 1283, 1079, 1033, 745 XRD: amorphous, figure 8

Reference： [1]Patent: WO2007/147889,2007,A2 .Location in patent: Page/Page column 37
[2]Patent: WO2007/147889,2007,A2 .Location in patent: Page/Page column 37-38

4
[ 6284-40-8 ]
[ 216167-82-7 ]
butanedioic acid, mono [4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenyl] ester meglumine salt [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In tetrahydrofuran; water; at 20℃; for 0.5h;	Meglumine [(N-METHYL-D-GLUCAMINE,] 1.95 g, 10 mmol) was dissolved in water (4 [ML).] THF (8 [ML)] was added. An appropriate amount of methanol can be substituted for [ THF. BUTANEDIOIC ACID, MONO [4-[ [1- [ [3,5-BIS (1,1-DIMETHYLETHYL) -4- HYDROXYPHENYL] THIO]-1-METHYLETHYL] THIO] -2,6-BIS (1,1-DIMETHYLETHYL) PHENYL] ESTER (6.17 G,] 10 mmol) was added followed by the addition of THF (20 [ML).] The resulting solution was stirred at room temperature for 30 minutes. The solution was evaporated. The residue was dissolved in THF (50 mL) and then evaporated. Crystallization from THF and hexane gave butanedioic acid, mono [4-[[1-[[3,5-bis (1,1-dimethylethyl)-4- [HYDROXYPHENYL] THIO]-1-METHYLETHYL] THIO] -2,6-BIS (1, 1-DIMETHYLETHYL) PHENYL] ESTER] meglumine salt as a white solid (7.30 g), m. p. [105-110C.] [1H] NMR (300 [MHZ,] [CDC13)] [8] 7.60 (s, 2H), 7.42 (s, 2H), 5.5-6. 05 (br. s, [5H),] 5.38 (s, 1H), 4.14 (br. s, 1H), 3.62-3. 85 (br. m, [5H),] 3.08 (br. s, 2H), 2.92 (br. s, 2H), 2.50-2. 61 (br. m, [5H),] 1.42 (s, 6H), 1.40 (s, 18H), 1.27 (s, [18H).] MS m/z = 616 [(M+).] Solubility in water: 0.39 mg/mL.

Reference： [1]Patent: WO2004/7423,2004,A1 .Location in patent: Page 62

5
[ 675610-06-7 ]
[ 6284-40-8 ]
3-(4-fluorobenzyl)-8-hydroxyquinoline-5,7-dicarboxylic acid 7-methyl ester meglumine salt [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
91.3%		3-(4-Fluorobenzyl)-8-hydroxyquinoline-5,7-dicarboxylic acid 7-methyl ester meglumine salt A suspension of compound I-3 (3.0g, 8.4mmol) obtained by Step 3 of Example 1 and megulumine (1.98 g, 10.14 mmol) in MeOH (60 mL) was stirred at 50C for 5 min. The resulting yellow solution was cooled to room temperature with stirring and stirred for 60min. To the resulting slurry was added dropwise MeCN (150 mL) during 30 min. After stirring for 3 hr, the resulting solids were collected by filtration and washed with MeCN (60 mL). The solids were dried in vacuo at 100C for 3 hr to give compound I-3-A (4.24 g, 91.3%) as pale yellow crystals. m.p.: 173.5C (from methanol-acetonitrile) NMR (CD3OD) delta: 2.70 (3H, s), 3.16 (2H, d, J=6.0 Hz), 3.61-3.84 (5H, m), 4.01-4.06 (1H, m), 4.03 (3H, s), 4.22 (2H, s), 7.00-7.05 (2H, m), 7.29-7.38 (2H, m), 8.43 (1H, s), 8.71 (1H, d, J=2.1 Hz), 9.18 (1H, d, J=2.1 Hz). Elemental analysis for C26H31FN2O10 Calcd. (%): C, 56.72; H, 5.68; F, 3.45; N, 5.09. Found. (%): C, 56.51; H, 5.73; F, 3.53; N, 5.12. The X-ray diffraction peaks were at 20=6.06, 6.84, 12.04, 13.64, 16.88, 18.10, 19,86, 20.20, 21.04, 22.40, 22.74, 25.30, 27.28, 30.18 and 34.48.

Reference： [1]Patent: EP1541558,2005,A1 .Location in patent: Page/Page column 51

6
[ 6284-40-8 ]
[ 57808-65-8 ]
N-methylglucamine salt of closantel [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In propylene glycol; ethanol; benzyl alcohol;	N-methylglucamine is added to a suspension of <strong>[57808-65-8]closantel</strong> in ethanol, benzyl alcohol, and propylene glycol. With stirring, the salt of <strong>[57808-65-8]closantel</strong> forms in situ, forming a solution. Moxidectin is then added, and stirred until solution is obtained. The formulation is then brought to volume with propylene glycol.

Reference： [1]Patent: WO2005/74912,2005,A2 .Location in patent: Page/Page column 11-12

7
[ 111-69-3 ]
[ 6284-40-8 ]
N-methyl-N-(5-cyanopentyl)-1-deoxyglucitylamine [ No CAS ]
N,N'-dimethyl-N,N'-bis(1-deoxyglucityl)hexamethylenediamine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
2%; 62%	With hydrogen;5%-palladium/activated carbon; In isopropyl alcohol; at 150℃; under 31789.8 - 65405.3 Torr; for 5h;	These examples illustrate another aspect of this invention, the ability to use dinitriles as linking groups to prepare the gemini surfactants of this invention. This transformation is represented by the following equation: A 100-mL Parr stainless steel reactor was charged with 8.19 gm (0.042 mole; 2.1 equivalents) <strong>[6284-40-8]1-deoxy-1-(methylamino)-D-glucitol</strong>, 2.16 gm of adiponitrile (0.02 mole; 1.0 equivalent), 0.52 gm (dry weight basis) 5% palladium on carbon, and 40 mL of 2-propanol. The reactor was closed, purged with nitrogen and hydrogen, and pressurized to ca 600 psig with hydrogen. The mixture was heated with stirring (1000 rpm) to 150 C. and pressurized with hydrogen to 1250 psig. The reaction was maintained at this temperature; pressure was maintained at 1250 psig via regulated hydrogen feed. After 5 hr, the mixture was cooled to room temperature, and the product removed from the reactor by filtration through an internal 0.5 mum sintered metal element. After trimethylsilylation, analysis of the product by GC and GC-MS indicated that it consisted of 62% N,N?-dimethyl-N,N?-bis(1-deoxyglucityl)hexamethylenediamine, 2% N-methyl-N-(5-cyanopentyl)-1-deoxyglucitylamine, 29% unchanged 1-deoxy-1-(octylamino)-D-glucitol, and minor amounts of byproducts. Additional N,N?-dialkyl-N,N?-bis(1-deoxyglucityl)-alkylenediamines were prepared and characterized using procedures similar to that above. Some of the N,N?-dialkyl-N,N?-bis(1-deoxyglucityl)alkylenediamines that were prepared according to this procedure and their designations are shown in Table 2.

Reference： [1]Patent: US2006/13780,2006,A1 .Location in patent: Page/Page column 8

8
[ 6284-40-8 ]
[ 189279-58-1 ]
[ 352458-37-8 ]

Yield	Reaction Conditions	Operation in experiment
88%	In ethanol; water; at 50 - 60℃;	(1) Compound 7 (10 g, 22.7 mmol);Meglumine (8.9 g, 45.4 mmol), ethanol (80 ml);Water (70ml) is stirred and dissolved, heated to 50-60 C, stirred for 2 to 3 hours, cooled, filtered, dried,Dexafloxacin (12.7 g yield 88%; HPLC ? 99.5%, single miscellaneous <0.1%.
88.2%	In water; at 80℃; for 1.0h;	Weigh <strong>[189279-58-1]delafloxacin</strong> (11.7g, 1.0eq) and meglumine (11.3g, 1.1eq) suspended in water,The temperature was raised to 80 C, dissolved, stirred for 1 hour, filtered, and the filtrate was cooled to 10 C and stirred for crystallization.Filtration, the filter cake was rinsed with ethanol, and dried under vacuum at 60 C. to obtain a crude dralafloxacin meglumine salt. The obtained crude product was suspended in ethanol, stirred, heated to 80 C, water was added to the solution dropwise, filtered, and the filtrate was kept under stirring for 1 hour, and then slowly cooled to 10 C for crystallization;After filtration, the filter cake was rinsed with ethanol and dried under vacuum at 60 C. to obtain 15 g of a pale yellow solid with a yield of 88.2%, a water content of 0.9%, and a liquid phase purity of 99.94%. The XRPD pattern was consistent with FIG. 1.
87%	In water; at 60℃; for 4.0h;	Will be 560g de la xa xing,496 g of meglumine in 2.6 L of water,The temperature was raised to 60 C for 4 hours.Hot filter,The filtrate naturally cools to 25 C and is warmed to a solid to precipitate.Continue to cool to 5 C and stir for 10 hours with stirring.filter,The filter cake was stirred in 460 ml of 30% (v%) aqueous ethanol for 0.5 h.filter,The filter cake was vacuum dried at 40 C,A pale yellow solid 7038, yield 87%Moisture 0.8%

83%	In water;Heating;	dexafloxacin 200 g prepared in Comparative Example 1 and120 g of meglumine was added to a 2 L reaction flask,Add 1L water,Stir and stir after heatingSlow cooling cooling,After crystallization, the mixture was filtered, washed with cold water and dried to give 240 g of a slightly yellow powder in 83% yield, HPLC purity98.6%.
	In water; at 0 - 60℃;	A mixture of EXAMPLE 1 (29.6 Kg) and 1-deoxy-1-(methylamino)-D-glucitol (18.4 Kg) was diluted with water (133 Kg), stirred at 60 C. until all solids dissolved, cooled to 38 C. and held there until solid formed, cooled to 0 C. and filtered. The filtrant was washed with isopropanol and dried at 50 C.
25 g	In water; at 50℃; for 6.0h;	Weigh <strong>[189279-58-1]delafloxacin</strong>20g, meglumine 11g added 100ml of pure water, heated to 50 stirred for 6h, cooled slowly to 10 stirred crystallization 5h, leaching,The filter cake was dried under reduced pressure to give <strong>[189279-58-1]delafloxacin</strong> meglumine polymorphs A 25g, X- ray powder diffraction test at 30 ~ 40 conditions, the results shown in Figure 1, the main test data values shown in Table 2(Listed relative strength of 10% or more of the test data), test DSC-TGA, the results shown in Figure 2.

Reference： [1]Patent: CN108084161,2018,A .Location in patent: Paragraph 0018; 0069-0071
[2]Patent: CN110467600,2019,A .Location in patent: Paragraph 0031-0037; 0072; 0073; 0076; 0077
[3]Patent: CN105017223,2017,B .Location in patent: Paragraph 0037-0038; 0040; 0041; 0043; 0045; 0048
[4]Patent: CN106256824,2016,A .Location in patent: Paragraph 0034
[5]Patent: US2006/228411,2006,A1 .Location in patent: Page/Page column 2
[6]Patent: CN105693695,2016,A .Location in patent: Paragraph 0028

9
[ 6284-40-8 ]
[ 189279-58-1 ]
1-deoxy-1-(methylamino)-D-glucitol 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxyazetidin-1-yl)-4-oxo-3-quinolinecarboxylate trihydrate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In water; isopropyl alcohol; at 45℃;Product distribution / selectivity;	EXAMPLE 1; A mixture of 1-(6-amino-3,5-difluoro2-pyridinyl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxyazetidin-1-yl)-4-oxo-3-quinolinecarboxylate (50 Kg) and 1-deoxy-1-(methylamino)-D-glucitol (26.1 Kg) was diluted with water (75.5 Kg) and isopropanol (60.2 Kg), stirred at 45 C., cooled to 30+/-5 C., treated with isopropanol (175.7 Kg) while maintaining the internal temperature at about 30 C. and filtered. The filtrant was washed with isopropanol and dried under reduced pressure at 30 C. for 12 hours then at 50 C. mp: 170-172 C. 1H (D2O/500 MHz) 8.22 (d, J=0.76 Hz, 1H), 7.71 (d, J=14.19 Hz, 1H), 7.52 (dd, J=9.31, 0.77 Hz, 1H), 4.58 (m, 2H), 4.53 (m, 1H), 4.15 (m, 3H), 3.83 (m, 2H), 3.774 (m, 1H), 3.662 (m, 2H), 3.2 (m, 2H), 2.79 (s, 3H).
	In water; at 60℃;Product distribution / selectivity;	EXAMPLE 2; A mixture of 1-(6-amino-3,5-difluoro2-pyridinyl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxyazetidin-1-yl)-4-oxo-3-quinolinecarboxylate (29.6 Kg) and 1-deoxy-1-(methylamino)-D-glucitol (18.4 Kg) was diluted with water (133 Kg), stirred at 60 C. until all solids dissolved, cooled to 38 C. and held there until solid formed, cooled to 0 C. and filtered. The filtrant was washed with isopropanol and dried at 50 C.

Reference： [1]Patent: US2007/43019,2007,A1 .Location in patent: Page/Page column 4-5
[2]Patent: US2007/43019,2007,A1 .Location in patent: Page/Page column 5

10
[ 6284-40-8 ]
[ 68302-57-8 ]
amlexanox meglumine salt [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In water; for 0.0333333h;	The compositions of instantly soluble <strong>[68302-57-8]amlexanox</strong> formulations with meglumine are listed in the Table below. The compositions were prepared by mixing of weighted amounts of dry powders for 90 minutes in a planetary mixer. Dissolution of the formulation was tested by placing the 85 mg of powder formulation in 5 mL water. The solution becomes clear in less than 2 minutes.

Reference： [1]Patent: US2007/135473,2007,A1 .Location in patent: Page/Page column 9

11
[ 6284-40-8 ]
[ 19545-26-7 ]
WmC₂₀-N-methyl-glucamine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
98.7%	In dimethyl sulfoxide; at 20℃; for 0.5h;	WmC20-N-methyl-glucamine was prepared by combining wortmannin(21.4 mg, 0.05 mmol) and N-methyl-glucamine (19.5 mg, 0.1 mmol) in anhydrous DMSO (0.5 mL) at room temperature with stirring for 0.5 hours. The product was purified by HPLC and lyophilized. Yield 30.7 mg, 98.7%. A BSA wortmannin conjugate can be prepared by combining WmC20- N-methyl-glucamine (2.4 mg, 3.79chilO~3 mmol) with BSA (25 mg, 3.79xlO"4 mmol) in phosphate buffered saline (0.4 mL) at 37" C with stirring overnight. The mixture can be purified by size exclusion chromatography. The ratio of Wm to BSA in the product can be calculated using a standard curve.; A mixture of wortmannin (21.4 mg, 0.05 mmol) andN-methyl glucamine (19.5 mg, 0.1 mmol) in anhydrous DMSO (0.5 mL) was stirred at room temperature for 0.5 hours. The mixture was purified by HPLC. A yellow powder, termed WmC20N(Me) glucamine, was obtained after lyophilization. Yield, 30.7mg, 98.7%. A solution of Erbitux (aka cetuximab, 30mg) and WmC20N(Me)glucamine (1.36 mg, 2.18xlO'3 mmol) were combined in PBS (5 mL) at 37 C for 20 hours. Unreacted WmC20N(Me)glucamine was removed with a Sephadex G-50 column in ImM phosphate buffer at pH 7. After lyophilization, a yellow powder was obtained. The ratio of Wm to cetuximab (6.0 Wm/mole) was obtained from the absorbances of certuximab at 280nm and conjugated Wm at 408 ran. The coupling efficiency was 55%. The WmC20-centuximab can be checked for immunoreactivity by using A549 cells and erbitux.

Reference： [1]Patent: WO2007/86943,2007,A2 .Location in patent: Page/Page column 49-50; 52

12
[ 6284-40-8 ]
[ 71125-38-7 ]
[ 244241-52-9 ]

Yield	Reaction Conditions	Operation in experiment
93%	In ethanol; at 60℃; for 0.5h;	This crude material is then taken up in 200 ml of ethanol along with 13.5 g of N-methylglucamine. After heating to 60 C. for 30 minutes, the undissolved solids are filtered off and 280 ml of ethyl acetate is added to the filtrate over 90 minutes maintaining a temperature of 60 C. throughout. After cooling to 5 C. for 2 hours, the desired N-methylglucamine salt of <strong>[71125-38-7]meloxicam</strong> is obtained by filtration in a yield of 34.7 g (93% of theory) in the form of a bright yellow solid.

Reference： [1]Patent: US2008/119647,2008,A1 .Location in patent: Page/Page column 2

13
[ 6284-40-8 ]
[ 90098-04-7 ]
[ 861243-15-4 ]

Yield	Reaction Conditions	Operation in experiment
61%		Example 7; 2- (4-chlorobenzoylamino)-3- (2-quinolon-4-yl) propionic acid- meglumine salt; To 3.7 g of 2- (4-chlorobenzoylamino)-3- (2-quinolon-4- yl) propionic acid (10 mmol) was added 1 mol/L aqueous solution of meglumine (10 mL, 10 mmol), and heated at 50C to be dissolved. To the solution was added an aqueous solution of equimolar mixture of meglumine and hydrochloric acid (0.5 mol/L; 20 mL), and the mixture was cooled. The resulting precipitates were separated by filtration, washed with water, and dried under a reduced pressure at room temperature to give 0.9 g of 2- (4-chlorobenzoylamino)-3- (2- quinolon-4-yl) propionic acid-meglumine salt (16% yield) as a white crystal. 1H NMR (DMSO-d6) 5 = 2.82-3. 14 (3H, m), 3.37-3. 73 (6H, m), 3.82-3. 94 (1H, m), 4.52 (1H, ddd, J = 9.6, 8.2, 3.5 Hz), 6.41 (1H, s), 7.20 (1H, dd, J = 8. 0,7. 2 Hz), 7.30 (1H, d, J = 7.8 Hz), 7. 48 (1H, dd, J = 7.8, 7.2 Hz), 7.51 (2H, d, J = 8.5 Hz), 7.80 (2H, d, J = 8.5 Hz), 7.94 (1H, d, J = 8.0 Hz), 8.37 ppm (1H, d, J = 8. 2 Hz).

Reference： [1]Patent: WO2005/70892,2005,A1 .Location in patent: Page/Page column 26-27

14
[ 6284-40-8 ]
[ 51037-35-5 ]
[ 869877-25-8 ]

Yield	Reaction Conditions	Operation in experiment
80%		The reaction was carried out, under nitrogen, in a 500 mL×4 neck flask equipped with a mechanical stirrer, water condenser (with gas inlet), and a thermocouple. The reactor was charged with 5-methylpyrazinecarboxylic acid-4-oxide, ethyl ester (8.12 g) and methanol (23 g). A solution of sodium hydroxide (1.96 g) in water (6 g) was added over 20 minutes at 6 C., and then the reaction mixture was warmed at 50 C. and stirred for 30 minutes. The reaction mixture was cooled to room temperature and concentrated HCl (0.41 g) was added bringing the pH to below 7. Methanol (40 g) was added to the reaction mixture with stirring. N-methyl-D-glucamine was added and the mixture refluxed for one hour. After stirring the suspension in an ice-bath for 3.5 h, the solid was collected and rinsed with ice-cold methanol (3×15 g). The collected solid is dried under vacuum (25 inches of Hg at 60 C.) to yield 80% of the glucamine salt as a off-white solid.

Reference： [1]Patent: US2005/261312,2005,A1 .Location in patent: Page/Page column 3

15
[ 186087-26-3 ]
[ 6284-40-8 ]
[ 1034125-74-0 ]

Yield	Reaction Conditions	Operation in experiment
100%	In water; at 20℃;pH ~ 7;	To a suspension of D-iGlu-D-Trp (1.00 g, 3 mmol) in 20 mL of deionized water was added a solution of 586 mg (1.0 equiv) of N-methyl-D-glucamine in 15 mL of deionized water at RT. The reaction mixture was stirred for over the weekend at RT. The reaction mixture was clear and the pH of the solution was about 7. Isopropanol was added, and volatile materials were removed in vacuo. The residual solid was suspended in acetone and the solid was collected by suction filtration. The solid was dried under vacuum at 40 C. for overnight to afford the product in quantitative yield. The XRPD pattern confirmed that this material is amorphous. 1H NMR (D2O) delta: 7.61 (d, J=7.9 Hz, 1H), 7.41 (d, J=8.1 Hz, 1H), 7.15-7.18 (m, 2H), 7.08 (t, J=7.5 Hz, 1H), 4.47 (dd, J=8.6, 4.8 Hz, 1H), 3.99-4.02 (m, 1H), 3.70-3.75 (m, 2H), 3.65-3.68 (m, 1H), 3.54-3.60 (m, 2H), 3.45 (t, J=6.2 Hz, 1H), 3.27 (dd, J=14.8, 4.7 Hz, 1H), 3.02-3.13 (m, 3H), 2.68 (s, 3H), 2.19-2.26 (m, 2H) and 1.75-1.95 (m, 2H). 14N NMR (D2O) delta (ppm): 29.6 and 39.2 (br. overlapping), *NH4NO3 was used as external reference with the reference signal set at 20.689 ppm. The water content by Karl-Fischer test is 3.1%. MS (m/z): 529.5 [M+1]+, 334.2 [C16H20N3O5]+, 187.9 (100%). The IR spectrum is shown in FIG. 8. UV (water, c=41.2 muM, lambdamax nm): 220 (epsilon27341), 280 (epsilon4419).
100%	In water; at 20℃; for 168h;pH Ca. 7;	To a suspension of D-iGlu-D-Trp (1.00 g, 3 mmol) in 20 mL of deionized water was added a solution of 586 mg (1.0 equiv) of N-methyl-D-glucamine in 15 mL of deionized water at RT. The reaction mixture was stirred for over the weekend at RT. The reaction mixture was clear and the pH of the solution was about 7. Isopropanol was added, and volatile materials were removed in vacuo. The residual solid was suspended in acetone and the solid was collected by suction filtration. The solid was dried under vacuum at 40 C. for overnight to afford the product in quantitative yield. The XRPD pattern confirmed that this material is amorphous. 1H NMR (D2O) delta: 7.61 (d, J=7.9 Hz, 1H), 7.41 (d, J=8.1 Hz, 1H), 7.15-7.18 (m, 2H), 7.08 (t, J=7.5 Hz, 1H), 4.47 (dd, J=8.6, 4.8 Hz, 1H), 3.99-4.02 (m, 1H), 3.70-3.75 (m, 2H), 3.65-3.68 (m, 1H), 3.54-3.60 (m, 2H), 3.45 (t, J=6.2 Hz, 1H), 3.27 (dd, J=14.8, 4.7 Hz, 1H), 3.02-3.13 (m, 3H), 2.68 (s, 3H), 2.19-2.26 (m, 2H) and 1.75-1.95 (m, 2H). 14N NMR (D2O) delta (ppm): 29.6 and 39.2 (br. overlapping), *NH4N03 was used as external reference with the reference signal set at 20.689 ppm. The water content by Karl-Fischer test is 3.1%. MS (m/z): 529.5 [M+1]+, 334.2 [C16H20N3O5I+, 187.9 (100%). The IR spectrum is shown in . UV (water, c=41.2 muM, lambdamax nm): 220 (epsilon 27341), 280 (epsilon 4419).

Reference： [1]Patent: US2010/56803,2010,A1 .Location in patent: Page/Page column 13-14
[2]Patent: US2015/225341,2015,A1 .Location in patent: Paragraph 0161

16
[ 1093108-50-9 ]
[ 6284-40-8 ]
[ 1309389-61-4 ]

Yield	Reaction Conditions	Operation in experiment
83%	In ethanol; at 50℃; for 5h;	1 Preparation of <strong>[6284-40-8]N-methyl-D-Glucamine</strong> Salt of the Compound of Formula (I)The acid- free form of the compound of formula (I) (4.0 g, 7.9 mmol), N-methyl-D- glucamine (1.713 g, 8.7 mmol) and ethanol (50 g) were mixed at 50C for about 5 hours. The resultant mixture was cooled to about 25, filtered, and the solids washed 1 x 10 g with EtOH. The solids were then dried at 50C under reduced pressure to provide the N- methyl- glucamine salt of the compound of formula (I) as off-white crystals. Yield: 4.56 g, 83 %. The XRPD data are shown in Table 1 and FIG. 1. The data show that the product is highly crystalline. DSC and TGA thermograms (FIG. 2) indicate the N- methyl-D-glucamine salt of the invention has a single melting of the compound with an onset temperature of about 175C and no weight loss during the melting. Additional weight loss is observed above 200C which is attributed to decomposition. The results indicate that the N-methyl-D-glucamine salt prepared by the above process is essentially free of water and organic solvent.
		The free acid of {4,6-bis(dimethylamino)-2-(4-(4-(trifluoromethyl)benzamido)-benzyl)pyrimidin-5-yl} acetic acid was screened with twenty two pharmaceutically acceptable bases and the results are summarized in Table 1, together with their aqueous solubility. Among the bases screened, ethylenediamine, piperazine, benzathine, and choline each produced crystalline solids suitable for pharmaceutical formulations and use as described herein.

Reference： [1]Patent: WO2011/66147,2011,A2 .Location in patent: Page/Page column 29
[2]Patent: WO2008/156781,2008,A1 .Location in patent: Page/Page column 40-41

17
[ 1035688-66-4 ]
[ 6284-40-8 ]
[ 1245555-08-1 ]

Yield	Reaction Conditions	Operation in experiment
87%	In tetrahydrofuran; methanol; at 20℃; for 0.5h;	275 mg (1.4 mmol) of meglumine were dissolved in 30 mL of methanol and said solution was added to a mixture of 500 mg (1.4 mmol) of 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid dissolved in the minimum amount of tetrahydrofurane (7 mL). After 30 min of stirring at room temperature, the solution was evaporated under vacuum. The precipitate formed was suspended in 20 mL of ethyl acetate at 77C during 30 min, the resulting suspension was then filtered and the obtained precipitate was dried under vacuum for 4 hours at 40C. 675 mg (yield: 87%) of a white solid was then obtained with a purity of 99.9% by HPLC. Figure 1 illustrates the DSC thermogram of the meglumine salt of 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid. The sample exhibits a characteristic high endotherm at onset 136C that corresponds to a melting or decomposition of the salt. This indicates that the sample does not convert into any other polymorphs and does not suffer any decomposition, confirming thus its high stability. Figure 2 illustrates the DVS pattern of the meglumine salt of 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid. Mass increase was measured at 80% (0.15% increase) and 90% (0.4% increase) relative humidity (RH). According to the results, said salt is not hygroscopic and exhibited no hysteresis. Figure 3 illustrates the IR spectra of the meglumine salt of 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid. Characteristic signals appear at 3207, 1595, 1524, 1491, 1384, 1260, 1144, 1062, 1046, 1016, 842, 776 and 701 cm-1.

Reference： [1]Patent: EP2228367,2010,A1 .Location in patent: Page/Page column 10

18
[ 1190221-43-2 ]
[ 6284-40-8 ]
[ 1190221-63-6 ]

Yield	Reaction Conditions	Operation in experiment
100%	In methanol; for 0.5h;	9 mL of methanol and 136.6 mg (0.70 mmol) of N-methyl-D-glucamine were added to 300 mg (0.70 mmol) of 5-chloro-2-([(2-([3-(furan-3-yl)phenyl]amino)-2-oxoethoxy)acetyl]amino)benzoic acid obtained in Example 58, and the mixture was stirred for 0.5 hours. Thereafter, the solvent was distilled off under reduced pressure, 10 mL of water was added thereto, and dissolution and freeze-drying were carried out to quantitatively give 5-chloro-2-([(2-([3-(furan-3-yl)phenyl]amino)-2-oxoethoxy)acetyl]amino)benzoic acid·N-methyl-D-glucamine salt. 1H-NMR (D2O) delta: 2.75(3H, s), 3.07-3.28 (2H, m), 3.58-3.89 (5H, m), 4.03-4.15 (1H, m), 4.09 (2H, s), 4.12 (2H, s), 6.72 (1H, s), 7.19-7.33 (2H, m), 7.33 (1H, dd, J = 8.9, 2.4 Hz), 7.45 (1H, s), 7.53 (1H, d, J = 7.7 Hz), 7.62 (1H, s), 7.80 (1H, s), 7.84 (1H, d, J = 2.4 Hz), 8.16 (1H, d, J = 8.9 Hz).

Reference： [1]Patent: EP2272822,2011,A1 .Location in patent: Page/Page column 84

19
[ 111-82-0 ]
[ 6284-40-8 ]
N-dodecanoyl-N-methyl-1-glucamine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
80.7%	With sodium methylate; In methanol; at 80 - 90℃; for 3h;Inert atmosphere;	Example 3 Synthesis of N-Dodecanoyl-N-Methylglucamine (C12-NMG) A slurry of N-Methylglucamine (40 g, 205 mmoles, Aldrich), Methyl-Laurate (44.7 g, 208 mmoles, Aldrich) and methanol (17 g, 20 wt % based on reactants) was heated to 80 C. under N2 blanket. Once at temperature, sodium methoxide (4.4 g of 25% in methanol, 20.5 mmoles, Aldrich) was added to reaction. Stirring for ?30 min at 80 C. yielded a homogenous solution from which the excess methanol was removed by short-path distillation. Heating was continued for an additional 30 min at 80 C. followed by 2 hrs at 90 C. The reaction mixture was then cooled to 50 C., and 200 ml methanol was added over 10 min yielding a homogenous solution. This solution was cooled and allowed to stand at ambient temperature for 18 hrs yielding a white precipitant which was collected by filtration and dried (62.4 g, 80.7% yield, 98.9% product by GC, using derivatization described in Example 1).

Reference： [1]Patent: US2014/255330,2014,A1 .Location in patent: Paragraph 0209
[2]Green Chemistry,2010,vol. 12,p. 1817 - 1825

20
[ 80003-64-1 ]
[ 6284-40-8 ]
2,5-dihydroxy-1,4-dithiane-2,5-dicarboxylic acid, bis-((2R,3R,4R,5S)-6-methylaminohexane-1,2,3,4,5-pentol) salt [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
99%	In water; at 20℃; for 0.166667h;	A solution of disodium 2,5-dihydroxy-l,4-dithiane-2,5-dicarboxylic acid tetrahydrate (prepared by the method of WO2008/005806) (0.25 g, 0.70 mmol) in H20 (7 mL) was applied to a column of ion-exchange resin Dowex 50WX8-200 (H ; 3 mL, 5 meq), and was eluted with H20 until the eluate tested negative for the presence of dithiane by KMn04 stain on TLC silica plate to provide compound 3 in solution. The eluate was treated with a solution of the desired amine (1.40 mmol) in H20 (15 mL), and the resulting solution was allowed to stir at room temperature for 10 min. The solution was subsequently lyophilized to yield a white solid.Characterization data for 2,5-dihydroxy- 1 ,4-dithiane-2,5-dicarboxylic acid (3). Yield99%. *H NMR (300 MHz, D20): delta 3.01 (2H, d, J= 14.4 Hz, major isomer), 3.21 (2H, d, J= 14.4 Hz, minor isomer), 3.45 (2H, d, J= 14.4 Hz, minor isomer), 3.90 (2H, d, J= 14.4 Hz). 13C NMR (75 MHz, D20): delta 35.2, 37.3, 76.0, 78.8, 174.5, 174.7. Anal. Calcd for C6H806S2: C, 30.00; H, 3.36; S, 26.69. Found: C, 30.12; H, 3.44; S, 26.48. Compound 4a:2.5-Dihydroxy-l,4-dithiane-2,5-dicarboxylic acid, bis-((2R,3R,4R,5S)-6- methylaminohexane-l,2,3,4,5-pentol) trihydrate salt (4a). Compound 4a was prepared by the general procedure of Example 6 in 99% yield. lU NMR (600 MHz, D20): delta 2.79 (6H, s), 2.83 (2H, d, J= 14.4 Hz, major isomer), 3.09 (2H, d, J= 14.4 Hz, minor isomer), 3.18-3.27 (5H, m), 3.58 (2H, d, J= 14.4 Hz, minor isomer), 3.65-369 (5H, m), 3.76-3.79 (2H, m), 3.82-3.84 (2H, m), 3.87 (2H, d, J= 14.4 Hz, major isomer), 4.10-4.13 (2H, m). 13C NMR (150 MHz, D20): delta 32.96, 35.92, 51.07, 62.64, 68.03, 70.51, 70.66, 70.87, 77.03, 176.84. Anal. Calcd forC20H42N2O16S2-3H2O: C, 35.08; H, 7.07; N, 4.09; S, 9.37. Found: C, 34.94; H, 6.87; N, 4.00; S, 9.67. mp: 1 19-120 C (dec).

Reference： [1]Patent: WO2011/133893,2011,A2 .Location in patent: Page/Page column 13

21
[ 1257792-41-8 ]
[ 6284-40-8 ]
(Z)-5-(2-hydroxy-3-{N'-[3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,5-dihydropyrazol-4-ylidene]hydrazino}phenyl)furan-2-carboxylic acid dimeglumine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
90.8%	In tetrahydrofuran; at 20℃;	Example 10: (Z)-5-(2-hydroxy-3-{N'-[3-methyl-5-oxo-1-(5,6,7,8-tetrahydro-naphthalen-2-yl)-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-phenyl)-furan-2-carboxylic acid bis-(meglumine); (Z)-5-(2-hydroxy-3-{N'-[3-methyl-5-oxo-1-(5,6,7,8-tetrahydro-naphthalen-2-yl)-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-phenyl)-furan-2-carboxylic acid 7d (100 mg, 0.22 mmol) was suspended in 5 mL of tetrahydrofuran to form a dark red suspension. The reaction mixture was added with meglumine (85 mg, 0.44 mmol), and stirred at room temperature overnight. The resulting solution was added with 4 mL of methanol and concentrated under reduced pressure to obtain the title compound (Z)-5-(2-hydroxy-3-(N'-[3-methyl-5-oxo-1-(5,6,7,8-tetrahydro-naphthalen-2-yl)-1,5-dihydro-pyrazol-4-ylidene]-hydrazino}-phenyl)-furan-2-carboxylic acid bis-(meglumine) 10 (168 mg, yield: 90.8%) as a dark red solid. HPLC: 97.7% MS m/z (ESI): 457.8 [M-1] 1H NMR (400 MHz, CD3OD): delta 7.56 (m, 4H), 7.06 (m, 2H), 6.98 (d, J=3.2 Hz, 1H), 6.75 (t, J=7.6 Hz, 1H), 4.08 (m, 2H), 3.81 (m, 2H), 3.77 (m, 2H), 3.63 (m, 6H), 3.11 (m, 4H), 2.76 (m, 4H), 2.64 (s, 6H), 2.33 (s, 3H), 1.79 (m, 4H)
90.8%	In tetrahydrofuran; at 20℃;	(Z)-5-(2-hydroxy-3-{N'-[3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,5-dihydropyrazol-4-ylidene]hydrazino}phenyl)furan-2-carboxylic acid 7d (100mg, 0.22mmol) was dissolved in 5mL of tetrahydrofuran to form a dark red suspension. To this was added dropwise meglumine (85mg, 0.44 mmol) with stirring. The reaction was stirred at room temperature overnight. 4mL methanol solution was added. It was concentrated under reduced pressure to give the title product (Z)-5-(2-hydroxy-3-{N'-[3-methyl-5-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,5-dihydropyrazol-4-ylidene]hydrazino}phenyl)furan-2-carboxylic acid dimeglumine salt 10 (168mg, dark red solid), yield : 90.8%.

Reference： [1]Patent: EP2441457,2012,A1 .Location in patent: Page/Page column 22-23
[2]Patent: TWI530497,2016,B .Location in patent: Page/Page column 44; 45

22
[ 6284-40-8 ]
[ 147526-32-7 ]
[ 1392469-67-8 ]

Yield	Reaction Conditions	Operation in experiment
	In isopropyl alcohol; at 25 - 35℃;	<strong>[147526-32-7]P<strong>[147526-32-7]itavastatin</strong></strong> free acid (4 g) and isopropyl alcohol (20 mL) are charged into a round bottom flask. Meglumine (2.2 g) is added at 25-35C and the mixture is maintained at this temperature for 5-6 hours. The formed solid is collected by filtration, washed with isopropyl alcohol (4 mL), and dried at about 50-55C to afford the title compound. Yield: 3 g; Moisture content: 2.2% w/w; HPLC purity: 98.68%. The product has a particle size distribution with D90 = 327.40 muiotatauiota, D10 = 7.89 pm, and D50 = 6.68 muetaeta.The PXRD pattern, DSC curve, and TGA curve of the product are shown, respectively, in Figs. 8-10.

Reference： [1]Patent: WO2012/106584,2012,A2 .Location in patent: Page/Page column 24-25

23
[ 518048-05-0 ]
[ 6284-40-8 ]
[ 1337990-98-3 ]

Yield	Reaction Conditions	Operation in experiment
	In methanol; at 20℃;	Preparation of meglumine salt of <strong>[518048-05-0]raltegravir</strong>2.0 g of <strong>[518048-05-0]raltegravir</strong> was dissolved in 20 ml of methanol. 1.05 g of meglumine was added to the slurry and the mixture was stirred at 20C for 10-15 hours. 40 ml of diisopropyl ether was added to the solution to precipitate the salt. The resulting mixture was stirred for 3-4 hours at 20-25C and filtered. The solid obtained was washed with 1: 1 mixture of diisopropyl ether and methanol and dried under vacuum.Yield = 1.5 gPurity = 99.5%

Reference： [1]Patent: WO2012/137142,2012,A1 .Location in patent: Page/Page column 9

24
[ 6284-40-8 ]
[ 594839-88-0 ]
[ 951395-08-7 ]

Yield	Reaction Conditions	Operation in experiment
82%	In water; isopropyl alcohol; at 10 - 79℃;	Example 1 - Preparation of Crystalline Compound 16-Carboxy-2-(3,5-dichlorophenyl)-benzoxazole free acid (2.5 g, 8.1 mmol) and 2- propanol (49 ml.) were charged to a 100 mL jacketed, 2-neck round bottom flask with magnetic stirrer. The resulting slurry was warmed to 70 C with stirring. Water (8.8 mL) was then charged. In a separate 15 mL round bottom flask a solution of N-methyl-D- glucamine (1.58 g, 8.1 mmol) in 5 mL water was prepared and dissolved with stirring. The aqueous N-methyl-D-glucamine solution was then transferred to the reaction flask over 2 min. Most (but not all) of the solids dissolved by the end of this addition. After 5 min stirring and warming to 79 C, a clear, pale yellow solution resulted. The solution was filtered through a bed of Celite, cooled to 60 C, then cooled to 10 C over 2 h. The resulting solids were collected by filtration, washing with 10 mL of 2-propanol. 3.35 g product was obtained (82% yield).
82%	In water; isopropyl alcohol; at 70 - 79℃;	6-Carboxy-2-(3,5-dichlorophenyl)-benzoxazole free acid (2.5 g, 8.1 mmol) and 2-propanol (49 ml.) were charged to a 100 mL jacketed, 2-neck round bottom flask with magnetic stirrer. The resulting slurry was warmed to 70 C with stirring. Water (8.8 mL) was then charged. In a separate 15 mL round bottom flask a solution of N-methyl-D-glucamine (1.58 g, 8.1 mmol) in 5 mL water was prepared and dissolved with stirring. The aqueous N-methyl-D-glucamine solution was then transferred to the reaction flask over 2 min. Most (but not all) of the solids dissolved by the end of this addition. After 5 min stirring and warming to 79 C, a clear, pale yellow solution resulted. The solution was filtered through a bed of Celite, cooled to 60 C, then cooled to 10 C over 2 h. The resulting solids were collected by filtration, washing with 10 mL of 2-propanol. 3.35 g product was obtained (82% yield).
	In ethyl acetate; at 15 - 30℃; for 20h;	50.1 mg of Tafamidis free acid and 31.7 mg of meglumine were mixed evenly, and were added into 2.5 mL of ethyl acetate. The mixture was stirred at room temperature for 20 hours to crystallize. White crystalline solid of Tafamidis meglumine was obtained by centrifugation and vacuum drying at room temperature. The obtained crystalline solid conformed to Form E of the present disclosure. Its XRPD pattern was substantially as depicted in FIG. 1, and the XRPD data were listed in Table 1. The DSC curve of Form E was substantially as depicted in FIG. 3, which comprises three endothermic peaks. Onset of the first endothermic peak is around 118 C., and the second is around 155 C. The third endothermic peak at 187 C. corresponds to the melting process. The thermal gravimetric analysis (TGA) curve of Form E was substantially as depicted in FIG. 4. It has approximate 2.6% weight loss when heated to 120 C. The 1HNMR spectrum was substantially as depicted in FIG. 5.

Reference： [1]Patent: WO2013/38351,2013,A1 .Location in patent: Page/Page column 27
[2]Patent: EP2764866,2014,A1 .Location in patent: Paragraph 0334
[3]Patent: US2019/119226,2019,A1 .Location in patent: Paragraph 0022; 0069-0075

25
3-(4-chloro-3-(((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)amino)methyl)phenyl)propanoic acid hydrochloride [ No CAS ]
[ 6284-40-8 ]
[ 76-05-1 ]
3-(4-chloro-3-(((1-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)cyclopropyl)amino)methyl)phenyl)-N-methyl-N-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)propanamide bis(trifluoroacetate) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
54%		To a mixture of Example 59 HC1 salt (8.2 mg, 0.016 mmol, 1 equiv.) and N-methyl glucamine (3.9 mg, 0.02 mmol) in DMF (0.1 mL) were added HATU (7.6 mg, 0.02 mmol) and DIEA (17 uL, 0.1 mmol). The mixture was stirred at room temperature for 1 h and purified by preparative HPLC to give 7.4 mg (54 %) of 3-(4-chloro-3-(((l-(4-cyclopropyl-l,2,3,4- tetrahydroquinoxaline-l-carbonyl)cyclopropyl)amino)methyl)-phenyl)-N-methyl-N- ((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)propanamide bis TFA salt as an off-white solid. MS (ES, m/z): 631 [M+H]+. H-NMR (400 MHz, CD3OD) 6 7.34-7.26 (m, 2H), 7.26-7.20 (m, 2H), 7.20-7.14 (m, 1H), 7.09 (dd, J = 12.2, 1.9 Hz, 1H), 6.76 (ddd, J = 9.2, 3.4, 1.7 Hz, 1H), 4.1 1 (d, J = 8.8 Hz, 2H), 3.99-3.84 (m, 3H), 3.81-3.54 (m, 6H), 3.48-3.34 (m, 3H), 3.09 (s, 1.4H), 2.96 (s, 1.6H), 2.87 (t, J= 7.5 Hz, 2H), 2.84-2.70 (m, 1H), 2.67 (t, J= 7.5 Hz, 1H), 2.49-2.36 (m, 1H), 1.44-1.33 (m, 2H), 1.28-1.20 (m, 2H), 0.83 (dt, J= 6.6, 1.6 Hz, 2H), 0.57-0.45 (m, 2H).

Reference： [1]Patent: WO2013/96771,2013,A1 .Location in patent: Page/Page column 156

26
[ 1445985-39-6 ]
[ 6284-40-8 ]
[ 76-05-1 ]
[ 1445982-24-0 ]

Yield	Reaction Conditions	Operation in experiment
70%		solution of 3-[2,5-dichloro-4-([l -[(4- cyclopropyl-l,2,3,4 etrahydroquinoxalm-l-yl)carbonyi]cyclopropoxy]m propanoic acid (100 mg, 0.20 mmol, 1.00 equiv), (2R,3R,4R,5S)-6- (methyIammo)hexane-L23,4,5--pento1 (60 mg, 0.31 mmol, 1.50 equiv), HATU (1 17 mg, 0.31 mmol, 1.50 equiv), and DIEA (53 mg, 0. 1 mmol, 2.00 equiv) in DMF (2 mL) was stirred overnight at room temperature. The resulting reaction mixture was concentrated under reduced pressure and the crude product residue (1 50 mg) was purified by preparative HPLC with the following conditions: Column, SunFire preparative C18, 19*150mm 5mupialpha; mobile phase gradient, water containing 0.05% "FFA : CH3CN (38.0% CJCN to 56.0% over 6 min); Detector, Waters 2545 UV detector at 254 and 220nm to provi de 95 mg (70%) of the title compound trifluoroacetate salt as an off-white solid. MS (ES, m/zy. 666 [M+Hf : 1H-NMR (300 MHz, CD3OD) 5 7.27 (dd, J - 4.8 Hz, 2H), 6,99-7.04 (rn, 2H), 6.50-6.68 (in, 2H), 4.32 (s, 2H), 3.87-3.94 (m, 3H), 3.55-3.75 (m; 3H), 3.27-3.36 (m, 3H), 2.89-3.06 (m, 5H), 2.60-2,63 (m, 2H), 2.24 (s, 1H), 1.39 (s, 21-1), 1.14-1.17 (m, 2H), 0.64-0.66 (m, 2H), 0.17 (s, 2H).

Reference： [1]Patent: WO2013/96771,2013,A1 .Location in patent: Page/Page column 181

27
[ 6284-40-8 ]
[ 259793-96-9 ]
[ 1370365-08-4 ]

Yield	Reaction Conditions	Operation in experiment
	In water;	Example 7 To a suspension of Compound A (132 g) in Water for Injection (1900 mL) was added meglumine (166 g), and the mixture was stirred to dissolve Compound A. To the obtained solution was added Water for Injection to give a total volume of 2200 mL. Thereafter, the mixture was filtered through a 0.22-mum membrane filter to obtain a liquid preparation (pH 8.0). Each vial was filled with the liquid preparation (10 mL), lyophilized and then closed airtight to obtain a lyophilized preparation of a crystal. Water content: 0.01 % In the powder X-ray diffraction pattern of the lyophilized preparation, the same peaks as those of the crystal of Salt A anhydrate observed in Example 3 were observed. Lyophilization method 1. Vials were cooled at the shelf temperature of -60C to freeze the content. 2. The temperature of the vials was increased to the shelf temperature of -10C and the vials were maintained at the same temperature for 24 hours. 3. The temperature of the vials was cooled to the shelf temperature of -55C or below and the vials were maintained at the same temperature for 2 hours. 4. The temperature of the vials was increased to the shelf temperature of 40C under vacuum (50 Pa or below) and the vials were maintained at the same pressure and the same temperature for 48 hours.

Reference： [1]Patent: EP2623497,2013,A1 .Location in patent: Paragraph 0040

28
1-(6-amino-3,5-difluoro-2-pyridyl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxy-1-azetidinyl)-4-oxo-3-quinolinecarboxylic acid ethyl ester [ No CAS ]
[ 6284-40-8 ]
[ 352458-37-8 ]

Reference： [1]Organic Process Research and Development,2006,vol. 10,p. 751 - 756

29
[ 6284-40-8 ]
[ 41340-25-4 ]
(S)-(+)-1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid D-(-)-meglumine salt [ No CAS ]
(R)-(-)-1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid D-(-)-meglumine salt [ No CAS ]

Reference： [1]Organic Process Research and Development,2000,vol. 4,p. 418 - 426

30
5-iodo-laquinimod [ No CAS ]
[ 6284-40-8 ]
N-ethyl-4-hydroxyl-1-methyl-5-(methyl (2,3,4,5,6-pentahydroxyhexyl)amino)-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
38%	With copper(l) iodide; In N,N-dimethyl-formamide; at 35 - 38℃; for 2h;Inert atmosphere;	Example IB: Formation of MEG-LAQ MEG-LAQ was obtained from the reaction below: 5-iodo-laquinimod, a new chemical entity, was prepared from 2- amino-6-iodobenzoic acid in a similar way that laquinimod was prepared from 2-amino-6-chlorobenzoic acid. (see, e.g., U.S. Patent No. 6,077,851 and ennerberg et al., Organic Process Research & Development (2007), 11 (4) : 674-680 , the entire content of each of which is hereby incorporated by reference) The preparation of 5-iodo-laquinimod is shown below: 5-iodo-laquinimod (2.0 g, 4.46 mmol, meglumine (3 eq, 2.6 g, 13.4 mmol ) and Cul (0.4 g, 1.9 mmol) were dissolved in dimethyl formami.de (DMF, 18 ml) at 35-38"C under inert atmosphere. The reaction mixture was stirred for 2 hours at 35-38C followed by DMF distillation at 2 mbar vacuum. The green oily residue was dissolved in 100 ml methanol and silica gel (15 g, 0.06-0,2 mm) was added. The suspension was evaporated to dryness. Pure product was obtained by flash column chromatography on silica gel (0.04- 0.06 mm). Mobile phase - 15% methanol in dichloromethane . Yield: 0.88g (38%).

Reference： [1]Patent: WO2013/169746,2013,A2 .Location in patent: Page/Page column 22-23

31
[ 1548842-90-5 ]
[ 6284-40-8 ]
[ 1548843-03-3 ]

Yield	Reaction Conditions	Operation in experiment
63%	With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 - 25℃; for 2h;Inert atmosphere;	Example 43. S3 S12 Preparation of compound S12: To a solution of acid S3 (10 mg, 0.024 mmol) in anhydrous DMF (0.25 mL) was added N-methyl-glucamine (9.5 mg, 0.048 mmol) followed by DIPEA (0.013 mL, 0.072 mmol). The reaction mixture was cooled to 0C and HATU (12 mg, 0.031 mmol) was added. Upon complete addition, the reaction as warmed up to 25C and stirred for 2 h under N2. The DMF was removed under reduced pressure and the mixture was purified by silica flash column chromatography (DCM:MeOH = 1000: 1 to 100: 1) to afford the title compound S12 (9 mg, 63%) as a yellow-brown solid. LC-HRMS, m/z 594.1439 [M+H]+; Calcd for C30H28NOioS+: 594.1389.

Reference： [1]Patent: WO2014/18919,2014,A1 .Location in patent: Paragraph 0385

32
gadolinium(III) oxide [ No CAS ]
[ 60239-18-1 ]
[ 6284-40-8 ]
gadoterate meglumine [ No CAS ]

Reference： [1]RSC Advances,2014,vol. 4,p. 9880 - 9884

33
[ 6284-40-8 ]
[ 248281-84-7 ]
[ 1609005-01-7 ]

Yield	Reaction Conditions	Operation in experiment
1.95 g	In methanol; acetone; at 18 - 37℃;	77 g of meglumine was added to 20 ml of absolute methanol while stirring. The solution was then heated. Complete solid dissolution was observed at 37 C. and then 1.39 g of <strong>[248281-84-7]laquinimod</strong> acid was added and dissolvedThe resulting solution was cooled to 18 C. and 40 ml of dry acetone was added while stirring. Turbidity developed and the mixture was held in a refrigerator at +5 C. overnightA tiny amount of precipitate was formed. The residue was evaporated under vacuum in a rotary evaporator (bath T=42 C.), the residue (3.52 g of colorless syrup) was stirred and 6.5 ml of dry acetone was added at ambient temperature. Precipitation was observed. Precipitate was colorless, sticky, honey-like, and not filterable. The mixture was evaporated under vacuum in a rotary evaporator (bath T=42 C.). The warm residue (3.77 g of colorless syrup) was introduced by drops into 25 ml of cold dry acetone at 7-8 C., on an ice-water bath. The mixture from the previous experiment was heated to 40 C. and evaporated under vacuum in a rotary evaporator (bath T=42-60 C.), the residue (2.10 g of semi-solid product) was dissolved in 25 ml of absolute ethanol and evaporated under the same conditions. The residue of the second evaporation (2.19 g of solid foam) was dissolved in 25 ml of absolute ethanol and evaporated under the same conditionsThe residue of the third evaporation (2.22 g) was dissolved in 3 ml of absolute ethanol, and the solution was added to cold 1,4-dioxane over a period of 45 minutesDuring the addition, the mixture was cooled on an ice-water bath and stirred vigorouslyNo product precipitation was observed. Only a part of the dioxane was crystallized. The mixture was evaporated under vacuum in a rotary evaporator at ambient temperature. After evaporation of half of the solvent, volume precipitation took place. Sticky, semi-solid and not filterable precipitate (soft gum) formed. Isolation of Salt by EvaporationEvaporation was continued while heating (bath T=60 C.). The residue, 2.16 g of solid white foam, was dried under high vacuum (2 mbar) at ambient temperature. The dry product, 1.95 g of white powder was sampled. Analysis and Tests: XRD identified amorphous structure. DSC identified amorphous structure and endotherm (endo) peaks at 48-80 C. and 147-162 C. Physical stability: Samples of powder were stored in sealed transparent glass vials at +5 C. for 6 months. Physical change was observed. The sample was lumped white powder, with signs of deliquescence] Sticky semi-solid precipitate was formed.

Reference： [1]Patent: US2014/128430,2014,A1 .Location in patent: Paragraph 0092; 0093-0099; 0100; 0101;0102; 0103-0107

34
[ 6284-40-8 ]
[ 66-25-1 ]
N-methyl hexyl glucamine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
23 g	With 5%-palladium/activated carbon; hydrogen; In methanol; at 20 - 75℃; under 15514.9 - 25858.1 Torr; for 20h;	Example 44 Synthesis of N-Methyl Hexyl Glucamine (NMHG) N-methylglucamine (25 g, 128.6 mmol, Aldrich), Hexanal (15.5 g, 155 mmol, Aldrich), 5% Pd on Carbon (1 gram, Aldrich) and 40 mL of methanol were added to a 160 mL Parr Reactor. The reactor was sealed, purged three times with 300 PSI N2 followed by three times with 300 PSI H2. The reactor was then charged with 500 PSI H2, at which point stiffing was begun at 400 RPM, and was allowed to remain at room temperature for 1 hr. The reactor was then externally heated to 50 C. for 18 hrs, then 75 C. for 1 hr, during which time pressure was maintained at 300-500 PSI H2. The reactor was cooled to ambient temperature, vented and purged three times with 300 PSI N2. The contents were filtered to remove the catalyst and the methanol removed to yield a white precipitant. Precipitant was filtered and washed with cold methanol to yield white powder, (23 g, 98% desired products using GC using derivatization described in Example 1).

Reference： [1]Patent: US2014/255330,2014,A1 .Location in patent: Paragraph 0267

35
[ 6284-40-8 ]
[ 81846-19-7 ]
treprostinil-N-methylglucamine salt [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In hexane; tert-butyl methyl ether; water; isopropyl alcohol; at 55 - 80℃;	A 500-mL, two-necked, round-bottom flask equipped with a magnetic stirrer, and a thermometer was charged with UT-iS (4.0 g), 2-propanol (108 mE), water (0.8 mE), and N-methylglucamine (2.00 g). The reaction mixture was stirred and heated to 70-80 C. to obtain a clear solution. At this temperature, MTI3E (120 mE) was added slowly keeping the temperature of solution higher than 55 C., followed by hexanes (40 mE). Afier complete addition of MTI3E and hexanes, the solution was allowed to cool to 45C. during 1-2 hours, then to 35 C. for one hour, and then to 25 C. for an additional 30 minutes. At ambient temperature, the product was isolated by filtration and washed with MTI3E/hexanes (1:1). The product was transferred from l3uchner funnel to a glass container for air-drying over night in thme hood. The product was dried thrther under vacuum at 50-55 C. for 4 hours. Table 14 provides results for N-methylglucamine salt.

Reference： [1]Patent: US2014/275616,2014,A1 .Location in patent: Paragraph 0088

36
(3-ethoxy-5-(5-((((R)-2-((R)-1-(N-hydroxyformamido)propyl)heptanamido)methyl)carbamoyl)furan-2-yl)phenyl)phosphonic acid [ No CAS ]
[ 6284-40-8 ]
(3-ethoxy-5-(5-((((R)-2-((R)-1-(N-hydroxyformamido)propyl)heptanamido)methyl)carbamoyl)furan-2-yl)phenyl)phosphonic acid (-)-1-deoxy-1-(methylamino)-D-glucitol salt [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
92%	In tetrahydrofuran; ethyl acetate; at 23℃; for 0.25h;	Step 1: (3-ethoxy-5-(5-((((R)-2-((R)-1-(N- hydroxyformamido)propyl)heptanam ido)methyl)carbamoyl)furan-2-yl)phenyl)phosphonic acid,(-)-1-Deoxy-1-(methylamino)-D-glucitol salt (3-ethoxy-5-(5-((((R)-2-((R)- 1 -(Nhydroxyformamido)propyl)heptanam ido)methyl)carbamoyl)furan-2-yl)phenyl)phosphonic acid (265 mg, 0.479 mmol) was slurried in ethyl acetate (2.65 ml) and tetrahydrofuran (27 ml). (2R,3R,4R,55)-6-(methylamino)hexane-1 ,2,3,4,5-pentaol (93 mg, 0.48 mmol) was added. The resulting slurry was stirred at 23 00 for 15 minutes and the slurry was seededwith seed crystals of title compound and then temperature cycled from 40 00 to 5 00 at 1 hour increments for 6 hours, followed by 18 hours at 23 00. The slurry was then temperature cycled from 40 00 to 5 00 at 1 hour increments for 6 hours, followed by 18 hours at 23 00 followed by temperature cycling from 45 00 to 5 00 at 1 hour increments for 6 hours, followed by 18 hours at 23 00 followed by temperature cycling from 45 00 to5 00 at 1 hour increments for 6 hours, followed by 18 hours at 23 00 followed bytemperature cycling from 45 00 to 5 00 at 1 hour increments for 6 hours. After the last 5 00 cycle, the slurry was filtered, rinsed with ethyl acetate, and the solid collected anddried under vacuum for 72 hours to the title compound (330 mg, 0.44 mmol, 92 % yield) as a white solid.

Reference： [1]Patent: WO2015/104684,2015,A1 .Location in patent: Page/Page column 276

37
4-[2,3-difluoro-4-[[10-hydroxy-6-methyl-8-oxo-9-[[4-(trifluoromethyl)-2-[6-(trifluoromethyl)pyrimidin-4-yl]phenyl]carbamoyl]-6,7-diazaspiro[4.5]dec-9-en-7-yl]methyl]phenoxy]butanoic acid [ No CAS ]
[ 6284-40-8 ]
7-[[2,3-difluoro-4-[4-[methyl-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]amino]-4-oxobutoxy]phenyl]methyl]-10-hydroxy-6-methyl-8-oxo-N-[4-(trifluoromethyl)-2-[6-(trifluoromethyl)pyrimidin-4-yl]phenyl]-6,7-diazaspiro[4.5]dec-9-ene-9-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
65%	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20℃; for 15h;	Example 418 7-[[2,3-Difluoro-4-[4-[methyl-[(2 S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]amino]-4-oxobutoxy]phenyl]methyl]-10-hydroxy-6-methyl-8-oxo-N-[4-(trifluoromethyl)-2-[6-(trifluoromethyl)pyrimidin-4-yl]phenyl]-6,7-diazaspiro[4.5]dec-9-ene-9-carboxamide 4-[2,3-Difluoro-4-[[10-hydroxy-6-methyl-8-oxo-9-[[4-(trifluoromethyl)-2-[6-(trifluoromethyl)pyrimidin-4-yl]phenyl]carbamoyl]-6,7-diazaspiro[4.5]dec-9-en-7-yl]methyl]phenoxy]butanoate (40 mg, 0.054 mmol) (Example 332) was dissolved in N,N-dimethyl formamide (1 mL), then (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol (31.5 mg, 0.161 mmol), HATU (40.9 mg, 0.108 mmol), and N-ethyl-N-isopropylpropan-2-amine (20.86 mg, 0.161 mmol) were added, and the mixture was stirred at room temperature for 15 hours. Water was added to the reaction mixture (0.2 mL), and the resultant was purified by C18 reverse-phase column chromatography to obtain the title compound (32 mg, 65%) as a white amorphous solid. LCMS: m/z 921[M+H]+ HPLC retention time: 1.01 minutes (analysis condition SQD-FA05)

Reference： [1]Patent: US2016/2251,2016,A1 .Location in patent: Paragraph 2210-2212

38
[ 1365888-06-7 ]
[ 6284-40-8 ]
(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxy-N-methylhexan-1-aminium (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
91%	In water; acetone; at 20 - 50℃; for 18.5h;Inert atmosphere; Cooling;	[00131] (E)-3-(4-((E)-2-(2-Chloro-4-fluorophenyl)-l-(lH-indazol-5-yl)but- l-en-l- yl)phenyl)acrylic acid (50.0 g, 111.9 mmol) and acetone (560 mL, HPLC grade) were charged to a 2 L 3-neck round bottom flask equipped with a mechanical stirrer, a reflux condenser, internal thermometer, and N2 inlet at room temperature. The resulting pale yellow solution was vigorously stirred and heated to 50C (internal temperature) in a water bath. N- Methylglucamine (also known as N-methyl-D-glucamine, NMG, meglumine or (2R,3R,4R,5S)- 6-(methylamino)hexane- l,2,3,4,5-pentol) (37.3 mL of a 3M aqueous solution, 111.9 mmol) was added dropwise via a syringe over 10 min to the reaction mixture at 50C resulting in the formation of a suspension with an oily residue noted the side of the flask. The suspension was vigorously stirred for 30 minutes at 50C prior to slowly cooling to room temperature with agitation over 2 hours. The suspension was stirred at room temperature for 16 h. The reaction mixture was filtered, collected solid washed with acetone (100 mL, HPLC grade) and dried under vacuum to afford the (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)- l-(lH-indazol-5-yl)but- l- en- l-yl)phenyl)acrylic acid, N-methyl glucamine salt as an off-white solid (65. lg, 91%)
87%	In methanol; water; at 57 - 63℃; for 0.166667h;	To a 250 mL reactor was added (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)- l-(lH- indazol-5-yl)but- l-en-l-yl)phenyl)acrylic acid I (20.0 g, 44.8 mmol) and methanol (95.6 g). This mixture was heated to 57-63 C and stirred until all solids were completely dissolved. The solution was polish filtered through an activated carbon filter and the filter was washed with methanol (2.0 g) at 57-63C. To this was added a solution of N-methyl-D-glucamine 13.1 g, 67.1 mmol) and water (34.4 g) at 60 C over 10 min. The solution was cooled to 50C, seeded and aged for an additional hour at 50 C. The suspension was then cooled to 20 C over 2 hrs and aged for an additional 18-24 hr at 20C. The suspension was further cooled to 0C over 1 hr and further aged for 18-24 hr at 0C. The solids were filtered off, washed with methanol (64 g) and dried in a vacuum oven at 120C for 24 hr to give (2S,3R,4R,5R)- 2,3,4,5, 6-pentahydroxy-N-methylhexan- l-aminium (E)-3-(4-((E)-2-(2-chloro-4- fluorophenyl)- l-(lH-indazol-5-yl)but-l-en- l-yl)phenyl)acrylate XVII as a white solid (25.0 g, 39.0 mmol, 87% yield). 1H NMR (300 MHz, DMSO-d6): delta 8.10 (d, IH), 7.69 (s, IH), 7.56 (d, IH), 7.36 (dd, 2H), 7.32 (dd, 2H), 7.23-7.09 (m, 3H), 6.92 (d, 2H), 6.32 (d, IH), 3.86-3.77 (m, IH), 3.66 (d, IH), 3.59 (dd, IH), 3.53-3.34 (m, 3H), 2.91-2.72 (m, 2H), 2.42 (s, 3H), 2.38 (q, 2H), 0.91 (t, 3H); LCMS: 447.1 [(M-C7H17N05)+H]+.

Reference： [1]Patent: WO2016/23847,2016,A1 .Location in patent: Paragraph 00131; 00132
[2]Patent: WO2017/60326,2017,A1 .Location in patent: Paragraph 45; 46

39
[ 6284-40-8 ]
C₇H₁₇NO₂₃S₆ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
Ca. 90%	With chlorosulfonic acid; In chloroform; at 0℃; for 7h;	A mixture of meglumine (1 g) and dry chloroform (20 ml) was poured in a two-necked, 100-ml, round-bottom flask equipped with ice bath in 0 C and mixed for awhile. Chlorosulfonic acid (0.6 ml) was added dropwise to the mixture during 60 min and stirred for 6 h. After that, the product was filtered, washed with ethanol (5 times), and separated meglumine sulfate was dried at 90 C for 4 h (Scheme 2). The yield of the obtained catalyst was about 90%. The concentration of Hon the meglumine sulfate was about 3.5 mmol/g from acid-base titration. Also elemental analysis (CHNS) demonstrated that meglumine was sulfated successfully (C: 24%, H: 5.3%, N: 4.3%, S: 17%).

Reference： [1]Synthetic Communications,2016,vol. 46,p. 1283 - 1291

40
[ 6284-40-8 ]
[ 135062-02-1 ]
C₂₇H₃₆N₂O₄*C₇H₁₇NO₅ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
95.2%	With 3-methyl-1-butyl acetate; In chloroform; at 65℃;	<strong>[135062-02-1]Repaglinide</strong> 45. 3g and meglumine 19. 6g, adding 634. 2ml Isoamyl acetate, 915.3 ml of chloroform, heated to 65 C, dissolved by stirring to get a clear solution. Slowly cooling for 6 hours, down to 10 C, 30 rpm stirring crystallization, standing for 5 hours after filtration, 35 C vacuum drying 5 hours to get repaglinide compounds 61. 8g,The yield was 95.2%.

Reference： [1]Patent: CN105254592,2016,A .Location in patent: Paragraph 0026; 0027

41
C₂₃H₂₀F₇N₄O₆P^(2-)*2C₄H₁₂N⁽¹⁺⁾ [ No CAS ]
[ 6284-40-8 ]
Fosaprepitant dimeglumine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
85%		Fosapinidine dibenzyl ester (3 g, 3.78 mmole, 1 equiv) was added at 20-30 & lt; 0 &Diethylamine (0.55 g, 7.56 mmole, 2 equiv) And methanol (60 mL) were added to a three-necked round bottom flask containing a stir bar. The mixture was stirred at 20-30 & lt; 0 & gt; C for about 10 minutes to form a homogeneous solution. 10% Pd / C (90 mg, 3 wt%) was added followed by a hydrogenation reaction (about 15 psi) at 20-30 & lt; 0 & gt; C for 1 h. The mixture was filtered through a bed of celite and the filter cake was washed with MeOH (12 mL). Si-Thiourea (0.9 g, 30 wt%) was added to the mixed filtrate and washings at 20 to 30 C, and the mixture was stirred at this temperature for about 15 hours. The mixture was filtered and the filter cake was washed with methanol (12 mL). N-Methyl-D-glucamine (1.62 g, 8.32 mmole, 2.2 equiv) was added to the mixed filtrate and washings at 20 to 30 C, and the mixture was stirred at this temperature for about 1 hour. The solution was concentrated to a volume of about 15 mL at a temperature of not more than 35C and 20 to 30 torr. This concentrated solution was added dropwise to isopropanol (60 mL) at 20-30 & lt; 0 & gt; C, and the resulting mixture was stirred at this temperature for about 1 hour. The mixture was filtered and the filter cake was washed with isopropanol (15 mL). Fosapentin (3.23 g) was obtained in 85% yield with a purity of greater than 99%, a white powder containing less than 0.3 ppm of palladium

Reference： [1]Patent: TW2016/20920,2016,A .Location in patent: Page/Page column 8

42
C₃₁H₃₀F₇N₄O₈P [ No CAS ]
[ 6284-40-8 ]
Fosaprepitant dimeglumine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
88%		Fosapentin dihydrofuran ester was added at 20-30 & lt; 0 & gt; C(5 g, 6.29 mmole, 1 equiv) and methanol (37.5 mL) were added to a three-neck round bottom flask containing a stir bar. The mixture was stirred at 20-30 & lt; 0 & gt; C for about 10 minutes to form a homogeneous solution. After addition of N-methyl-D-glucamine (2.70 g, 2.2 equiv) and 10% Pd / C (0.15 g, 3 wt%), the mixture was subjected to a hydrogenation reaction (about 15 psi) at 20-30 C for 16 hours. The mixture was filtered through a bed of celite and the filter cake was washed with MeOH (10 mL). The mixed filtrate and washings were concentrated to a volume of about 20 mL at a temperature of not more than 35 C and 20 to 30 torr. The concentrated solution was added dropwise to isopropanol (100 mL) at 20 to 30 C, and the resulting mixture was stirred at this temperature for about 1 hour. The mixture was filtered,And the filter cake was washed with isopropanol (10 mL). (5.56 g) was obtained in 88% yield with purity greater than 99% and was a white powder containing less than 30.6 ppm of palladium.

Reference： [1]Patent: TW2016/20920,2016,A .Location in patent: Page/Page column 9

43
C₂₃H₂₀F₇N₄O₆P^(2-)*2C₆H₁₆N⁽¹⁺⁾ [ No CAS ]
[ 6284-40-8 ]
Fosaprepitant dimeglumine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
91.6%		For 20-30 C will luck Sha Bitan two animal pen ester (2g, 2.52mmole, 1 equiv), triethylamine (0.51g, 5 . 04mmole, 2 equiv) and methanol (40 ml) containing the sample to a three-necked round-bottom flask. In 20-30 C stirring this mixture under about 10 minutes to form a homogeneous solution. Adding 10% Pd/C (60 mg, 3 wt %), then this mixture in 20-30 C to carry out hydrogenation reaction under (about 15psi) 1 hour. Silicon, through a filter bed filtering the mixture, and to MeOH (8 ml) to wash the filter cake. In 20-30 C has been mixed in is added to the filtrate and wash liquid Si-Thiol (0.2g, 10 wt %), then the mixture is stirred at this temperature for about 15 hours. Filtering the mixture, and in MeOH (4 ml) to wash the filter cake. In 20-30 C has been mixed in is added to the filtrate and wash liquid N-methyl-D- grape amine (1.08g, 5 . 54mmole, 2.2 equiv), then the mixture is stirred at this temperature for about 1 hour. In the solution does not exceed 35 C, 20-30torr volume under the concentrated to about 10 ml. In 20-30 C instillment to of this concentrated solution of isopropanol (40 ml), then the generated mixture stirring at this temperature for about 1 hour. Filtering the mixture, and in isopropanol (10 ml) to wash the filter cake. Obtain fosaprepitant diformic cyclophosphadenosine (2.25g), the yield is 90%, the purity is greater than 99%, to contains less than 0.3 PPM palladium white powder.In addition to using Si-Thiol outside (0.6g, 30 wt %), a new round of duplication of the embodiment of the embodiment 1 to the stated condition. Obtain fosaprepitant diformic cyclophosphadenosine (2.29g), its yield of 91.6%, the purity is greater than 99%, to contains less than 0.3 PPM palladium white powder.

Reference： [1]Patent: TW2016/20920,2016,A .Location in patent: Page/Page column 7

44
(3-ethoxy-5-(5-((((R)-2-((R)-1-(N-hydroxyformamido)propyl)heptanamido)methyl)carbamoyl)furan-2-yl)phenyl)phosphonic acid [ No CAS ]
[ 6284-40-8 ]
(3-ethoxy-5-(5-((((R)-2-((R)-1-(N-hydroxyformamido)propyl)heptanamido)methyl)carbamoyl)furan-2-yl)phenyl)phosphonic acid (-)-1-deoxy-1-(methylamino)-D-glucitol salt [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
92%	In tetrahydrofuran; ethyl acetate; at 5 - 45℃;	(3-ethoxy-5-(5-((((R)-2-((R)-1-(N-hydroxyformamido)propyl)heptanamido)methyl)carbamoyl)furan-2-yl)phenyl)phosphonic acid (265 mg, 0.479 mmol) was slurried in ethyl acetate (2.65 ml) and tetrahydrofuran (27 ml). (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentaol (93 mg, 0.48 mmol) was added. The resulting slurry was stirred at 23 C. for 15 minutes and the slurry was seeded with seed crystals of title compound and then temperature cycled from 40 C. to 5 C. at 1 hour increments for 6 hours, followed by 18 hours at 23 C. The slurry was then temperature cycled from 40 C. to 5 C. at 1 hour increments for 6 hours, followed by 18 hours at 23 C., followed by temperature cycling from 45 C. to 5 C. at 1 hour increments for 6 hours, followed by 18 hours at 23 C., followed by temperature cycling from 45 C. to 5 C. at 1 hour increments for 6 hours, followed by 18 hours at 23 C., followed by temperature cycling from 45 C. to 5 C. at 1 hour increments for 6 hours. After the last 5 C. cycle, the slurry was filtered, rinsed with ethyl acetate, and the solid collected and dried under vacuum for 72 hours to the title compound (330 mg, 0.44 mmol, 92% yield) as a white solid.

Reference： [1]Patent: US2016/340328,2016,A1 .Location in patent: Paragraph 0847; 0848

45
(S)-2-((5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenamido)-4-methylpentanoic acid [ No CAS ]
[ 6284-40-8 ]
C₇H₁₇NO₅*C₂₆H₄₁NO₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
100%	In methanol; at 20℃; for 2h;	A solution of meglumine (94 mg), and compound 3 (200 mg) in methanol (20 mL) was stirred at RT for 2 hrs and evaporated in vacuo and the obtained residue was co-evaporated with ether and hexanes to afford quasi solid in quantitative yield.

Reference： [1]Patent: US2016/318850,2016,A1 .Location in patent: Paragraph 0188; 0189

46
[ 6284-40-8 ]
[ 93360-08-8 ]
fosphenytoin N-methyl-D-glucamine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
81.5%		In a 50L dry clean high pressure reactor,Add methanol 21L,2, 4-imidazolidinone-5,5-diphenyl-3 - [(phosphoryloxy) _methyl] -dibenzyl esterAnd 1200 g of N-methyl-D-glucamine were dissolved in 10 L of water,Temperature at 30 C,Maintain 20min,A 6 L solution of 5% Pt / C in 15 g of methanol was added,Replace the air with the team three times,H2 was replaced with H2 three times,H 2,The pressure maintained at 3 ~ 3.5kg / cm2, the temperature maintained at 35 C,Stirring 5h,TLC identification of end points,After completion of the reaction,Filtered with diatomaceous earth,The Celite was washed with 10 L of methanol,The filtrate was concentrated under reduced pressure at 40 C,The residue was dissolved in methanol (6 L)To the solution was added 30 L of isopropyl alcohol,The mixture was aged for 30 min at room temperature.Precipitation of solid,filter,Washed with 5 L of isopropyl alcohol and 5 L of petroleum ether,Vacuum drying at 50 C under vacuum 6h,P-phenytoin N-methyl-D-glucosamine 1685g,The yield was 81.5%Melting point: 175 C ~ 182 C, melting at the same time decomposition.

Reference： [1]Patent: CN103288877,2016,B .Location in patent: Paragraph 0029; 0041; 0042

47
O-[1-(propofol-O-yl)]cyclobut-1-yl-monoester phosphoric acid [ No CAS ]
[ 6284-40-8 ]
O-[1-(propofol-O-yl)]cyclobut-1-yl-monoester dimeglumine phosphate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
100%	In water; at 20℃; for 1h;	A solution of 0- [1 - (propenoyl-0-yl)] cyclobut-1-yl monoester phosphoric acid (4.7 g, 14.3 mmol) Was dissolved in water (30 mL) Addition of meglumine (5. 58 g, 28.6 mmol) at room temperature. Stirring at room temperature for 1 hour, vacuum distillation of water, drying, To give 7.5 g of a light yellow solid, yield 100.0% HPLC purity: 97.8% (254 nm).

Reference： [1]Patent: CN103588810,2016,B .Location in patent: Paragraph 0048-0050

48
4-[4-[[5(3,4-dimethoxy-N-methylanilino)-1-(4-fluoro-3-methoxyphenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorophenyl]benzoic acid [ No CAS ]
[ 6284-40-8 ]
4-[4-[[5-(3,4-dimethoxy-N-methylanilino)-1-(4-fluoro-3-methoxyphenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorophenyl]-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]benzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
40%	With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 20℃;	In a 5 mL flask were added 4-[4-[[5-(3,4-dimethoxy-N-methyl-anilino)-1-(4-fluoro-3-methoxy-phenyl)imidazol-2-yl] sulfanylmethyl] -3 ,5-difluoro-phenyl]benzoic acid (194 mg, 0.31 mmol), NEt3 (41.18 tL, 0.31 mmol), DCC (62.97 mg, 0.31 mmol), HOBt (41.24 mg, 0.31 mmol), and (2R,3R,4R,55)-6- (methylamino)hexane-1,2,3,4,5-pentol (59.58 mg, 0.31 mmol) in 1 mL of dichioromethane (QS 0.3 M). The reaction mixture was stuffed overnight at roomtemperature. The reaction mixture was evaporated to dryness and purified by preparative HPLC to give 100 mg of the desired product as a yellowish oil, leading to a 40% yield.MS: [M+H] mlz = 813.?H NMR (MeOD): oe (ppm) 2.92 (s, 3H) ; 3.12 (s, 1.7H) ; 3.17 (s, 1.3H) ; 3.37 (s,3H) ; 3.48-3.83 (m, 7H) ; 3.70 (s, 3H) ; 3.75 (s, 3H) ; 3.97-4.09 (m, 0.5H) ; 4.04(s, 2H) ; 4.16-4.20 (m, 0.5H) ; 6.18 (dd, J= 8.7, 2.8 Hz, 1H) ; 6.34 (d, J= 2.8 Hz,1H) ; 6.46 (dd, J= 7.2, 2.6 Hz, 1H) ; 6.48-6.54 (m, 1H) ; 6.80 (d, J= 8.7 Hz, 1H);6.97 (dd, J= 10.9, 8.7 Hz, 1H) ; 7.05 (s, 1H) ; 7.26 (dd, J= 8.5, 3.1 Hz, 2H) ; 7.58(t, J= 8.1 Hz, 2H) ; 7.71 (t, J= 8.1 Hz, 2H).?3C NMR (MeOD): oe (ppm) 26.8 ; 32.5 ; 38.6 ; 39.2 ; 51.0 ; 55.3 ; 55.9 ; 63.3;70.1 ; 71.2 ; 71.6 ; 72.2; 101.1 ; 106.8 ; 109.4 (d, J= 25.3 Hz) ; 113.3 ; 113.4113.4 (t, J= 7.4Hz); 115.2 (d, J= 19.9Hz); 120.3 (d, J= 7.8 Hz); 123.7; 126.4126.6 ; 127.5 ; 128.0 ; 130.9 (d, J = 3.6 Hz) ; 136.5 (d, J = 16.8 Hz) ; 137.3140.3 ; 143.1 ; 143.6 ; 147.4 (d, J= 11.4 Hz) ; 149.9 ; 152.1 (d, J= 248.5 Hz),161.3 (dd, J= 248.5, 8.6Hz); 172.3.

Reference： [1]Patent: WO2017/42380,2017,A1 .Location in patent: Page/Page column 66; 67

49
[ 6284-40-8 ]
[ 170729-80-3 ]
Fosaprepitant dimeglumine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
98%		Step The formula V compound 5 - [[2 (R) - [1 (R) - [3,5- bis (trifluoromethyl) phenyl] ethoxy] -3 (S) - (4- fluorophenyl ) -4-morpholinyl] methyl] -1,2-dihydro--3H-1,2,4- triazol-3-(5.3g, 10mmol), pyrophosphoric acid tetrabenzyl ester (7.0g, 13mmol ) was dissolved in THF (60ml), ice-water bath, a solution of NaHMDS 2.0M (12ml, 24mmol), controlling the reaction temperature at about -3 . Dropwise to a stirred for 2h the reaction was complete, methyl tert-butyl ether was added (150ml) and saturated sodium bicarbonate solution (150ml), separated, saturated sodium bicarbonate solution (150ml), sodium bisulfite solution (150ml), water ( 150ml) washed, and concentrated to dryness, dried to obtain 5.9 g of a white solid, a yield of 86.7%. Step B The resulting product from the previous step (5.9g, 8.4mmol), N- methyl-glucamine -D- (2.2g, 11.3mmol) was dissolved in methanol (25ml) / water (1ml), was added 10% Pd / C (0.1 g), to atmospheric hydrogenation 4h the reaction was complete. Filtered and washed with methanol, concentrated to dryness, methanol (15ml), tributylphosphine (0.03 ml of), stirred overnight, isopropanol precipitated solid was filtered and washed with methanol (1ml). Added dropwise to ethanol (30ml) / acetonitrile (30ml), stirred IH, filtered and washed with acetonitrile, and dried in vacuo to give a white solid 7.5g. The solid was dissolved in methanol (50ml), added dropwise to acetone (150ml), stirred for 2h, filtered, washed with acetone and dried in vacuo to give a white solid 5.7g, yield 98%, proven a compound of formula I, the purity of the product 99.9%.

Reference： [1]Patent: CN103030668,2016,B .Location in patent: Paragraph 0048-0053

50
[(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl]phenyl}-2-oxooxazolidin-5-yl]methyl dihydrogen phosphate [ No CAS ]
[ 6284-40-8 ]
tedizolid phosphate dimeglumine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
99.5%	In water; at 20℃;	10.0 g (0.0226 mol) of N-methyl-D-glucamine was added dropwise to the above solution, and after the addition was completed, the mixture was stirred at room temperature for 1 to 2 hours , The reaction solution was filtered, the mother liquor was collected, and the mother liquor was freeze-dried to obtain 18.57 g (yield: 99.5%) as a white solid, which was dimethazolyl phosphate.

Reference： [1]Patent: CN106146558,2016,A .Location in patent: Paragraph 0041; 0042; 0043; 0044;

51
[(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl]phenyl}-2-oxooxazolidin-5-yl]methyl dihydrogen phosphate [ No CAS ]
[ 6284-40-8 ]
tedizolid phosphate monomeglumine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
98.9%	In water; at 20℃;	(0.0222 mol) of N-methyl-D-glucamine was added dropwise to the above solution, and after the addition was completed, the mixture was stirred at room temperature for 1 to 2 hours, and 10 g (0.0222 mol) of terazosin phosphate was added to 100 ml of water ,The reaction solution was filtered, and the mother liquor was collected and the mother liquor was lyophilized to give 14.2 g of a white solid (yield: 98.9%), which was azithromycin monomethylglucide.

Reference： [1]Patent: CN106146558,2016,A .Location in patent: Paragraph 0045

52
[(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl]phenyl}-2-oxooxazolidin-5-yl]methyl dihydrogen phosphate [ No CAS ]
[ 6284-40-8 ]
C₁₇H₁₆FN₆O₆P*0.5C₇H₁₇NO₅ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
97.8%	In water; at 20℃;	(0.0221 mol) of N-methyl-D-glucamine was added dropwise to the above solution, and after the addition was carried out, the mixture was stirred at room temperature for 1 to 2 hours, and 10 g (0.0222 mol) of terazosin phosphate was added to 100 ml of water , The reaction solution was filtered, the mother liquor was collected, and the mother liquor was lyophilized to give 11.9 g (yield: 97.8%) as a white solid, which was Compound I ''.

Reference： [1]Patent: CN106146558,2016,A .Location in patent: Paragraph 0046

53
dibenzyl (R)-[3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-2-oxo-5-oxazolidinyl]methyl phosphoric acid [ No CAS ]
[ 6284-40-8 ]
tedizolid phosphate dimeglumine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
94%	With 5%-palladium/activated carbon; hydrogen; In methanol; water; at 20℃;	The compound of formula 2 (315.3 g, 0.5 mol) was addedN-methyl-D-glucamine (195.21, 1.0 mol)And dissolved in methanol (2.0 L) and water (120 ml).5% Pd / C (16.0 g) was slurried in 360 ml of methanol,The catalyst was then concentrated again at room temperature and 40 pasi,Was added to the above compound of formula 2 and N-methyl-D-glucosamine slurry, and the system was hydrogenated overnight. After completion of the reaction, the hydrogenated slurry was filtered and washed with methanol (2 * 2 L). The filtrate was concentrated in vacuo and the room temperature was kept at a temperature of not higher than 18 C until the final concentration was 200 g / L.To a solution of the compound of formula I (294 g) in methanol was added tri-n-butylphosphine (TBP) (1.8 ml) and stirred overnight at 20 C (TBP was added to remove excess Pd). The solution was then slowly added to a mixture of 8.5 L of acetonitrile and 8.5 L of ethanol at 20 C for about 1 hour. The acetonitrile (17 L) was then added slowly to the mixture and added over about 120 minutes. The slurry was allowed to settle for about 30 minutes and the 70% supernatant was decanted and transferred to a filter. The remaining slurry was resuspended and filtered under pressure. The filter cake was washed with acetonitrile (3.5 L), the product was collected, dried in vacuo, About 94%, purity of more than 99.3%.

Reference： [1]Patent: CN106146559,2016,A .Location in patent: Paragraph 0056; 0057

54
(R)-3-methyl-6-(2-((5-methyl-2-(6-(trifluoromethyl)pyridin-3-yl)-1H-imidazol-1-yl)methyl)phenoxy)hexanoic acid [ No CAS ]
[ 6284-40-8 ]
C₂₄H₂₆F₃N₃O₃*C₇H₁₇NO₅ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
98.95%	In tetrahydrofuran; water; at 20℃; for 16h;	In a 500 mL round bottom flask, a stirred solution of Compound A (20 g, 43.33 mmol) in THF (100 mL) and water (100 mL) was treated meglumine (8.45 g, 43.33 mmol) at 0 C. The resulting reaction mixture was stirred at RT for 6 h. The reaction mixture was concentrated under reduced pressure and solid obtained was dried under reduced pressure (3h) to afford the title compound as a white solid (28.5 g, 98.95%). (0097) 1H NMR (400 MHz, CD3OD): delta 8.75 (s, 1H), 8.02 (d, = 8.4 Hz, 1H), 7.82 (d, = 8.0 Hz 1H), 7.26 (t, = 8.4 Hz, 1H), 7.03 (s, 1H), 6.99 (d, = 8 Hz, 1H), 6.85 (t, = 7.6 Hz, 1H), 6.50 (d, = 7.6 Hz, 1H), 5.25 (s, 2H), 4.09-3.99 (m, 3H), 3.97-3.77 (m, 2H), 3.74-3.61 (m, 3H), 3.29-3.06 (m, 2H), 2.64 (s, 3H), 2.22 (s, 3H), 2.18-2.14 (m, 1H), 1.99 - 1.94 (m, 2H), 1.83 - 1.75 (m, 2H), 1.51 - 1.38 (m, 1H), 1.32-1.22 (m, 1H), 0.86 (d, = 6.0 Hz, 3H). (0098) 19F NMR (400 MHz, CD3OD): delta -69.39 (0099) Elemental Analysis: Calcd for C3iH43F3N408. H20: C, 55.18; H, 6.72; N, 8.30. Found: C, 54.95; H, 6.89; N, 8.07 Moisture Content (Karl Fischer): 2.33%
	In isopropyl alcohol; at 25 - 50℃; for 1.33333h;Sealed tube;	Compound 2n (102.7 mg) was combined with meglumine (43.7 mg) and 2 mL of 2- propanol in a 4 mL glass vial. The vial was sealed with a cap and the contents were subjected to sonication at 25 C for 20 minutes followed by stirring at 50 C for 60 minutes. The vial was then moved to a new stir plate and the slurry in the vial was stirred at 25 C.
	In isopropyl alcohol; at 25 - 50℃; for 1.33333h;Sealed tube; Sonication;	Compound B (102.7 mg) was combined with meglumine (43.7 mg) and 2 mL of 2- propanol in a 4 mL glass vial. The vial was sealed with a cap and the contents were subjected to sonication at 25 C for 20 minutes followed by stirring at 50 C for 60 minutes. The vial was then moved to a new stir plate and the slurry in the vial was stirred at 25 C.

Reference： [1]Patent: WO2018/67857,2018,A1 .Location in patent: Page/Page column 12-13
[2]Patent: WO2017/62468,2017,A1 .Location in patent: Page/Page column 84-85
[3]Patent: WO2018/67860,2018,A1 .Location in patent: Page/Page column 31; 32

55
C₄₉H₄₂F₇N₄O₆P [ No CAS ]
[ 6284-40-8 ]
Fosaprepitant dimeglumine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
97%	With 10% palladium hydroxide on charcoal; hydrogen; In methanol; water; at 25℃; under 1034.32 Torr; for 1h;	A mixture of 21.0 g of compound IV (22.2 mmol ) Was dissolved in 150 mL of methanol,8.7 g of N-methyl-D-glucosamine (44.4 mmol) and 3.0 g of 10% Pd (OH) 2 / C (water content 66%) were added and catalytically hydrogenated at 25 C, 20 psi hydrogen for 1 h,The reaction was complete by filtration, and the filter cake was rinsed with 10 mL of methanol. The filtrate was added dropwise to a stirred mixture of 1.1 L of acetone, filtered under nitrogen and the filter cake was washed with 100 mL of acetone and dried in vacuo at room temperature to give 21.6 g of the title compound as a white solid in 97% yield.

Reference： [1]Patent: CN104098604,2016,B .Location in patent: Paragraph 0049; 0050; 0051; 0052; 0053; 0060-0064; 0071-0075

56
[ 108-30-5 ]
[ 6284-40-8 ]
[ 64-72-2 ]
chlortetracycline succinic acid monoester meglumine salt [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
89.9%		Chlortetracycline hydrochloride (1.0 muM) dissolved in 90% of the 1, 4 - dioxane solution, adding sodium carbonate (1.0 muM) solid stirring, 50 C conditions into homogeneous mixing solution; addition of succinic anhydride (2.0 muM) and DCC/DMAP/pyridine mixture (all 0.1 muM), reflux stirring 5 hours, acidified to pH=6 with hydrochloric acid, cooling and getting the Chlortetracycline succinic acid monoester solid.The prepared Chlortetracycline succinic acid monoester (1 muM), dissolved in acetonitrile/acetone (b nitrile/acetone of volume ratio of 1.0: 0.5) in the mixed solvent, reflux, batch add Meglumine (2.0 muM), mixing, cooling, that is to generate the target product Chlortetracycline succinic acid monoester Meglumine salt. The product is a pale yellow powder, yield of 89.9%. By HPLC determination, product purity of 99.7%; by the FAB - MS determination, the molecular weight of products is 775.20, with target products is the molecular weight of the theoretical calculated 775.18 consistent.

Reference： [1]Patent: CN105001112,2017,B .Location in patent: Paragraph 0029; 0032; 0035; 0038; 0041; 0047; 0049-0051

57
[ 6284-40-8 ]
[ 106-89-8 ]
C₁₀H₂₂ClNO₆ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
100%	In methanol; at 20℃; for 72h;	Epichlorohydrin 2 (2.96 g; 32 mmol) was added to a suspension of /V-methyl-D- glucamine 1 (2.5 g; 12.8 mmol) in methanol (150 mL). The mixture was stirred at room temperature for 72h then evaporated under vacuum to give the alkylating molecule 3 (3.7 g) as colourless oil. Quantitative yield.1H-NMR, 13C-NMR and mass spectrum were consistent with the expected structure.

Reference： [1]Patent: WO2017/98038,2017,A1 .Location in patent: Page/Page column 55

58
[ 6284-40-8 ]
fosaprepitant [ No CAS ]
C₂₃H₂₂F₇N₄O₆P*C₇H₁₇NO₅ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
98%	With palladium 10% on activated carbon; hydrogen; In methanol; water; for 4h;	The product of the preceding step (5.9 g, 8.4 mmol)N-methyl-D-glucamine (2.2 g, 11.3 mmol) was dissolved in methanol (25 ml) / water (1 ml)Plus 10% Pd / C (0.1g), hydrogenation at atmospheric pressure for 4h to complete the reaction.Filtered and washed with methanol, concentrated to dryness, methanol (15 ml) and tributylphosphine (0.03 ml). The mixture was stirred overnight and isopropanol was added to precipitate a solid which was filtered and washed with methanol (1 ml).This was added dropwise to ethanol (30 ml) / acetonitrile (30 ml), stirred for 1 h, filtered and washed with acetonitrile and dried in vacuo to give 7.5 g of a white solid. The solid was dissolved in methanol (50 ml) and added dropwise to acetone (150 ml), stirred for 2 h, filtered, washed with acetone and dried in vacuo to give 5.7 g of a white solid in 98% yield.

Reference： [1]Patent: CN102977142,2017,B .Location in patent: Paragraph 0033-0035

59
2-(5-nitrothiazol-2-yl-carbamoyl)phenyl dihydrogen phosphate [ No CAS ]
[ 6284-40-8 ]
2-(5-nitrothiazol-2-ylcarbamoyl)phenyl dihydrogen phosphate methylglucamine salt [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
100%	In methanol; at 20℃; for 0.333333h;	Example 16 Preparation of 2-(5-nitrothiazol-2-yl-carbamoyl)phenyl hydrogen phosphate meglumine salt (Compound 16) Compound 2 (354.23mg, 1mmol) prepared in Example 2 was suspended in methanol 20mL, and a solution of meglumine (195.22mg, 1mmol) in methanol 10ml, stirred at room temperature for 20 min, the resultant mixture was concentrated, and dried at 50C in vacuum to obtain the title compound 550mg, as amorphous solid, with a yield of 100%.

Reference： [1]Patent: EP3239160,2017,A1 .Location in patent: Paragraph 0074-0075

60
[ 25601-41-6 ]
[ 6284-40-8 ]
N-methyl-N-dec-9-enoylglucamine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In propylene glycol;	[0128] The solution comprising 50% active N-methyl-Ndec-9-enoylglucamine substance was prepared as follows:first of all, 9-decenoic acid (Aldrich) was reacted with an excess of methanol to give methyl 9-decenoate. The methyl 9-decenoate was distilled and then reacted with N-methylglucamine in the presence of 1,2-propylene glycol as solvent according to EP 0 550 637 and obtained as a solid consisting of 90% active substance and 10% 1,2-propylene glycol. This solid was dissolved at 40 to 500 C. in water, so as to give a solution with a 50% content of N-methyl-N-dec-9-enoylg- lucamine. This is a clear colorless solution.
528 g		In a 500 mL glass flask (equipped with stirrer, dropping funnel, water separator, nitrogen line and vacuum line) 649.0 g of a ca. 42 % aqueous solution ofN-methyl-glucamine (1.40 mol) are placed. While stirring, this solution is heated up to 135 C to evaporate water. Then 30 mbar vacuum is applied for 1 h at 135 C and then vacuum is broken with nitrogen. Afterwards 53.8 g of propylene glycol are added. 252.8 g (1.42 mol) of tempered decenoic acid methylester (120 C) is added slowly to the hot melt of N-Methyl-Glucamine to avoid foaming. Then 5.59 g sodium methoxide are added. Meanwhile the temperature of the reaction mixture reached 110C and methanol is distilling off. After half an hour, vacuum is applied step by step to gain 30 mbar finally. Temperature is hold at 90 - 100C and also vacuum is hold at 30 mbar for 90 min. Then vacuum is broken with nitrogen. The hot mixture is filled in a suitable glass bottle. You get 528 g of a slightly yellowish and highly viscous paste. The resultant product contains 76 % of the desired N-decenoyl-N-methyl-glucamine measured by GC after derivatisation.

Reference： [1]Patent: US2017/339949,2017,A1 .Location in patent: Paragraph 0128
[2]Patent: WO2019/115478,2019,A1 .Location in patent: Page/Page column 76

61
[ 6284-40-8 ]
[ 82571-53-7 ]
ozagrel meglumine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
92.77%	In ethanol; at 10℃;Reflux;	At 10-15 C, 60.00g (0.263 mol) meglumine was added to 95% ethanol. Stirring and heating at reflux. Add 57.17g (0.250 mol) <strong>[82571-53-7]ozagrel</strong> solid. Reaction liquid becomes clear. Maintain temperature of reaction. At reaction end, naturally cool to 10-15 C, continuing to stir crystallization, filtered, the filter cake is washed with ethanol, filter cake 40 C blast drying to obtain white powder. The room temperature will be <strong>[82571-53-7]ozagrel</strong> Meglumine salt crude product added to the 400 ml 50% in ethanol, heating to reflux to complete dissolution, then naturally to room temperature to continue stirring crystallization 5h, filtered, the filter cake is anhydrous ethanol washing, the filter cake 40 C blast drying to obtain the white crystalline powder, the output 98.40g, yield 92.77%, content 100.2%.

Reference： [1]Patent: CN104610153,2017,B .Location in patent: Paragraph 0078-0095

62
[ 760-93-0 ]
[ 6284-40-8 ]
N-methacryloyl-N-methyl-1-amino-1-deoxy-D-glucitol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
99%	In methanol; at 15 - 25℃; for 2h;	After putting in 9.8 g of N-methyl-D-glucamines in a three mouth flask with a capacity of 100 ml which attached the agitating blade, the thermometer, and the dropping funnel, 20g of methyl alcohol was put in and suspension dispersion liquid were obtained. It was dropped into these suspension dispersion liquid, having methacrylic poured [ 9.2g ] it for 1 minute, adjusting the solution temperature in a flask to 15-25 degrees C by water bath. Then, while adjusting solution temperature to 15-25 degrees C, it stirred. The reaction mixture which the suspended solid dissolved completely was obtained from the end of dropping after the lapse for 5 minutes. Reaction mixture becomes cloudy after a lapse for 20 minutes from the end of dropping, and a white thing began to deposit after that. After stirring for further 2 hours, reaction mixture was filtered and the sludge was washed by a small amount of methyl ethyl ketone. The mass of the dry sludge after vacuum drying a sludge at 40 degrees C was 9.4g (71% of acquisition yield). [0050] This dry sludge was dissolved in heavy water, and as a result of conducting NMR analysis, it was checked that it is a high-purity compound (2). The NMR spectrum of a dry sludge is shown in Fig.1. Filtrate was dissolved in heavy water, and as a result of conducting NMR analysis, all N-methyl-D-glucamines were changing to the compound (2). The reaction yield for which it asked from the analysis result of a dry sludge and filtrate was 99%.

Reference： [1]Patent: JP2017/226628,2017,A .Location in patent: Paragraph 0044; 0045; 0048; 0051; 0052; 0054; 0056

63
2-(4-(4-((bis(pyridin-2-ylmethyl)amino)methyl)-1H-1,2,3-triazol-1-yl)phenyl)acetic acid [ No CAS ]
[ 6284-40-8 ]
2-(4-(4-((bis(pyridin-2-ylmethyl)amino)methyl)-1H-1,2,3-triazol-1-yl)phenyl)-N-methyl-N-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)acetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
74%	With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 - 50℃; for 16h;	2-(4-(4-((bis(pyridin-2-ylmethyl)amino)methyl)-lH- 1,2,3 -triazol- l-yl)phenyl) acetic acid from example 96d (302 mg, 0.73 mmol, 1.0 eq.) was dissolved in 3 mL dry DMF at room temperature. N-Methyl-£>-Glucamine (213 mg, 1.059 mmol, 1.5 eq.), EDC1 (209.9 mg, 1.095 mmol, 1.5 eq.), HO At (149 mg, 1.095 mmol, 1.5 eq.) and NMM (120 mu, 1.095 mmol, 1.5 eq.) were then added. The mixture was heated to 50 C for 16 h with stirring and then concentrated under reduced pressure. Purification of the product was achieved by way of dry column vacuum chromatography on CI 8 material, using a stepwise elution from 10% to 90% methanol in water affording 321.1 mg (0.542 mmol, 74%) of product as a pale yellow foam. The product appears as a syn/anti mixture regarding the amide bond. 1H NMR (400 MHz, MeOD) delta 8.50 - 8.39 (m, 3H), 7.78 (dd, J= 13.8, 7.2 Hz, 4H), 7.69 (d, J= 7.8 Hz, 2H), 7.47 (d, J= 8.0 Hz, 2H), 7.32 - 7.20 (m, 2H), 4.08 - 3.96 (m, 2H), 3.93 (s, 2H), 3.87 (s, 5H), 3.83 - 3.57 (m, 6H), 3.46 (dd, J= 13.3, 6.5 Hz, 1H), 3.19, 3.02 (2xs, 3H). 13C NMR (101 MHz, MeOD) delta 174.01, 173.91, 160.20, 149.49, 146.06, 138.69, 138.29, 137.62, 137.13, 137.04, 131.81, 131.70, 124.99, 123.82, 123.51, 121.66, 121.54, 74.11, 73.69, 73.11, 73.04, 72.76, 72.22, 71.61, 71.24, 64.77, 64.75, 60.63, 54.09, 52.73, 40.92, 40.49, 38.25, 34.79. APCI- HRMS e/z calc. for C30H37N7O6: 591.2805, found: 592.2878 [M+H].

Reference： [1]Patent: WO2018/33719,2018,A1 .Location in patent: Page/Page column 123-124

64
2-(4-(6-((bis(pyridin-2-ylmethyl)amino)methyl)nicotinamido)phenyl)acetic acid [ No CAS ]
[ 6284-40-8 ]
6-((bis(pyridin-2-ylmethyl)amino)methyl)-N-(4-(2-(methyl((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)amino)-2-oxoethyl)phenyl)nicotinamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
54%	With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 - 50℃; for 16h;	The 2-(4-(6-((bis(pyridin-2-ylmethyl)amino)methyl)nicotinamido)phenyl)acetic acid from example 99b (276 mg, 0.59 mmol, 1.0 eq.) was dissolved in 2.5 mL dry DMF at room temperature. N-Methyl-D-Glucamine (173 mg, 0.885 mmol, 1.5 eq.), EDC1 (169 mg, 0.885 mmol, 1.5 eq.), HOAt (120 mg, 0.885 mmol, 1.5 eq.) and NMM (98 iL, 0.885 mmol, 1.5 eq.) were then added. The mixture was heated to 50C for 16 h with stirring and then concentrated under reduced pressure. Purification of the product was achieved by way of dry column vacuum chromatography on CI 8 material, using a stepwise elution from 10% to 90% methanol in water affording 207.4 mg (0.322 mmol, 54%) of product as a white foam. The product appears as a syn/anti mixture regarding the amide bond. NMR (400 MHz, MeOD) delta 9.00 - 8.93 (m, 1H), 8.44 (dd, J= 4.9, 0.7 Hz, 2H), 8.25 (dd, J= 8.2, 1.7 Hz, 1H), 7.79 (td, J= 7.7, 1.8 Hz, 3H), 7.65 (dd, J= 16.4, 7.7 Hz, 4H), 7.27 (dd, J= 9.5, 4.5 Hz, 4H), 4.06 - 3.97 (m, 1H), 3.93 (s, 2H), 3.89 (s, 4H), 3.82 - 3.58 (m, 7H), 3.43 (ddd, J= 7.9, 5.1, 1.4 Hz, 1H), 3.15, 3.00 (2xs, 3H). 13C NMR (101 MHz, MeOD) delta 174.60, 174.50, 166.30, 163.54, 163.52, 159.93, 149.60, 148.94, 138.66, 138.32, 138.22, 137.51, 133.40, 132.71, 130.98, 130.55, 130.45, 124.95, 124.28, 123.89, 122.40, 122.30, 74.12, 73.78, 73.09, 73.04, 72.80, 72.33, 71.56, 71.24, 64.76, 64.74, 61.21, 60.94, 54.14, 52.71, 41.09, 40.66, 38.29, 34.82. ESI- HRMS e/z calc. for C34H40N6O7: 644.2958, found: 707.2166 [(M-H)Zn]+.

Reference： [1]Patent: WO2018/33719,2018,A1 .Location in patent: Page/Page column 127-128

65
5-((bis(pyridin-2-ylmethyl)amino)methyl)thiophene-2-carboxylic acid [ No CAS ]
[ 6284-40-8 ]
5-((bis(pyridin-2-ylmethyl)amino)methyl)-N-methyl-N-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)thiophene-2-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
75%	With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 - 50℃; for 16h;	The 5-((bis(pyridin-2-ylmethyl)amino)methyl)thiophene-2-carboxylic acid obtained in the previous reaction (0.312 g, 0.919 mmol, 1.0 eq.) was dissolved in 5 mL dry DMF at room temperature. N-Methyl-D-Glucamine (0.269 g, 1.378 mmol, 1.5 eq.), EDC1 (0.264 g, 1.378 mmol, 1.5 eq.), HO At (0.187 g, 1.378 mmol, 1.5 eq.) and NMM (0.152 mL, 1.378 mmol, 1.5 eq.) were then added. The mixture was heated to 50 C for 16 h with stirring and then concentrated under reduced pressure. Purification of the product was achieved by way of dry column vacuum chromatography on CI 8 bondesil material, using a stepwise elution from 10% to 90% methanol in water affording 0.357 g (0.691 mmol, 75%) of product. 1H NMR (400 MHz, MeOD) delta 8.44 (d, J= 4.5 Hz, 2H), 7.83 (t, J= 7.6 Hz, 2H), 7.72 (d, J= 7.9 Hz, 2H), 7.39 (d, J= 7.2 Hz, 1H), 7.32 - 7.26 (m, 2H), 6.98 (s, 1H), 4.16 - 4.06 (m, 1H), 3.90 (s, 2H), 3.84 (s, 4H), 3.81 - 3.55 (m, 6H), 3.34 (d, J= 8.2 Hz, 1H), 2.15 (s, 3H). 13C NMR (101 MHz, MeOD) delta 149.21, 138.53, 131.04, 126.94, 124.36, 123.67, 72.73, 64.47, 60.16, 53.80, 30.39. APCI-HRMS e/z calc. for C25H32N406S: 516.2043, found 517.2115 [M+H]

Reference： [1]Patent: WO2018/33719,2018,A1 .Location in patent: Page/Page column 165

66
[ 440367-79-3 ]
[ 6284-40-8 ]
6-((bis(pyridin-2-ylmethyl)amino)methyl)-N-methyl-N-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)nicotinamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
33%	With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 - 50℃; for 16h;	The 6-((bis(pyridin-2-ylmethyl)amino)methyl)nicotinic acid prepared in Example 13 (194 mg, 0.58 mmol, 1 eq.) was dissolved in 5 mL dry DMF at room temperature. N-Methyl-D- glucamine (170 mg, 0.87 mmol, 1.5 eq.), EDCl (167 mg, 0.87 mmol, 1.5 eq.), HOAt (118 mg, 0.87 mmol, 1.5 eq.) and NMM (96 mu, 0.87 mmol, 1.5 eq.) was then added. Upon addition of the HOAt the mixture turned from colorless to yellow. The mixture was heated to 50C for 16 h with stirring and then concentrated under reduced pressure. The product was isolated via chromatography on reverse phase silica-C18 using 10-90% MeOH in H20 affording 99 mg (33%) of product as a yellow glassy oll. The product appears as a syn/anti mixture regarding the amide bond. 1H NMR (300 MHz, MeOH) delta 8.57 (d, J= 11.3 Hz, 1H), 8.44 (d, J= 4.7 Hz, 2H), 7.89 (dd, J - 20.9, 7.9 Hz, 1H), 7.79 (t, J= 7.7 Hz, 2H), 7.72 (d, J= 7.6 Hz, 1H), 7.67 (d, J= 7.9 Hz, 2H), 7.34 - 7.22 (m, 2H), 4.08 (dt, J= 18.6, 6.6 Hz, 1H), 3.87 (s, J= 3.1 Hz, 6H), 3.84 - 3.46 (m, 7H), 3.14, 3.07 (2 x s, 3H). 13C NMR (101 MHz, MeOD) delta 170.57, 169.95, 160.31, 159.73, 158.51, 148.12, 147.03, 146.52, 137.21, 136.23, 135.55, 131.20, 130.93, 123.50, 122.84, 122.60, 122.43, 72.52, 72.02, 71.59, 71.51, 70.97, 70.24, 70.10, 69.65, 63.27, 59.88, 59.73, 59.60, 59.43, 53.78, 51.00, 38.54, 32.37. APCI-HRMS e/z calc. for C26H33N506: 511.2431, found 512.2503 [M+H]

Reference： [1]Antimicrobial Agents and Chemotherapy,2020,vol. 64
[2]Patent: WO2018/33719,2018,A1 .Location in patent: Page/Page column 82

67
2-(4-(2-((2-(bis(pyridin-2-ylmethyl)amino)ethyl)(pyridin-2-ylmethyl)amino)acetamido)phenyl)acetic acid [ No CAS ]
[ 6284-40-8 ]
2-(4-(2-((2-(bis(pyridin-2-ylmethyl)amino)ethyl)(pyridin-2-ylmethyl)amino)acetamido)phenyl)-N-methyl-N-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)acetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
40%	With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 - 50℃; for 12.5h;Inert atmosphere;	The acid prepared in Example 21 (203.2 mg, 0.387 mmol, 1 eq.) was dissolved in 2 mL dry DMF under N2 atmosphere at room temperature. N-Methyl-D-glucamine (1 13 mg, 0.581 mmol, 1.5 eq.), EDC1 (111 mg, 0.581 mmol, 1.5 eq.), HOAt (79 mg, 0.581 mmol, 1.5 eq.) and NMM (64 mu,, 1.5 eq.) was then added and the mixture stirred at room temperature for 30 min, then heated to 50C for 12 h. The reaction mixture was concentrated under reduced pressure and the product isolated via chromatography on reverse phase silica- C18 using 10-90% MeOH in H20 affording 109.6 mg (40%) of the product as a yellow oll. The product appears as a syn/anti mixture regarding the amide bond. 1H NMR (600 MHz, MeOD) delta 8.48 - 8.45 (m, 1H), 8.39 (d, J= 4.1 Hz, 2H), 7.71 (td, J= 7.7, 1.3 Hz, 1H), 7.67 (tt, J= 7.7, 2.1 Hz, 2H), 7.55 (dd, J= 11.3, 8.5 Hz, 2H), 7.50 (d, J= 8.0 Hz, 2H), 7.35 (d, J= 7.8 Hz, 1H), 7.24 (dd, J= 14.8, 8.0 Hz, 5H), 4.05 - 3.98 (m, 1H), 3.94 - 3.78 (m, 2H), 3.78 - 3.74 (m, 4H), 3.72 (s, 5H), 3.70 - 3.60 (m, 4H), 3.44 (ddd, J= 8.0, 5.2, 1.4 Hz, 1H), 3.28 (d, J= 3.1 Hz, 2H), 3.15, 3.00 (2xs, 3H), 2.79 (t, J= 6.5 Hz, 2H), 2.68 (t, J = 6.5 Hz, 2H). 13C NMR (201 MHz, MeOD) delta 174.65, 174.54, 172.19, 172.16, 160.14, 159.46, 150.23, 149.54, 138.61, 138.54, 138.03, 137.93, 132.89, 132.22, 130.54, 130.45, 125.00, 124.89, 124.02, 123.81, 121.45, 121.34, 74.09, 73.74, 73.07, 73.01, 72.82, 72.32, 71.54, 71.24, 64.77, 64.74, 62.03, 61.20, 59.69, 54.12, 53.59, 53.03, 52.72, 49.00, 41.07, 40.65, 38.31, 34.81. APCI-HRMS e/z calc. for C37H47N707: 701.3537, found 702.3607 [M+H]

Reference： [1]Patent: WO2018/33719,2018,A1 .Location in patent: Page/Page column 81

68
[ 24758-59-6 ]
[ 6284-40-8 ]

Yield	Reaction Conditions	Operation in experiment
69.3%	With ammonia borane; palladium/alumina; at 78℃; under 975.098 - 48004.8 Torr; for 2h;Inert atmosphere; Large scale;	The catalyst Pd/Al2O3 was added to the reactor, the air was purged by nitrogen and the reaction pressure was adjusted to 0.13 MPa, and the temperature of the reactor was raised to 78 C, and stirring was started.10 kg of the glucose methylamine solution prepared in Example 1 and 0.3 kg of borane were added.Until the reactor pressure is 6.4 MPa, the reaction time is 2.0 hours, the reaction is finished, venting, discharging, and the material is cooled to below 5 C, and the solid is collected, ie, 1.90 kg of crude meglumine.

Reference： [1]Patent: CN108610263,2018,A .Location in patent: Paragraph 0020-0022; 0025

69
[ 24424-99-5 ]
[ 6284-40-8 ]
C₁₂H₂₅NO₇ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
96.32%	With sodium hydrogencarbonate; In methanol; at 20℃; for 2h;	a) 18 g (92.2 mmol) of meglumine, 360 mL of methanol, 38.7 g (460.7 mmol) of sodium hydrogencarbonate, and 36 mL of water were sequentially added to a 1 L round bottom flask at room temperature, and magnetically stirred, 24 g (110 mmol) of di-tert-butyl dicarbonate(di-tert-butyl dicarbonate dissolved in methanol) was added dropwise, after the completion of the dropwise addition, the reaction was continued for 2 hours, and the reaction was terminated for post-treatment. The reaction solution was suction filtered (The filter funnel was padded with diatomaceous earth), the filtrate was concentrated under reduced pressure at 60 C until dry viscous liquid, 200 mL of absolute ethanol was added and stirred for 30 minutes, the precipitated solid was filtered off with suction(The filter funnel was padded with diatomaceous earth), the filtrate was concentrated under reduced pressure at 55 C to dryness to a viscous liquid, 30 mL of acetone was added, stirred, dissolved completely, and 200 mL of petroleum ether was added dropwise, after crystallization for 2 hours, rapid filtration, the filter cake was rinsed with petroleum ether, and quickly drained, the filter cake was dried in a vacuum oven at 40 C for 8 hours to obtain 26.2 g of a white solid intermediate 1 in a yield of 96.32%.

Reference： [1]Patent: CN108558685,2018,A .Location in patent: Paragraph 0057-0058

70
[ 6284-40-8 ]
[ 265121-01-5 ]
fosaprepitant dimeglumine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		A mixture of 150gm of fosaprepitant dibenzyl ester, compound of formula III (prepared by example 1) 90gm of N-methyl glucamine and 30gm of palladium on carbon catalyst in 3000ml of methanol stirred under hydrogen atmosphere (hydrogen pressure about 5.0 to 7.0 kg/cm2) for about 2 hours at 25-30C. The progress of reaction monitored by HPLC. The reaction mass was filtered through hyflo bed and the filtrate was distilled and degassed under vacuum at about 30C. The degassed mass was dissolved in about 1350ml of methanol and 0.3ml of tributylphosphine (TBP) was added into reaction mass and stirred for about 24 hours. 4500ml isopropyl alcohol was added into reaction mass after charcolisation to give a white precipitate under nitrogen atmosphere. The slurry mass stirred, filtered and dried under vacuum at about 25-30C to yield 160gm crude fosaprepitant dimeglumine, which was then purified using methanol and acetone to yield pure titled compound. Purity: 99.90%; Aprepitant (Formula III): 0.06%; Impurity F: Not detected.

Reference： [1]Patent: WO2018/211410,2018,A1 .Location in patent: Page/Page column 15

71
[(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid [ No CAS ]
[ 6284-40-8 ]
(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)glycine meglumine salt [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
86%	In tetrahydrofuran; water; at 50℃; for 0.333333h;	Roxadustat (40 mg, form A) was dissolved in THF (1 ml) at 50C. Meglumine (1.1 equivalents in the form of a solution of 25 mg of meglumine in 1 ml of water) was added to the solution and the solution was stirred for 20 min at 50C. The solution was subsequently left to cool down freely to 25C and stirred at this temperature in an open vial. The solid fraction was filtered, washed with water and dried for 0.5 h at the temperature of 45C in vacuum. The product was isolated in the yield of 86% (53 mg) in the form of white powder. An IR measurement confirmed formation of a salt. The ratio of roxadustat:meglumine = 1:1 was determined by means of NMR. 1H-NMR (500 MHz, DMSO-d6): 8.78 (1H, t, J= 4.5 Hz, NH), 8.30 (1Eta, d, J= 9.1 Hz, ArH), 7.63 (1H, s, ATH), 7.54 (1H, d, J = 9.1 Hz, ArH), 7.49 (2H, t, J = 7.7 Hz, ArH), 7.26 (1H, t, J = 7.3 Hz, ArH), 7.19 (2Eta, d, J = 8.0 Hz, ArH), 5.81 (2Eta, br. s), 4.73 (1Eta, br. s, OH), 3.87 (1Eta, m, CH), 3.73 (2Eta, d, J = 4.5 Hz, CH2), 3.68 (1Eta, d, J = 4.9 Hz, CH), 3.60 (1Eta, dd, J = 10.8, 2.7 Hz, CHaHb), 3.50 (1H, m, CH), 3.44 (1Eta, d, J = 8.8 Hz, CH), 3.41 (1Eta, dd, J = 10.8, 5.6 Hz, CHaHb), 2.99 (1Eta, dd, J = 12.3, 2.7 Hz, CHcHd), 2.89 (1Eta, dd, J = 12.3, 9.1 Hz, CHcHd), 2.70 (3H, s, CHs), 2.51 (3Eta, s, CH3). (0269) 13C NMR (125 MHz, DMSO-d6): 170.84, 168.68, 157.58, 155.59, 152.70, 146.59, 131.25, 130.35, 125.17, 124.47, 123.66, 122.39, 119.77, 119.43, 112.19, 71.24, 70.31(2x), 68.78, 63.39, 51.24, 42.81, 33.36, 21.55. (0270) The X-ray powder pattern is shown in Fig. 1, the DSC record is shown in Fig. 2, Tt = 181C

Reference： [1]Patent: WO2019/42485,2019,A1 .Location in patent: Page/Page column 60-61

72
[ 6284-40-8 ]
[ 27740-01-8 ]
scutellarin meglumine salt [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
79%	In tetrahydrofuran; water; at 10℃; for 0.5h;pH 9.5;	In a 500 mL round bottom flask, 2 g (4 mmol) of <strong>[27740-01-8]scutellarin</strong> was added, and 150 ml of pure water and 50 ml of tetrahydrofuran were sequentially added. A 4 mol/L aqueous meglumine solution was slowly added dropwise at 10 C to a pH of 9.5, and stirring was continued for about half an hour until the reaction was completed. The reaction solution was filtered under suction, and about 100 ml of tetrahydrofuran was added to the filtrate to precipitate a large amount. Stirring was continued for half an hour, followed by suction filtration, and the filter cake was washed with acetone until the filtrate was colorless. The filter cake was collected and dried under reduced pressure at 30 to 40 C to obtain 2.3 g of orange-yellow <strong>[27740-01-8]scutellarin</strong> meglumine salt, the yield was 79%, and the chromatographic purity was 99% or more.

Reference： [1]Patent: CN104086611,2016,B .Location in patent: Paragraph 0102-0108

73
[ 599-79-1 ]
[ 6284-40-8 ]
D(-)-N-methylglucamine 2-hydroxy-5-[2-[4-[(2-pyridinylamino)sulfonyl]phenyl]diazenyl]benzoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
97.4%	In acetone; at 60℃;	Sulfasalazine (2.00 g, 5.0 mmol) and D(-)-N-methylglucamine (1 .00 g, 5.1 mmol) were weighed into a 250 ml round-bottomed flask equipped with magnetic stirrer. Acetone (200 ml) was added and the mixture stirred at 60 C. The solid materials gradually dissolved and after a few hours a new precipitate started to form. The mixture was never completely dissolved. After 24 h at 60 C tert- butyl methylether (40 ml) was added from a dropping funnel (5 min) and crystal seeds (1 mg Form A meglumine sulfasalazine salt obtained as described in Example 5) were added. After 30 min the heating was turned off and the mixture stirred another 60 h at ambient temperature. It was then filtered (Robu-Glas borosilicate glass filter porosity 3) and the solid washed with 20% mixture of tert- butyl methylether in acetone (50 ml). The material was dried 17 h in vacuo and weighed on the filter to give 2.92 g (97.4%) yellow crystalline powder. This material was analysed by 1 H-NMR and found to contain 0.53 % w/w acetone and traces of tert- butyl methylether (< 0.02 % w/w). 1H NMR (400 MHz, DMSO-d6) d 8.27 (d, J = 2.7 Hz, 1 H), 8.03 - 7.95 (m, 3H), 7.91 - 7.83 (m, 2H), 7.80 (dd, J = 8.9, 2.7 Hz, 1 H), 7.75 (ddd, J = 8.9, 7.1 , 1 .9 Hz, 1 H), 7.21 (d, J = 8.7 Hz, 1 H), 6.86 (t, J = 6.6 Hz, 1 H), 6.73 (d, J = 8.9 Hz, 1 H), 5.38 (s, 1 H), 4.57 (s, 1 H), 4.43 (s, 1 H), 3.89 - 3.80 (m, 1 H), 3.66 (dd, J = 5.3, 1 .6 Hz, 1 H), 3.60 (dd, J = 10.8, 3.2 Hz, 1 H), 3.49 (dt, J = 8.9, 4.2 Hz, 1 H), 3.45 - 3.37 (m, 2H), 3.05 (dd, J = 12.6, 3.3 Hz, 1 H), 2.94 {dd, J = 12.6, 9.5 Hz, 1 H), 2.55 (s, 3H); 13C NMR (101 MHz, DMSO-d6) d 170.96, 170.29, 154.12, 141 .99, 127.70, 126.94, 126.78, 122.02, 1 19.07, 1 18.24, 71.28, 70.39, 70.10, 68.34, 63.27, 50.80; loss on drying (TGA; %w/w) is 0.2; melting point (DSC) is 163.5 C ± 2.5 C (onset); water vapor uptake (GVS; %w/w) at 30% RH is 54 mg/mlstoichiometry, base to acid, of 1 :1 was confirmed by NMR.

Reference： [1]Patent: WO2019/101904,2019,A1 .Location in patent: Page/Page column 35-37

74
[ 50-00-0 ]
C₃₆H₃₆O₂₀S₄^(4-)*4Na⁽¹⁺⁾ [ No CAS ]
[ 6284-40-8 ]
C₆₈H₁₀₄N₄O₄₀S₄^(4-)*4Na⁽¹⁺⁾ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82%		A mixture of N-methyl-d-glucamine (0.78 g, 4 mmole) and paraformaldehyde (0.12 g, 4 mmole)was stirred in 10 mL of methanol at 70 C until the completely dissolution. Then, a solution of sulfonatoethylcalix[4]resorcinarene (1 g, 1 mmole) in water (10 mL) and methanol (50 mL) was added slowly in portions of 5 mL over 30 min. The reaction mixture temperature wasn?t allowed to riseabove 65 C. The precipitate formed after 24 h of heating was filtered, triturated in methanol and dialyzed (15 mL of an aqueous solution vs. 300 mL of water, 30 min 3 times). Yield: 1.5 g (82 %).M.p. > 350 C. 1H-NMR (D2O, 600 MHz): delta (ppm) = 7.27 (4H, Har.), 4.60 (4H, CH), 4.23 (16H, CH2N),3.94-3.57 (24H, CHOH), 3.26 (12H, CH3N), 2.96 (8H, CH2SO3), 2.75 (8H, CH2CH2SO3). 13C-NMR(D2O, 150.9 MHz): delta(ppm) =1 56, 124, 122, 107, 70, 67, 62, 57, 53, 49, 39, 34. IR (KBr, cm-1): 3500-3000(O-H), 1610, 1460 (C-C), 1180 (C-O), 1045 (S=O). Elemental analysis for C68H104N4Na4O40S4: found C44.14, H 6.35, N 3.03, Na 5.11, S 6.49, calculated C 44.44, H 5.70, N 3.05, Na 5.00, S 6.98.

Reference： [1]Molecules,2019,vol. 24

75
[ 50-00-0 ]
[ 260786-76-3 ]
[ 6284-40-8 ]
N-methyl-D-glucaminemethyl methylcalix[4]resorcinarene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
88%		A mixture of N-methyl-d-glucamine (0.715 g, 3.7 mmole) and paraformaldehyde (0.110 g,3.7 mmole) was stirred in ethanol (10 mL) at 70 C until complete dissolution. Then, a solution of methylcalix[4]resorcinarene (0.5 g, 0.9 mmole) in ethanol (30 mL) was slowly added over 30 min.The reaction mixture was stirred at 70 C for 24 h. The precipitate was filtered, dialyzed (15 mL ofan aqueous solution vs. 300 mL of water, 30 min x 3 times) and recrystallized from ethanol. Yield:1.1 g (88%). M.p. > 350 C. 1H-NMR (D2O, 600 MHz): delta (ppm) = 7.38 (4H, Har.), 4.48 (4H, CH), 4.4-4.0(16H, CH2N), 3.75-3.5 (24H, CHOH), 3.20 (12 H, CH3N), 1.71 (12H, CH3). 13C-NMR (D2O, 150.9MHz):delta (ppm) = 151, 125, 124, 102, 70, 68, 62, 57, 51, 29, 22 ppm. IR (KBr, cm-1): 3500-3000 (O-H), 1610,1540 and 1460 (C-C), 1210 (C-O). Elemental analysis for C64H100N4O28: found C 55.89, H 7.50, N 4.09,calculated C 55.97, H 7.34, N 4.08.

Reference： [1]Molecules,2019,vol. 24

76
(3Z)-6-oxo-3-[[4-(pyridin-2-ylsulfamoyl)phenyl]hydrazinylidene]cyclohexa-1,4-diene-1-carboxylic acid [ No CAS ]
[ 6284-40-8 ]
C₇H₁₇NO₅*C₁₈H₁₄N₄O₅S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
97.4%	In acetone; at 60℃; for 24h;	Sulfasalazine (2.00 g, 5.0 mmol) and D(-)-/V-methylglucamine (1.00 g, 5.1 mmol) were weighed into a 250 ml round-bottomed flask equipped with magnetic stirrer. Acetone (200 ml) was added and the mixture stirred at 60 C. The solid materials gradually dissolved and after a few hours a new precipitate started to form. The mixture was never completely dissolved. After 24 h at 60 C tert- butyl methylether (40 ml) was added from a dropping funnel (5 min) and crystal seeds (1 mg Form A meglumine sulfasalazine salt obtained as described in Example 5) were added. After 30 min the heating was turned off and the mixture stirred another 60 h at ambient temperature. It was then filtered (Robu-Glas borosilicate glass filter porosity 3) and the solid washed with 20% mixture of tert- butyl methylether in acetone (50 ml). The material was dried 17 h in vacuo and weighed on the filter to give 2.92 g (97.4%) yellow crystalline powder. This material was analysed by 1 H-NMR and found to contain 0.53 % w/w acetone and traces of tert- butyl methylether (< 0.02 % w/w). 1H NMR (400 MHz, DMSO-d6) d 8.27 (d, J = 2.7 Hz, 1 H), 8.03 - 7.95 (m, 3H), 7.91 - 7.83 (m, 2H), 7.80 (dd, J = 8.9, 2.7 Hz, 1 H), 7.75 (ddd, J = 8.9, 7.1 , 1 .9 Hz, 1 H), 7.21 (d, J = 8.7 Hz, 1 H), 6.86 (t, J = 6.6 Hz, 1 H), 6.73 (d, J = 8.9 Hz, 1 H), 5.38 (s, 1 H), 4.57 (s, 1 H), 4.43 (s, 1 H), 3.89 -3.80 (m, 1 H), 3.66 (dd, J = 5.3, 1.6 Hz, 1 H), 3.60 (dd, J = 10.8, 3.2 Hz, 1 H), 3.49 (dt, J = 8.9, 4.2Hz, 1 H), 3.45 - 3.37 (m, 2H), 3.05 (dd, J = 12.6, 3.3 Hz, 1 H), 2.94 (dd, J = 12.6, 9.5 Hz, 1 H), 2.55 (s, 3H); 13C NMR (101 MHz, DMSO-d6) d 170.96, 170.29, 154.12, 141 .99, 127.70, 126.94, 126.78, 122.02, 1 19.07, 1 18.24, 71.28, 70.39, 70.10, 68.34, 63.27, 50.80; loss on drying (TGA; %w/w) is 0.2; melting point (DSC) is 163.5 C ± 2.5 C (onset); water vapor uptake (GVS; %w/w) at 30% RH is 54 mg/mlstoichiometry, base to acid, of 1 :1 was confirmed by NMR

Reference： [1]Patent: WO2019/101903,2019,A1 .Location in patent: Page/Page column 31; 32; 34

77
[ 6284-40-8 ]
[ 24801-88-5 ]
N-methyl-N-(2,3,4,5,6-pentahydroxyhexyl)-N'-(3-triethoxysilylpropyl)urea [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
99%	In tetrahydrofuran; at 80 - 90℃; for 2.5h;	A solution of 2.00 g (8.09 mmol) of 3-triethoxysilylpropylisocyanate in 25 mL of THF was added dropwise to a suspension of 1.59 g (8.09 mmol) of N-methylglucamine in 25 mL of THF for 30 min under stirring. The reaction mixture was stirred for 2 h under warming (80-90 ), then THF was removed in vacuo. The residue was washed with hexane. This afforded 3.45g (99%) of white powdered compound 1. Found (%): , 42.11;H, 8.15; Si, 5.14. C17H38N2O9Si. Calculated (%): , 46.14;H, 8.65; Si, 6.35. IR, nu/cm-1: 3330, 3271 (NH, OH); 2977, 2933,2926 (CH); 1700, 1608, 1545 (=, NH); 1104 (C-O-H); 1080(Si-O-C); 953, 775, 723 (Si-O-Et). 1H NMR ((CD3)2CO),delta: 0.61-0.58 (m, 2 , 2Si); 1.18 (t, 9 , 32, 3J, == 7.0 Hz); 1.61-1.56 (m, 2 , 222); 2.96 (s, 3 ,N); 3.15-3.12 (m, 2 , NH2); 3.45-3.42 (m, 2 H,MeNCH2); 3.61-3.59 (m, 2 H, CH2OH); 3.73-3.69 (m, 4 ,()); 3.80 (q, 6 32, 3J, = 7.0 Hz); 3.92-3.90(m, 2 , ()); 4.09-4.07 (m, 1 , ()); 4.20-4.18(m, 1 , ()); 4.86 (br.d, 1 , 2); 5.98 (br.t, 1 ,N2). 29Si NMR (DMSO-d6), delta: -45.

Reference： [1]Russian Chemical Bulletin,2019,vol. 68,p. 1075 - 1080
Izv. Akad. Nauk, Ser. Khim.,2019,p. 1075 - 1080,6

78
2-ethyl-4-methylheptanal [ No CAS ]
[ 6284-40-8 ]
C₁₇H₃₇NO₅ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
77.5%Chromat.	With 5 wt% ruthenium/carbon; hydrogen; In methanol; at 110℃; under 63756.4 Torr; for 6h;	General procedure: 10.0 g N-methylglucamine (NMG; 51.2 mmol), 6.6 g 2-ethylhexanal (51.5 mmol), 0.850 g 5 wt % Ru/C catalyst, and 15.0 g methanol were placed in a 100-mL stainless steel high-pressure reactor equipped with a mechanical stirrer, a thermocouple, an electric heating jacket, and inlets and outlets for feeds, products, and sampling. Prior to reaction, the reactor was flushed three times with nitrogen and three times with hydrogen at room temperature. After a reaction of 230 minutes at 60 bar H2, the reaction mixture was cooled, vented, and filtered. After drying under vacuum using a rotary evaporator, ca. 11 g product was obtained. Analysis of the product was done by GC-FID and GC-MS. Conversion of the starting 2-ethylhexanal was 99.5% with a selectivity to the desired N-(2-ethylhexyl)-N-methylglucamine of 88.0% and 2-ethylhexanol being the main by-product. Finally, N-(2-ethylhexyl)-N-methylglucamine was isolated by using a simple acid-base extraction workup.

Reference： [1]Patent: US2019/218170,2019,A1 .Location in patent: Paragraph 0370; 0373; 0374; 0375

79
2-ethyl-4-methylhept-2-enal [ No CAS ]
[ 6284-40-8 ]
C₁₇H₃₅NO₅ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
74%Chromat.	With 5 wt% ruthenium/carbon; hydrogen; In methanol; at 110℃; under 45004.5 Torr; for 6h;	General procedure: 10.0 g N-methylglucamine (NMG; 51.2 mmol), 6.6 g 2-ethylhexanal (51.5 mmol), 0.850 g 5 wt % Ru/C catalyst, and 15.0 g methanol were placed in a 100-mL stainless steel high-pressure reactor equipped with a mechanical stirrer, a thermocouple, an electric heating jacket, and inlets and outlets for feeds, products, and sampling. Prior to reaction, the reactor was flushed three times with nitrogen and three times with hydrogen at room temperature. After a reaction of 230 minutes at 60 bar H2, the reaction mixture was cooled, vented, and filtered. After drying under vacuum using a rotary evaporator, ca. 11 g product was obtained. Analysis of the product was done by GC-FID and GC-MS. Conversion of the starting 2-ethylhexanal was 99.5% with a selectivity to the desired N-(2-ethylhexyl)-N-methylglucamine of 88.0% and 2-ethylhexanol being the main by-product. Finally, N-(2-ethylhexyl)-N-methylglucamine was isolated by using a simple acid-base extraction workup.

Reference： [1]Patent: US2019/218170,2019,A1 .Location in patent: Paragraph 0370; 0373

80
(E)-4-ethyl-2-methyloct-2-enal [ No CAS ]
[ 6284-40-8 ]
C₁₈H₃₇NO₅ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
67.8%Chromat.	With 5 wt% ruthenium/carbon; hydrogen; In methanol; at 110℃; under 45004.5 Torr; for 6h;	General procedure: 10.0 g N-methylglucamine (NMG; 51.2 mmol), 6.6 g 2-ethylhexanal (51.5 mmol), 0.850 g 5 wt % Ru/C catalyst, and 15.0 g methanol were placed in a 100-mL stainless steel high-pressure reactor equipped with a mechanical stirrer, a thermocouple, an electric heating jacket, and inlets and outlets for feeds, products, and sampling. Prior to reaction, the reactor was flushed three times with nitrogen and three times with hydrogen at room temperature. After a reaction of 230 minutes at 60 bar H2, the reaction mixture was cooled, vented, and filtered. After drying under vacuum using a rotary evaporator, ca. 11 g product was obtained. Analysis of the product was done by GC-FID and GC-MS. Conversion of the starting 2-ethylhexanal was 99.5% with a selectivity to the desired N-(2-ethylhexyl)-N-methylglucamine of 88.0% and 2-ethylhexanol being the main by-product. Finally, N-(2-ethylhexyl)-N-methylglucamine was isolated by using a simple acid-base extraction workup.

Reference： [1]Patent: US2019/218170,2019,A1 .Location in patent: Paragraph 0370; 0373

81
[ 123-05-7 ]
[ 6284-40-8 ]
N-(2-ethylhexyl)-N-methylglucamine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
88%	With 5 wt% ruthenium/carbon; hydrogen; In methanol; under 45004.5 Torr; for 3.83333h;	10.0 g N-methylglucamine (NMG; 51.2 mmol), 6.6 g 2-ethylhexanal (51.5 mmol), 0.850 g 5 wt % Ru/C catalyst, and 15.0 g methanol were placed in a 100-mL stainless steel high-pressure reactor equipped with a mechanical stirrer, a thermocouple, an electric heating jacket, and inlets and outlets for feeds, products, and sampling. Prior to reaction, the reactor was flushed three times with nitrogen and three times with hydrogen at room temperature. After a reaction of 230 minutes at 60 bar H2, the reaction mixture was cooled, vented, and filtered. After drying under vacuum using a rotary evaporator, ca. 11 g product was obtained. Analysis of the product was done by GC-FID and GC-MS. Conversion of the starting 2-ethylhexanal was 99.5% with a selectivity to the desired N-(2-ethylhexyl)-N-methylglucamine of 88.0% and 2-ethylhexanol being the main by-product. Finally, N-(2-ethylhexyl)-N-methylglucamine was isolated by using a simple acid-base extraction workup.

Reference： [1]Patent: US2019/218170,2019,A1 .Location in patent: Paragraph 0370

82
[ 37935-50-5 ]
[ 6284-40-8 ]
N-(4-ethyl-2-methyloctyl)-N-methylglucamine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
80%Chromat.	With 5 wt% ruthenium/carbon; hydrogen; In methanol; at 110℃; under 45004.5 Torr; for 6h;	General procedure: 10.0 g N-methylglucamine (NMG; 51.2 mmol), 6.6 g 2-ethylhexanal (51.5 mmol), 0.850 g 5 wt % Ru/C catalyst, and 15.0 g methanol were placed in a 100-mL stainless steel high-pressure reactor equipped with a mechanical stirrer, a thermocouple, an electric heating jacket, and inlets and outlets for feeds, products, and sampling. Prior to reaction, the reactor was flushed three times with nitrogen and three times with hydrogen at room temperature. After a reaction of 230 minutes at 60 bar H2, the reaction mixture was cooled, vented, and filtered. After drying under vacuum using a rotary evaporator, ca. 11 g product was obtained. Analysis of the product was done by GC-FID and GC-MS. Conversion of the starting 2-ethylhexanal was 99.5% with a selectivity to the desired N-(2-ethylhexyl)-N-methylglucamine of 88.0% and 2-ethylhexanol being the main by-product. Finally, N-(2-ethylhexyl)-N-methylglucamine was isolated by using a simple acid-base extraction workup.

Reference： [1]Patent: US2019/218170,2019,A1 .Location in patent: Paragraph 0370; 0373

83
tafamidis acetic acid [ No CAS ]
[ 6284-40-8 ]
[ 951395-08-7 ]

Yield	Reaction Conditions	Operation in experiment
91.2%	In methanol; water; ethyl acetate; at 30 - 65℃;	9.0818 g Tafamidis*CH3COOH solvate was suspended in 3000 ml EtOAc and heated to 65 C until a transparent solution was obtained. The solution was cooled to 30-32C and was 10 times washed with 1000 ml deionized water. The resulting -2000 ml EtOAc solution was charged with MeOH/fEO solution (1000 ml MeOH/150 ml H2O). 4,8155g D-Meglumine was dissolved in 40 ml H2O and added at room temperature to a MeOH/fbO mixture (1000 ml MeOH/150ml H2O 34C). The monophasic transparent solution was heated to 50 C and was concentrated under reduced pressure to approximately 2000 ml target volume. The concentrated reaction mixture was cooled to 32-34 C and filtered via gravity filtration with a funnel and a filter paper. The mother liquor was evaporated at 50 C and 200 mbar via rotavapor until a gel like mass was obtained. The residual gel was removed to a beaker and stored for 3 days in oven at 25-27 C and 100 mbar. The dried product was grinded and stored overnight at 50 C and 100 mbar. The chemical yield was 11.33g (91.2%) and the purity was 99.98 % (HPLC). The product shows a phase transition followed by melting at 298-303 C.

Reference： [1]Patent: WO2019/175263,2019,A1 .Location in patent: Page/Page column 23; 24

84
[ 13402-02-3 ]
[ 6284-40-8 ]
C₂₆H₅₃NO₇ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
78%	In 1,4-dioxane; water; at 50℃; for 5h;	Into a 30 mL flaskWeigh out 1.1713 g (6 mmol) of N-methylglucamine,1,4-dioxane 4mL and water 1mLAddSuspended.After adding 1.4825 g (5 mmol) of <strong>[13402-02-3]hexadecyl acrylate</strong>,The mixture was heated to 50 C and stirred for 5 hours.After returning the reaction solvent to room temperature,Precipitation was added to 100 mL of water.Filter the deposit,After washing well with water,White solid was obtained by drying under reduced pressure.Yield: 78%

Reference： [1]Patent: JP2019/156826,2019,A .Location in patent: Paragraph 0055

85
[ 4813-57-4 ]
[ 6284-40-8 ]
C₂₈H₅₇NO₇ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
98%	In 1,4-dioxane; water; at 50℃; for 5h;	Into a 30 mL flaskWeigh out 1.1723 g (6 mmol) of N-methylglucamine,1,4-dioxane 4mL and water 1mLAddSuspended.After adding 1.6240 g (5 mmol) of stearyl acrylate (Shin Nakamura Chemical Co., Ltd .: S-1800A), the mixture was heated to 50 C. and stirred for 5 hours. After returning the reaction solvent to room temperature, it was added to 50 mL of water to precipitate a viscous material. The viscous material was isolated by decantation, thoroughly washed with water, and then dried under reduced pressure to obtain a highly viscous material. Yield: 98%

Reference： [1]Patent: JP2019/156826,2019,A .Location in patent: Paragraph 0051; 0056

86
[ 2499-95-8 ]
[ 6284-40-8 ]
C₁₆H₃₃NO₇ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
86%	In 1,4-dioxane; water; at 50℃; for 5h;	1.1711 g (6 mmol) of N-methylglucamine in a 30 mL flaskWeighAdd 4 mL of 1,4-dioxane and 1 mL of waterAnd suspended.After adding 0.879 mL (5 mmol) of hexyl acrylate,The mixture was heated to 50 C. and stirred for 5 hours.The solvent is distilled off under reduced pressure and dissolved in 30 mL of dichloromethane,After washing with 10 mL of water,The organic layer is distilled off under reduced pressure,White solid was obtained by drying under reduced pressure. Yield: 86%

Reference： [1]Patent: JP2019/156826,2019,A .Location in patent: Paragraph 0052

87
[ 2156-97-0 ]
[ 6284-40-8 ]
C₂₂H₄₅NO₇ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
91%	In 1,4-dioxane; water; at 50℃; for 5h;	Into a 30 mL flaskWeigh out 1.1714 g (6 mmol) of N-methylglucamine,1,4-dioxane 4mL and water 1mLWas added and suspended.After adding 1.374 mL (5 mmol) of dodecyl acrylate,The mixture was heated to 50 C and stirred for 5 hours.After returning the reaction solvent to room temperature,Precipitation was added to 100 mL of water.After filtering the precipitate and washing it well with water,White solid was obtained by drying under reduced pressure.Yield: 91%

Reference： [1]Patent: JP2019/156826,2019,A .Location in patent: Paragraph 0054

88
[ 6284-40-8 ]
[ 121808-62-6 ]
pidotimod meglumine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In water at 20℃;	4 Comparative Example 4 Pidomod meglumine salt (1:1) Take 5.0 g (0.02 mol) of pidotimod and 4.0 g (0.02 mol) of meglumine into 100 ml of water, stir at room temperature until all the raw materials are dissolved, and spray-dried white powder, that is, salt of pidotimod meglumine

Reference： [1]Current Patent Assignee: LUNAN PHARMACEUTICAL GROUP CO LTD - CN113004265, 2021, A Location in patent: Paragraph 0075; 0076

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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CAS No. :	6284-40-8	MDL No. :	MFCD00004707
Formula :	C₇H₁₇NO₅	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	MBBZMMPHUWSWHV-BDVNFPICSA-N
M.W :	195.21	Pubchem ID :	8567
Synonyms :	Methylglucamin;Meglumin;Sorbitol, 1-deoxy-1-methylamino-;N-Methyl-D-glucamine;Iosulamide;1-Deoxy-1-(methylamino)-D-glucitol;Methylglucamine	Chemical Name :	(2R,3R,4R,5S)-6-(Methylamino)hexane-1,2,3,4,5-pentaol

Signal Word:	Warning	Class:	N/A
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Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

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P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 6284-40-8 ] {[proInfo.proName]}

Quality Control of [ 6284-40-8 ]

Related Doc. of [ 6284-40-8 ]

Product Details of [ 6284-40-8 ]

Safety of [ 6284-40-8 ]

Application In Synthesis of [ 6284-40-8 ]

[ 6284-40-8 ] Synthesis Path-Upstream 1~6

[ 6284-40-8 ] Synthesis Path-Downstream 1~88

Similar Product of
[ 6284-40-8 ]

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

[ CAS No. 6284-40-8 ] {[proInfo.proName]}

Quality Control of [ 6284-40-8 ]

Related Doc. of [ 6284-40-8 ]

Product Details of [ 6284-40-8 ]

Safety of [ 6284-40-8 ]

Application In Synthesis of [ 6284-40-8 ]

[ 6284-40-8 ] Synthesis Path-Upstream 1~6

[ 6284-40-8 ] Synthesis Path-Downstream 1~88

Similar Product of [ 6284-40-8 ]

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Similar Product of
[ 6284-40-8 ]