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Chemical Structure| 62124-77-0 Chemical Structure| 62124-77-0

Structure of 62124-77-0

Chemical Structure| 62124-77-0

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Product Details of [ 62124-77-0 ]

CAS No. :62124-77-0
Formula : C9H10N2O3
M.W : 194.19
SMILES Code : O=C(OCC)CC(C1=NC=CN=C1)=O
MDL No. :MFCD04114374
InChI Key :OPBDMDPBJKVMNL-UHFFFAOYSA-N
Pubchem ID :6454349

Safety of [ 62124-77-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Application In Synthesis of [ 62124-77-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 62124-77-0 ]

[ 62124-77-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 179543-88-5 ]
  • [ 62124-77-0 ]
  • [ 741288-62-0 ]
YieldReaction ConditionsOperation in experiment
45% [Referential Example 22] 1-(6-Methoxy-3-pyridyl)-5-(2-pyrazinyl)-1H-pyrazole-3-carboxylic acid; [Show Image] [Show Image] A 1.0M solution of lithium bis(trimethylsilyl)amide in tetrahydrofuran (11.0 ml) was added to a solution of 1-(2-pyrazinyl)-1-ethanone (1.22g) intetrahydrofuran (10ml) at-78C, and the mixture was stirred for 55 minutes. Diethyl oxalate (2.05 ml) was then added to the solution and the temperature of the mixture was gradually elevated to room temperature. After stirring the mixture for 6.5 hours, 1N aqueous hydrochloric acid (11 ml), water, and diethylether were added to the reaction liquid and the phases were separated. The aqueous layer was then saturated with sodium chloride and extracted with ethyl acetate, and the combined organic layers were evaporated under reduced pressure to give crude ethyl 4-(2-pyrazinyl)-2,4-dioxobutanoate (1.83 g, 82%) as a solid. To a suspension of this crude product (1.58 g) in ethanol (20 ml) was added a solution prepared by adding triethylamine (1.9 ml) to a suspension of the <strong>[179543-88-5]5-hydrazino-2-methoxypyridine hydrochloride</strong> (1.50 g) of Referential Example 1 in ethanol (80 ml), and the mixture was heated under reflux for 19 hours. Acetic acid (5 ml) was added to the reaction liquid, and the mixture was heated under reflux for 1.5 days. After cooling with air, ethyl acetate and saturated aqueous sodium bicarbonate was added to the reaction liquid and the phases were separated, and the organic layer was dried over anhydrous sodium sulfate. After filtration, the solvent was evaporated under reduced pressure, and the residue was purified by column chromatography on silica gel (ethyl acetate-hexane) to give ethyl 1-(6-methoxy-3-pyridyl)-5-(2-pyrazinyl)-1H-pyrazole-3-carboxylate (1.05 g, 45%) as a solid. 1N aqueous sodium hydroxide (10.0 ml) was added to a solution of this ethyl 1H-pyrazole-3-carboxylate derivative (1.05g) in ethanol (30 ml) at room temperature for 16 hours. 1N aqueous hydrochloric acid (15 ml), water, and ethyl acetate were added to the reaction liquid and the phases were separated, and the organic layer was dried over anhydrous magnesium sulfate. After filtration, the solvent was evaporated under reduced pressure to give the crude product of the title compound (0.883 g, 92%) as a solid. This crude product was used in the subsequent reaction without further purification.
  • 2
  • [ 62124-77-0 ]
  • [ 64224-21-1 ]
 

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Related Parent Nucleus of
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Pyrazines

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