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Chemical Structure| 64224-21-1 Chemical Structure| 64224-21-1

Structure of Oltipraz
CAS No.: 64224-21-1

Chemical Structure| 64224-21-1

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Oltipraz can inhibit the insulin-activated HIF-1α (IC50 = 10 µM) in a time-dependent manner.

Synonyms: RP 35972; NSC 347901; CD1400

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Product Details of Oltipraz

CAS No. :64224-21-1
Formula : C8H6N2S3
M.W : 226.34
SMILES Code : S=C1SSC(C2=NC=CN=C2)=C1C
Synonyms :
RP 35972; NSC 347901; CD1400
InChI Key :CKNAQFVBEHDJQV-UHFFFAOYSA-N
Pubchem ID :47318

Safety of Oltipraz

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Oltipraz

epigenetics

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01393678 Chronic Liver Disease Phase 3 Completed - Korea, Republic of ... More >> Hanyang University Hospital Seoul, Seongdong-gu,, Korea, Republic of Less <<
NCT00006457 Lung Cancer Phase 1 Completed - United States, Illinois ... More >> Robert H. Lurie Comprehensive Cancer Center, Northwestern University Chicago, Illinois, United States, 60611-3013 United States, North Carolina Duke Comprehensive Cancer Center Durham, North Carolina, United States, 27710 Less <<
NCT01373554 Non-alcoholic Fatty Liver Dise... More >>ase Less << Phase 2 Completed - Korea, Republic of ... More >> Inje University Ilsan Paik Hospital Dahwa-dong, Ilsanseo-gu, Goyang-si, Gyeonggi-do, Korea, Republic of, 411-706 NHUS Ilsan Hospital Ilsan-ro Ilsan-donggu, Goyang-si, Korea, Republic of, 410-719 Seoul National University Hospital Daehak-ro Jongno-gu, Seoul, Korea, Republic of, 110-744 Korea University Guro hospital Gurodong-ro, Seoul, Korea, Republic of, 152-703 Boramae Hospital Sindaebang-dong Dongjak-gu, Seoul, Korea, Republic of, 156-707 Less <<
NCT00956098 Liver Fibrosis ... More >> Liver Cirrhosis Less << Phase 2 Completed - Korea, Republic of ... More >> The Catholic University of Korea Holy Family Hospital Sosa-Dong, Wonmi-Gu, Kyungki-Do, Korea, Republic of The Catholic University of Korea Seoul St. Mary's Hospital Banpo-Dong, Seocho-Gu, Seoul, Korea, Republic of Less <<
NCT02068339 Non-alcholic Fatty Liver Disea... More >>se Less << Phase 3 Completed - Korea, Republic of ... More >> NHUS Ilsan Hospital Ilsan-ro Ilsan-donggu, Goyang-si, Korea, Republic of, 410-719 Inje University Ilsan Paik Hospital Dahwa-dong, Ilsanseo-gu, Goyang-si, Gyeonggi-do, Korea, Republic of, 411-706 Seoul National University Hospital Daehak-ro Jongno-gu, Seoul, Korea, Republic of, 110-744 Korea University Guro hospital Gurodong-ro, Seoul, Korea, Republic of, 152-703 Boramae Hospital Sindaebang-dong Dongjak-gu, Seoul, Korea, Republic of, 156-707 Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.42mL

0.88mL

0.44mL

22.09mL

4.42mL

2.21mL

44.18mL

8.84mL

4.42mL

References

[1]Manandhar S, Cho JM, et al. Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes. Eur J Pharmacol. 2007 Dec 22;577(1-3):17-27. Epub 2007 Aug 23.

[2]Maher JM, Dieter MZ, et al. Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology. 2007 Nov;46(5):1597-610.

[3]Merrell MD, Augustine LM, et al. Induction of drug metabolism enzymes and transporters by oltipraz in rats. J Biochem Mol Toxicol. 2008 Mar-Apr;22(2):128-35.

[4]Lee DY, Kim JW, et al. Pharmacokinetic interaction between oltipraz and omeprazole in rats: Competitive inhibition of metabolism of oltipraz by omeprazole via CYP1A1 and 3A2, and of omeprazole by oltipraz via CYP1A1/2, 2D1/2, and 3A1/2. Eur J Pharm Sci. 2007 Dec;32(4-5):328-39. Epub 2007 Aug 31.

[5]Bae SK, Lee SJ, et al. Interspecies pharmacokinetic scaling of oltipraz in mice, rats, rabbits and dogs, and prediction of human pharmacokinetics. Biopharm Drug Dispos. 2005 Apr;26(3):99-115.

[6]Manandhar S, Cho JM, Kim JA, Kensler TW, Kwak MK. Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes. Eur J Pharmacol. 2007 Dec 22;577(1-3):17-27. doi: 10.1016/j.ejphar.2007.08.018. Epub 2007 Aug 23. PMID: 17854798.

[7]Maher JM, Dieter MZ, Aleksunes LM, Slitt AL, Guo G, Tanaka Y, Scheffer GL, Chan JY, Manautou JE, Chen Y, Dalton TP, Yamamoto M, Klaassen CD. Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology. 2007 Nov;46(5):1597-610. doi: 10.1002/hep.21831. PMID: 17668877.

[8]Merrell MD, Augustine LM, Slitt AL, Cherrington NJ. Induction of drug metabolism enzymes and transporters by oltipraz in rats. J Biochem Mol Toxicol. 2008 Mar-Apr;22(2):128-35. doi: 10.1002/jbt.20225. PMID: 18418891.

 

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