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Chemical Structure| 614-47-1 Chemical Structure| 614-47-1
Chemical Structure| 614-47-1

trans-Chalcone

CAS No.: 614-47-1

Trans-Chalcone is a flavonoid precursor with anticancer and antifungal activities, effectively inhibiting fatty acid synthase and α-amylase, offering therapeutic value in cancers like breast cancer.

4.5 *For Research Use Only !

Cat. No.: A131628 Purity: 97%

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Product Details of trans-Chalcone

CAS No. :614-47-1
Formula : C15H12O
M.W : 208.26
SMILES Code : O=C(C1=CC=CC=C1)/C=C/C2=CC=CC=C2
InChI Key :DQFBYFPFKXHELB-VAWYXSNFSA-N
Pubchem ID :637760

Safety of trans-Chalcone

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of trans-Chalcone

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 614-47-1 ]

[ 614-47-1 ] Synthesis Path-Downstream   1~12

  • 1
  • [ 17374-26-4 ]
  • [ 614-47-1 ]
  • [ 102703-85-5 ]
  • 2
  • [ 538-28-3 ]
  • [ 614-47-1 ]
  • [ 5452-33-5 ]
  • 3
  • [ 1004-38-2 ]
  • [ 614-47-1 ]
  • [ 20732-44-9 ]
  • 5
  • [ 123-75-1 ]
  • [ 538-28-3 ]
  • [ 614-47-1 ]
  • 4,6-diphenyl-2-pyrrolidin-1-yl-pyrimidine [ No CAS ]
  • 6
  • [ 110-89-4 ]
  • [ 538-28-3 ]
  • [ 614-47-1 ]
  • [ 22539-53-3 ]
  • 7
  • [ 110-91-8 ]
  • [ 538-28-3 ]
  • [ 614-47-1 ]
  • 4-(4,6-diphenylpyrimidin-2-yl)morpholine [ No CAS ]
  • 9
  • [ 94465-25-5 ]
  • [ 614-47-1 ]
  • 3-(4-methoxyphenyl)-1,3-diphenyl-1-propanone [ No CAS ]
  • 10
  • [ 50-01-1 ]
  • [ 614-47-1 ]
  • [ 40230-24-8 ]
YieldReaction ConditionsOperation in experiment
31% With sodium hydroxide; In ethanol; water; for 6h;Heating / reflux; A mixture benzylidenacetophenone (38. 6 g, 0.185 mol, 1.1 eq. ) and guanidine hydrochloride (16 g, 0.168 mol, 1 eq. ) were refluxed in ethanol (150 mL). Sodium hydroxide (21.6 g, 0.539 mol, 3.2 eq. ) was dissolved in a minimum amount of water (40mL), and added dropwise to the refluxing mixture. The reaction mixture was then stirred at reflux for a further 6 h. Upon cooling, the reaction mixture was concentrated and then separated between ethyl acetate (200 mL) and water (200 mL). The aqueous layer was then extracted with ethyl acetate (2 x 100 mL). The combined organics were washed with water (200 mL) and brine (200 mL), dried over MgSO¢, and concentrated in vacuo. The crude product was then purified by column chromatography on Si02, eluting with dichloromethane. Recrystallisation from ethyl acetate gave clear colourless crystals yield 31% ; 1H NMR 8 (CDCIs) : 8. 09-8.04 (m, 4H, Ar), 7.54- 7.48 (m, 7H, Ar), 5. 25 (br s, 2H, NH2).
  • 11
  • [ 614-47-1 ]
  • [3-([(1R,2S)-2-(dimethylamino)-1-phenylpropyl]oxy}methyl)thiophen-2-yl]Cu(n-Bu)}Li [ No CAS ]
  • [ 40230-24-8 ]
  • 12
  • [ 1190-39-2 ]
  • [ 614-47-1 ]
  • [ 1012918-95-4 ]
 

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