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Chemical Structure| 17374-26-4 Chemical Structure| 17374-26-4

Structure of TBB
CAS No.: 17374-26-4

Chemical Structure| 17374-26-4

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TBB is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2)with IC50s of 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively).

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Product Details of TBB

CAS No. :17374-26-4
Formula : C6HBr4N3
M.W : 434.71
SMILES Code : BrC1=C(NN=N2)C2=C(Br)C(Br)=C1Br
MDL No. :MFCD06411399
InChI Key :OMZYUVOATZSGJY-UHFFFAOYSA-N
Pubchem ID :1694

Safety of TBB

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of TBB

DNA
Hedgehog

Isoform Comparison

Biological Activity

Target
  • CK2

    CK2, Ki:0.4 μM

  • CK1

    CK1, Ki:47 μM

In Vitro:

Cell Line
Concentration Treated Time Description References
Jurkat cells 30 µM 15 hours TBB induces apoptosis in Jurkat cells, leading to PARP protein degradation, cytochrome c release, and DNA fragmentation. PMC1222543

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.30mL

0.46mL

0.23mL

11.50mL

2.30mL

1.15mL

23.00mL

4.60mL

2.30mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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