607373-82-0|4-Methoxy-5-nitropyridin-2(1H)-one| Ambeed

CAS No. :	607373-82-0
Formula :	C₆H₆N₂O₄
M.W :	170.12
SMILES Code :	COC1=CC(=O)NC=C1[N+]([O-])=O
MDL No. :	MFCD07367779
InChI Key :	BBXOGUKAXIFZAE-UHFFFAOYSA-N
Pubchem ID :	26370134

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Yield	Reaction Conditions	Operation in experiment
70%		Into a 1 L flask containing 250 ml_ of dry THF cooled to -78°C was condensed NH3 (100-150 ml_). Solid t-BuOK (200 mmole, 22.5 g) was added to the THF and was completely dissolved after 10 min of vigorous stirring. In a separate 500 ml_ flask, 10OmL of dry THF containing <strong>[31872-62-5]4-methoxy-3-nitropyridine</strong> (12.3 g, 80 mmole) was cooled to 00C. To this solution was added t-BuOOH (88 mmole, 16 ml_). The t-BuOOH/THF solution was then added to the -78°C ammonia >solution over 20 min via dropping funnel. The reaction solution was allowed to warm to -400C and then stirred at this temperature for 1 h. The reaction was quenched with saturated NH4CI solution (20 mL) and the cooling bath removed. The reaction solution was allowed to stir overnight at RT. The precipitate was filtered and dried under vacuum to give (9.5 g, 70percent) of product as a tan solid: LC/MS: m/z 171 [M+H]+, single component.
51%	With tert.-butylhydroperoxide; potassium tert-butylate; ammonia; In tetrahydrofuran; decane; at -78 - 0℃; for 3.16667h;	Step 1. 2-Hydroxy-4-methoxy-5-nitropyridine THF (100 mL) was cooled to-78 °C and anhydrous NH3 (-200 mL) was condensed into the THF. Potassium t-butoxid (45.5 g, 405 mmol) was added and the mixture was allowed to warm to--35 °C. <strong>[31872-62-5]4-Methoxy-3-nitropyridine</strong> (25.0 g, 162 mmol) was cooled to 0 °C in THF (200 mL) and a solution of t-BuOOH (5 M in decane, 34 mL, 170 mmol) was added over 10 min. This solution was then added dropwise to the KOt-Bu solution over 1 h, then stirred for 2 h at-35 °C and then carefully quenched with-50 mL of sat. NH4C1 solution. The mixture was allowed to vent and warm to rt overnight, then the organics were concentrated and the residue made acidic with NH4C1 solution and filtered. The solid was washed with cold H20 and dried to give the title compound as a tan solid (14.0 g, 51percent).
90 g	With tert.-butylhydroperoxide; potassium tert-butylate; ammonia; In tetrahydrofuran; at -30 - -25℃; for 1h;	Example 1 Preparation of 2-hydroxy-4-methoxy-5-nitro pyridine(4-methoxy-5-nitropyridin-2-ol) Charged ammonia gas at -70° C. to a solution of THF (1800 ml). After achieving 1.0 Kg, stopped the gas flow. Charged potassium tert butoxide (182 gms). Temperature was raised to -30° C., charged a solution of <strong>[31872-62-5]4-methoxy-3-nitro pyridine</strong> (100 g) dissolved in THF (250 ml) and tert butyl hydro peroxide (144 ml) to the above mixture at -30 to -25° C. After addition, continued the reaction for 1.0 hr. Saturated ammonium chloride solution (450 ml) was cautiously added and the mixture was allowed to warm to room temperature. The ammonia was evaporated and the residue diluted with water (500 mL). The resulting solid was collected, washed with water and dried to give 2-hydroxy-4-methoxy-5-nitro pyridine(4-methoxy-5-nitropyridin-2-ol) (90.0 g).

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4-Methoxy-5-nitropyridin-2(1H)-one

CAS No.: 607373-82-0

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Product Details of [ 607373-82-0 ]

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Application In Synthesis [ 607373-82-0 ]

[ 607373-82-0 ] Synthesis Path-Downstream 1~1

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H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
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H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
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H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
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H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed