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Chemical Structure| 58584-83-1 Chemical Structure| 58584-83-1

Structure of 58584-83-1

Chemical Structure| 58584-83-1

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Product Details of [ 58584-83-1 ]

CAS No. :58584-83-1
Formula : C6H2Cl3NO
M.W : 210.45
SMILES Code : O=C(C1=CC=C(Cl)N=C1Cl)Cl
MDL No. :MFCD11656165

Safety of [ 58584-83-1 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:3261
Packing Group:

Application In Synthesis of [ 58584-83-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 58584-83-1 ]

[ 58584-83-1 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 58584-83-1 ]
  • [ 55304-90-0 ]
YieldReaction ConditionsOperation in experiment
(2,6-dichloropyridin-3-yl)methanolTo a solution of 2,6-dichloronicotinic acid (1Og) in MeOH (300 mL) was added oxalyl chloride (5.5 mL) dropwise at O0C. The mixture was heated to 6O0C for a couple of hours until reaction complete. Upon concentration, the residue was dissolved in ether and added lithium aluminum hydride (2.3 g) slowly at O0C. The reaction was stirred at O0C for Ih and added water (2.3 mL) dropwise to quench excess lithium aluminum hydride. The resulting mixture was added 15% NaOH (2.3 mL) slowly, water (6.9 mL) and stirred at O0C for an additional Ih. The slush solution was filtered through celite and washed with ether. The filtrate was concentrated to give the title compound (6.5 g).1H NMR (CDCl3) delta : 7.90 ( d, 1 H)5 7.33 (d, 1 H), 4.79 (s, 2 H).
  • 2
  • [ 58584-83-1 ]
  • [ 1138549-36-6 ]
  • 3
  • [ 35216-39-8 ]
  • [ 58584-83-1 ]
  • 6-chloro-2-(4-fluoro-2-methoxyphenoxy)-N-(3-methylsulfonylphenyl)pyridine-3-carboxamide [ No CAS ]
  • 4
  • [ 35216-39-8 ]
  • [ 58584-83-1 ]
  • 2,6-dichloro-N-(3-methylsulfonylphenyl)pyridine-3-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
378 mg With N-ethyl-N,N-diisopropylamine; In chloroform; at 20℃; for 24h; A mixture of 2,6-dichloropyridine-3-carbonyl chloride (200 mg, 0.950 mmol), 3-methylsulfonylaniline (179 mg, 1.05 mmol) and DIPEA (414 pL, 2.38 mmol) in chloroform (5 mL) was stirred at room temperature for 24 h. The contents were treated with 10% Na2C03, extracted with CHCb (3x) and the solvent removed in vacuo to give 2,6-dichloro-N-(3-methylsulfonylphenyl)pyridine-3-carboxamide (378 mg, 1.10 mmol, 115 % yield) as a yellow foam, which was used without further purification.. MS, ES+ m/z 344.9 [M+H]+.
 

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