Structure of 5765-65-1
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
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Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
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CAS No. : | 5765-65-1 |
Formula : | C11H13NO3 |
M.W : | 207.23 |
SMILES Code : | O=C(ON1CCOCC1)C2=CC=CC=C2 |
MDL No. : | MFCD09032166 |
InChI Key : | ZTURCWOWVLVNPE-UHFFFAOYSA-N |
Pubchem ID : | 11252758 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
96% | With norbornene; palladium diacetate; caesium carbonate; triphenylphosphine; In 1,4-dioxane; at 100℃; for 18h;Inert atmosphere; Schlenk technique; | In a dry 25 mL Schlenk reaction tube, add 109 mg of o-methyliodobenzene, 114 mg of benzoyloxymorpholine, 96 mg of 2-methyl-4-phenyl-3-butyn-2-ol,11mg of palladium acetate, 26mg of triphenylphosphine, 94mg of norbornene,489mg of cesium carbonate and 2.5mL of 1,4-dioxane. Under the protection of nitrogen,Stir at 100 C for 18 hours. After the reaction, cool to room temperature,Directly through the silica gel column (the body of ethyl acetate and petroleum ether(Product ratio is 1:30), to obtain 133mg of product, yield 96%, |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
40% | With norborn-2-ene; trifuran-2-yl-phosphane; caesium carbonate; palladium dichloride; In toluene; at 80℃; for 24h;Inert atmosphere; | Palladium chloride 0.01mmol, tris(2-furyl)phosphine 0.025mmol, norbornene 0.2mmol, cesium carbonate 0.25mmol, <strong>[103962-05-6]1-iodo-4-(trifluoromethoxy)benzene</strong> 0.1mmol, morpholin-4-yl benzoate Add 0.2 mmol of allyl acetate, and 1 mL of toluene into a 15 mL reaction tube, fill it with nitrogen repeatedly 10 times, place it in an oil bath at 80C, and react for 24 hours; cool to room temperature, filter, concentrate, and thin-layer chromatography 17.3mg of the target product was obtained through purification, with a yield of 40%. |
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