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Chemical Structure| 5312-73-2 Chemical Structure| 5312-73-2

Structure of 5312-73-2

Chemical Structure| 5312-73-2

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Product Details of [ 5312-73-2 ]

CAS No. :5312-73-2
Formula : C5H10Cl2O
M.W : 157.04
SMILES Code : ClC(OCCCC)Cl
MDL No. :MFCD00191420

Safety of [ 5312-73-2 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H315-H319-H225
Precautionary Statements:P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P403+P235
Class:3
UN#:1993
Packing Group:

Application In Synthesis of [ 5312-73-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5312-73-2 ]

[ 5312-73-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 638-02-8 ]
  • [ 5312-73-2 ]
  • [ 26421-44-3 ]
  • 2
  • [ 459-60-9 ]
  • [ 5312-73-2 ]
  • [ 19415-51-1 ]
YieldReaction ConditionsOperation in experiment
86% With iron(III) chloride; In dichloromethane; at 20℃; for 0.533333h;Cooling with ice; 2d (2.12 g, 13.5 mmol) was added to a mixture of 3b (1.27 g, 10.1 mmol) and FeCl3 (2.10 g, 12.9 mmol) in CH2Cl2 (5mL) over a period of 2 min with cooling in an ice bath. The mixture was stirred at room temperature for 0.5 h, and then poured into EtOAc-H2O. 5-Fluoro-2-methoxybenzaldehyde (4b) was obtained in quantitative yield (1.54 g). GC-MS: m/z = 154 (M+, 65%), 153 (21%), 137 (28%), 136 (34%), 108 (49%), 95 (67%), 83 (100%). A portion of the product was purified by bulb-to-bulb distillation (150C, 1 torr) and was recovered in 86% yield as a colorless liquid. 1H-NMR (300MHz,CDCl3) delta: 3.92 (s, 3H), 6.96 (dd, J =8.7, 3.6 Hz, 1H), 7.23-7.29 (m, 1H), 7.49 (dd, J =8.4, 3.0 Hz, 1H), 10.41 (d, J =3.0 Hz, 1H). 13C-NMR (75MHz, CDCl3) delta: 188.63, 158.38, 156.64 (d, J =217.7 Hz), 125.35 (d, J =5.5 Hz), 122.39 (d, J =23.4 Hz), 113.89 (d, J =23.4 Hz), 113.12 (d, J =7.4 Hz), 56.09. The NMR spectroscopic data matched those previously reported. 24)
 

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