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Chemical Structure| 517-23-7 Chemical Structure| 517-23-7
Chemical Structure| 517-23-7

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Product Details of 2-Acetylbutyrolactone

CAS No. :517-23-7
Formula : C6H8O3
M.W : 128.13
SMILES Code : O=C1OCCC1C(C)=O
MDL No. :MFCD00005394
InChI Key :OMQHDIHZSDEIFH-UHFFFAOYSA-N
Pubchem ID :10601

Safety of 2-Acetylbutyrolactone

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 2-Acetylbutyrolactone

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 517-23-7 ]

[ 517-23-7 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 517-23-7 ]
  • [ 17356-08-0 ]
  • [ 21585-16-0 ]
YieldReaction ConditionsOperation in experiment
56% To a solution of sodium (55.6 g, 2.4 mol) in ethanol (1000 ml) was added slowly 2-acetylbutyrolactone 155 g, 1.2 mol) after which thiourea (128 g, 1.65 mol) was added in small portions. The mixture was heated under reflux for 16 h, then concentrated, water (800 ml) was added and acidified slowly with concentrated hydrochloric acid (200 ml). The precipitate was collected and washed with water, isopropyl alcohol and petroleum ether. Yield 125 g (56%) of a white solid.
  • 2
  • [ 517-23-7 ]
  • [ 4922-98-9 ]
  • [ 74258-83-6 ]
  • 3
  • [ 517-23-7 ]
  • [ 10167-97-2 ]
  • [ 108-88-3 ]
  • 3-(2-chloroethyl)-7-methoxy-2-methyl-4H-pyrido[1,2-a]-pyrimidin-4-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
10 parts (30.4%) With ammonium hydroxide; trichlorophosphate; In hexane; ethyl acetate; a) A mixture of 17 parts of 5-methoxy-2-pyridinamine, 61 parts of phosphoryl chloride and 348 parts of methylbenzene was stirred for 2 hours at 60° C. 18 Parts of 3-acetyl-4,5-dihydro-2(3H)-furanone were added and the reaction mixture was stirred overnight at 90° C. The whole was poured into crushed ice and treated with ammonium hydroxide. The product was extracted with trichloromethane. The extract was dried, filtered and evaporated. The residue was stirred in a mixture of hexane and ethyl acetate (50:50 by volume). The precipitated product was filtered off and dried, yielding 10 parts (30.4percent) of 3-(2-chloroethyl)-7-methoxy-2-methyl-4H-pyrido-[1,2-a]pyrimidin-4-one; mp. 150° C. (intermediate 3)
 

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