21585-16-0|5-(2-Hydroxyethyl)-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one| Ambeed

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Quality Control of [ 21585-16-0 ] Purity: 97% SDS Specification

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Product Details of [ 21585-16-0 ]

CAS No. :	21585-16-0
Formula :	C₇H₁₀N₂O₂S
M.W :	186.23
SMILES Code :	O=C(C(CCO)=C(C)N1)NC1=S
MDL No. :	MFCD01316114
InChI Key :	ADOJVBUVXRZBHE-UHFFFAOYSA-N
Pubchem ID :	1511006

Safety of [ 21585-16-0 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 21585-16-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 21585-16-0 ]

[ 21585-16-0 ] Synthesis Path-Downstream 1~14

1
[ 517-23-7 ]
[ 17356-08-0 ]
[ 21585-16-0 ]

Yield	Reaction Conditions	Operation in experiment
56%		To a solution of sodium (55.6 g, 2.4 mol) in ethanol (1000 ml) was added slowly 2-acetylbutyrolactone 155 g, 1.2 mol) after which thiourea (128 g, 1.65 mol) was added in small portions. The mixture was heated under reflux for 16 h, then concentrated, water (800 ml) was added and acidified slowly with concentrated hydrochloric acid (200 ml). The precipitate was collected and washed with water, isopropyl alcohol and petroleum ether. Yield 125 g (56%) of a white solid.

References: [1]Patent: US2006/122206,2006,A1 .Location in patent: Page/Page column 4.
[2]Tanabe seiyaku kenkyu nenpo = Annual report of Gohei Tanabe Co.,1958,vol. 3,p. 4,7.
Chem.Abstr.,1958,p. 20183.

2
[ 21585-16-0 ]
[ 74-88-4 ]
[ 98489-83-9 ]

Yield	Reaction Conditions	Operation in experiment
64%	With sodium hydride; In N,N-dimethyl-formamide; at 30.0℃; for 2.0h;	To a suspension of <strong>[21585-16-0]2-thio-5-(2-hydroxyethyl)-6-methyluracil</strong> (50 g, 0.26 mol) in DMF (320 ml) was added slowly one equivalent of sodium hydride. Next was added slowly one equivalent of methyl iodide (16.6 ml). The mixture was stirred for two hours at 30 C., after which water (800 ml) was added. The precipitate was collected and washed with water, isopropyl alcohol and petroleum ether. Yield 34.4 g (64%).

3
[ 21585-16-0 ]
[ 89943-37-3 ]

References: [1]Tanabe seiyaku kenkyu nenpo = Annual report of Gohei Tanabe Co.,1958,vol. 3,p. 4,8.
Chem.Abstr.,1958,p. 20183.

4
[ 21585-16-0 ]
[ 23935-66-2 ]

References: [1]Tanabe seiyaku kenkyu nenpo = Annual report of Gohei Tanabe Co.,1958,vol. 3,p. 4,8.
Chem.Abstr.,1958,p. 20183.

5
[ 86351-01-1 ]
[ 17356-08-0 ]
[ 21585-16-0 ]

References: [1]Tanabe seiyaku kenkyu nenpo = Annual report of Gohei Tanabe Co.,1958,vol. 3,p. 4,7.
Chem.Abstr.,1958,p. 20183.

6
[ 21585-16-0 ]
[ 108-24-7 ]
[ 78831-55-7 ]