51586-20-0|2,3-Dimethylbenzylamine| Ambeed

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Quality Control of [ 51586-20-0 ] Purity: 98% SDS Specification

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Product Details of [ 51586-20-0 ]

CAS No. :	51586-20-0
Formula :	C₉H₁₃N
M.W :	135.21
SMILES Code :	NCC1=CC=CC(C)=C1C
MDL No. :	MFCD00052680
Boiling Point :	No data available
InChI Key :	UKLRWOHZBISUMI-UHFFFAOYSA-N
Pubchem ID :	2800811

Safety of [ 51586-20-0 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of [ 51586-20-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 51586-20-0 ]

[ 51586-20-0 ] Synthesis Path-Downstream 1~36

1
[ 111-85-3 ]
[ 51586-20-0 ]
[ 959-55-7 ]

References: [1]Chemische Berichte,1940,vol. 73,p. 1007.

2
[ 5724-56-1 ]
[ 51586-20-0 ]

References: [1]Chemische Berichte,1959,vol. 92,p. 1662,1664.
[2]Hoppe-Seyler's Zeitschrift fur Physiologische Chemie,1965,vol. 343,p. 52 - 60.
[3]Journal of medicinal chemistry,1973,vol. 16,p. 101 - 106.

3
[ 51586-20-0 ]
[ 13651-14-4 ]

References: [1]Chemische Berichte,1959,vol. 92,p. 1662,1664.

4
[ 51586-20-0 ]
[ 99-73-0 ]
[ 78500-95-5 ]

References: [1]Journal of the Chemical Society,1930,p. 2107,2112.

5
[ 109-83-1 ]
[ 51586-20-0 ]
[ 74787-87-4 ]

References: [1]European Journal of Medicinal Chemistry,1980,vol. 15,p. 41 - 53.

6
[ 51586-20-0 ]
[ 15761-39-4 ]
[ 143060-31-5 ]
1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid 2,3-dimethyl-benzylamide [ No CAS ]

References: [1]Journal of Medicinal Chemistry,1998,vol. 41,p. 1011 - 1013.

7
[ 51586-20-0 ]
2-bromo-1-<2-nitro-phenyl>-ethanone-(1) [ No CAS ]
benzyl-dimethyl-(2-nitro-phenacyl)-ammonium; bromide [ No CAS ]

References: [1]Journal of the Chemical Society,1932,p. 1926,1929.

8
[ 51586-20-0 ]
(3'-chlorocarbonyl-biphenyl-4-sulfonyl)-acetic acid methyl ester [ No CAS ]
[3'-(2,3-dimethyl-benzylcarbamoyl)-biphenyl-4-sulfonyl]-acetic acid methyl ester [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2004,vol. 47,p. 18 - 21.

9
[ 51586-20-0 ]
[3-tert-butoxycarbonylmethyl-2-(2,4-dichloro-phenyl)-4-oxo-thiazolidin-5-yl]-acetic acid [ No CAS ]
{2-(2,4-dichloro-phenyl)-5-[(2,3-dimethyl-benzylcarbamoyl)-methyl]-4-oxo-thiazolidin-3-yl}-acetic acid tert-butyl ester [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2004,vol. 14,p. 1619 - 1624.

10
[ 51586-20-0 ]
(S)-1-[(S)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid [ No CAS ]
((S)-1-{(S)-1-[(S)-2-(2,3-Dimethyl-benzylcarbamoyl)-pyrrolidine-1-carbonyl]-2-methyl-propylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2004,vol. 47,p. 4417 - 4426.

11
[ 51586-20-0 ]
[(3S,5S)-1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-5-(2,4-dichloro-phenyl)-2-oxo-pyrrolidin-3-yl]-acetic acid [ No CAS ]
2-[1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-(2,4-dichloro-phenyl)-2-oxo-pyrrolidin-3-yl]-N-(2,3-dimethyl-benzyl)-acetamide [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2004,vol. 14,p. 5537 - 5542.

12
[ 51586-20-0 ]
[(3S,5S)-1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-5-(2,4-difluoro-phenyl)-2-oxo-pyrrolidin-3-yl]-acetic acid [ No CAS ]
2-[1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-(2,4-difluoro-phenyl)-2-oxo-pyrrolidin-3-yl]-N-(2,3-dimethyl-benzyl)-acetamide [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2004,vol. 14,p. 5537 - 5542.

13
[ 6068-70-8 ]
[ 51586-20-0 ]
N-(2,3-dimethyl-benzyl)-2,2,2-triphenyl-acetamide [ No CAS ]

References: [1]Journal of the American Chemical Society,2005,vol. 127,p. 8686 - 8696.

14
[ 33166-49-3 ]
[ 51586-20-0 ]
N-(2,3-dimethyl-benzyl)-3,3,3-triphenyl-propionamide [ No CAS ]

References: [1]Journal of the American Chemical Society,2005,vol. 127,p. 8686 - 8696.

15
[ 98027-74-8 ]
[ 51586-20-0 ]
(2,3-dimethyl-benzyl)-(5-nitro-4-thiocyanato-pyrimidin-2-yl)-amine [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2007,vol. 17,p. 225 - 230.

16
[ 1001390-60-8 ]
[ 51586-20-0 ]
[ 1001389-71-4 ]

Yield	Reaction Conditions	Operation in experiment
	With N-ethylmorpholine;; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;	Example 50 N-[(2,3-dimethylphenyl)methyl]-1-ethyl-5-oxoprolinamide (E50) 1-ethyl-5-oxoproline (0.080 g, 0.51 mmol, prepared in an analogous manner to that described for example 12, method A) was dissolved in dichloromethane (5 ml) and to this was added N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (0.117 g, 0.61 mmol), N-ethyl morpholine (0.195 ml, 1.53 mmol), and 2,3-dimethyl benzylamine (0.082 g, 0.61 mmol). The mixture was stirred for ~17 hrs and then left to stand over the weekend. The mixture was then treated with saturated aqueous sodium hydrogen carbonate (~3 ml) and stirred vigorously for ~10 minutes. The organic layer was separated using a hydrophobic frit and the aqueous layer was extracted with more dichloromethane (~2 ml). The combined organic layers were concentrated to give a yellow oil (~0.2 g). This was purified further by mass-directed automated HPLC to give pure N-[(2,3-dimethylphenyl)methyl]-1-ethyl-5-oxoprolinamide (0.072 g) as white solid. LC/MS [M+H]+=275, retention time=2.12 minutes.

References: [1]Patent: US2008/9541,2008,A1 .Location in patent: Page/Page column 27.

17
[ 51586-20-0 ]
{(3R,5R)-5-(2,4-Dichloro-phenyl)-3-[(2,3-dimethyl-benzylcarbamoyl)-methyl]-2-oxo-pyrrolidin-1-yl}-acetic acid [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2004,vol. 14,p. 5537 - 5542.

18
[ 51586-20-0 ]
{(3R,5R)-5-(2,4-Difluoro-phenyl)-3-[(2,3-dimethyl-benzylcarbamoyl)-methyl]-2-oxo-pyrrolidin-1-yl}-acetic acid [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2004,vol. 14,p. 5537 - 5542.

19
[ 51586-20-0 ]
2-{(3R,5R)-5-(2,4-Dichloro-phenyl)-3-[(2,3-dimethyl-benzylcarbamoyl)-methyl]-2-oxo-pyrrolidin-1-yl}-N-(3-morpholin-4-yl-propyl)-acetamide [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2004,vol. 14,p. 5537 - 5542.

20
[ 51586-20-0 ]
2-{(3R,5R)-5-(2,4-Difluoro-phenyl)-3-[(2,3-dimethyl-benzylcarbamoyl)-methyl]-2-oxo-pyrrolidin-1-yl}-N-(3-morpholin-4-yl-propyl)-acetamide [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2004,vol. 14,p. 5537 - 5542.

21
[ 51586-20-0 ]
2-[3'-(2,3-dimethylbenzylcarbamoyl)biphenyl-4-sulfonyl]acetic acid sodium salt [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2004,vol. 47,p. 18 - 21.

22
[ 51586-20-0 ]
[ 13651-55-3 ]

References: [1]Chemische Berichte,1959,vol. 92,p. 1662,1664.

23
[ 51586-20-0 ]
[ 107772-25-8 ]

References: [1]Chemische Berichte,1959,vol. 92,p. 1662,1664.

24
[ 51586-20-0 ]
[ 101499-45-0 ]

References: [1]Chemische Berichte,1959,vol. 92,p. 1662,1664.

25
[ 51586-20-0 ]
[ 110150-06-6 ]

References: [1]Chemische Berichte,1959,vol. 92,p. 1662,1664.

26
[ 904309-78-0 ]
[ 51586-20-0 ]
[ 904310-71-0 ]

Yield	Reaction Conditions	Operation in experiment
	With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In ISOPROPYLAMIDE; at 20℃; for 24h;	In a 20 mL scintillation vial, 4-amino-5-cyano-6-ethoxy-pyrindine-2-carboxylic acid (19 mg, 0.09 mmol) was dissolved in DMA (0.7 mL). Then TBTU (30 mg, 0.09 mmol) dissolved in DMA (0.7 mL) was added, followed by the addition of 2,3-Dimethylbenzylamine (14 mg, 0.11 mmol, 1.2 eq.) in DMA (0.6 mL). Then TEA (9.37 mg, 0.09 mmol) dissolved in DMA (0.7 mL) was added. The mixture was shaken at room temperature for 24 hours. The crude mixture was purified using reverse phase HPLC (TFA). 1H NMR (500 MHz, DMSO-D6/D2O) δ ppm 1.31 (t, 3H) 2.17-2.22 (m, 3H) 2.24-2.28 (m, 3H) 4.30-4.57 (m, 4H) 6.82-7.22 (m, 4H) 8.86 (t, 1H). MS (ESI) positive ion 325 (M+H)+; negative ion 323(M-H)-.

References: [1]Patent: US2006/173050,2006,A1 .Location in patent: Page/Page column 58.

27
[ 403850-66-8 ]
[ 51586-20-0 ]
[ 581066-24-2 ]

Yield	Reaction Conditions	Operation in experiment
		Example 17 In analogy to example 1, on reaction of 7-iodo-2-methyl-4-pyrrolidin-1-yl-quinoline with <strong>[51586-20-0]2,3-dimethylbenzylamine</strong> there was obtained: (2,3-dimethyl-benzyl)-(2-methyl-4-pyrrolidin-1-yl-quinolin-7-yl)-amine as light brown foam. ISP mass spectrum, m/e: 346.4 (M+1 calculated for C23H27F3N3: 346).

References: [1]Patent: US2003/153553,2003,A1 .

28
[ 317364-83-3 ]
[ 51586-20-0 ]
[ 317823-68-0 ]

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE 3 2-[(S)-1-Phenylethyl-N-methylamino]-4-[benzimidazol-1-yl]pyrimidine 2-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine was reacted with (S)-N-α-dimethylbenzylamine according to the procedure described in EXAMPLE 1, Step C to afford the title compound. Mass Spectrum (ESI): m/e 330.2 (M+1). 1H NMR (500 MHz, CD3OD): δ 8.89 (s, 1H); 8.48 (d, J=5.5 Hz, 1H); 8.28 (br s, 1H); 7.73 (m, 1H); 7.36 (m, 6H); 7.25 (m, 1H); 7.04 (d, J=5.5 Hz, 1H); 6.28 (m, 1H); 2.98 (s, 3H); 1.66 (d, J=7.1 Hz, 3H).

References: [1]Patent: US6498165,2002,B1 .

29
[ 120-57-0 ]
[ 51586-20-0 ]
[ 56-40-6 ]
2-acetamido-3,4-methylenedioxycinnamic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
65%	With acetic anhydride; In water;	EXAMPLE 6 A mixture of 225 grams (1.5 moles) of 3,4-methylenedioxybenzaldehyde, 75 grams (1.0 mole) of glycine, 357 grams (3.5 moles) of acetic anhydride and 135 grams (1.0 mole) of N, N-dimethylbenzylamine were heated and first held for 3 hours at the reflux temperature and then after the addition of 1800 ml of water held at reflux for a further 1.5 hours. There were recovered 162 grams of 2-acetamido-3,4-methylenedioxycinnamic acid, corresponding to a yield of 65% based on the glycine added.

References: [1]Patent: US4254035,1981,A .

30
[ 51586-20-0 ]
[ 79-22-1 ]
3-acetoxymethyl-7-aminoceph-3-em-4-carboxylic acid [ No CAS ]
[ 64420-27-5 ]
3-[(Acetyloxy)methyl]-7β-[[[[[(2,4-dioxo-1-imidazolidinyl)-amino]carbonyl]amino]phenylacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With bis-(trimethylsilyl)acetamide; In water; ethyl acetate; acetonitrile;	3-[(acetyloxy)methyl]-7β-[[DL-[[[(2,4-dioxo-1-imidazolidinyl)-amino]carbonyl]amino]phenylacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 2.72 g. (0.01 mol.) of 7-aminocephalosporanic acid are suspended in 30 ml. of anhydrous acetonitrile, 4.8 ml. of bis(trimethylsilyl)acetamide are added and the suspension is stirred until a clear solution results (solution A). 3.01 g. (0.01 mol.) of DL-α-[[[(2,4-dioxo-1-imidazolidinyl)amino]carbonyl]amino]benzeneacetic acid are added to 30 ml. of anhydrous acetonitrile and 1.35 g (0.01 mol.) of N-dimethylbenzylamine are added at room temperature. A viscous mass results which, on cooling, solidifies and divides. This is then added to 0.011 mol. of methyl chloroformate at -10. The salt goes into solution with slight turbidity. To this solution A is added dropwise over a period of 10 minutes at -10. The mixture becomes very turbid. This is stirred for 90 minutes whereupon the temperature slowly rises to 3. 30 ml. of water are added, the mixture is stirred for 5 minutes and then 200 ml. of ethylacetate are added. By the addition of slightly dilute hydrochloric acid the pH is adjusted to 2. The layers are separated, the aqueous phase is extracted once with ethylacetate and the ethylacetate extracts are combined, then washed with water, dried with magnesium sulfate and concentrated in vacuum.

References: [1]Patent: US4063019,1977,A .

31
[ 1943-83-5 ]
[ 51586-20-0 ]
((2,3-dimethylphenyl)methyl)(1,3-oxazolin-2-yl)amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE 1; EPO <DP n="33"/>This example illustrates one protocol for the preparation of ((2,3- dimethylphenyl)methyl)-l,3-oxazolin-2-ylamine (Compound A25) A mixture of 1.0 gram (0.0074 mole) of <strong>[51586-20-0]2,3-dimethylbenzylamine</strong> and 0.69 gram (0.0081 mole) of 2-chloroethylisocyanate in 10 mL of 1,4-dioxane was heated to reflux where it stirred for about 18 hours. The reaction mixture was allowed to cool and an aqueous solution of sodium hydroxide (4.0 mL of a 3.0 molar solution) was added. The reaction mixture was heated to reflux for about 18 hours then allowed to cool to ambient temperature. The reaction mixture was concentrated under reduced pressure to leave a viscous oil residue. The residue was suspended in 50 mL of ethyl acetate and washed with 20 mL of water. The organic phase was extracted with 20 mL of 3.0 molar aqueous hydrochloric acid. The aqueous extract was made basic by adding 3.0 molar aqueous sodium hydroxide and the basic mixture was extracted with 50 mL of ethyl acetate. The extract was dried with sodium sulfate, filtered and the filtrate concentrated under reduced pressure to yield 0.81 gram of the title compound as an oil. The NMR spectrum was consistent with the proposed structure.

References: [1]Patent: WO2006/127426,2006,A2 .Location in patent: Page/Page column 31-32.

32
[ 51586-20-0 ]
[ 6099-88-3 ]
[ 915153-44-5 ]

Yield	Reaction Conditions	Operation in experiment
	In 1,4-dioxane; at 80℃; for 18h;	EXAMPLE 4; This example illustrates one protocol for the preparation of ((2,3- dimethylphenyl)methyl)-l,3-thiazolin-2-ylamine hydrochloride (Compound Cl 1),((2,3-dimethylphenyl)methyl)-l,3-thiazolin-2-ylamine (Compound C66), methyl 2-(l-aza-2-(2,3-dimethylphenyl)ethylidene)-l,3-thiazolidine-3-carboxylate EPO <DP n="35"/>(Compound C53) and N-((2,3-dimethylphenyl)methyl)methoxy-N-(l,3-thiazolin-2- yl)carboxamide (Compound D5) Step A; Synthesis of ((2,3-dimethylphenyl)methyl)- 1 ,3-thiazolin-2-ylamine hydrochloride (Compound CI l); Under a dry nitrogen atmosphere, a stirred mixture of 5.56 grams (0.041 mole) of <strong>[51586-20-0]2,3-dimethylbenzylamine</strong> and 5.0 grams (0.041 mole) of 2- chloroethylisothiocyanate in 100 mL of 1,4-dioxane was heated to 80 0C where it stirred for about 18 hours. The reaction mixture was allowed to cool and a solid precipitate that had formed was collected by filtration. The solid was rinsed with diethyl ether and was dried under reduced pressure to yield 8.0 grams of the title compound. The NMR spectrum was consistent with the proposed structure.

References: [1]Patent: WO2006/127426,2006,A2 .Location in patent: Page/Page column 33-34.

33
[ 51586-20-0 ]
[ 936219-10-2 ]

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE 8 3-(2,3-dichlorophenyl)-4-(2,3-dimethylbenzyl)-4H-1,2,4-triazole The title compound was prepared using the procedure as described in Example 1D substituting <strong>[51586-20-0]2,3-dimethylbenzylamine</strong> for benzylamine. The residue was purified by preparative HPLC on a Waters Symmetry C8 column (25 mm*100 mm, 7 μm particle size) using a gradient of 10% to 100% acetonitrile:0.1% aqueous trifluoroacetic acid over 8 minutes (10 minute run time) at a flow rate of 40 mL/minute. MS (ESI) m/z 332 (M+H)+; 1H NMR (DMSO-d6) δ 1.92 (s, 3H), 2.16 (s, 3H), 5.15 (s, 2H), 6.54 (d, 1H), 6.90 (t, 1H), 7.05 (d, 1H), 7.37 (dd, 1H), 7.42 (t, 1H), 7.79 (dd, 1H), 8.66 (s, 1H).

References: [1]Patent: US2007/105842,2007,A1 .Location in patent: Page/Page column 16.

34
[ 1028338-59-1 ]
[ 51586-20-0 ]
[ 1028337-05-4 ]

Yield	Reaction Conditions	Operation in experiment
23.6%	With sodium t-butanolate;tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In ISOPROPYLAMIDE; at 80℃; for 1h;	Example 106: 4-Chloro-6-(2,3-dimethyl-benzylamino)-2H-phthalazin-l-one; A mixture 6-bromo-4-chloro-2H-phthalazin-l-one (150 mg, 0.58 mmol), 2,3- dimethyl-benzylamine (87 mg, 0.64 mmol), Pd2(dba)3 (53 mg, 0.058 mmol), rac-BINAP ( 132 mg, 0.17 mmol) and NaOf-Bu ( 140 mg, 1.45 mmol) in DMA (6 mL) was heated at 8O0C for Ih. The mixture was allowed to cool, diluted with EtOAc (25 mL) and washed with water (25 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated. Chromatography on silica (EtOAc/hexanes) yielded the title compound. 4- Chloro-6-(2,3-dimethyl-benzylamino)-2H-phthalazin-l-one: 43 mg (23.6%): m/z (M+η)=314. 1H-NMR (DMSO-^) δ: 12.34 (s,lH), 7.92 (d,lH), 7.44 (m,lH), 7.10 (m,4H), 6.85 (s,lH), 4.36 (d,2H), 2.62 (s,3H), 2.22 (s,3H).

References: [1]Patent: WO2008/61108,2008,A2 .Location in patent: Page/Page column 93.

35
[ 936220-67-6 ]
[ 51586-20-0 ]
[ 1024003-55-1 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2008,vol. 18,p. 2089 - 2092.

36
[ 89-93-0 ]
[ 2620-50-0 ]
[ 6068-70-8 ]
[ 5824-40-8 ]
[ 33166-49-3 ]
[ 51586-20-0 ]
[ 100-81-2 ]
[ 108-44-1 ]
[ 618-36-0 ]
[ 95-68-1 ]
[ 87-62-7 ]
[ 88-05-1 ]
[ 95-53-4 ]
[ 91-00-9 ]
2,2,2-triphenyl-N-m-tolyl-acetamide [ No CAS ]
2,2,2-triphenyl-N-(1-phenyl-ethyl)-acetamide [ No CAS ]
2,2,2-triphenyl-N-o-tolyl-acetamide [ No CAS ]
N-(3-methyl-benzyl)-2,2,2-triphenyl-acetamide [ No CAS ]
3,3,3-triphenyl-N-o-tolyl-propionamide [ No CAS ]
3,3,3-triphenyl-N-m-tolyl-propionamide [ No CAS ]
N-(2-methyl-benzyl)-2,2,2-triphenyl-acetamide [ No CAS ]
3,3,3-triphenyl-N-(1-phenyl-ethyl)-propionamide [ No CAS ]
N-(2,6-dimethyl-phenyl)-2,2,2-triphenyl-acetamide [ No CAS ]
N-(2,4-dimethyl-phenyl)-2,2,2-triphenyl-acetamide [ No CAS ]
N-(2,3-dimethyl-benzyl)-2,2,2-triphenyl-acetamide [ No CAS ]
N-(3-methyl-benzyl)-3,3,3-triphenyl-propionamide [ No CAS ]
N-(2,4-dimethyl-phenyl)-3,3,3-triphenyl-propionamide [ No CAS ]
N-(2-methyl-benzyl)-3,3,3-triphenyl-propionamide [ No CAS ]
N-benzhydryl-2,2,2-triphenyl-acetamide [ No CAS ]
N-(2,6-dimethyl-phenyl)-3,3,3-triphenyl-propionamide [ No CAS ]
2,2,2-triphenyl-N-(2,4,6-trimethyl-phenyl)-acetamide [ No CAS ]
N-(2,3-dimethyl-benzyl)-3,3,3-triphenyl-propionamide [ No CAS ]
N-benzo[1,3]dioxol-5-ylmethyl-2,2,2-triphenyl-acetamide [ No CAS ]
3,3,3-triphenyl-N-(2,4,6-trimethyl-phenyl)-propionamide [ No CAS ]
N-benzhydryl-3,3,3-triphenyl-propionamide [ No CAS ]
N-benzo[1,3]dioxol-5-ylmethyl-3,3,3-triphenyl-propionamide [ No CAS ]
C₃₉H₃₁NO [ No CAS ]
N-triphenylmethyl-3,3',3''-triphenylpropanamide [ No CAS ]

References: [1]Patent: WO2005/44191,2005,A2 .Location in patent: Figure 13.

Historical Records

Technical Information

• Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Chan-Lam Coupling Reaction • Hydride Reductions • Leuckart-Wallach Reaction • Mannich Reaction • Petasis Reaction • Preparation of Amines • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Specialized Acylation Reagents-Vilsmeier Reagent • Ugi Reaction

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P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
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P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 51586-20-0

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