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Chemical Structure| 1001390-60-8 Chemical Structure| 1001390-60-8

Structure of 1001390-60-8

Chemical Structure| 1001390-60-8

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Product Details of [ 1001390-60-8 ]

CAS No. :1001390-60-8
Formula : C7H11NO3
M.W : 157.17
SMILES Code : O=C(C(CC1)N(CC)C1=O)O
MDL No. :MFCD15730152

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Application In Synthesis of [ 1001390-60-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1001390-60-8 ]

[ 1001390-60-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1001390-60-8 ]
  • [ 51586-20-0 ]
  • [ 1001389-71-4 ]
YieldReaction ConditionsOperation in experiment
With N-ethylmorpholine;; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; Example 50 N-[(2,3-dimethylphenyl)methyl]-1-ethyl-5-oxoprolinamide (E50) 1-ethyl-5-oxoproline (0.080 g, 0.51 mmol, prepared in an analogous manner to that described for example 12, method A) was dissolved in dichloromethane (5 ml) and to this was added N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (0.117 g, 0.61 mmol), N-ethyl morpholine (0.195 ml, 1.53 mmol), and 2,3-dimethyl benzylamine (0.082 g, 0.61 mmol). The mixture was stirred for ~17 hrs and then left to stand over the weekend. The mixture was then treated with saturated aqueous sodium hydrogen carbonate (~3 ml) and stirred vigorously for ~10 minutes. The organic layer was separated using a hydrophobic frit and the aqueous layer was extracted with more dichloromethane (~2 ml). The combined organic layers were concentrated to give a yellow oil (~0.2 g). This was purified further by mass-directed automated HPLC to give pure N-[(2,3-dimethylphenyl)methyl]-1-ethyl-5-oxoprolinamide (0.072 g) as white solid. LC/MS [M+H]+=275, retention time=2.12 minutes.
 

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